DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment frac and FBN3

DIOPT Version :9

Sequence 1:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster
Sequence 2:	XP_016882868.1	Gene:	FBN3 / 84467	HGNCID:	18794	Length:	2851	Species:	Homo sapiens

Alignment Length:	1406	Identity:	374/1406 - (26%)
Similarity:	503/1406 - (35%)	Gaps:	494/1406 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 GADSKPEPQIVIE-----INDDHANEVVESEPALAETETENEVLENETPLKAEVQTDVLNSSNAS 231
            |:.::|.|..|.:     .|.||.    ..||.            ...|.|...:...|.||  .
Human   669 GSCARPFPGTVTKSECCCANPDHG----FGEPC------------QLCPAKDSAEFQALCSS--G 715

  Fly   232 VKVTNDPYEPTFLDNNCGEDNGGCAH-ICKRLLYPDENQPINKCDCREGYTLDPNDYASCLDIDE 295
            :.:|.|..:    .|.|..|...||: :|:.|      :...:|.|..||....:. ..|.|:||
Human   716 LGITTDGRD----INECALDPEVCANGVCENL------RGSYRCVCNLGYEAGASG-KDCTDVDE 769

  Fly   296 C-----LESNGGCSEICENLPGEYKCSCQEGYYLDESGKSCVDINECANPELSSNC-QGACENLP 354
            |     |..||.    |:|.||.|.|||..|::..:..:.|.|::||    |||.| .|.|.||.
Human   770 CALNSLLCDNGW----CQNSPGSYSCSCPPGFHFWQDTEICKDVDEC----LSSPCVSGVCRNLA 826

  Fly   355 GSYRC-------VEP--------------LEENPEITEVVENPIEKTNEV----------PVNVS 388
            |||.|       ::|              |:......||........:|.          |....
Human   827 GSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPCERC 891

  Fly   389 ESQPAGKTCNSGFQLSADGTDCQDINECEVDGPEDLDNNAVCQQ-KCENTIGSFRCTCVEGYHL- 451
            |..||   |..|| ....|..|.|:||||       ....||.. :|.||.|||||.|.||..|
Human   892 EIDPA---CARGF-ARMTGVTCDDVNECE-------SFPGVCPNGRCVNTAGSFRCECPEGLMLD 945

  Fly   452 ----------LE------DQRSCAL-----------------------DSCTDLENPQLNRTRC- 476
                      ||      |:..|.:                       ::|.|.|:.:. .:.|
Human   946 ASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEF-ASLCP 1009

  Fly   477 -------------------AHECQDLP-----------EGSYRCVCPKGYELSEDQHSCL-VQES 510
                               .:||:..|           .||:.|.|..|:.|...:.:|. :.|.
Human  1010 RGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDEC 1074

  Fly   511 PCSTEKGVEKCSPGTCLASEDNT--SFSCICPTGYRSEAF---SCQDIDECAEDTHLC-SHTCQN 569
            ..|.    :.|..|||:    ||  ||.|.|..||.|...   :|.|:||||.|..|| ..||.|
Human  1075 RISP----DLCGQGTCV----NTPGSFECECFPGYESGFMLMKNCMDVDECARDPLLCRGGTCTN 1131

  Fly   570 TPGGYQCQCPEGLNLVEEYT-CLAENLCEVNNNGCEQ-ICLTARGGV-CACREGFRLSADGKSCE 631
            |.|.|:||||.|..|..:.| |...:.|.:::..|.. .|:...|.. |:|..||:.:.|.:.|.
Human  1132 TDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCV 1196

  Fly   632 DVDECLVNNGGCQQVCRNLPGSYGCICAAGYELLKLDGIRGYCFDIDECSQRTHGCSDQMLCENL 696
            |::||.|.||||...|.|..|||.|.|..||.|:. ||  ..|.|:|||.:....| ||..|.|:
Human  1197 DINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMP-DG--RACADVDECEENPRVC-DQGHCTNM 1257

  Fly   697 NGSYTCLCPPGYALGLDNHIVTSLNSSFITDSTSSETPSAHTCLDIDECSLANGNCSH-FCQNEP 760
            .|.:.|||..|:                      ..||...||:|:|||.|....|.| .|:|..
Human  1258 PGGHRCLCYDGF----------------------MATPDMRTCVDVDECDLNPHICLHGDCENTK 1300

  Fly   761 GGFQCACPLGYALSEDMRTCQDIDEC------LDSNGQCSQL----------------------- 796
            |.|.|.|.|||.:.:....|.|:|||      .||:..|..:
Human  1301 GSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECHDLD 1365

  Fly   797 --------------CLNQPGGFACACETGFELTPDGFGCADIDECSQDYGNCSD-ICINLLGTHA 846
                          |||.||.:.|.|..||  ..|||.|.|.|||:::...|.: .|:|..|.:.
Human  1366 ECVSQEHRCSPRGDCLNVPGSYRCTCRQGF--AGDGFFCEDRDECAENVDLCDNGQCLNAPGGYR 1428

  Fly   847 CACERGYELAKDKLSCLDVDECA--------------GLL-------------SGGCSH------ 878
            |.||.|::..:|..:|.||||||              |:.             .|.|:.
Human  1429 CECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINECAD 1493

  Fly   879 -------ECINKAGTFECGCPLGYILN----------------------DDGRSCSPALVGCPPG 914
                   .|||..|::.|.||..:.||                      |.|.||| |.:|.  |
Human  1494 PVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCS-AEIGV--G 1555

  Fly   915 TQRSADGCA-------PIE-CNPGYTLGSDDKC---------------VDIDECQKQNGGC-SHR 955
            ..|::..|:       |.| |....|......|               .||||||:..|.| ...
Human  1556 VTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGD 1620

  Fly   956 CSNTEGSFKCSCPPGYELDSDQKTCQDIDECDQDKTSCITGTCINEIGGFRCEFP---------- 1010
            |.||.|||:|.|||||.|....:.|:|||||......|..|||.|.:|.:.|..|
Human  1621 CVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGN 1685

  Fly  1011 ----------------------KFPVLPEIPTAS-SLPES---PKIELKTPKYPDFTEL-SNEIP 1048
                                  .|.|..::...| ::.::   |.....||..||:..| .|:.|
Human  1686 NCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAP 1750

  Fly  1049 ENPKKPAEFDYPEPKFPSLPKWEGLPKLPPLADIPTSKAPVPLRP--EVP----KSLWVNQL--- 1104
                                   |.     |.||.|.| |:.:..  |:|    ..:.:||:
Human  1751 -----------------------GF-----LTDIHTGK-PLDIDECGEIPAICANGICINQIGSF 1786

  Fly  1105 -----------------QPRDLCPRFQAPRNGKSHC----NRYRHKQKLFYYSRCRISCNSGYIL 1148
                             :..|.|...::|....:.|    ..||.|            |..||.|
Human  1787 RCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCK------------CTRGYKL 1839

  Fly  1149 QGPEIKSCDANGIWEGPETKCVAINQPRAQSPGICPALKPAQNGVILPASC--TQGPSRFGDVCR 1211
                           .|...||..|:.| :.|.:|      .:|     .|  |:|    ..:|
Human  1840 ---------------SPGGACVGRNECR-EIPNVC------SHG-----DCMDTEG----SYMC- 1872

  Fly  1212 LQCNAGFVSTGSLLTACMMLQGWSFGADLNCQPFGNGLLGN 1252
             .|:.||.::.. .|.||.:.      :.:.||.|||...|
Human  1873 -LCHRGFQASAD-QTLCMDID------ECDRQPCGNGTCKN 1905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342	13/39 (33%)
		cEGF	396..415	CDD:289433	6/18 (33%)
		FXa_inhibition	425..458	CDD:291342	17/50 (34%)
		FXa_inhibition	476..505	CDD:291342	10/59 (17%)
		vWFA	<550..586	CDD:294047	21/36 (58%)
		FXa_inhibition	596..630	CDD:291342	9/35 (26%)
		FXa_inhibition	636..>664	CDD:291342	15/27 (56%)
		EGF_CA	676..715	CDD:284955	14/38 (37%)
		FXa_inhibition	745..780	CDD:291342	13/35 (37%)
		FXa_inhibition	786..821	CDD:291342	16/77 (21%)
		FXa_inhibition	827..862	CDD:291342	10/35 (29%)
		FXa_inhibition	874..904	CDD:291342	13/64 (20%)
		FXa_inhibition	945..980	CDD:291342	17/35 (49%)
		CCP	1110..1170	CDD:153056	11/63 (17%)
		CCP	1183..1235	CDD:153056	12/53 (23%)
		DUF5011	1468..1536	CDD:295940
FBN3	XP_016882868.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BA2W
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D4721at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100900
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2524
SonicParanoid	1	1.000	-	-		X1431
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750