DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment frac and Efemp2

DIOPT Version :9

Sequence 1:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster
Sequence 2:	NP_001157824.1	Gene:	Efemp2 / 58859	MGIID:	1891209	Length:	462	Species:	Mus musculus

Alignment Length:	361	Identity:	119/361 - (32%)
Similarity:	153/361 - (42%)	Gaps:	88/361 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   651 PGSYGCICAAGYELLKLDGIRGYCFDIDECSQRTHGCSDQMLCENLNGSYTCLCPPGYALGLDNH 715
            |.|| ..|..|||   .|....:|.|::||......|..:|.|.|..|.|.|| |...|:..|.|
Mouse    52 PDSY-TECTDGYE---WDADSQHCRDVNECLTIPEACKGEMKCINHYGGYLCL-PRSAAVISDLH 111

  Fly   716 IVTSLNSSFITDSTSSETPSAHTCLDIDECSLANGNCSHFCQNEPGGFQCACPLGYALSEDMRTC 780
                        ......|:||.                   .:|.    .||.||. .::..:|
Mouse   112 ------------GEGPPPPAAHA-------------------QQPN----PCPQGYE-PDEQESC 140

  Fly   781 QDIDECLDSNGQC--SQLCLNQPGGFACACETGF-ELTPDGFGCADIDECSQDYGNCSDICINLL 842
            .|:|||..:...|  ||.|.|.||.:.|.|..|: ::.|:   |.|||||...|  |...|:||.
Mouse   141 VDVDECTQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPE---CVDIDECRYRY--CQHRCVNLP 200

  Fly   843 GTHACACERGYELAKDKLSCLDVDECAGLLSGGCSHECINKAGTFECGCPLGYILNDDGRSCSPA 907
            |:..|.||.|::|..:..||:||:||.  :...|...|.|..|||.|.|..||.|:.||.|||
Mouse   201 GSFRCQCEPGFQLGPNNRSCVDVNECD--MGAPCEQRCFNSYGTFLCRCNQGYELHRDGFSCS-- 261

  Fly   908 LVGCPPGTQRSADGCAPIECNPGYTLGSDDKCVDIDECQKQNGGCSHRCSNTEGSFKCSCPPGYE 972
                                             |||||...:..|.:||.|..|.|.|.||.||:
Mouse   262 ---------------------------------DIDECGYSSYLCQYRCVNEPGRFSCHCPQGYQ 293

  Fly   973 LDSDQKTCQDIDECDQDKTSCITG-TCINEIGGFRC 1007
            |.: .:.|||||||:.....|... ||:|..||:||
Mouse   294 LLA-TRLCQDIDECETGAHQCSEAQTCVNFHGGYRC 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342
		cEGF	396..415	CDD:289433
		FXa_inhibition	425..458	CDD:291342
		FXa_inhibition	476..505	CDD:291342
		vWFA	<550..586	CDD:294047
		FXa_inhibition	596..630	CDD:291342
		FXa_inhibition	636..>664	CDD:291342	6/12 (50%)
		EGF_CA	676..715	CDD:284955	14/38 (37%)
		FXa_inhibition	745..780	CDD:291342	5/34 (15%)
		FXa_inhibition	786..821	CDD:291342	12/37 (32%)
		FXa_inhibition	827..862	CDD:291342	12/34 (35%)
		FXa_inhibition	874..904	CDD:291342	13/29 (45%)
		FXa_inhibition	945..980	CDD:291342	13/34 (38%)
		CCP	1110..1170	CDD:153056
		CCP	1183..1235	CDD:153056
		DUF5011	1468..1536	CDD:295940
Efemp2	NP_001157824.1	EGF_CA	142..182	CDD:214542	15/42 (36%)
		EGF_CA	183..216	CDD:214542	16/34 (47%)
		vWFA	<217..257	CDD:294047	17/41 (41%)
		vWFA	<260..295	CDD:294047	18/69 (26%)
		EGF_CA	302..>329	CDD:304395	13/27 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24034
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010