DRSC/TRiP Functional Genomics Resources

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Protein Alignment frac and LRP8

DIOPT Version :10

Sequence 1:NP_648137.3 Gene:frac / 38850 FlyBaseID:FBgn0035798 Length:1618 Species:Drosophila melanogaster
Sequence 2:NP_004622.2 Gene:LRP8 / 7804 HGNCID:6700 Length:963 Species:Homo sapiens


Alignment Length:850 Identity:181/850 - (21%)
Similarity:256/850 - (30%) Gaps:325/850 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   415 ECEVDGPEDLDNNAVCQQKCENTIGSFRC-----TCVEGYHLLE--DQRSCALDSCTDLENPQLN 472
            :||.|           |.:|.|.    ||     .|.|....|:  |:..|...:|.| .:...:
Human    46 DCEKD-----------QFQCRNE----RCIPSVWRCDEDDDCLDHSDEDDCPKKTCAD-SDFTCD 94

  Fly   473 RTRCAHECQDLPEGSYRC----VCPKGYELSEDQHSCLVQESPCSTEKGVEKCSPGTCLASEDNT 533
            ...|.||       .::|    .||.|.:  |.:.:|..|  .|..||  ..|.|         |
Human    95 NGHCIHE-------RWKCDGEEECPDGSD--ESEATCTKQ--VCPAEK--LSCGP---------T 137

  Fly   534 SFSCICPTGYRSEAFSCQDIDEC--AEDTHLCSHTCQNTPGGYQC---QCPEGLNLVEEYTCLAE 593
            |..|: |..:|     |....:|  ..|...|:..|  .|..:||   .|     |...:.|..:
Human   138 SHKCV-PASWR-----CDGEKDCEGGADEAGCATLC--APHEFQCGNRSC-----LAAVFVCDGD 189

  Fly   594 NLC--EVNNNGCEQICLTARGGVCACREGFRLSADGKS--------CEDVDECLVNNGGCQQVC- 647
            :.|  ..:..||..       ..|..|| ||...||..        |:...:|...:....::| 
Human   190 DDCGDGSDERGCAD-------PACGPRE-FRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCG 246

  Fly   648 RNLPG--SYGCICAAGYELL-----------KLDGIRGYCFD-IDECSQRTHGC-SDQMLCENLN 697
            |..||  |....||...:..           :.||.|. |.| .||.......| .|:..|    
Human   247 RPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRD-CKDKSDEADCPLGTCRGDEFQC---- 306

  Fly   698 GSYTCL-----------CPPGYALGLDNHIVTSLNSSFITDSTSSETPSAHTCLD-IDECSLANG 750
            |..||:           ||.|                      |.|.    .||. ::||...||
Human   307 GDGTCVLAIKHCNQEQDCPDG----------------------SDEA----GCLQGLNECLHNNG 345

  Fly   751 NCSHFCQNEPGGFQCACPLGYALSEDMRTCQDIDECLDSNGQCSQLCLNQPGGFACACETGFE-- 813
            .|||.|.:...||:|.||.|:.|. |.:||.|||||.|.:. |||:|:|..|.|.|.|..|:|  
Human   346 GCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKDPDA-CSQICVNYKGYFKCECYPGYEMD 408

  Fly   814 -LTPDGFGCAD---------------IDECSQDYGNCSDICINLLG---------THAC--ACER 851
             ||.:....|.               ||...::|.....:..|::.         .:.|  :..:
Human   409 LLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRK 473

  Fly   852 GYELAKDKLSCLDVDECAGLLS------GGCSHECINK--AGTFECGCPLGYILNDDGRS----- 903
            .|....||.|  |..|...|:.      .|.:.:.::|  ..|......:.....|.||.     
Human   474 IYSAYMDKAS--DPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFS 536

  Fly   904 ---CSPALVGCPP----------------------GTQRSADGCAPIECNPGYTL---------- 933
               ..|..:...|                      |..|.......||...|.||          
Human   537 RNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWV 601

  Fly   934 -------------GSDDKCV--------------------------------------------- 940
                         |.:.|.:                                             
Human   602 DSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILA 666

  Fly   941 -------DI------------DECQ---KQNGGCSHRC------SNTEGSFKCSCPPGYELDSDQ 977
                   ||            |.|:   :.||||.:.|      |:....:.|:||....|..|.
Human   667 ENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDM 731

  Fly   978 KTCQDIDECDQDKTSCIT------------GTCINEIGGFRCEFPKFPVL-PEIPTASSLPESPK 1029
            |.|....:.....|...|            ||.::. ..::....:.|.| ..:|::.|:|.:|.
Human   732 KRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHR-STYQNHSTETPSLTAAVPSSVSVPRAPS 795

  Fly  1030 IELKT 1034
            |...|
Human   796 ISPST 800

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fracNP_648137.3 FXa_inhibition 296..331 CDD:464251
cEGF 396..415 CDD:463661 180/849 (21%)
FXa_inhibition 425..458 CDD:464251 9/39 (23%)
FXa_inhibition 476..505 CDD:464251 8/32 (25%)
EGF_CA 552..>581 CDD:214542 8/33 (24%)
FXa_inhibition 596..630 CDD:464251 10/43 (23%)
FXa_inhibition 636..>664 CDD:464251 8/30 (27%)
EGF_CA 676..711 CDD:214542 12/47 (26%)
FXa_inhibition 745..780 CDD:464251 15/34 (44%)
FXa_inhibition 786..821 CDD:464251 15/37 (41%)
vWFA <821..861 CDD:469594 9/65 (14%)
FXa_inhibition 874..904 CDD:464251 6/39 (15%)
FXa_inhibition 945..980 CDD:464251 13/43 (30%)
PTZ00449 <1017..>1098 CDD:185628 5/17 (29%)
CCP 1110..1170 CDD:153056
CCP 1183..1235 CDD:153056
HYR 1468..1536 CDD:460572
LRP8NP_004622.2 LDLa 47..81 CDD:238060 12/48 (25%)
LDLa 85..117 CDD:197566 9/41 (22%)
LDLa 127..163 CDD:238060 13/52 (25%)
LDLa 206..240 CDD:197566 9/34 (26%)
Ldl_recept_a 262..294 CDD:395011 7/32 (22%)
Ldl_recept_a 298..333 CDD:395011 11/64 (17%)
FXa_inhibition 340..374 CDD:464251 15/34 (44%)
EGF_CA 376..406 CDD:214542 16/30 (53%)
LY 445..480 CDD:214531 3/34 (9%)
LDL-receptor class B 1 462..508 9/47 (19%)
LY 489..531 CDD:214531 6/41 (15%)
LDL-receptor class B 2 509..551 7/41 (17%)
LDL-receptor class B 3 552..595 7/42 (17%)
Ldl_recept_b 552..592 CDD:459654 6/39 (15%)
LY 576..618 CDD:214531 6/41 (15%)
LDL-receptor class B 4 596..639 2/42 (5%)
Ldl_recept_b 639..679 CDD:459654 2/39 (5%)
LDL-receptor class B 5 640..681 2/40 (5%)
FXa_inhibition 697..734 CDD:464251 12/36 (33%)
Clustered O-linked oligosaccharides 740..798 11/58 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 754..815 9/47 (19%)
Blue background indicates that the domain is not in the aligned region.

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