DRSC/TRiP Functional Genomics Resources

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Protein Alignment frac and fbn2b

DIOPT Version :10

Sequence 1:NP_648137.3 Gene:frac / 38850 FlyBaseID:FBgn0035798 Length:1618 Species:Drosophila melanogaster
Sequence 2:NP_001129262.1 Gene:fbn2b / 571786 ZFINID:ZDB-GENE-090112-3 Length:2868 Species:Danio rerio


Alignment Length:1817 Identity:457/1817 - (25%)
Similarity:629/1817 - (34%) Gaps:653/1817 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    94 NGISEMFCSNQKWV--DEIPTCIPQLNFEEHDEKVGYDLEDYSDETVPNDYVENSDIDEDDDEEV 156
            ||:   .|.|.:.|  |....||....||...:  |.:..|:.:....|..:....|:||...:.
Zfish   542 NGV---MCRNGRCVNTDGSFQCICNAGFEISPD--GKNCIDHDECATTNMCLNGMCINEDGSFKC 601

  Fly   157 SEREPPPPPPPPVVDGADSKPEPQIVIEINDDHANEV--------------VESEPALAETETEN 207
            ..:           .|....|..:...:|::.|.:.:              .|..|.|| .:.:.
Zfish   602 ICK-----------PGFALAPNGRYCTDIDECHTSGICMNGRCVNTEGSFRCECPPGLA-IDVDG 654

  Fly   208 EVLENETPLKAEVQTDVLNSSNASVK--VTNDPYEPTFLDNNCGEDNGGCAHICKRLLYPDEN-- 268
            .|.         |.|.:..:...::|  |.:.|:......:.|     .||:       |:..  
Zfish   655 RVC---------VDTHMRTTCYGAIKMGVCSRPFPGAVTKSEC-----CCAN-------PEHGFG 698

  Fly   269 ---QP---INK------CDCREGYTLDPNDYASC-LDIDECLESNGGCSEICENLPGEYKCSCQE 320
               ||   .|.      |....|.|.|..|...| ||.|.|  .||    |||||.|.|:|.|..
Zfish   699 EPCQPCPAFNSAEFQAVCSSGPGITTDGRDINECALDPDIC--QNG----ICENLRGSYRCICNI 757

  Fly   321 GYYLDESGKSCVDINEC-ANPELSSNCQGACENLPGSYRC-----------------VEPLEENP 367
            ||..|.|||:||||||| .|..|..|  |.|.|.||||.|                 :...:.||
Zfish   758 GYESDASGKNCVDINECLVNRLLCDN--GMCRNTPGSYTCSCPKGFSFKADSETCEDINECDSNP 820

  Fly   368 EITEVVEN-------------PIEKTNEV------------------PVNVS------------- 388
            .|..:..|             .::.||.|                  .||::             
Zfish   821 CINGICRNIAGSFNCECSHGSKLDSTNTVCVDSMKGTCWLNIQDGRCEVNINGATLKSECCSTLG 885

  Fly   389 ----------ESQPAGKTCNSGFQLSADGTDCQDINECEVDGPEDLDNNAVCQQ-KCENTIGSFR 442
                      |..||   |:.||. ...|..|:|||||||       ...||.. :|.||.||||
Zfish   886 AAWGSPCERCEIDPA---CSKGFG-RMKGLVCEDINECEV-------FPGVCTNGRCVNTQGSFR 939

  Fly   443 CTCVEGYHLLEDQRSCA-------------------------LDSC---------TDLE---NPQ 470
            |.|.||..|....|:|.                         :|.|         .|.|   .|.
Zfish   940 CECPEGLTLDGAGRTCVDVRSEQCYMKWDEDECVEPLPGRYRVDMCCCTVGAAWGVDCEACPKPN 1004

  Fly   471 LN----------------------------------RTRCAH-ECQDLPEGSYRCVCPKGYELSE 500
            .|                                  |..|.| .|:: ..||::|.|..|:.|:.
Zfish  1005 TNEFKTICPRGPGIANRGDILTGRPFYKDVNECKVFRGLCTHGTCRN-TIGSFKCRCDSGFALTM 1068

  Fly   501 DQHSCL-VQESPCSTEKGVEKCSPGTCLASEDNT--SFSCICPTGYRSEAF---SCQDIDECAED 559
            ::.:|. :.|...|.    :.|..|.|:    ||  ||.|.|..||.|...   :|.|||||..|
Zfish  1069 EERNCTDIDECTISP----DLCGHGVCV----NTPGSFECECFDGYESGFMMMKNCMDIDECERD 1125

  Fly   560 THLC-SHTCQNTPGGYQCQCPEGLNL-VEEYTCLAENLCEVNNNGCEQ-ICLTARGGV-CACREG 620
            ..|| ..||.||.|.|:|.||.|..| .|...|...|.|::::|.|:. .|:...|.. |:|..|
Zfish  1126 PLLCRGGTCLNTEGSYECDCPPGHQLSTEASACEDVNECQLSDNLCKHGQCVNMVGTYQCSCETG 1190

  Fly   621 FRLSADGKSCEDVDECLVNNGGCQQVCRNLPGSYGCICAAGYELLKLDGIRGYCFDIDECSQRTH 685
            ::::.|.:.|.|:|||.:.||||...|.|..|||.|.|:.||.|  :..:| .|.|||||.....
Zfish  1191 YQVTPDRQGCVDIDECTIMNGGCDTHCTNSEGSYECSCSEGYAL--MPDLR-TCADIDECEDTPD 1252

  Fly   686 GCSDQMLCENLNGSYTCLCPPGYALGLDNHIVTSLN------------------SSFI------- 725
            .| |...|.|:.|.|.|||..|:...:|......:|                  .|||       
Zfish  1253 IC-DGGQCTNIPGEYRCLCYDGFMASMDMRTCIDVNECDLNPNICLHGDCENTKGSFICHCQLGY 1316

  Fly   726 ---------TDSTSSETPSAHT----------------------------CLDIDECSLANGNC- 752
                     ||....|. .||.                            |:|:|||.....|| 
Zfish  1317 FVKKGSTGCTDVDECEI-GAHNCDLHAACVNAPGSFKCRCRDGWEGDGIKCIDVDECVTEEHNCN 1380

  Fly   753 -SHFCQNEPGGFQCACPLGYALSEDMRTCQDIDECLDS-----NGQCSQLCLNQPGGFACACETG 811
             :..|.|.||.::|:|..|:  :.|..:|.|:|||.|:     |||    |||.|||:.|.||.|
Zfish  1381 PNAECLNTPGSYRCSCKEGF--NGDGFSCSDMDECADNVNLCENGQ----CLNAPGGYRCECEMG 1439

  Fly   812 FELTPDGFGCADIDECSQDYGNCSDICI-----NLLGTHACACERGYELAKDKLSCLDVDEC--- 868
            |..|.|...|.|||||     |..:||:     ||.|...|.|:.||||.:...:|.|::||   
Zfish  1440 FTPTEDSKACQDIDEC-----NFQNICVFGSCQNLPGMFRCVCDYGYELDRSGGNCTDINECFDP 1499

  Fly   869 AGLLSGGCSHECINKAGTFECGCPLGYILNDDGRSCSPALVG-CPPGTQRSADG---C------- 922
            ...::|    .|:|..|::.|.||..:.||..|..|....|| |...|....||   |       
Zfish  1500 VNCING----VCVNLPGSYLCNCPPDFELNPSGVGCVDTRVGNCFLDTLDRGDGGISCSAEIGVG 1560

  Fly   923 ---APIECNPGYTLGSD-DKC---------------------------VDIDECQKQNGGC-SHR 955
               |...|:.|...|:. :.|                           .||||||:..|.| ...
Zfish  1561 VTRASCCCSLGGAWGNPCELCPFVNSTEYKTLCPGGEGFRPNPITVILEDIDECQELPGLCQGGN 1625

  Fly   956 CSNTEGSFKCSCPPGYELDSDQKTCQDIDECDQDKTSCITGTCINEIGGFRCEFPKFPVLPEIPT 1020
            |.||.|||:|.||.||.|:.:.:.|:|||||......|..|||.|.:|.:.|..|          
Zfish  1626 CVNTFGSFQCECPAGYYLNEETRICEDIDECTAHIGICGPGTCYNTLGNYTCVCP---------- 1680

  Fly  1021 ASSLPESPKIE--------LKTPKYPDFTE-LSNEIPENPKK----------------------P 1054
                ||..::.        .|:..|.:|.: ..||:..|..|                      |
Zfish  1681 ----PEYMQVNGGNNCMDMRKSVCYRNFNDTCENELSFNMTKKMCCCAYNVGKAWNRPCEACPTP 1741

  Fly  1055 AEFDY------PEPKFPSLPKWEGLPKLPPLADIPTSKAPVPLRP--EVP----KSLWVNQLQP- 1106
            |..:|      ..|.|              :.||.|.| |:.:..  |:|    ..:.:||:.. 
Zfish  1742 ATSEYQLLCGNQAPGF--------------IIDIHTGK-PIDIDECREIPGICANGVCINQIGSF 1791

  Fly  1107 RDLCPRFQAPRN-------------GKSHCNRYRHKQKLFYYSRCRISCNSGYILQGPEIKSCDA 1158
            |..||...:..|             |.:.|.|..:...:....||  .|::|:.|          
Zfish  1792 RCECPMGFSYNNILLICEDIDECNSGDNLCQRNANCINIPGSYRC--ECSAGFKL---------- 1844

  Fly  1159 NGIWEGPETKCVAINQPRAQSPGICPALKPAQNGVILPASCTQGPSRFGDVCRLQCNAGFVSTGS 1223
                 .|...|:..|:.: :.|.:|      .:|..:.   |||..|    |  .|:.||.:|..
Zfish  1845 -----SPSGACIDRNECQ-EIPNVC------SHGECID---TQGSFR----C--LCHNGFKTTPD 1888

  Fly  1224 LLTACMMLQGWSFGADLNCQPFGNGLLGNQLSPMWNSPKTVTPHQIQNVEQIRPYINCPENVVIL 1288
             .|.||.:.      :.:.||.|||...|          ||..:            ||      |
Zfish  1889 -QTMCMDID------ECDRQPCGNGTCKN----------TVGSY------------NC------L 1918

  Fly  1289 LHAGEQKAH---------VTLQRPQTNVKNGRLVAHPAWAGQ-----LQGH--LPAGVHKVDFRV 1337
            ...|.:..|         .::...|. .:||:.:.:   .|.     |.|:  .|.|.:.||  :
Zfish  1919 CFPGFELTHNNDCMDIDECSVHASQV-CRNGQCINN---MGSFKCLCLDGYNLTPDGKNCVD--I 1977

  Fly  1338 NDPETKLTIKCHTIITVKAATPRESNPFTLFRISDYSRSSLP----------------------- 1379
            |:        |.|:       |....|.|...:....|...|                       
Zfish  1978 NE--------CVTL-------PGACQPGTCQNLDGSFRCICPPGYEVQNDKCVDINECNVEPNIC 2027

  Fly  1380 -------RPAPFATL---------------STGSSFSFPAFKA-LDATPKPVSFTKFQ----VFP 1417
                   .|..|..:               .|..||.|..|:| ..:.|||.:.||.:    :.|
Zfish  2028 QFGTCKNTPGSFQCICQPGFVLSDNGRRCFDTRESFCFTRFEAGKCSVPKPRNTTKAKCCCSLLP 2092

  Fly  1418 DSESSEHSKL-----GSSSFFRLEPLFHESSKLISAAPASSENTRVDLGSDTSNYCPPSIEV 1474
            .....:..:|     ..::|..|.|..||      |.|...       |.:..|.|..:.|:
Zfish  2093 GEGWGDPCELCPRDTEEAAFHTLCPYGHE------AVPKPE-------GREDMNECVENPEI 2141

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fracNP_648137.3 FXa_inhibition 296..331 CDD:464251 18/34 (53%)
cEGF 396..415 CDD:463661 7/18 (39%)
FXa_inhibition 425..458 CDD:464251 15/33 (45%)
FXa_inhibition 476..505 CDD:464251 9/29 (31%)
EGF_CA 552..>581 CDD:214542 17/29 (59%)
FXa_inhibition 596..630 CDD:464251 9/35 (26%)
FXa_inhibition 636..>664 CDD:464251 14/27 (52%)
EGF_CA 676..711 CDD:214542 15/34 (44%)
FXa_inhibition 745..780 CDD:464251 11/36 (31%)
FXa_inhibition 786..821 CDD:464251 18/39 (46%)
vWFA <821..861 CDD:469594 18/44 (41%)
FXa_inhibition 874..904 CDD:464251 10/29 (34%)
FXa_inhibition 945..980 CDD:464251 16/35 (46%)
PTZ00449 <1017..>1098 CDD:185628 21/123 (17%)
CCP 1110..1170 CDD:153056 12/72 (17%)
CCP 1183..1235 CDD:153056 14/51 (27%)
HYR 1468..1536 CDD:460572 2/7 (29%)
fbn2bNP_001129262.1 Fibrillin_U_N 45..81 CDD:436338
TB 193..>226 CDD:459903
EGF_CA 287..328 CDD:214542
TB 342..386 CDD:459903
EGF_CA 495..525 CDD:214542
EGF_CA 535..576 CDD:214542 11/38 (29%)
EGF_CA 577..617 CDD:214542 7/50 (14%)
EGF_CA 618..658 CDD:214542 7/49 (14%)
TB 673..716 CDD:459903 9/54 (17%)
EGF_CA 728..769 CDD:214542 23/46 (50%)
EGF_CA 770..802 CDD:214542 16/33 (48%)
TB 865..>897 CDD:459903 2/31 (6%)
EGF_CA 915..956 CDD:214542 22/47 (47%)
TB 970..1012 CDD:459903 6/41 (15%)
EGF_CA 1075..1109 CDD:214542 13/41 (32%)
EGF_CA 1118..1150 CDD:214542 18/31 (58%)
FXa_inhibition 1206..1241 CDD:464251 16/37 (43%)
EGF_3 1331..1366 CDD:463759 3/35 (9%)
EGF_3 1372..1407 CDD:463759 11/36 (31%)
EGF_CA 1492..1523 CDD:214542 10/34 (29%)
TB 1553..1593 CDD:459903 6/39 (15%)
EGF_CA 1610..1642 CDD:214542 18/31 (58%)
TB 1706..1750 CDD:459903 7/43 (16%)
EGF_CA 1768..1800 CDD:214542 7/31 (23%)
EGF_CA 1810..>1842 CDD:214542 6/33 (18%)
vWFA <1850..1889 CDD:469594 14/55 (25%)
EGF_CA 1894..1928 CDD:214542 12/67 (18%)
EGF_CA 1976..2008 CDD:214542 9/48 (19%)
EGF_CA 2016..2056 CDD:214542 2/39 (5%)
TB 2071..2116 CDD:459903 8/44 (18%)
EGF_CA 2173..2212 CDD:214542
EGF_CA 2298..2334 CDD:214542
TB 2354..2397 CDD:459903
EGF_CA 2409..2450 CDD:214542
vWFA <2441..2489 CDD:469594
vWFA <2487..2523 CDD:469594
EGF_CA 2574..>2603 CDD:214542
Blue background indicates that the domain is not in the aligned region.

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