DRSC/TRiP Functional Genomics Resources

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Protein Alignment frac and Svep1

DIOPT Version :10

Sequence 1:NP_648137.3 Gene:frac / 38850 FlyBaseID:FBgn0035798 Length:1618 Species:Drosophila melanogaster
Sequence 2:NP_073725.2 Gene:Svep1 / 64817 MGIID:1928849 Length:3567 Species:Mus musculus


Alignment Length:1729 Identity:358/1729 - (20%)
Similarity:531/1729 - (30%) Gaps:666/1729 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   211 ENETPLKAEVQTDVLNSSNASVKVTNDPYEPTFLDNNCGEDNGGCAHICKRLLYPDENQPINKCD 275
            |:..||.|.      ..|....:|::..:...|| |.| .::|.|..:.:..:          |.
Mouse  1171 ESIVPLVAP------GHSQNKYEVSSQVFHECFL-NPC-HNSGTCQQLGRGYV----------CL 1217

  Fly   276 CREGYTLDPNDYASC-LDIDECLE---SNGGCSEICENLPGEYKCSCQEGYYLDESGKSCVD-IN 335
            |..|||     ...| .|||||..   .|||   ||.:..|.:.|.|..||    ||:.|.: ||
Mouse  1218 CPPGYT-----GLKCETDIDECSSLPCLNGG---ICRDQVGGFTCECSLGY----SGQICEENIN 1270

  Fly   336 ECANPELSSNC--QGACENLPGSYRCVEPLEENPEITEVVENPIEKTNEVPVNVSESQPAGKTCN 398
            ||    :||.|  :|.|.:...||||                                    ||.
Mouse  1271 EC----ISSPCLNKGTCTDGLASYRC------------------------------------TCV 1295

  Fly   399 SGFQLSADGTDCQ-DINECEVDGPEDLDNNAVCQQKCENTIGSFRCTCVEGYHLLEDQRSCALDS 462
            .|:.    |..|: |:|||:   .....|||||:.:    :|.|.|.|..|:  |..:....:|.
Mouse  1296 KGYM----GVHCETDVNECQ---SSPCLNNAVCKDQ----VGGFSCKCPPGF--LGTRCEKNVDE 1347

  Fly   463 CTDLENPQLNRTRCAHECQDLPEGSYRCVCPKGY-----ELSEDQHSCLVQESPCSTEKGVEKCS 522
            |  |..|..|...|....     .|:||.||.|:     ||:.::  |  |.:||..:       
Mouse  1348 C--LSQPCQNGATCKDGA-----NSFRCQCPAGFTGTHCELNINE--C--QSNPCRNQ------- 1394

  Fly   523 PGTCLASEDNTSFSCICPTGYRSEAFSCQDIDECAEDTHLCSHTCQNTPGGYQCQC--PEGLNL- 584
             .||:  ::..|:||.|..|:                            .|::|:.  |.|.|| 
Mouse  1395 -ATCV--DELNSYSCKCQPGF----------------------------SGHRCETEQPSGFNLD 1428

  Fly   585 ------------------VEEYTCL----------------------AEN---LCEVNN-----N 601
                              :...||.                      .:|   |.:.|.     |
Mouse  1429 FEVSGIYGYVLLDGVLPTLHAITCAFWMKSSDVINYGTPISYALEDDKDNTFLLTDYNGWVLYVN 1493

  Fly   602 GCEQI--CLTARGGV--------CACREGFRLSADGKSCEDVDECLVNNGGCQQVCRNLPGSYGC 656
            |.|:|  |.:...|:        .:....:|:..||:        |.:.|....:.:.:||. |.
Mouse  1494 GKEKITNCPSVNDGIWHHIAITWTSTGGAWRVYIDGE--------LSDGGTGLSIGKAIPGG-GA 1549

  Fly   657 ICAAGYELLKLDGIR---------------GYCFDIDECSQRTHGCSDQMLCENLNGSYTCLCPP 706
            :.....:..|.:|..               .|.....:.......|.:::...|:      |..|
Mouse  1550 LVLGQEQDKKGEGFNPAESFVGSISQLNLWDYVLSPQQVKLLASSCPEELSRGNV------LAWP 1608

  Fly   707 GYALGLDNHIVTSLNSSFITDSTSSE-------------TPSAHTCLDIDECSLANGNCSHFCQN 758
            .:..|:...:....:|.|.:|..|.|             .|.:...|..|......||...:|.|
Mouse  1609 DFLSGITGKVKVDSSSMFCSDCPSLEGSVPHLRPASGNRKPGSKVSLFCDPGFQMVGNPVQYCLN 1673

  Fly   759 E---------------------PGGFQCA------------CPLGYALSEDMR------------ 778
            :                     ..||..|            |..||.|..|.|            
Mouse  1674 QGQWTQPLPHCERIRCGLPPALENGFYSAEDFHAGSTVTYQCTSGYYLLGDSRMFCTDNGSWNGI 1738

  Fly   779 --TCQDIDECLDSNGQCSQ--LCLNQPGGFACACETGFELTPDGFGCADIDEC----SQDYGNCS 835
              :|.|:|||. ....||:  .|||..|.:.|:|...:  |.||..||:..:|    :.:.|:.|
Mouse  1739 SPSCLDVDECA-VGSDCSEHASCLNTNGSYVCSCNPPY--TGDGKNCAEPVKCKAPENPENGHSS 1800

  Fly   836 DICINLLGTHAC-ACERGYEL-AKDKLSCLDVDE-------CAGLL--------SGGCSHECINK 883
            .. |..:||... :|:.|:|| ....::||:..|       |..:.        :||........
Mouse  1801 GE-IYTVGTAVTFSCDEGHELVGVSTITCLETGEWDRLRPSCEAISCGVPPVPENGGVDGSAFTY 1864

  Fly   884 AGTFECGCPLGYILNDDGRS-------------------CS------------------------ 905
            .......|..||.|:.|..|                   ||                        
Mouse  1865 GSKVVYRCDKGYTLSGDEESACLASGSWSHSSPVCELVKCSQPEDINNGKYILSGLTYLSIASYS 1929

  Fly   906 ---------PALVGC---------PPGTQRSADGCAPI-------------------ECNPGYTL 933
                     |:|:.|         ||..|..:.|..||                   .|..||||
Mouse  1930 CENGYSLQGPSLLECTASGSWDRAPPSCQLVSCGEPPIVKDAVITGSNFTFGNTVAYTCKEGYTL 1994

  Fly   934 GSDDKCVDIDECQKQNG---GCSHRCSNTEGSFKCSCPP------------------------GY 971
            ...|..|    || .||   ..:|:|.    :..|..||                        ||
Mouse  1995 AGPDTIV----CQ-ANGKWNSSNHQCL----AVSCDEPPNVDHASPETAHRLFGDTAFYYCADGY 2050

  Fly   972 EL-DSDQKTCQD----IDECDQDKTSCITGTCINEIGGFRCEFPKFPVLPEIPTAS-SLPES-PK 1029
            .| |:.|..|..    :....|....||         ...||.|        |:.| |:.|| .|
Mouse  2051 SLADNSQLICNAQGNWVPPAGQAVPRCI---------AHFCEKP--------PSVSYSILESVSK 2098

  Fly  1030 IELKTPKYPDFTELSNEIPENPKKPAEFDYPEPKFPSLPKWEGLPKLPPLADIPTSKAPVPLRPE 1094
            .:........|..:...:...          ..|...|...|..|.       |.|...:|:|..
Mouse  2099 AKFAAGSVVSFKCMEGFVLNT----------SAKIECLRGGEWSPS-------PLSVQCIPVRCG 2146

  Fly  1095 VPKSLWVNQLQPRDLCPRFQAPRNGKSHCNRYRHKQKLFYYSRCRISCNSGYILQGPEIKSCDAN 1159
            .|.|:                 .||......|.....:.|      ||:.|:.::|.:..:|:|.
Mouse  2147 EPPSI-----------------ANGYPSGTNYSFGAVVAY------SCHKGFYIKGEKKSTCEAT 2188

  Fly  1160 GIWEGPETKC--VAINQPRAQSPGICPALKPAQNGVILPASCTQGPSRFGDVCRLQCNAGFVSTG 1222
            |.|..|...|  |:.|:|    |.:       :||.:   ..|.|.: |....|.|||.|:.:.|
Mouse  2189 GQWSKPTPTCHPVSCNEP----PKV-------ENGFL---EHTTGRT-FESEARFQCNPGYKAAG 2238

  Fly  1223 SLLTACMMLQGWSFGADLNCQPFGNG------------------------------LLGN----- 1252
            |.:..|...:.|...|.|:|.|...|                              |:|:     
Mouse  2239 SPVFVCQANRHWHSDAPLSCTPLNCGKPPPIQNGFLKGESFEVGSKVQFVCNEGYELVGDNSWTC 2303

  Fly  1253 QLSPMWN---SPKTVTPHQIQNVEQIRPYINCPENVVILLHAGEQKAHVTLQRPQTNVKNGRLVA 1314
            |.|..|:   |||.|.....:     .|.:   ||.::|.....:...:|:...:.:...|..|.
Mouse  2304 QKSGKWSKKPSPKCVPTKCAE-----PPLL---ENQLVLKELASEVGVMTISCKEGHALQGPSVL 2360

  Fly  1315 HPAWAGQLQGHLPAGVHKVDFRVNDPETKLTIKC-----HTIITVKAATP----RESNPFTLFRI 1370
            ....:||..|..|  :.|:....:.|.....:..     |...|||....    ...:|..|.:.
Mouse  2361 KCLPSGQWNGSFP--ICKMVLCPSPPLIPFGVPASSGALHFGSTVKYLCVDGFFLRGSPTILCQA 2423

  Fly  1371 SDYSRSSLPRPAP------------------FATLSTGSSFSFPAFKAL-DATP----------- 1405
            .....|.||...|                  .|.|||......|.|:.: :||.           
Mouse  2424 DSTWSSPLPECVPVECPQPEEILNGIIHVQGLAYLSTTLYTCKPGFELVGNATTLCGENGQWLGG 2488

  Fly  1406 ----KPVSFTKFQVFPDSESSEHSKLGSSSF-------------FRLEPLFHESSKLISAAPASS 1453
                ||:.      .|:.:...:.:..|.||             ||||            .|.|.
Mouse  2489 KPMCKPIE------CPEPKEILNGQFSSVSFQYGQTITYFCDRGFRLE------------GPKSL 2535

  Fly  1454 ENTRVDLGSDTSNYCPPSIE-VYLKENQNLRSVVWDEPRFEGKLLKIYKSHFPGSLFKVGDHAIK 1517
              |.::.|....:  |||.: ::..:.|.:.:...:...:....:.|| |.|||  |:|..||::
Mouse  2536 --TCLETGDWDMD--PPSCDAIHCSDPQPIENGFVEGADYRYGAMIIY-SCFPG--FQVLGHAMQ 2593

  Fly  1518 YEATTTDGKTLSCTFFIYVRSAKPTPAPTE----PKISF 1552
                |.:....|        |:.||..|.:    |.|.|
Mouse  2594 ----TCEESGWS--------SSSPTCVPIDCGLPPHIDF 2620

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fracNP_648137.3 FXa_inhibition 296..331 CDD:464251 13/37 (35%)
cEGF 396..415 CDD:463661 6/19 (32%)
FXa_inhibition 425..458 CDD:464251 11/32 (34%)
FXa_inhibition 476..505 CDD:464251 9/33 (27%)
EGF_CA 552..>581 CDD:214542 3/30 (10%)
FXa_inhibition 596..630 CDD:464251 10/48 (21%)
FXa_inhibition 636..>664 CDD:464251 5/27 (19%)
EGF_CA 676..711 CDD:214542 4/34 (12%)
FXa_inhibition 745..780 CDD:464251 13/81 (16%)
FXa_inhibition 786..821 CDD:464251 12/36 (33%)
vWFA <821..861 CDD:469594 12/45 (27%)
FXa_inhibition 874..904 CDD:464251 8/48 (17%)
FXa_inhibition 945..980 CDD:464251 14/62 (23%)
PTZ00449 <1017..>1098 CDD:185628 16/82 (20%)
CCP 1110..1170 CDD:153056 14/61 (23%)
CCP 1183..1235 CDD:153056 13/51 (25%)
HYR 1468..1536 CDD:460572 16/68 (24%)
Svep1NP_073725.2 VWA 84..259 CDD:459670
Ephrin_rec_like 311..361 CDD:429604
CCP 379..435 CDD:153056
CCP 439..495 CDD:153056
CCP <514..556 CDD:153056
HYR 560..642 CDD:460572
HYR 644..722 CDD:460572
Ephrin_rec_like 1004..1051 CDD:429604
Ephrin_rec_like 1058..1105 CDD:429604
Ephrin_rec_like 1112..1159 CDD:429604
EGF_CA 1195..1228 CDD:238011 11/49 (22%)
EGF_CA 1230..1266 CDD:238011 17/42 (40%)
EGF_CA 1268..1304 CDD:238011 17/79 (22%)
EGF_CA 1306..1342 CDD:238011 15/44 (34%)
EGF_CA 1344..1380 CDD:238011 12/42 (29%)
EGF_CA 1382..1418 CDD:238011 12/77 (16%)
PTX 1423..1621 CDD:238086 30/212 (14%)
PHA02927 1643..1899 CDD:222943 56/259 (22%)
EGF_3 1748..1782 CDD:463759 12/36 (33%)
PHA02817 1899..>2008 CDD:165167 22/113 (19%)
PHA02927 1957..2198 CDD:222943 62/306 (20%)
PHA02927 2093..2318 CDD:222943 59/279 (21%)
PHA02831 2277..>2435 CDD:165176 31/167 (19%)
PHA02927 2400..2608 CDD:222943 50/244 (20%)
Important for the interaction with integrin ITGA9:ITGB1. /evidence=ECO:0000269|PubMed:22654117 2638..2645
CCP <2670..2710 CDD:153056
PHA02927 2709..2941 CDD:222943
PHA02927 2903..3113 CDD:222943
PHA02927 3012..3225 CDD:222943
PHA02927 3232..3464 CDD:222943
Blue background indicates that the domain is not in the aligned region.

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