DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment frac and Fbn2

DIOPT Version :9

Sequence 1:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster
Sequence 2:	NP_114014.2	Gene:	Fbn2 / 689008	RGDID:	620910	Length:	2907	Species:	Rattus norvegicus

Alignment Length:	1429	Identity:	381/1429 - (26%)
Similarity:	520/1429 - (36%)	Gaps:	527/1429 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   241 PTFLD-NNCGEDNGGCAH-ICKRLLYPDENQPINKCDCREGYTLDPNDYASCLDIDECLESNGGC 303
            |.:.| |.|....|.|.: .|:..:      ...||.|..|:.||..: .:|.|||||..|...|
  Rat  1062 PFYKDINECKAFPGMCTYGKCRNTI------GSFKCRCNSGFALDMEE-RNCTDIDECRISPDLC 1119

  Fly   304 -SEICENLPGEYKCSCQEGYYLDESG----KSCVDINEC-ANPELSSNCQ-GACENLPGSYRCVE 361
             |.||.|.||.:.|.|.|||   |||    |:|:||:|| .||.|   |: |.|.|..||::|..
  Rat  1120 GSGICVNTPGSFDCECFEGY---ESGFMMMKNCMDIDECERNPLL---CRGGTCVNTEGSFQCDC 1178

  Fly   362 PL--EENPEITEVVENPIEKTNEVPV--NVSESQPAGK----------TCNSGFQLSADGTDCQD 412
            ||  |.:|...:.::     .||..:  |:..:   ||          :||.|:|.:.|...|.|
  Rat  1179 PLGHELSPSREDCID-----INECSLSDNLCRN---GKCVNMIGTYQCSCNPGYQATPDRQGCSD 1235

  Fly   413 INECEVDGPEDLDNNAVCQQKCENTIGSFRCTCVEGYHLLEDQRSCA-LDSCTDLENPQLNRTRC 476
            |:||.:       .|..|..:|.|:.||:.|:|.|||.|:.|.|||| :|.|.:  ||.:    |
  Rat  1236 IDECMI-------MNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECEN--NPDI----C 1287

  Fly   477 -AHECQDLPEGSYRCVCPKGYELSEDQHSCL-VQE----------SPCSTEKG------------ 517
             ..:|.::| |.|||:|..|:..|.|..:|: |.|          ..|...||
  Rat  1288 DGGQCTNIP-GEYRCLCYDGFMASMDMRTCIDVNECDLNPNICMFGECENTKGSFICHCQLGYSV 1351

  Fly   518 ---------VEKCSPG--------TCLASEDNT--SFSCICPTGYRSEAFSCQDIDECAEDTHLC 563
                     |::|..|        :||    |.  ||.|.|..|:......|.|:|||:..||.|
  Rat  1352 KKGATGCTDVDECEIGAHNCDMHASCL----NVPGSFKCSCREGWVGNGIKCIDLDECSNGTHQC 1412

  Fly   564 S--HTCQNTPGGYQCQCPEGLNLVEEYTCLAENLCEVNNNGCEQ-ICLTARGGV-CACREGFRLS 624
            |  ..|.||||.|:|.|.||.. .:.:||...:.|..|.|.||. .||...|.. |.|..||..:
  Rat  1413 SINAQCVNTPGSYRCACSEGFT-GDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPA 1476

  Fly   625 ADGKSCEDVDECLVNNGGCQQVCRNLPGSYGCICAAGYELLKLDGIRGYCFDIDECSQRTH---- 685
            :|.:||:|:|||...|......|.||||.:.|||..|||   ||...|.|.|||||:...:
  Rat  1477 SDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYE---LDRTGGNCTDIDECADPINCVNG 1538

  Fly   686 ------------------------GCSDQ------------------------------------ 690
                                    ||.|.
  Rat  1539 LCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEVGVGVSRSSCCCSL 1603

  Fly   691 ----------------------------------------------------------------- 690

  Rat  1604 GKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQC 1668

  Fly   691 ------------MLCENLN------------------GSYTCLCPPGYALGLDNHIVTSLNSSFI 725
                        .:||:::                  |:|||:|||.|......|....:..||.
  Rat  1669 ECPQGYYLSEETRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFC 1733

  Fly   726 TDS---TSSE------------------------------TPSA-----------------HT-- 738
            ..|   |:.|                              ||..                 ||
  Rat  1734 YRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGK 1798

  Fly   739 CLDIDECSLANGNCSH-FCQNEPGGFQCACPLGYALSEDMRTCQDIDECLDSNGQCSQL--CLNQ 800
            .:|||||....|.|:: .|.|:.|.|:|.||.|::.::.:..|:|||||.:.:..|.:.  |:|.
  Rat  1799 AVDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINS 1863

  Fly   801 PGGFACACETGFELTPDGFGCADIDECSQDYGNCS-DICINLLGTHACACERGYELAKDKLSCLD 864
            ||.:.|.|..||:|:|:| .|.|.:||.:....|| .:|::|.|::.|.|..|::.::|:..|:|
  Rat  1864 PGSYRCECAAGFKLSPNG-ACVDRNECLEIPNVCSHGLCVDLQGSYQCICNNGFKASQDQTMCMD 1927

  Fly   865 VDECAGLLSGGCSHECINKAGTFECGCPLGYIL---ND--DGRSCSPALVG--CPPGTQRSADGC 922
            ||||.....|  :..|.|..|::.|.|..|:.|   ||  |...|| :..|  |..|...:..|.
  Rat  1928 VDECERHPCG--NGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECS-SFFGQVCRNGRCFNEIGS 1989

  Fly   923 APIECNPGYTLGSDDK-CVDIDECQKQNGGCS-HRCSNTEGSFKCSCPPGYELDSDQKTCQDIDE 985
            ....||.||.|..|.| |:|.:||....|.|| ..|.|.||||:|.||||||:.|:  .|.||:|
  Rat  1990 FKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSE--NCIDINE 2052

  Fly   986 CDQDKTSCITGTCINEIGGFRCEFPKFPVLPE-----IPTASSLPESPKIELKTPKYPDFTELSN 1045
            ||:|...|:.|:|.|..|||:|..|...||.:     ..|..|.              .||..
  Rat  2053 CDEDPNICLFGSCTNTPGGFQCICPPGFVLSDNGRRCFDTRQSF--------------CFTNF-- 2101

  Fly  1046 EIPENPKKPAEFDYPEPKFPSLPKWEGLPKLPPLADIPTSKAPVPLRPEVPKSLWVNQLQPRDLC 1110
               ||.|            .|:||           ...|:||.. ...::|...|.:   |.:||
  Rat  2102 ---ENGK------------CSVPK-----------AFNTTKAKC-CCSKMPGEGWGD---PCELC 2136

  Fly  1111 PR-----FQ-----------APRNGKSHCNRYRHKQKLFYYSRC-------RISCNSGYILQGPE 1152
            |:     ||           :..:.:...|.......:....:|       |..|..||.|....
  Rat  2137 PKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYSG 2201

  Fly  1153 IK-------------------------SCDAN-GIWEGPETKCVAINQPRAQSP----------- 1180
            ::                         .|:.| |...||...|..||: .||:|
  Rat  2202 VRCVDTDECSIGNPCGNGTCANVIGSFECNCNEGFEPGPMMNCEDINE-CAQNPLLCAFRCMNTF 2265

  Fly  1181 ------------------------------------------------GICP---ALKPAQNGVI 1194
                                                            .|||   |.:|...|.:
  Rat  2266 GSYECTCPVGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCV 2330

  Fly  1195 LPASCTQGPSRFGDVC------------RLQCNAGFVSTGSLLTACM-MLQGWSFGADLN--CQ 1243
            ....|...|.    :|            |.:||.||.|:.| .|.|: ..||..|...|.  ||
  Rat  2331 DENECRTKPG----ICENGRCVNIIGSYRCECNEGFQSSSS-GTECLDNRQGLCFAEVLQTMCQ 2389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342	18/39 (46%)
		cEGF	396..415	CDD:289433	8/18 (44%)
		FXa_inhibition	425..458	CDD:291342	14/32 (44%)
		FXa_inhibition	476..505	CDD:291342	11/29 (38%)
		vWFA	<550..586	CDD:294047	19/37 (51%)
		FXa_inhibition	596..630	CDD:291342	13/35 (37%)
		FXa_inhibition	636..>664	CDD:291342	12/27 (44%)
		EGF_CA	676..715	CDD:284955	18/197 (9%)
		FXa_inhibition	745..780	CDD:291342	11/35 (31%)
		FXa_inhibition	786..821	CDD:291342	13/36 (36%)
		FXa_inhibition	827..862	CDD:291342	10/35 (29%)
		FXa_inhibition	874..904	CDD:291342	11/34 (32%)
		FXa_inhibition	945..980	CDD:291342	18/35 (51%)
		CCP	1110..1170	CDD:153056	16/108 (15%)
		CCP	1183..1235	CDD:153056	19/67 (28%)
		DUF5011	1468..1536	CDD:295940
Fbn2	NP_114014.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BA2W
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D4721at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44463
orthoMCL	1	0.900	-	-		OOG6_100900
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1431
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.720