DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG14838 and DYNC1I1

DIOPT Version :9

Sequence 1:NP_648138.1 Gene:CG14838 / 38851 FlyBaseID:FBgn0035799 Length:1132 Species:Drosophila melanogaster
Sequence 2:NP_004402.1 Gene:DYNC1I1 / 1780 HGNCID:2963 Length:645 Species:Homo sapiens


Alignment Length:675 Identity:133/675 - (19%)
Similarity:231/675 - (34%) Gaps:243/675 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   217 EPIDVEIQSVYPIQMPRHVAFDYRMTRDVRDGVLELLPNENIKWENVTKKRVNVSVQSAPPKIER 281
            :|..:::||...:....|.....::|:      ::.||.|.:.:                   .:
Human   129 DPSVLQLQSDSELGRRLHKLGVSKVTQ------VDFLPREVVSY-------------------SK 168

  Fly   282 EQQTNPTFPSNAWSQYLYEIDDEDLELDETDVD-----EEEEKKK--AQAKPGTYVEPEKKPPEM 339
            |.||       ..:.:..|.|:||.|:.|:.|.     |.::||:  .:|.|....|.||     
Human   169 ETQT-------PLATHQSEEDEEDEEMVESKVGQDSELENQDKKQEVKEAPPRELTEEEK----- 221

  Fly   340 SAQIEMLLNTLEFNQIDSYRDDYSLISSRQVVQ-------YTNPYLQE----FLCFANIS----- 388
                :.:|::.||.   .:.|....:..|.:.:       |:...|:|    ....||:|     
Human   222 ----QQILHSEEFL---IFFDRTIRVIERALAEDSDIFFDYSGRELEEKDGDVQAGANLSFNRQF 279

  Fly   389 ----KSNKRFVAGYDW---YPKLSGLIAVSYAFSTPATVNEATNRVDYVQRAVLEPNPV-LLWSF 445
                .|..|.|...||   ||:   |:..||           .|..|    |..||:.| |:|  
Human   280 YDEHWSKHRVVTCMDWSLQYPE---LMVASY-----------NNNED----APHEPDGVALVW-- 324

  Fly   446 SDNLNYK-----LEFEAPIETTALTFCPFNGDILLGGSKNGQVVLWDLQGRCEKLDEEEYLTAAQ 505
              |:.:|     ..|.......::.|..|:.::::||:.:||:||||.:.......:...|:||.
Human   325 --NMKFKKTTPEYVFHCQSSVMSVCFARFHPNLVVGGTYSGQIVLWDNRSHRRTPVQRTPLSAAA 387

  Fly   506 AKYRIMIGEFLNWTIDIEDNVIVPATISLLDCSPKGAITAFYWLGRSIYLSQFGKVYNDPDIRNH 570
            ..:.:.                         |                        .|....:|.
Human   388 HTHPVY-------------------------C------------------------VNVVGTQNA 403

  Fly   571 HKFFVTCAFDGTISFWDLDGKGGKSAKDKMRNRMLPKELTQSESAFKSMVIKPTYNLYFPEPITG 635
            |. .:|.:.||.:..|.||              ||.   |..||      ::..||...|..:||
Human   404 HN-LITVSTDGKMCSWSLD--------------MLS---TPQES------MELVYNKSKPVAVTG 444

  Fly   636 IIADTSCLSCLTPVAKLIQANPSNYPIKTIAKDPPTMRQSMIVSTFYGHVSRIDWQGTYTEGEAT 700
            :...|              .:.:|:.:.:         :...|.|...|.|:.. .|...||   
Human   445 MAFPT--------------GDVNNFVVGS---------EEGTVYTACRHGSKAG-IGEVFEG--- 482

  Fly   701 EVINSSIPFAMVHDGPVVMVK----KNPF-YPELF--ASIGRTILAIWKEDYNYSPIF-WRKRAC 757
                        |.|||..:.    ..|. :..||  :|...|: .:|...:| .|:: :...|.
Human   483 ------------HQGPVTGINCHMAVGPIDFSHLFVTSSFDWTV-KLWTTKHN-KPLYSFEDNAD 533

  Fly   758 DLTAVAWSETRPAVLYLTRIDGI--LEAWDILARDDDACLTEILGGGI----ITAITEHRPSLPH 816
            .:..|.||...||:  ...:||:  |:.|::   ::|   ||:....:    .:|:...|.:...
Human   534 YVYDVMWSPVHPAL--FACVDGMGRLDLWNL---NND---TEVPTASVAIEGASALNRVRWAQAG 590

  Fly   817 KILGIGDYNSSIRM-----VKLPHS 836
            |.:.:||....|.:     :.:||:
Human   591 KEVAVGDSEGRIWVYDVGELAVPHN 615

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG14838NP_648138.1 WD40 328..>599 CDD:225201 58/299 (19%)
WD40 repeat 462..505 CDD:293791 12/42 (29%)
WD40 repeat 510..547 CDD:293791 1/36 (3%)
RE_R_Pab1 807..>863 CDD:286594 7/35 (20%)
DYNC1I1NP_004402.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..58
Interaction with DCTN1. /evidence=ECO:0000250 2..123
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 95..125
Dynein_IC2 147..173 CDD:371592 7/57 (12%)
Interaction with DYNLT1. /evidence=ECO:0000269|PubMed:27502274 147..163 3/21 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 169..221 16/58 (28%)
WD40 283..606 CDD:392136 94/466 (20%)
WD 1 285..334 20/70 (29%)
WD40 repeat 291..337 CDD:293791 17/67 (25%)
WD 2 338..378 10/39 (26%)
WD40 repeat 346..385 CDD:293791 11/38 (29%)
WD 3 387..428 13/107 (12%)
WD40 repeat 393..434 CDD:293791 15/113 (13%)
WD 4 437..477 9/63 (14%)
WD40 repeat 442..481 CDD:293791 9/62 (15%)
WD 5 482..527 13/61 (21%)
WD40 repeat 488..529 CDD:293791 8/42 (19%)
WD 6 530..570 13/47 (28%)
WD40 repeat 535..573 CDD:293791 12/45 (27%)
WD 7 576..615 7/38 (18%)
WD40 repeat 581..607 CDD:293791 5/25 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1587
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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