DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment frac and LTBP4

DIOPT Version :9

Sequence 1:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster
Sequence 2:	NP_001036009.1	Gene:	LTBP4 / 8425	HGNCID:	6717	Length:	1624	Species:	Homo sapiens

Alignment Length:	1211	Identity:	323/1211 - (26%)
Similarity:	431/1211 - (35%)	Gaps:	418/1211 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   292 DIDECLESNGGCSE--------ICENLPGEYKCSCQEGYYLDESGKSCVDINECANPELSSNC-Q 347
            :|.|...|:|.|..        .|.:.|..|.|:|..|:.|...|..|:|::||.  .:...| .
Human   538 EIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECR--RVPPPCAP 600

  Fly   348 GACENLPGSYRCVEPLEENPEITEVVENPIEKTNEVPVNVSESQPAGKTCNSGFQLSADGTDCQD 412
            |.|||.|||:|||                                    |..||:......:|.|
Human   601 GRCENSPGSFRCV------------------------------------CGPGFRAGPRAAECLD 629

  Fly   413 INEC-EVDGPEDLDNNAVCQQKCENTIGSFRCTCVEGYHLLEDQRSCA-LDSCTDLENPQLNRTR 475
            ::|| .|..|.||.       :||||.|||.|.|..||.......||. :|.||  ::|.|
Human   630 VDECHRVPPPCDLG-------RCENTPGSFLCVCPAGYQAAPHGASCQDVDECT--QSPGL---- 681

  Fly   476 CAH-ECQDLPEGSYRCVCPKGYELS---EDQHSCLVQESPCSTEKGVEKCSPGTCLASEDNT--S 534
            |.. .|::|| ||:|||||.|:..|   ||...| .||.|        .|.||.|    |||  |
Human   682 CGRGACKNLP-GSFRCVCPAGFRGSACEEDVDEC-AQEPP--------PCGPGRC----DNTAGS 732

  Fly   535 FSCICPTGYRSE--AFSCQDIDECAEDTHLCSH-TCQNTPGGYQCQCPEGLNLVEEYTCLAENLC 596
            |.|.||.|:||.  ...|||:||||.....|:: .|:||.|.:||.||
Human   733 FHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCP----------------- 780

  Fly   597 EVNNNGCEQICLTARGGVCACREGFRLSADGKSCEDVDECLVNNGGCQ-QVCRNLPGSYGC-ICA 659
                                  .||:.:..|..||||||| .|:..|. |.|.|.|||:.| .|.
Human   781 ----------------------MGFQPNTAGSECEDVDEC-ENHLACPGQECVNSPGSFQCRTCP 822

  Fly   660 AGYELLKLDGIRGYCFDIDECSQRTHGCSDQMLCENLNGSYTCLCPPGYAL-----GLDNHIVTS 719
            :|:.|     .||.|.|:||||.....|.....|.|..||:.|.|.|||..     |....:...
Human   823 SGHHL-----HRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNEC 882

  Fly   720 LNSSFI--------TDSTSSET--------PSAHTCLDIDECSLANGNCSHFCQNEPGGFQCACP 768
            |...|.        ||.:.:.|        |...:|||:||||..:...|..|.|..|.|:|.||
Human   883 LEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICP 947

  Fly   769 LGYALSEDMRTCQDIDECLD-------------------------------SNGQC--------- 793
            .|:....|:.:|.|:|||.:                               ..|.|
Human   948 PGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEY 1012

  Fly   794 ------SQLCLNQPGGFAC--ACETGFELTPDGFGCADIDEC-SQDYGNCSDICINLLGTHACAC 849
                  :|.|.|.||.:.|  ||:.|::.||.| ||.|:||| ::.:.....:|.||.|:..|.|
Human  1013 GPEICGAQRCENTPGSYRCTPACDPGYQPTPGG-GCQDVDECRNRSFCGAHAVCQNLPGSFQCLC 1076

  Fly   850 ERGYELAKDKLSCLDVDECAGLLSGGCSHE-CINKAGTFECGCPLGYILND-------DGRSCSP 906
            ::|||.|:|...|:||:||. .|.|.|... |.|..|:|.|.||     |.       .||...|
Human  1077 DQGYEGARDGRHCVDVNECE-TLQGVCGAALCENVEGSFLCVCP-----NSPEEFDPMTGRCVPP 1135

  Fly   907 -ALVGCPPGTQRSA------------------------------------DGCAPIECN------ 928
             ...|..||:|..|                                    |..||..|:
Human  1136 RTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARN 1200

  Fly   929 --------------------------------------PGYTLGSDDKCV--DIDECQK-QNGGC 952
                                                  .||...|.|..:  |:||||. ::..|
Human  1201 VTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVC 1265

  Fly   953 -SHRCSNTEGSFKCSCPPGYELDSDQKTCQDIDECDQDKTSCITGTCINEIGGFRCEFPKFPVLP 1016
             |..|.||...:.|.|..||...:.:..|.|.|||..::.:|..|.|:|.:|.:.|......||.
Human  1266 KSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLD 1330

  Fly  1017 EIP------TASSLPES----------------PKIELKTPKY---------------------- 1037
            ...      .:.||.::                |::: :...|
Human  1331 GSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLD-RQATYTECCCLYGEAWGMDCALCPAQD 1394

  Fly  1038 -PDFTELSNEI---PENPKKPAEFDYPEPKFPSL-PKWEGLPKLP-------------------- 1077
             .||..|.|.:   ..:|.:|..|..|....|.| |.::|||..|
Human  1395 SDDFEALCNVLRPPAYSPPRPGGFGLPYEYGPDLGPPYQGLPYGPELYPPPALPYDPYPPPPGPF 1459

  Fly  1078 ---------PLADIP----------TSKAPVPLRPEVPKSLW-VNQLQPRDLCPRFQAPRNGKSH 1122
                     |..|:|          .|:||.   |..|.:.| ......|...|..:.|..|.|:
Human  1460 ARREAPYGAPRFDMPDFEDDGGPYGESEAPA---PPGPGTRWPYRSRDTRRSFPEPEEPPEGGSY 1521

  Fly  1123 CNRYRHKQKLFYYSRCRI--SCNSGYILQGPEIKSCDANGIWEGPETK--CVAIN---QPRAQSP 1180
            ........:......|.|  .|.:|..::.||..:|.....:....|:  ||.||   :..|.||
Human  1522 AGSLAEPYEELEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASP 1586

  Fly  1181 GICPALKPAQNGVILPASCTQGPSRFGDVCRLQCNAGFVST 1221
             :|           :.|.|......|..:||    .||..|
Human  1587 -LC-----------VNARCLNTDGSFRCICR----PGFAPT 1611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342	11/42 (26%)
		cEGF	396..415	CDD:289433	5/18 (28%)
		FXa_inhibition	425..458	CDD:291342	11/32 (34%)
		FXa_inhibition	476..505	CDD:291342	15/32 (47%)
		vWFA	<550..586	CDD:294047	16/36 (44%)
		FXa_inhibition	596..630	CDD:291342	3/33 (9%)
		FXa_inhibition	636..>664	CDD:291342	12/29 (41%)
		EGF_CA	676..715	CDD:284955	16/43 (37%)
		FXa_inhibition	745..780	CDD:291342	12/34 (35%)
		FXa_inhibition	786..821	CDD:291342	15/82 (18%)
		FXa_inhibition	827..862	CDD:291342	12/35 (34%)
		FXa_inhibition	874..904	CDD:291342	12/37 (32%)
		FXa_inhibition	945..980	CDD:291342	11/36 (31%)
		CCP	1110..1170	CDD:153056	12/63 (19%)
		CCP	1183..1235	CDD:153056	9/39 (23%)
		DUF5011	1468..1536	CDD:295940
LTBP4	NP_001036009.1	cEGF	567..590	CDD:289433	8/22 (36%)
		EGF_CA	587..623	CDD:214542	17/73 (23%)
		EGF_CA	629..670	CDD:214542	19/47 (40%)
		EGF_CA	671..708	CDD:238011	18/43 (42%)
		EGF_CA	710..744	CDD:214542	19/46 (41%)
		EGF_CA	752..792	CDD:284955	17/78 (22%)
		EGF_CA	834..867	CDD:214542	14/32 (44%)
		EGF_CA	878..914	CDD:214542	5/35 (14%)
		EGF_CA	920..955	CDD:214542	14/34 (41%)
		EGF_CA	961..999	CDD:214542	4/37 (11%)
		EGF_CA	1005..1048	CDD:214542	13/43 (30%)
		EGF_CA	1049..1090	CDD:214542	15/40 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1130..1179		8/48 (17%)
		TB	1193..1230	CDD:279073	1/36 (3%)
		EGF_CA	1296..>1325	CDD:238011	10/28 (36%)
		TB	1361..1397	CDD:279073	2/36 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1446..1524		14/80 (18%)
		EGF_CA	1574..>1608	CDD:214542	11/49 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	125..146
		EGF_CA	357..>387	CDD:214542
		TB	418..453	CDD:279073
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	474..546		2/7 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D4721at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24034
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020