DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14838 and Dync1i2

DIOPT Version :9

Sequence 1:	NP_648138.1	Gene:	CG14838 / 38851	FlyBaseID:	FBgn0035799	Length:	1132	Species:	Drosophila melanogaster
Sequence 2:	NP_446332.2	Gene:	Dync1i2 / 116659	RGDID:	620174	Length:	638	Species:	Rattus norvegicus

Alignment Length:	786	Identity:	147/786 - (18%)
Similarity:	263/786 - (33%)	Gaps:	253/786 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 KESKMAMSIIQNMEHFERWRMQRRLRKKPRRWVSHG-TDEEMTIMVERFKDEPIDVEIQSVYPIQ 230
            ::.:.|:|:.:..:      ::::.|:......|.| |.:...:..|.:...|:....:||   .
  Rat    39 QKKEAAVSVQEESD------LEKKRREAEALLQSMGLTTDSPIVFSEHWVPPPMSPSSKSV---S 94

  Fly   231 MPRHVAFDYRMTRDVRDGVLELLPNENIKWE---NVTKKRVNVSVQSAPPKIEREQQTNPTFPSN 292
            .|....     ::|..||.   :.:..:.|:   :..:...:..:...|.|:...:.|...||..
  Rat    95 TPSEAG-----SQDSGDGA---VGSRTLHWDTDPSALQLHSDSDLGRGPIKLGMAKITQVDFPPR 151

  Fly   293 AWSQYLYEIDDEDLELDETDV------DEEEEKKKAQAKPGTYVEPE-------------KKPPE 338
            ....|..|        .:|.|      |||||...|..||.  ||||             |.||.
  Rat   152 EIVTYTKE--------TQTPVTAQPKEDEEEEDDVAAPKPP--VEPEEEKILKKDEENDSKAPPH 206

  Fly   339 MSAQIE--MLLNTLEFNQIDSYRDDYSLISSRQVVQYTNPYLQ-----------EFLCFANISK- 389
            ...:.|  .:|::.||.   |:.|..:.|..|.:.:..|.:..           |....|.:|.
  Rat   207 ELTEEEKQQILHSEEFL---SFFDHSTRIVERALSEQINIFFDYSGRDLEDKEGEIQAGAKLSLN 268

  Fly   390 --------SNKRFVAGYDWYPKLSGLIAVSYAFSTPATVNEATNRVDYVQRAVLEPNPV-LLWSF 445
                    |..|.|:..||..:...|:..||           .|.    :.|..||:.| |:|
  Rat   269 RQFFDERWSKHRVVSCLDWSSQYPELLVASY-----------NNN----EEAPHEPDGVALVW-- 316

  Fly   446 SDNLNYK-----LEFEAPIETTALTFCPFNGDILLGGSKNGQVVLWDLQGRCEKLDEEEYLTAAQ 505
              |:.||     ..|.......:.||..|:.::::||:.:||:||||.:.......:...|:||.
  Rat   317 --NMKYKKTTPEYVFHCQSAVMSATFAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAA 379

  Fly   506 AKYRIMIGEFLNWTIDIEDNVIVPATISLLDCSPKGAITAFYWLGRSIYLSQFGKVYNDPDIRNH 570
            ..:.:.                         |                        .|....:|.
  Rat   380 HTHPVY-------------------------C------------------------VNVVGTQNA 395

  Fly   571 HKFFVTCAFDGTISFWDLDGKGGKSAKDKMRNRMLPKELTQSESAFKSMVIKPTYNLYFPEPITG 635
            |. .::.:.||.|..|.||..  ...:|.|       ||...:|
  Rat   396 HN-LISISTDGKICSWSLDML--SHPQDSM-------ELVHKQS--------------------- 429

  Fly   636 IIADTSCLSCLTPVAKLIQANPSNYPIKTIAKDPPTMRQSMIVSTFYGHVSRIDWQGTYTEGEAT 700
                           |.:.....::|:..:        .:.:|.:..|.|......|  ::...:
  Rat   430 ---------------KAVAVTSMSFPVGDV--------NNFVVGSEEGSVYTACRHG--SKAGIS 469

  Fly   701 EVINSSIPFAMVHDGPVVMVKKNPF-----YPELF--ASIGRTILAIWKEDYNYSPIFWRKRACD 758
            |:...       |.||:..:..:..     :..||  :|...|: .:|... |..|::..:...|
  Rat   470 EMFEG-------HQGPITGIHCHAAVGAVDFSHLFVTSSFDWTV-KLWTTK-NNKPLYSFEDNSD 525

  Fly   759 -LTAVAWSETRPAVLYLTRIDGI--LEAWDILARDDDACLTEILGGGIITAITEHRPSLPHKILG 820
             :..|.||.|.||:  ...:||:  |:.|::   ::|   ||:             |:....:.|
  Rat   526 YVYDVMWSPTHPAL--FACVDGMGRLDLWNL---NND---TEV-------------PTASISVEG 569

  Fly   821 IGDYNSSIRMVKLPHS-FDVPLPNELDQLIKYVLKEERRKMGIQSWE---QKYYELNKDIIEAKR 881
                |.::..|:..|| .::.:.:...|::.|.:.|:........|.   :...|:|....:|:.
  Rat   570 ----NPALNRVRWTHSGREIAVGDSEGQIVIYDVGEQIAVPRNDEWARFGRTLAEINASRADAEE 630

  Fly   882 EAAAEI 887
            |||..|
  Rat   631 EAATRI 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14838	NP_648138.1	WD40	328..>599	CDD:225201	62/311 (20%)
		WD40 repeat	462..505	CDD:293791	13/42 (31%)
		WD40 repeat	510..547	CDD:293791	1/36 (3%)
		RE_R_Pab1	807..>863	CDD:286594	9/56 (16%)
Dync1i2	NP_446332.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..135		15/112 (13%)
		Interaction with DYNLT1. /evidence=ECO:0000269\|PubMed:27502274	133..165		8/39 (21%)
		Dynein_IC2	135..163	CDD:402922	7/35 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..209		19/64 (30%)
		WD 1	277..326		18/67 (27%)
		WD40 repeat	282..331	CDD:293791	17/67 (25%)
		WD40	329..>599	CDD:225201	69/408 (17%)
		WD 2	330..370		11/39 (28%)
		WD40 repeat	339..377	CDD:293791	12/37 (32%)
		WD 3	379..420		10/92 (11%)
		WD40 repeat	385..426	CDD:293791	14/99 (14%)
		WD 4	429..469		7/85 (8%)
		WD40 repeat	434..481	CDD:293791	9/63 (14%)
		WD 5	474..519		10/53 (19%)
		WD40 repeat	489..521	CDD:293791	7/33 (21%)
		WD40 repeat	527..565	CDD:293791	14/58 (24%)
		WD 6	568..607		8/42 (19%)
		WD40 repeat	573..599	CDD:293791	5/25 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810