DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment frac and Ltbp2

DIOPT Version :9

Sequence 1:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster
Sequence 2:	XP_006240412.1	Gene:	Ltbp2 / 59106	RGDID:	68380	Length:	1831	Species:	Rattus norvegicus

Alignment Length:	1278	Identity:	341/1278 - (26%)
Similarity:	475/1278 - (37%)	Gaps:	399/1278 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 NSDI----DEDDDEEVS-----EREPPPPPPPPVVDGADSKP---------EPQIVIEINDDHAN 191
            :|||    .:.::||::     :|:....|||   ..|:.:|         |.:.:.:..|..|.
  Rat   740 SSDIRLSMRKAEEEELASPVREQRQQSSGPPP---GAAERQPLRAATATWIEAETLPDKGDSRAI 801

  Fly   192 EVVESEPALAETETENEVLENETPL-------KAEVQTDVLNSSNASVKVTNDP--YEPTF--LD 245
            ::..|.|.| ......:.....||.       :...:..|:.||:  |.||:.|  ::|.|  ..
  Rat   802 QITTSAPHL-PARVPGDATGRPTPSLPGQGIPEGPAEEQVIPSSD--VLVTHGPPGFDPCFAGAS 863

  Fly   246 NNCGEDNGGCAHICKRLLYPDENQPINKCDCREGYTLDPN-DYASCLDIDECL----ESNGGCSE 305
            |.||.  |.|..:      |:.    .:|.|..||.|.|: ||  |.|.:|||    |..|.
  Rat   864 NICGP--GTCVKL------PNG----YRCVCSPGYQLHPSQDY--CTDDNECLRNPCEGRGR--- 911

  Fly   306 ICENLPGEYKCSCQEGYYLDESG--KSCVDINECANPELSSNCQGACENLPGSYRCVEPLEENPE 368
             |.|..|.|.|.|..||.|...|  :.|.|::||..|.:.|.  |.|.|..|||.|
  Rat   912 -CVNSVGSYSCLCYPGYTLATLGDTQECQDVDECEQPGVCSG--GRCSNTEGSYHC--------- 964

  Fly   369 ITEVVENPIEKTNEVPVNVSESQPAGKTCNSGFQLSADGTDCQDINECEVDGPEDLDNNAVCQQ- 432
                                       .|:.|:.:...| .|||||||...|        .|..
  Rat   965 ---------------------------ECDQGYVMVRRG-HCQDINECRHPG--------TCPDG 993

  Fly   433 KCENTIGSFRC-TCVEGYHLLEDQRSCALDSCTDLENPQLNRTRCAH-ECQDLPEGSYRCVCPKG 495
            :|.|:.||:.| .|.|||       .....:|.|: |..|....||| .|.:: |||:||.|..|
  Rat   994 RCVNSPGSYTCLACEEGY-------IGQSGNCVDM-NECLTPGICAHGRCINM-EGSFRCSCEPG 1049

  Fly   496 YELSEDQHSCL-VQESPCSTEKGVEKCSPGTCLASEDNTSFSC-ICPTGY--RSEAFSCQDIDEC 556
            |||:.|:..|. |.|  |::.   ..|..|.||.:|.  ||:| .|.:||  ..:..:|:|:|||
  Rat  1050 YELTPDKKGCRDVDE--CASR---ASCPTGLCLNTEG--SFTCSACQSGYWVNEDGTACEDLDEC 1107

  Fly   557 AEDTHLCSHTCQNTPGGYQCQCPEGLNLVEEYTCLAENLCEVNNNGCEQICLTARGGVCACREGF 621
            |......:..|.||.|.:.|:                                      .|..||
  Rat  1108 AFPGVCPTGVCTNTVGSFSCK--------------------------------------DCDRGF 1134

  Fly   622 RLSADGKSCEDVDECLVNNGGC-QQVCRNLPGSYGCICAAGYELLKLDGIRGYCFDIDECSQRTH 685
            |.|..|.||||||||......| ...|:|..|||.|:|..|::|  .:|.  .|.|:|||....|
  Rat  1135 RPSPLGNSCEDVDECEGPQNSCLGGECKNTDGSYQCLCPQGFQL--ANGT--VCEDVDECVGEEH 1195

  Fly   686 GCSDQMLCENLNGSYTCLCPPGYALGLDNHIVTSLNSSFITDSTSSETPSAHTCLDIDECSLANG 750
             |:....|.|..||:.|||.||:|                    |:|  ....|.|:|||:....
  Rat  1196 -CAPHGECLNSPGSFFCLCAPGFA--------------------SAE--GGTRCQDVDECATTEP 1237

  Fly   751 NCSHFCQNEPGGFQCACPLGYALSEDMRTCQDIDECLDSNGQ-CSQ-LCLNQPGGFAC--ACETG 811
            .....|.|..|.|.|.|..|:..:.|...|.|||||.|.... |.. .|.|.||.:.|  .|:.|
  Rat  1238 CLGGHCVNTEGSFNCLCETGFQPAPDSGECVDIDECEDQGDPVCGDWRCENSPGSYRCVLGCQPG 1302

  Fly   812 FELTPDGFGCADIDECSQD--YGNCSDICINLLGTHACACERGYELAKDKLSCLDVDECAGLLSG 874
            |.:.|.| .|.|||||:.|  .|| ...|.|..|:..|.|::|:|.:.....|:||:||..:|:.
  Rat  1303 FYVAPTG-DCIDIDECANDTVCGN-HGFCDNTDGSFRCLCDQGFETSPSGWECVDVNECELMLAV 1365

  Fly   875 GCSHECINKAGTFECGC------------------------------------------------ 891
            .....|.|..|:|.|.|
  Rat  1366 CGDALCENVEGSFLCLCASDLEEYDAEEGHCRPRVAGAQRIPEVPTEEQAAGLTGMECYAEHNGG 1430

  Fly   892 -PLGYILNDD--------------GRSCSPALVGCPPGTQ-------RSADGCAPIECNPGYTLG 934
             |...||..:              |.:|.|    ||....       .|..|..|:|  ..:|.|
  Rat  1431 PPCSQILGQNSTQAECCCTQGARWGETCDP----CPSEDSVEFSELCPSGQGYIPVE--GAWTFG 1489

  Fly   935 -----SDDKCVDIDECQKQNGGCSHRCSNTEGSFKCSCPPGYELDSDQKTCQDIDECDQDKTSCI 994
                 ..|:|:.......|||    ||.||...:.|.|.|||..|:..:.|||.:|| || .:|.
  Rat  1490 QAMYTDADECILFGPALCQNG----RCLNTVPGYICLCNPGYHYDAVSRKCQDHNEC-QD-LACE 1548

  Fly   995 TGTCINEIGGFRCEFPKFPVLPEIPTASSLPESPKIELKTPKYPD--------FTELSNEIPENP 1051
            .|.|:|..|.|.| |...|::.::.....:..:...|    .:||        :.:::|::...|
  Rat  1549 NGECVNTEGSFHC-FCSPPLILDLSGQRCVNSTSSSE----DFPDHDIHMDICWKKVTNDVCSQP 1608

  Fly  1052 KKPAEFDYPEPKFPSLPKWEGLPKL-PP-----------LADIPTSK-APVPLRP---------E 1094
            .:.....|.|........|.....| ||           :|.|...: |.:..||         :
  Rat  1609 LRGHHTTYTECCCQDGEAWSQQCALCPPRSSEVYAQLCNVARIEAEREAGIHFRPGYEYGPGPDD 1673

  Fly  1095 VPKSLW-------VNQLQPRDLCPRFQAP-RNGKSHCN-----------------RY--RHKQKL 1132
            :|::|:       .|.|.|.|..|  :.| .|..||..                 .|  .|.:.|
  Rat  1674 LPETLYGPDGAPFYNYLGPEDTVP--EPPFSNTASHLGDNTPILEPPLQPSELQPHYIPSHSEPL 1736

  Fly  1133 FYY-----SRCRI--SCNSGYILQGPEIKSCDANGIWEGPE-----TKCVAINQPRAQSPGICPA 1185
            ..:     ..|.|  .|.:|..::..|..:||.   :||.:     ..||.:|:        |..
  Rat  1737 ASFEGLQAEECGILNGCENGRCVRVREGYTCDC---FEGFQLDTALMACVDVNE--------CED 1790

  Fly  1186 LKPAQNGVILPAS-CTQGPSRFGDVC-------RLQCNAGFVS 1220
            |    ||   ||: |..|.      |       |..|:.|:|:
  Rat  1791 L----NG---PAALCAHGH------CENTEGSYRCHCSPGYVA 1820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342	14/40 (35%)
		cEGF	396..415	CDD:289433	7/18 (39%)
		FXa_inhibition	425..458	CDD:291342	10/34 (29%)
		FXa_inhibition	476..505	CDD:291342	15/29 (52%)
		vWFA	<550..586	CDD:294047	11/35 (31%)
		FXa_inhibition	596..630	CDD:291342	6/33 (18%)
		FXa_inhibition	636..>664	CDD:291342	10/28 (36%)
		EGF_CA	676..715	CDD:284955	16/38 (42%)
		FXa_inhibition	745..780	CDD:291342	9/34 (26%)
		FXa_inhibition	786..821	CDD:291342	13/38 (34%)
		FXa_inhibition	827..862	CDD:291342	11/36 (31%)
		FXa_inhibition	874..904	CDD:291342	10/92 (11%)
		FXa_inhibition	945..980	CDD:291342	13/34 (38%)
		CCP	1110..1170	CDD:153056	17/91 (19%)
		CCP	1183..1235	CDD:153056	13/46 (28%)
		DUF5011	1468..1536	CDD:295940
Ltbp2	XP_006240412.1	EGF_CA	628..>657	CDD:214542
		TB	689..725	CDD:279073
		EGF_CA	897..931	CDD:238011	15/37 (41%)
		EGF_CA	940..>970	CDD:214542	13/67 (19%)
		EGF_CA	980..1015	CDD:238011	16/49 (33%)
		EGF_CA	1020..1051	CDD:214542	14/32 (44%)
		EGF_CA	1061..1101	CDD:284955	14/46 (30%)
		EGF_CA	1103..1143	CDD:284955	16/77 (21%)
		EGF_CA	1145..1184	CDD:284955	16/42 (38%)
		EGF_CA	1186..1227	CDD:214542	18/63 (29%)
		EGF_CA	1228..1259	CDD:214542	11/30 (37%)
		EGF_CA	1313..1346	CDD:214542	14/33 (42%)
		TB	1433..1468	CDD:279073	7/38 (18%)
		EGF_CA	1495..1528	CDD:214542	13/36 (36%)
		TB	1605..1640	CDD:279073	7/34 (21%)
		EGF_CA	1784..>1818	CDD:214542	12/54 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D4721at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44463
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24034
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020