DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14838 and dnai4

DIOPT Version :9

Sequence 1:	NP_648138.1	Gene:	CG14838 / 38851	FlyBaseID:	FBgn0035799	Length:	1132	Species:	Drosophila melanogaster
Sequence 2:	NP_001106504.1	Gene:	dnai4 / 100127694	XenbaseID:	XB-GENE-5890871	Length:	795	Species:	Xenopus tropicalis

Alignment Length:	664	Identity:	127/664 - (19%)
Similarity:	230/664 - (34%)	Gaps:	174/664 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   202 GTDEEMTIMVERFKDEPIDVEIQSVYPIQMPRHVAFDYRMTRDVRDGVLELLPNENIKWENVT-K 265
            |.|:.:..|::.|...|...|      :|..|.:..|..:|..|.|     |.:.....|::| |
Frog   248 GNDKYIERMMQTFSGAPKSKE------VQCDRIILEDIGVTASVWD-----LYDSYYSPESLTVK 301

  Fly   266 KRVNVSVQSAPPKIEREQQTNPT-----------FPSNAWSQYLYEIDDEDLEL----DETDVDE 315
            :.|:.:.:|......|..::..|           |.|:|       .|.|.|.|    ||.:.|.
Frog   302 ETVDRATESKNISTSRSSESRGTRSVNSLGRADSFSSSA-------TDIEGLPLARIPDEAEPDS 359

  Fly   316 EEEKKKAQAKPGTYVEPEKKPPEMSAQIEMLLNTLEFNQIDSYR------------DDYSLISSR 368
            ||           .::.||...::.....:::.....:::.:||            |..|.:||
Frog   360 EE-----------ILKLEKFQQDLFFMERVVVENTFQSRLAAYRQLPVIADHEEDEDKISAVSS- 412

  Fly   369 QVVQYTNPYLQEFLCFA-NISKSNKRFVAGYDWYPKLSGLIAVSYAFSTPATVNEATNRVDYVQR 432
               ...:|.|.....|| :::|.:.  |:...|..|.|.|:||.|            .:..:.::
Frog   413 ---NIMSPSLNRLWSFACDVTKGHN--VSSISWNKKNSDLLAVGY------------GQFGFTEQ 460

  Fly   433 AVLEPNPVLLWSFSDNLNYKLEFEAPIETTALTFCPFNGDILLGGSKNGQVVLWDLQGRCEKLDE 497
               :......||..:.:..:..|......||:.|...:.::|..|..||.|.::::|      :.
Frog   461 ---KGGMACCWSLKNIMWPERIFHCECGVTAVDFSAVHPNLLAVGMYNGTVAIYNVQ------NN 516

  Fly   498 EEYLTAAQAKYRIMIGEFLNWTIDIEDNVIVPATISLLDCSPKGAITAFYWLGRSIYLSQFGKVY 562
            |::.                 .:|..||   |..    ..||   :....|:..     ..|.:.
Frog   517 EDFP-----------------VLDSSDN---PNK----HTSP---VWQLKWIEH-----DRGNLG 549

  Fly   563 NDPDIRNHHKFFVTCAFDGTISFWDLDGKGGKSAKDKMRNRMLPKELTQSESAFKSMVIKPTYNL 627
            :|..     :..|:...||.|:.|.:  :.|....|.|:.:.     |.||.:.||...|....
Frog   550 DDKG-----EILVSVCADGRITRWHI--RKGLDCNDLMKLKR-----TGSEKSKKSSNEKEKKG- 601

  Fly   628 YFPEPITGIIADTSCLSCLTPVAKLIQANPSNYPIKTIAKDPPTMRQSMIVSTFYGHVSRIDWQG 692
               |......|...|...|                       |......:..|..||:.:...
Frog   602 ---EAFISRQAPGMCFDFL-----------------------PKDSNIYLAGTEEGHIHKCSC-- 638

  Fly   693 TYTEGEATEVINSSIPFAMVHDGPVVMVKKNPFYPELFASIGRT-ILAIWKEDYNYSPIFWRKRA 756
            :|.|        ..:.....|.|||..:..:||.|::|.|.... .:.:|::|. .|||......
Frog   639 SYNE--------QFLDTYRGHKGPVYKIAWSPFCPDVFLSCSADWCIHLWQQDV-LSPILTFSNT 694

  Fly   757 CD-LTAVAWSETRPAVLYLTRIDGILEAWDILARDDDACLTEILGGGI-ITAITEHRPSLPHKIL 819
            .: :..:.||.: .|:::....:..:|.||:.....|..:......|: :|:|...:.:   ..:
Frog   695 TNAVYDIMWSPS-SALMFGAVTENRVEIWDLGTSTIDPLIVNEANPGVKLTSILFAKNT---NCV 755

  Fly   820 GIGDYNSSIRMVKL 833
            .|||.:..:.:.:|
Frog   756 LIGDSDGQVNVYEL 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14838	NP_648138.1	WD40	328..>599	CDD:225201	49/283 (17%)
		WD40 repeat	462..505	CDD:293791	10/42 (24%)
		WD40 repeat	510..547	CDD:293791	6/36 (17%)
		RE_R_Pab1	807..>863	CDD:286594	5/27 (19%)
dnai4	NP_001106504.1	WD40	359..782	CDD:225201	97/535 (18%)
		WD40	431..768	CDD:295369	82/445 (18%)
		WD40 repeat	435..480	CDD:293791	10/59 (17%)
		WD40 repeat	487..523	CDD:293791	10/58 (17%)
		WD40 repeat	613..650	CDD:293791	8/69 (12%)
		WD40 repeat	656..693	CDD:293791	10/37 (27%)
		WD40 repeat	698..736	CDD:293791	7/38 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910