Protein Alignment frac and Svep1

DIOPT Version :10

• Sequence 1: NP_648137.3
• Gene: frac / 38850
• FlyBaseID: FBgn0035798
• Length: 1618
• Species: Drosophila melanogaster
• Sequence 2: NP_001406613.1
• Gene: Svep1 / 685899
• RGDID: 1588987
• Length: 3568
• Species: Rattus norvegicus
• Alignment Length: 2219
• Identity: 434/2219 - (19%)
• Similarity: 656/2219 - (29%)
• Gaps: 944/2219 - (42%)

  Fly    14 VAFASASPSSERKRKNV--------MNIPEDPKVSDSLAA--SLDMSCSSAKILPPEINHGRVSV 68
            |.:.:..||...:..::        ..:|..|...|.:.|  |..::||
  Rat   702 VWYTATDPSGNNRTCDIHIVIKGSPCEVPFTPVNGDFICAQDSAGVNCS---------------- 750

  Fly    69 FDRRRRGKKVFLVAFFVCDDNYDFENGISE-MFCSNQKWV------DEIPTCIPQLNFEEHD--- 123
                           ..|.:.|||..|.:| .:|:.:..:      .|.|.|..: .|..|.
  Rat   751 ---------------LTCREGYDFTEGSTEKYYCAFEDGIWRPPYSTEWPDCAIK-RFANHGFKS 799

  Fly   124 ----------------EKVGYDLEDYSDETVPNDYVENSDID---EDDDE----EVSEREPPPPP 165
                            :|.....|....:.||:...:..|||   ||..:    |.:........
  Rat   800 FEMLYKTTRCDDMDLFKKFSAAFETTLGKMVPSFCSDADDIDCRLEDLTKKYCIEYNYNYENGFA 864

  Fly   166 PPPVVDGADSKPEPQIVIEINDDHANEVVESEPALAETETENEVLENETPLKAEVQTDVLNSSNA 230
            ..|...||.::      ::.:.||..:||:..|| ...:|.:..::...|| ::.|..::.:..|
  Rat   865 IGPGGWGAGNR------LDYSYDHFLDVVQETPA-DVGKTRSSRIKRTVPL-SDPQIQLIFNITA 921

  Fly   231 SVKVTNDPYEPTFLDNNCGEDNGGCAHICKRLLYPDE------NQPINK--------------CD 275
            ||.:..:..:...|:|.            :||:...|      ...:||              .|
  Rat   922 SVPLPEERNDTVELENQ------------QRLIRTLETITNRLKSTLNKGPMYSFQLASETVVAD 974

  Fly   276 ------------CREG----------------YTLDPNDYASCL--------------------- 291
                        ||.|                |:|:.:...|||
  Rat   975 SNSLETEKAFLFCRPGSVLRGRMCVNCPLGTSYSLEHSTCESCLMGSYQDEEGQLECKLCPPRTH 1039

  Fly   292 -------DIDEC--------LESNGGCSEICENLP------------------------------ 311
                   .|.||        ..|:|  .|.||:.|
  Rat  1040 TEYLHSRSISECKAQCKQGTYSSSG--LETCESCPLGTYQPDFGSRSCLPCPETTTTVKRGAVDI 1102

  Fly   312 ---------GEYKCS-------CQEGYYLDESGKS-CV--------------DINECAN------ 339
                     ||:..|       |...||...:||| |:              .|.:|::
  Rat  1103 SACGVPCPVGEFSRSGLTPCYPCPRDYYQPNAGKSFCLACPFYGTTTITGATSITDCSSFSSTFS 1167

  Fly   340 -------------P-----ELSSN---------C--QGACENLPGSYRCVEPLEENPEITEV-VE 374
                         |     |:||.         |  .|.|:.|...|.|:.|    |..|.: .|
  Rat  1168 AAEESIVPLAAPGPTQNKYEVSSQVFHECFLNPCHNSGTCQQLGRGYVCLCP----PGYTGLKCE 1228

  Fly   375 NPIEKTNEVPV---NVSESQPAGKT--CNSGFQLSADGTDCQD-INECEVDGPEDLDNNAVCQQK 433
            ..|::.:.:|.   .:...:..|.|  |:||:    .|..|:: ||||         :::.|..|
  Rat  1229 TDIDECSSLPCLNGGICRDKVGGFTCECSSGY----TGQICEENINEC---------SSSPCLNK 1280

  Fly   434 --CENTIGSFRCTCVEGY---HLLEDQRSCALDSCTDLENPQLNRTRCAHECQDLPEGSYRCVCP 493
              |.:.:.|:|||||.||   |...|...|....|       ||...|..:.     |.:.|.||
  Rat  1281 GTCTDGLASYRCTCVSGYVGVHCETDVNECQSSPC-------LNNAVCKDQV-----GGFSCKCP 1333

  Fly   494 KGY-----ELSEDQHSCLVQESPCSTEKGVEKCSPGTCLASEDNTSFSCICPTGYRSEAFSCQ-D 552
            .|:     |.:.|:  ||.|  ||.        :..||  .:...||.|.||.|:...  .|: :
  Rat  1334 PGFLGTRCEKNVDE--CLSQ--PCQ--------NGATC--KDGANSFRCQCPAGFTGP--HCELN 1382

  Fly   553 IDECAEDTHLCSHTCQNTPGGYQCQC-------------PEGLNL-------------------V 585
            |:||..:......||.:....|.|:|             |.|.||                   :
  Rat  1383 INECQSNPCRNQATCVDELNSYSCKCRPGFSGRRCETEQPSGFNLDFEVSGIYGYVLLDGVLPTL 1447

  Fly   586 EEYTC-------------------LAEN------LCEVNN-----NGCEQI--CLTARGGV---- 614
            ...||                   |..|      |.:.|.     ||.|:|  |.:...|:
  Rat  1448 HAITCAFWMKSSDVINYGTPISYALEGNKDNTFLLTDYNGWVLYVNGKEKITNCPSVNDGIWHHI 1512

  Fly   615 ----CACREGFRLSADGKSCEDVDECLVNNGGCQQVCRNLPGSYGCICAAGYELLKLDGIR---- 671
                .:....:|:..||:        |.::|....|.:.:||. |.:.....:..|.:|..
  Rat  1513 AITWTSTGGAWRVYIDGE--------LSDSGTGLSVGKAIPGG-GALVLGQEQDKKGEGFNPAES 1568

  Fly   672 -----------GYCFDIDECSQRTHGCSDQMLCENLNGSYTCLCPPGYALGLDNHIVTSLNSSFI 725
                       .|.....:.......|.:::...|:      |..|.:..|:...:....:|.|.
  Rat  1569 FVGSISQLNLWDYVLSPQQVKSLASSCPEELSRGNV------LAWPDFVSGITGKVKVDSSSIFC 1627

  Fly   726 TDSTSSE-------------TPSAHTCLDIDECSLANGNCSHFCQNE------------------ 759
            :|..|.|             .|.:...|..|......||...:|.|:
  Rat  1628 SDCPSLEGSVPHLRPASGDRKPGSKVSLFCDPGFQMVGNPVQYCLNQGQWSQPLPHCERIRCGLP 1692

  Fly   760 ---PGGFQCA------------CPLGYALSEDMR--------------TCQDIDECLDSNGQCSQ 795
               ..||..|            |..||.|..|.|              :|.|:|||. ....||:
  Rat  1693 PTLENGFYSAEDLHAGSTVTYQCTSGYYLLGDSRMFCTDNGSWNGISPSCLDVDECA-VGSDCSE 1756

  Fly   796 --LCLNQPGGFACACETGFELTPDGFGCADIDEC------------SQDYGNCSDICIN------ 840
              .|||..|.:.|:|:..:  |.||..||:..:|            .:.|...:::..:
  Rat  1757 HASCLNTNGSYICSCKPPY--TGDGKNCAEPVKCKAPENPENGHSLGKIYSVGAEVTFSCEEGHQ 1819

  Fly   841 LLGTH--------------------ACA------------------------CERGYELAKDKLS 861
            |:|..                    :|.                        |::||.||.|
  Rat  1820 LVGVRKITCLESGEWDHLRPSCEAISCGAPPVPENGGVDGSAFTYGSKVRYRCDKGYTLAGD--- 1881

  Fly   862 CLDVDECAGLLSGGCSHE---CINKAGTFECGCPLG-----YILN------------DDGRSC-S 905
                :|.|.|.||..||.   |    ...:|..|..     |||:            :||.|. .
  Rat  1882 ----EESACLASGSWSHSSPVC----ELVKCSQPENINNGKYILSGLTYLSIASYSCEDGYSLQG 1938

  Fly   906 PALVGC---------PPGTQRSADGCAPI-------------------ECNPGYTLGSDDKCVDI 942
            |:|:.|         ||..|..:.|..|:                   .|..||||...|..:
  Rat  1939 PSLIECTASGSWDRAPPSCQLVSCGEPPMVKDALTTGSNFTFGNMVTYTCKEGYTLAGPDTII-- 2001

  Fly   943 DECQKQNG---GCSHRCSNTEGSFKCSCPP------------------------GYEL-DSDQKT 979
              || .||   ..:|:|.    :..|..||                        ||.| |:.|..
  Rat  2002 --CQ-ANGKWNSSNHQCL----AVSCDEPPNVDHASPETAHRLFGDTAFYYCADGYSLADNSQLI 2059

  Fly   980 C-----------QDIDECDQDKTSCITGTCINEIGGFRCEFPKFPVLPEIPTAS-SLPES-PKIE 1031
            |           |.:..|               |..| ||.|        |:.| |:.|| .|.:
  Rat  2060 CNAQGNWVPPEGQAVPRC---------------IAHF-CEKP--------PSVSYSILESVSKAK 2100

  Fly  1032 LKTPKYPDFTELSNEIPENPKKPAEFDYPEPKFPSLPKWEGLPKLPPLADIPTSKAPVPLRPEVP 1096
            ........|..:...:...          ..|...|...:..|.       |.|...:|:|...|
  Rat  2101 FAAGSVVSFKCMEGFVLNT----------SAKIECLRGGQWSPS-------PLSVQCIPVRCGEP 2148

  Fly  1097 KSLWVNQLQPRDLCPRFQAPRNGKSHCNRYRHKQKLFYYSRCRISCNSGYILQGPEIKSCDANGI 1161
            .|:                 .||......|.....:.|      ||:.|:.::|.:..:|:|.|.
  Rat  2149 PSI-----------------TNGYPSGTNYSFGAVVAY------SCHKGFYIKGEKKSTCEATGQ 2190

  Fly  1162 WEGPETKC--VAINQPRAQSPGICPALKPAQNGVILPASCTQGPSRFGDVCRLQCNAGFVSTGSL 1224
            |..|...|  |:.|:|    |.:       :||.:   ..|.|.: |....|.|||.|:.:.||.
  Rat  2191 WSRPLPTCHPVSCNEP----PKV-------ENGFL---EHTTGRT-FESEARFQCNPGYKAVGSP 2240

  Fly  1225 LTACMMLQGWSFGADLNCQPFGNG------------------------------LLGN-----QL 1254
            :..|...:.|...|.|:|.|...|                              |:|:     |.
  Rat  2241 VFVCQANRHWHSDAPLSCTPLNCGKPPPIQNGFLRGESFEVGSKVQFVCNEGYELVGDNSWTCQK 2305

  Fly  1255 SPMWN---SPKTVTPHQIQNVEQIRPYINCPENVVILLHAGEQKAHVTLQRPQTNVKNGRLVAHP 1316
            |..|:   |||.|.....:     .|.:   ||.::|.....:...:|:     :.|.|..:..|
  Rat  2306 SGKWSKKPSPKCVPTKCAE-----PPLL---ENQLVLKELTSEVGVMTI-----SCKEGHALQGP 2357

  Fly  1317 AWAGQLQGHLPAGVHKVDFRVNDPETKLTIKCHTIITVKAATPRES------------------- 1362
            :    :...||:|.....|    |..||.: |.:...:....|..|
  Rat  2358 S----VLKCLPSGQWNGSF----PVCKLVL-CQSPPLIPFGVPASSGALHFGSTVKYLCVDGFFL 2413

  Fly  1363 --NPFTLFRISDYSRSSLPRPAP------------------FATLSTGSSFSFPAFKALDATP-- 1405
              ||..|.::.....|.||...|                  .|.|||......|.|:.:..|.
  Rat  2414 RGNPIILCQVDGTWSSPLPECVPVECPQPEEILNGIIHVQGLAYLSTTLYTCKPGFELVGNTTTL 2478

  Fly  1406 --------------KPVSFTKFQVFPDSESSEHSKLGSSSF-------------FRLEPLFHESS 1443
                          :|:.      .|:.:...:.:..|.||             ||||
  Rat  2479 CGENGQWLGGKPMCRPIE------CPEPKEILNGQFSSVSFQYGQTITYSCDRGFRLE------- 2530

  Fly  1444 KLISAAPAS-----SENTRVDLGSDTSNYC--PPSIEVYLKENQNLRSVVWDEPRFEGKLLKIYK 1501
                 .|.|     :.|..:|..|..:.:|  |..||....|..:.|         .|.:: ||
  Rat  2531 -----GPKSLTCLETGNWDMDAPSCNAIHCSDPQPIENGFVEGADYR---------YGAMI-IY- 2579

  Fly  1502 SHFPGSLFKVGDHAIKYEATTTDGKTLSCTFFIYVRSAKPTPAPTE----PKISFDSEPETLSDV 1562
            |.|||  |:|..||::    |.:....|        |:.||..|.:    |.|.| .:...:||
  Rat  2580 SCFPG--FQVVGHAMQ----TCEETGWS--------SSSPTCVPIDCGLPPHIDF-GDCTRVSD- 2628

  Fly  1563 SQTYVVCPD 1571
            .|.|.|..|
  Rat  2629 GQGYFVQED 2637

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_648137.3	FXa_inhibition	296..331	CDD:464251	16/89 (18%)
		cEGF	396..415	CDD:463661	7/21 (33%)
		FXa_inhibition	425..458	CDD:464251	13/37 (35%)
		FXa_inhibition	476..505	CDD:464251	8/33 (24%)
		EGF_CA	552..>581	CDD:214542	9/41 (22%)
		FXa_inhibition	596..630	CDD:464251	10/48 (21%)
		FXa_inhibition	636..>664	CDD:464251	6/27 (22%)
		EGF_CA	676..711	CDD:214542	4/34 (12%)
		FXa_inhibition	745..780	CDD:464251	13/81 (16%)
		FXa_inhibition	786..821	CDD:464251	12/36 (33%)
		vWFA	<821..861	CDD:469594	13/101 (13%)
		FXa_inhibition	874..904	CDD:464251	11/49 (22%)
		FXa_inhibition	945..980	CDD:464251	14/62 (23%)
		PTZ00449	<1017..>1098	CDD:185628	15/82 (18%)
		CCP	1110..1170	CDD:153056	14/61 (23%)
		CCP	1183..1235	CDD:153056	13/51 (25%)
		HYR	1468..1536	CDD:460572	19/69 (28%)
Svep1	NP_001406613.1	Important for the interaction with integrin ITGA9:ITGB1. /evidence=ECO:0000250|UniProtKB:A2AVA0	2638..2645		434/2219 (20%)