DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment frac and Scube2

DIOPT Version :9

Sequence 1:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster
Sequence 2:	NP_064436.2	Gene:	Scube2 / 56788	MGIID:	1928765	Length:	968	Species:	Mus musculus

Alignment Length:	1221	Identity:	273/1221 - (22%)
Similarity:	401/1221 - (32%)	Gaps:	481/1221 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   279 GYTLDPNDYASCLDIDECLESNGGC--SEICENLPGEYKCSCQEGYYLDESGKSCVDINECANPE 341
            |.|..|::     |:|||.:....|  ..:|:|.|..|||||:.||  ...|:.|.|::||.| .
Mouse    35 GLTNGPSE-----DVDECAQGLDDCHADALCQNTPTSYKCSCKPGY--QGEGRQCEDMDECDN-T 91

  Fly   342 LSSNCQGACENLPGSYRCVEPLEENPEITEVVENPIEKTNEVPVNVSESQPAGKTCNSGFQLSAD 406
            |:..|...|.|:||:|||                                    ||..||.|:.|
Mouse    92 LNGGCVHDCLNIPGNYRC------------------------------------TCFDGFMLAHD 120

  Fly   407 GTDCQDINECEVDGPEDLDNNAVCQQKCENTIGSFRCTCVEGYHLLEDQRSCALD-----SCTDL 466
            |.:|.|::||       |:||..||..|.|.|||:.|.|.||:.|.::|.:|...     ||.:.
Mouse   121 GHNCLDMDEC-------LENNGGCQHICTNVIGSYECRCKEGFFLSDNQHTCIHRSEEGLSCMNK 178

  Fly   467 ENPQLNRTRCAHECQDLPEGSYRCVCPKGYELSEDQHSCLVQESPCSTEKGVEKCSPGTCLASED 531
            ::      .|.|.|::.|.||..|.|..|:||:::|..|::
Mouse   179 DH------GCGHICKEAPRGSVACECRPGFELAKNQKDCIL------------------------ 213

  Fly   532 NTSFSCICPTGYRSEAFSCQDIDECAEDTHLCSHTCQNTPGGYQCQCPEGLNLVEEYTCLAENLC 596
                                          .|:|
Mouse   214 ------------------------------TCNH------------------------------- 217

  Fly   597 EVNNNGCEQICL-TARGGVCACREGFRLSADGKSCEDVDECLVNNGGCQQVCRNLPGSYGCICAA 660
              .|.||:..|. ||.|..|:|...:||.|||:||.:.:                    |.:
Mouse   218 --GNGGCQHSCEDTAEGPECSCHPRYRLHADGRSCLEQE--------------------GTV--- 257

  Fly   661 GYELLKLDGIRGYCFDIDECSQRTHGCSDQMLCENLNGSYTCLCPPGYALGLDNHIVTSLNSSFI 725
                  |:|                                                |..|::.:
Mouse   258 ------LEG------------------------------------------------TESNATSV 268

  Fly   726 TDSTSSETPSAHTCLDIDECSLANGNCSHFCQNEPGGFQCACPLGYALSEDMRTCQDIDECLDSN 790
            .|...    .....|.::.|::.||.|...|::...|..|:||.|:.|..|.:||:|||||...|
Mouse   269 ADGDK----RVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPTGFTLQVDGKTCKDIDECQTRN 329

  Fly   791 GQCSQLCLNQPGGFACACETGFELTPDGFGCADIDECSQDYGNCSDICINLLGTHACACERGYEL 855
            |.|:..|.|..|.|.|:|:.||:|..|...|.|:||||
Mouse   330 GGCNHFCKNTVGSFDCSCKKGFKLLTDEKSCQDVDECS--------------------------- 367

  Fly   856 AKDKLSCLDVDECAGLLSGGCSHECINKAGTFECGCPLGYILNDDGRSCSPALVGCPPGTQRSAD 920
                            |...|.|.|||..|||.|.
Mouse   368 ----------------LERTCDHSCINHPGTFICA------------------------------ 386

  Fly   921 GCAPIECNPGYTLGSDDKCVDIDECQKQNGGCSHRCSNTEGSFKCSCPPGYELDSDQKTCQDIDE 985
                  |||||||.|...|.|.:||...||||...|.||.||::|.|.||::|..::|.|.::..
Mouse   387 ------CNPGYTLYSFTHCGDTNECSVNNGGCQQVCINTVGSYECQCHPGFKLHWNKKDCVEVKG 445

  Fly   986 C-DQDKTSCITGTCINEIGGFRCEFPKFPVLPEIPTASSLPE-------SPKIELKTPKYPDF-- 1040
            . ....|..::..|....||.|| |.:  ....|..:|.|.|       |..:..|..|..|.
Mouse   446 FPPTSMTPRVSLHCGKSGGGDRC-FLR--CRSGIHLSSGLQEAYSVTCGSSSLRSKQQKSNDSAF 507

  Fly  1041 -------TELSNEIPEN--PKKPAEFDYPEPKFPSLPKWEGLPK----LPPLADIPTSKAPVPL- 1091
                   |.::.::.|.  ..:.|:.. ||...|:||:.....|    ...|...|..:.|..|
Mouse   508 GDVVTVRTSVTFKLNEGKCSLQKAKLS-PEGLRPALPERHSSVKESFQYANLTCSPGKQVPGALG 571

  Fly  1092 RPEVPKSLWVNQLQPRDLCPRFQAPRNGKSHCN--------------------RYRHKQKLFYYS 1136
            |...||.:::.....|:     ...:...:.||                    |..|::: |:..
Mouse   572 RLNAPKEMFITVEFERE-----TYEKEVTASCNLSCVVKRTEKRLRKALRTLKRAAHREQ-FHLQ 630

  Fly  1137 RCRISCNSGYI---LQGPEIKSCDANGIWEGPETKCVAINQPRAQSP-GICPALKPAQNGVILP- 1196
            ...:..:....   :.|...::|   |:.:|.|.....:.||...|. |..|....|. |...|
Mouse   631 LSGMDLDMAKTPSRVSGQHEETC---GVGQGHEESQCGLCQPGEYSANGFAPCQLCAL-GTFQPD 691

  Fly  1197 ---ASCTQ----------GPSRFGDVC--RLQCNAG-FVSTGSLLTACMMLQGWSFGADLNCQPF 1245
               .||..          |.:.|.| |  |:||:.| |.:|.:  ..|           :.| |.
Mouse   692 VGRTSCLSCGGGLPTKHLGATSFQD-CETRVQCSPGHFYNTTT--HRC-----------IRC-PL 741

  Fly  1246 GNGLLGNQLSPMWNSPKTVTPHQIQNVEQIRPYINCPENVVILLHAGEQKAHVTLQRPQTNV--- 1307
            |                |..|...:|     ..::||.|.            .|.....||:
Mouse   742 G----------------TYQPEFGKN-----NCVSCPGNT------------TTDFDGSTNITQC 773

  Fly  1308 KNGRLVAHPAWAGQL------------QGHLPAGVHKVDFRVNDPETKLTIKCHTIITVKAATPR 1360
            ||.:.      .|:|            .|:.||. .:..:.:|.|..:..:    |:..:...|.
Mouse   774 KNRKC------GGELGDFTGYIESPNYPGNYPAN-SECTWTINPPPKRRIL----IVVPEIFLPI 827

  Fly  1361 ESNPFTLFRISDYSRSSLPRPAPFATLSTGSSFSFPAFKALDATPKPVSFT 1411
            |.:      ..||          .....|.||.|...::......:|::||
Mouse   828 EDD------CGDY----------LVMRKTSSSNSVTTYETCQTYERPIAFT 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342	13/36 (36%)
		cEGF	396..415	CDD:289433	9/18 (50%)
		FXa_inhibition	425..458	CDD:291342	15/32 (47%)
		FXa_inhibition	476..505	CDD:291342	12/28 (43%)
		vWFA	<550..586	CDD:294047	2/35 (6%)
		FXa_inhibition	596..630	CDD:291342	14/34 (41%)
		FXa_inhibition	636..>664	CDD:291342	1/27 (4%)
		EGF_CA	676..715	CDD:284955	0/38 (0%)
		FXa_inhibition	745..780	CDD:291342	12/34 (35%)
		FXa_inhibition	786..821	CDD:291342	14/34 (41%)
		FXa_inhibition	827..862	CDD:291342	2/34 (6%)
		FXa_inhibition	874..904	CDD:291342	9/29 (31%)
		FXa_inhibition	945..980	CDD:291342	16/34 (47%)
		CCP	1110..1170	CDD:153056	10/82 (12%)
		CCP	1183..1235	CDD:153056	17/68 (25%)
		DUF5011	1468..1536	CDD:295940
Scube2	NP_064436.2	EGF_3	47..82	CDD:289699	13/36 (36%)
		FXa_inhibition	93..124	CDD:291342	15/66 (23%)
		FXa_inhibition	130..165	CDD:291342	17/41 (41%)
		FXa_inhibition	175..211	CDD:291342	13/41 (32%)
		FXa_inhibition	215..250	CDD:291342	16/67 (24%)
		FXa_inhibition	284..319	CDD:291342	12/34 (35%)
		vWFA	<310..359	CDD:294047	22/48 (46%)
		vWFA	<357..393	CDD:294047	21/114 (18%)
		FXa_inhibition	405..440	CDD:291342	16/34 (47%)
		GCC2_GCC3	670..717	CDD:285001	11/48 (23%)
		GCC2_GCC3	726..773	CDD:285001	16/93 (17%)
		CUB	778..889	CDD:238001	19/112 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910