DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14838 and dnai3

DIOPT Version :9

Sequence 1:	NP_648138.1	Gene:	CG14838 / 38851	FlyBaseID:	FBgn0035799	Length:	1132	Species:	Drosophila melanogaster
Sequence 2:	NP_001120428.1	Gene:	dnai3 / 100145513	XenbaseID:	XB-GENE-980327	Length:	896	Species:	Xenopus tropicalis

Alignment Length:	984	Identity:	231/984 - (23%)
Similarity:	409/984 - (41%)	Gaps:	227/984 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 SSRRSKPYFKKFKEPDS---------DEDVA----DPRQLFNVQESWRTLMSLSSCQKVMVSEKA 86
            |:||.|   .|.|:|.|         |.:||    .|..:.                .::::.|.
Frog    17 SARRPK---SKEKKPGSGKRKAKKQEDSEVASSPGQPDYII----------------PLVLTSKT 62

  Fly    87 QKALKIEVGINVTQEFPWKQVQFKDLRDVLFDELENSAELMKKFKNFNPEHFILIGFCPLLTEQE 151
            |:..:..:..::|||.|:|.::    :|.:.::|:..|.:    .:|:|       |..|:||..
Frog    63 QEIFQCRIDEDITQENPFKLIR----KDDIINDLKGRAAV----SDFHP-------FKALVTEYP 112

  Fly   152 DDP---------PEGEPF--IFYSSIKESKM----AMSIIQNMEHFERWRMQRRLRKKPRRWVSH 201
            .|.         ..|:.|  :.....|||.:    |::..::.|..|:....:....||  |||.
Frog   113 GDELLLVFDRDFKYGQNFYLVITEEAKESILHPPEALTEEEDKEDDEQEYSYKPPSPKP--WVSL 175

  Fly   202 GTDEEMTIMVERFKDEPIDVEIQSVYPIQMPRHVAFDYRMTR-----------------DVRDGV 249
            |:::|:       :||.:.   ||        |....:.::|                 ||:||.
Frog   176 GSEKEI-------EDEMVK---QS--------HTKIKFMISRIQRKFGAKVNFGDHNASDVKDGY 222

  Fly   250 LELLPNENIKWENVTKKRVNVSVQSAPPKIEREQQTNPTFPSNAWSQYLYEIDDEDLELDETDVD 314
            :|....::.::.....:| :..:|..|...|...||...:|.||.:||           ...:..
Frog   223 MECTSYQDKRFSIKINER-DTGIQVVPFTQENSTQTKWGYPRNACTQY-----------TPREFT 275

  Fly   315 EEEEKKKAQAKP-GTYVEPEKKPPEMSAQIEMLLNTLEFNQIDSYRDDYSLISSRQVV--QYTNP 376
            |||.|....:|. ..:|.      .:|.::|:.|...|.  ::::.||:..:|..:..  ..::.
Frog   276 EEERKACLSSKDFKDFVN------SVSLRLELALQQNEI--MNAFLDDWKALSEEENTFGGKSDS 332

  Fly   377 YLQEFLCFANISKSNKRFVAGYDWYPKLSGLIAVS----YAFSTPATVNEATNRVDYVQRAVLEP 437
            :|:|...|.:...||.:.::|.:|:||:.||:|||    .:|.         :||:...:.:|:|
Frog   333 HLKESQSFTDHLFSNAKTISGINWHPKIHGLVAVSMTERLSFE---------DRVNISSKILLKP 388

  Fly   438 NPVLLWSFSDNLNYKLEFEAPIETTALTFCPFNGDILLGGSKNGQVVLWDLQGRCEKLDEEEYLT 502
            :.:|.|||:|.|:.:|..|.|.:.....|||.:.:|:.||..||||||||:         .:|..
Frog   389 SLILFWSFTDPLHPQLMLECPDDIYCFQFCPSDPNIIAGGCFNGQVVLWDI---------SKYQE 444

  Fly   503 AAQAKYRIMIGEF----LNWTIDIEDNVIVPATISLLDCSPKGAITAFYWLGRSIYLSQFGKVYN 563
            :..||..:.....    |..::.....::....:|.::...|..||..:||..:..||..|..|.
Frog   445 SLMAKAGVSKNTAPKTGLEPSVPKGPQLVRYCAVSSIEHGHKNVITDIHWLPNNFELSNAGNPYE 509

  Fly   564 DPDIRNHHKFFVTCAFDGTISFWD------LDGKGGKSAKDKMRNRMLPKELTQSESAFKSMV-- 620
            :..  .:....|||:.|.:|.|||      |.....|:.:||.....:|......:..::..:
Frog   510 NKS--GYCLQLVTCSPDCSIMFWDIRPQKTLTAAEKKNVEDKQMPHGVPDTFKYIDLTWRPFIRA 572

  Fly   621 IKPTYNL---YFPEPITGIIADTSCLS-----CLTPVAKLIQANPSN----YPIKTI----AKDP 669
            |.|..::   |.|..|:        ||     |.|.....|||....    ...|::    ||:|
Frog   573 ILPKSDMSGEYSPMKIS--------LSEEHHHCRTLDKLQIQAKEDKTEGVVEYKSLRAASAKNP 629

  Fly   670 PTM---RQSMIVSTFYGHVSRIDWQGTYTEGEATEVINSS-IPFAMVHDGPVVMVKKNPFYPELF 730
            ..:   .....|.|..|.:...||: ...:.:..::|:|. :...::|||.|..|:::||..:..
Frog   630 KLLDDINTKYFVGTEDGELVYTDWK-MEKDSDTGKLISSKPLQANILHDGAVNTVQRSPFLKDFI 693

  Fly   731 ASIGRTILAIWKEDYNYSPIFW----RKRACDLTAVAWSETRPAVLYLTRIDGILEAWDILARDD 791
            .::|....|||:|.....|||.    :||   |||..||.:|..|.::.:.||.::.||:|.:..
Frog   694 LTVGGWNFAIWREGVTSGPIFHSCCSQKR---LTAAHWSLSRTGVFFIGKEDGNVDVWDLLEKTH 755

  Fly   792 DACLTEILGGGIITAITEHRPSLPHKILGIGDYNSSIRMVKLPHSFDVPLPNE-------LDQLI 849
            :...|:.:....||.|.....|.....|.:||...::.::::|.:...|..||       .::.:
Frog   756 EPSQTQNIAAAPITYIRPWIASSKQHFLAVGDDQGTLHILEIPWNLRHPSANENASVQHYFEREV 820

  Fly   850 KYVLKEERRKMGIQSWEQKYYELNKDI---------IEAKREAAAEIRKEME------------- 892
            |:|....:|: |:::..:|..|| ||:         ::.|.:...|..||.|
Frog   821 KHVEYSNQRE-GLRATAKKQLEL-KDLSAKTETSPPVKTKEQTEVEQSKEYELYLQFEGSILSGL 883

  Fly   893 --KKEKEEQ 899
              .|||||:
Frog   884 GLSKEKEER 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14838	NP_648138.1	WD40	328..>599	CDD:225201	74/286 (26%)
		WD40 repeat	462..505	CDD:293791	15/42 (36%)
		WD40 repeat	510..547	CDD:293791	5/40 (13%)
		RE_R_Pab1	807..>863	CDD:286594	13/62 (21%)
dnai3	NP_001120428.1	WD40	<343..>548	CDD:225201	63/224 (28%)
		WD40 repeat	723..763	CDD:293791	13/39 (33%)
		WD40 repeat	769..814	CDD:293791	10/44 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	185	1.000	Domainoid score	I3315
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H44922
Inparanoid	1	1.050	186	1.000	Inparanoid score	I3801
OMA	1	1.010	-	-		QHG56355
OrthoDB	1	1.010	-	-		D176332at33208
OrthoFinder	1	1.000	-	-		FOG0005463
OrthoInspector	1	1.000	-	-		oto102499
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5617
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.100