DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14838 and Dync1i1

DIOPT Version :9

Sequence 1:	NP_648138.1	Gene:	CG14838 / 38851	FlyBaseID:	FBgn0035799	Length:	1132	Species:	Drosophila melanogaster
Sequence 2:	XP_006505045.1	Gene:	Dync1i1 / 13426	MGIID:	107743	Length:	645	Species:	Mus musculus

Alignment Length:	722	Identity:	136/722 - (18%)
Similarity:	244/722 - (33%)	Gaps:	258/722 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 EPIDVEIQSVYPIQMPRHVAFDYRMTRDVRDGVLELLPNENIKWENVTKKRVNVSVQSAPPKIER 281
            :|..:::||...:....|.....::|:      ::.||.|.:.:                   .:
Mouse   129 DPSVLQLQSDSELGRRLHKLGVSKVTQ------VDFLPREVVSY-------------------SK 168

  Fly   282 EQQTNPTFPSNAWSQYLYEIDDEDLELDETDVD-----EEEEKKK--AQAKPGTYVEPEKKPPEM 339
            |.||       ..:.:..|.|:||.|:.|..:.     |.:|||:  .:|.|....|.||
Mouse   169 ETQT-------PLATHQSEEDEEDEEMVEPKIGHDSELENQEKKQETKEAPPRELTEEEK----- 221

  Fly   340 SAQIEMLLNTLEFNQIDSYRDDYSLISSRQVVQ-------YTNPYLQE----FLCFANIS----- 388
                :.:|::.||.   .:.|....:..|.:.:       |:...|:|    ....||:|
Mouse   222 ----QQILHSEEFL---IFFDRTIRVIERALAEDSDIFFDYSGRELEEKDGDVQAGANLSFNRQF 279

  Fly   389 ----KSNKRFVAGYDW---YPKLSGLIAVSYAFSTPATVNEATNRVDYVQRAVLEPNPV-LLWSF 445
                .|..|.|...||   ||:   |:..||           :|..|    |..||:.| |:|
Mouse   280 YDEHWSKHRVVTCMDWSLQYPE---LMVASY-----------SNNED----APHEPDGVALVW-- 324

  Fly   446 SDNLNYK-----LEFEAPIETTALTFCPFNGDILLGGSKNGQVVLWDLQGRCEKLDEEEYLTAAQ 505
              |:.:|     ..|.......::.|..|:.::::||:.:||:||||.:.......:...|:||.
Mouse   325 --NMKFKKTTPEYVFHCQSSVMSVCFARFHPNLVVGGTYSGQIVLWDNRSHRRTPVQRTPLSAAA 387

  Fly   506 AKYRIMIGEFLNWTIDIEDNVIVPATISLLDCSPKGAITAFYWLGRSIYLSQFGKVYNDPDIRNH 570
            ..:.:.                         |                        .|....:|.
Mouse   388 HTHPVY-------------------------C------------------------VNVVGTQNA 403

  Fly   571 HKFFVTCAFDGTISFWDLDGKGGKSAKDKMRNRMLPKELTQSESAFKSMVIKPTYNLYFPEPITG 635
            |. .:|.:.||.:..|.||              ||.   |..||      ::..||...|..:||
Mouse   404 HN-LITVSTDGKMCSWSLD--------------MLS---TPQES------MELVYNKSKPVAVTG 444

  Fly   636 IIADTSCLSCLTPVAKLIQANPSNYPIKTIAKDPPTMRQSMIVSTFYGHVSRIDWQGTYTEGEAT 700
            :...|              .:.:|:.:.:         :...|.|...|.|:.. .|...||
Mouse   445 MAFPT--------------GDVNNFVVGS---------EEGTVYTACRHGSKAG-IGEVFEG--- 482

  Fly   701 EVINSSIPFAMVHDGPVVMVK----KNPF-YPELF--ASIGRTILAIWKEDYNYSPIF-WRKRAC 757
                        |.|||..:.    ..|. :..||  :|...|: .:|...:| .|:: :...|.
Mouse   483 ------------HQGPVTGINCHMAVGPIDFSHLFVTSSFDWTV-KLWTTKHN-KPLYSFEDNAD 533

  Fly   758 DLTAVAWSETRPAVLYLTRIDGI--LEAWDILARDDDACLTEILGGGIITAITEHRPSLPHKILG 820
            .:..|.||...||:  ...:||:  |:.|::.:..:....:..:.|.  :|:...|.:...|.:.
Mouse   534 YVYDVMWSPVHPAL--FACVDGMGRLDLWNLNSDTEVPTASVAIEGA--SALNRVRWAQGGKEVA 594

  Fly   821 IGDYNSSIRM-----VKLPHSFDVPLPNELDQLIKYVLKEERRKMGIQSWEQKYYELNKDIIEAK 880
            :||....|.:     :.:||:         |:..::.              :...|:..:..:::
Mouse   595 VGDSEGRIWIYDVGELAVPHN---------DEWTRFA--------------RTLVEIRANRADSE 636

  Fly   881 REAAAEI 887
            .|.|.|:
Mouse   637 EEGAVEL 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14838	NP_648138.1	WD40	328..>599	CDD:225201	58/299 (19%)
		WD40 repeat	462..505	CDD:293791	12/42 (29%)
		WD40 repeat	510..547	CDD:293791	1/36 (3%)
		RE_R_Pab1	807..>863	CDD:286594	8/60 (13%)
Dync1i1	XP_006505045.1	Dynein_IC2	147..173	CDD:371592	7/57 (12%)
		WD40	283..606	CDD:392136	92/462 (20%)
		WD40 repeat	291..337	CDD:293791	17/67 (25%)
		WD40 repeat	346..385	CDD:293791	11/38 (29%)
		WD40 repeat	393..434	CDD:293791	15/113 (13%)
		WD40 repeat	442..481	CDD:293791	9/62 (15%)
		WD40 repeat	488..529	CDD:293791	8/42 (19%)
		WD40 repeat	535..573	CDD:293791	9/39 (23%)
		WD40 repeat	581..607	CDD:293791	5/25 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810