DRSC/TRiP Functional Genomics Resources

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Protein Alignment frac and VLDLR

DIOPT Version :10

Sequence 1:NP_648137.3 Gene:frac / 38850 FlyBaseID:FBgn0035798 Length:1618 Species:Drosophila melanogaster
Sequence 2:NP_003374.3 Gene:VLDLR / 7436 HGNCID:12698 Length:873 Species:Homo sapiens


Alignment Length:936 Identity:194/936 - (20%)
Similarity:299/936 - (31%) Gaps:395/936 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly   252 NGGCAHICKRLLYPDENQPINKCDCREGYTLDPNDYASCLDIDECLES-----NGGCSEICENLP 311
            ||.|.    .||:        |||..|. .:|.:|..:|:. ..|.||     ||.|      :|
Human    42 NGRCI----TLLW--------KCDGDED-CVDGSDEKNCVK-KTCAESDFVCNNGQC------VP 86

  Fly   312 GEYKC----SCQEGYYLDESGKSCVDINECANPELSSNCQGACENLPGSYRCVEPLEENPEITEV 372
            ..:||    .|::|  .|||.:.| .:..|...|:|.... :.:.:|.|:||  ..|.:.:..|.
Human    87 SRWKCDGDPDCEDG--SDESPEQC-HMRTCRIHEISCGAH-STQCIPVSWRC--DGENDCDSGED 145

  Fly   373 VENPIEKTNEVPVNVSESQPAGKTCNSGFQLSADGTDCQDINECEVDGPEDLDNNAVCQQKCENT 437
            .||        ..|::.| |...||:||..:|.:.. |...::|. ||.::||    |   ...|
Human   146 EEN--------CGNITCS-PDEFTCSSGRCISRNFV-CNGQDDCS-DGSDELD----C---APPT 192

  Fly   438 IGS--FRC---TCVEGYHLLEDQRSCALDSCTDLENPQLNRTRCAHECQDLPEGSYRCVCPKGYE 497
            .|:  |:|   :|:....:.:|...|:..|...||  |..|....|           ..||    
Human   193 CGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLE--QCGRQPVIH-----------TKCP---- 240

  Fly   498 LSEDQHSCLVQESPCSTEKGVEKCSPGTCLASEDNTSFSCICPTGYRSEAFSCQDIDEC---AED 559
            .||.|                  |..|.|:                 .:.:.|....:|   :::
Human   241 ASEIQ------------------CGSGECI-----------------HKKWRCDGDPDCKDGSDE 270

  Fly   560 THLCSHTCQNTPGGYQCQCPEGLNLVEEYTCLAENLCEVNNNGCEQICLTARGGVCACREGFRLS 624
            .:..|.||:  |..::|         |:.:|:         :|..| |    .|:..|.:|    
Human   271 VNCPSRTCR--PDQFEC---------EDGSCI---------HGSRQ-C----NGIRDCVDG---- 306

  Fly   625 ADGKSCEDVDECLVNNGGCQQVCRNLPGSYGCICAAGYELLKLDGIRGYCFDIDECSQRTHGC-- 687
            :|..:|::|::||.            ||.:.|             ..|.|.||.:...:...|  
Human   307 SDEVNCKNVNQCLG------------PGKFKC-------------RSGECIDISKVCNQEQDCRD 346

  Fly   688 -SDQMLCENLNGSYTCLCPPGYALGLDNHIVTSLNSSFITDSTSSETPSAHTCLDIDECSLANGN 751
             ||:.|.|                                            | .|:||.:.||.
Human   347 WSDEPLKE--------------------------------------------C-HINECLVNNGG 366

  Fly   752 CSHFCQNEPGGFQCACPLGYALSEDMRTCQDIDECLDSNGQCSQLCLNQPGGFACACETGFELTP 816
            |||.|::...|::|.|..|:.|. |.:||.||||| .:.|.|||:|:|..||:.|.|..|:::..
Human   367 CSHICKDLVIGYECDCAAGFELI-DRKTCGDIDEC-QNPGICSQICINLKGGYKCECSRGYQMDL 429

  Fly   817 DGFGCADI-DECSQDYGNCSDI---------CINLLGTHACACERGYELAKDKLSCLDVDECAGL 871
            ....|..: .|.|..:.|..||         .|.|:...........::|..||...|:.:.| :
Human   430 ATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKA-I 493

  Fly   872 LSGGCSHECINKAG-------------------------------------TFECGCPLGYILND 899
            .|....    :|.|                                     |.: |....::.|.
Human   494 FSASID----DKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLD-GTKRKFLFNS 553

  Fly   900 DGRSCSPALVGCPP----------------------GTQRSADGCAPIECNPGYTL--------- 933
            |.|  .||.:...|                      |..|.....|.|:...|.||         
Human   554 DLR--EPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYW 616

  Fly   934 --------------GSDDKCV-------------------------------------------- 940
                          |.|.:.|                                            
Human   617 LDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATL 681

  Fly   941 --------DI------------DECQK--QNGGCSHRC------SNTEGSFKCSCPPGYELDSDQ 977
                    ||            :.|::  :||||.:.|      ::....:.||||.||.::.:.
Human   682 VNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENG 746

  Fly   978 KTCQD------IDECDQDKTSCITGT 997
            :.||.      ..|.....|:.|:.|
Human   747 RDCQSTATTVTYSETKDTNTTEISAT 772

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fracNP_648137.3 FXa_inhibition 296..331 CDD:464251 14/43 (33%)
cEGF 396..415 CDD:463661 6/18 (33%)
FXa_inhibition 425..458 CDD:464251 8/37 (22%)
FXa_inhibition 476..505 CDD:464251 6/28 (21%)
EGF_CA 552..>581 CDD:214542 6/31 (19%)
FXa_inhibition 596..630 CDD:464251 7/33 (21%)
FXa_inhibition 636..>664 CDD:464251 5/27 (19%)
EGF_CA 676..711 CDD:214542 7/37 (19%)
FXa_inhibition 745..780 CDD:464251 13/34 (38%)
FXa_inhibition 786..821 CDD:464251 12/34 (35%)
vWFA <821..861 CDD:469594 10/49 (20%)
FXa_inhibition 874..904 CDD:464251 7/66 (11%)
FXa_inhibition 945..980 CDD:464251 12/42 (29%)
PTZ00449 <1017..>1098 CDD:185628
CCP 1110..1170 CDD:153056
CCP 1183..1235 CDD:153056
HYR 1468..1536 CDD:460572
VLDLRNP_003374.3 LDLa 33..67 CDD:238060 11/37 (30%)
LDLa 71..103 CDD:197566 11/39 (28%)
Ldl_recept_a 111..149 CDD:395011 11/48 (23%)
LDLa 154..188 CDD:238060 13/40 (33%)
Ldl_recept_a 192..224 CDD:395011 8/31 (26%)
Ldl_recept_a 237..273 CDD:395011 10/74 (14%)
Ldl_recept_a 276..312 CDD:395011 13/64 (20%)
Ldl_recept_a 320..350 CDD:395011 9/54 (17%)
FXa_inhibition 360..394 CDD:464251 13/34 (38%)
EGF_CA 396..426 CDD:214542 16/30 (53%)
Ldl_recept_b 481..522 CDD:459654 7/45 (16%)
LY 505..547 CDD:214531 2/42 (5%)
Ldl_recept_b 568..608 CDD:459654 6/39 (15%)
LY 592..634 CDD:214531 6/41 (15%)
Ldl_recept_b 655..695 CDD:459654 2/39 (5%)
FXa_inhibition 706..749 CDD:464251 12/42 (29%)
Blue background indicates that the domain is not in the aligned region.

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