DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment frac and MATN4

DIOPT Version :9

Sequence 1:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster
Sequence 2:	NP_001380459.1	Gene:	MATN4 / 8785	HGNCID:	6910	Length:	581	Species:	Homo sapiens

Alignment Length:	330	Identity:	82/330 - (24%)
Similarity:	123/330 - (37%)	Gaps:	111/330 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   351 ENLPGSYRCVEPLEENP--------------EITEVVENPIEKTNEVPVNVSESQPAGKTCNSGF 401
            |::..:.|.:.||.:..              .:.|....|.|:...|.|.|::.:|..:......
Human    95 EDMERAIRDLVPLAQGTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDGRPQDRVAEVAA 159

  Fly   402 QLSADGTDCQDINECEVDGPEDLDNNAVCQQKCENTIGSFRCTC----------VEGYHLLED-- 454
            |..|.|                ::..||..|:.:  :||.|...          ||.:.|:::
Human   160 QARARG----------------IEIYAVGVQRAD--VGSLRAMASPPLDEHVFLVESFDLIQEFG 206

  Fly   455 ----QRSCALDSCTDLENPQLNRTRCAHECQDLPEGSYRCVCPKGYELSEDQHSCLVQESPCSTE 515
                .|.||:|.|.:      ....|.|.|.:.| |||.|.|..|:.|.:||.
Human   207 LQFQSRLCAIDLCAE------GTHGCEHHCVNSP-GSYFCHCQVGFVLQQDQR------------ 252

  Fly   516 KGVEKCSPGTCLASEDNTSFSCICPTGYRSEAFSCQDIDECAEDTHLCSHTCQNTPGGYQCQCPE 580
                                             ||:.||.|:...|.|.|.|.:||||.:|.|.|
Human   253 ---------------------------------SCRAIDYCSFGNHSCQHECVSTPGGPRCHCRE 284

  Fly   581 GLNLVEE-YTCLAENLCEVNNNGCEQICLTARGGV---CACREGFRLSADGKSCE-----DVDEC 636
            |.:|..: .:|...:||...::|||..|::.  |:   |.|.||.:|.||||||.     .||..
Human   285 GHDLQPDGRSCQVRDLCNGVDHGCEFQCVSE--GLSYRCLCPEGRQLQADGKSCNRCREGHVDLV 347

  Fly   637 LVNNG 641
            |:.:|
Human   348 LLVDG 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342
		cEGF	396..415	CDD:289433	3/18 (17%)
		FXa_inhibition	425..458	CDD:291342	10/48 (21%)
		FXa_inhibition	476..505	CDD:291342	13/28 (46%)
		vWFA	<550..586	CDD:294047	17/35 (49%)
		FXa_inhibition	596..630	CDD:291342	15/36 (42%)
		FXa_inhibition	636..>664	CDD:291342	2/6 (33%)
		EGF_CA	676..715	CDD:284955
		FXa_inhibition	745..780	CDD:291342
		FXa_inhibition	786..821	CDD:291342
		FXa_inhibition	827..862	CDD:291342
		FXa_inhibition	874..904	CDD:291342
		FXa_inhibition	945..980	CDD:291342
		CCP	1110..1170	CDD:153056
		CCP	1183..1235	CDD:153056
		DUF5011	1468..1536	CDD:295940
MATN4	NP_001380459.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BA2W
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810