DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment frac and Notch3

DIOPT Version :9

Sequence 1:NP_001137905.1 Gene:frac / 38850 FlyBaseID:FBgn0035798 Length:1618 Species:Drosophila melanogaster
Sequence 2:NP_064472.3 Gene:Notch3 / 56761 RGDID:620761 Length:2319 Species:Rattus norvegicus


Alignment Length:1747 Identity:389/1747 - (22%)
Similarity:556/1747 - (31%) Gaps:621/1747 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   161 PPPPPP------------------PPVVDGADSKPEPQIVIEINDDHANEVVESEPALAETETEN 207
            ||||||                  ||.:||:...            :.......:|         
  Rat    18 PPPPPPMRALPLLLLLLAGLGAAAPPCLDGSPCA------------NGGRCTHQQP--------- 61

  Fly   208 EVLENETPLKAEVQTDVLNSSNASVKVTNDPYEPTFLDNNCG-ED---NGGCA--HICKRLLYPD 266
                               |..|:....     |.::...|. ||   :|.||  .:|:..:...
  Rat    62 -------------------SREAACLCL-----PGWVGERCQLEDPCHSGPCAGRGVCQSSVVAG 102

  Fly   267 ENQPINKCDCREGYTLDPNDYASCLDIDECLESNGGCSEICE-NLPGEYKCSCQEGYYLDESGKS 330
            ..:  ..|.|..|:. .|:    |...|.|..|.......|. ...|.|.|:|..||    .|::
  Rat   103 VAR--FSCRCLRGFR-GPD----CSLPDPCFSSPCAHGAPCSVGSDGRYACACPPGY----QGRN 156

  Fly   331 C-VDINECANPELSSNCQ--GACENLPGSYRCVEPLEENPEITEVVENPIEKTNEVPVNVSESQP 392
            | .||:||   ...::|:  |.|.|.|||:.|:.||.....:   .||||     ||...|..:.
  Rat   157 CRSDIDEC---RAGASCRHGGTCINTPGSFHCLCPLGYTGLL---CENPI-----VPCAPSPCRN 210

  Fly   393 AGKTCNSGFQLSAD--------GTDCQ-DINECE----------VDG-----------------P 421
            .| ||.....::.|        |.:|: ::::|.          |||                 .
  Rat   211 GG-TCRQSSDVTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCT 274

  Fly   422 EDLDNNAVCQQK---------CENTIGSFRCTCVEGYHLLEDQRSCA--LDSCTDLENPQLNRTR 475
            ||:|.   ||.:         |.|.:|...|.||.|:    ...||:  :|.|.        ...
  Rat   275 EDVDE---CQLQPNACHNGGTCFNLLGGHSCVCVNGW----TGESCSQNIDDCA--------TAV 324

  Fly   476 CAH--ECQDLPEGSYRCVCPKGYE--LSEDQHSCLVQESPCSTEKGVEKCSPGTCLASEDNTSFS 536
            |.|  .|.| ...|:.|.||.|..  |.....:|:  .:||..:        ..|..:..:....
  Rat   325 CFHGATCHD-RVASFYCACPMGKTGLLCHLDDACV--SNPCHED--------AICDTNPVSGRAI 378

  Fly   537 CICPTGYRSEAFSC-QDIDECAEDTHLCSH--TCQNTPGGYQCQCPEG----------------- 581
            |.||.|:...|  | ||:|||:...:.|.|  .|.||.|.:.|||..|                 
  Rat   379 CTCPPGFTGGA--CDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGP 441

  Fly   582 -------LNLVEEYTCL-----AENLCEVNNNGCEQI-CLTARGGV---------CACREGFRLS 624
                   |:.:.::||:     ....|||:.:.|:.. |:  .|||         |.|..||   
  Rat   442 CRNQATCLDRIGQFTCICMAGFTGTFCEVDIDECQSSPCV--NGGVCKDRVNGFSCTCPSGF--- 501

  Fly   625 ADGKSCE-DVDECL---VNNGGCQQVCRNLPGSYGCICAAGYE--LLK----------------L 667
             .|.:|: |||||.   ..||.   .|.:.|..|.|.||.|:|  |.:                :
  Rat   502 -SGSTCQLDVDECASTPCRNGA---KCVDQPDGYECRCAEGFEGTLCERNVDDCSPDPCHHGRCV 562

  Fly   668 DGIR--------GY----C-FDIDECSQRTHGCSDQMLCENLNGSYTCLCPPGYALGLDNHIVTS 719
            |||.        ||    | ..:|||  |:..|.....|.:|...|.|.||||         .|.
  Rat   563 DGIASFSCACAPGYTGIRCESQVDEC--RSQPCRYGGKCLDLVDKYLCRCPPG---------TTG 616

  Fly   720 LNSSFITDSTSSETPSAHTCLD---------------------IDECS----------------- 746
            :|.....|..:|...:...|.|                     |:||:                 
  Rat   617 VNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGF 681

  Fly   747 -------------------LANGNCSH-FCQNEPGGFQCACPLGYALSEDMRTCQDI--DECLDS 789
                               .|:..||| .|.:.||||||.|..|::   ..|..|.:  |.|...
  Rat   682 HCLCPPGSLPPLCLPVNHPCAHKPCSHGVCHDAPGGFQCVCEPGWS---GPRCSQSLAPDACESQ 743

  Fly   790 NGQCSQLCLNQPGGFACACETGFELTPDGFGCADIDECS----QDYGNCSDICINLLGTHACACE 850
            ..|....|.:...||.|.|..||:    |..|..:..|:    :..|:|......|.   .|:|.
  Rat   744 PCQAGGTCTSDGIGFHCTCAPGFQ----GHQCEVLSPCTPSLCEHGGHCESDPDQLT---VCSCP 801

  Fly   851 RGYELAKDKLSC-LDVDECAGLLSGGCSHECINKAGTFECGCPLGYILNDDGRSCSPALVGCPP- 913
            .|::..:    | .|||||||....|....|.|..|:|.|.|..||    .|..|...:..|.| 
  Rat   802 PGWQGPR----CQQDVDECAGASPCGPHGTCTNLPGSFRCICHGGY----TGPFCDQDIDDCDPN 858

  Fly   914 -----GTQRSADGCAPIECNPGYTLGSDDKCV-DIDECQKQNGGCSHRCSNTEGSFKCSCPPGY- 971
                 |:.:...|.....|..|:   :..:|. |:|||.....| ...|::...||.|:||||| 
  Rat   859 PCLNGGSCQDGVGSFSCSCLSGF---AGPRCARDVDECLSSPCG-PGTCTDHVASFTCTCPPGYG 919

  Fly   972 --ELDSDQKTCQDIDECDQDKTSCIT-GTCINEIGGF-----------RCEFPKFPVL--PEIPT 1020
              ..::|...|        ..:||.. |||::.:..|           .|::...|..  |.:..
  Rat   920 GFHCETDLLDC--------SPSSCFNGGTCVDGVNSFSCLCRPGYTGTHCQYKVDPCFSRPCLHG 976

  Fly  1021 ASSLPESPKIELKTPKYPDFTELSNEIPENPKKPAEFD-----------YPEPKFPSLPKWEGLP 1074
            ....|.....|....:.....:..|.:....:.|.:..           .|       |:|.|  
  Rat   977 GICNPTHSGFECTCREGFTGNQCQNPVDWCSQAPCQNGGRCVQTGAYCICP-------PEWSG-- 1032

  Fly  1075 KLPPLADIPTSKAPVPLRPEVPKSLWV---------NQLQPRD-----LCPRFQAPRNGKSHCNR 1125
               ||.|||:    :|. .|....:.|         .|...:|     :||.   .|.| |||.:
  Rat  1033 ---PLCDIPS----LPC-TEAAAHMGVRLEQLCQAGGQCIDKDHSHYCVCPE---GRMG-SHCEQ 1085

  Fly  1126 YRH---KQKLFYYSRCRISCNSGYILQGPEIKSCDANGIWEGPETKCVAINQPRAQSPGICPALK 1187
            ...   .|...:...|| ....||:.:.|...|.|:   .|....:|               |.:
  Rat  1086 EVDPCTAQPCQHGGTCR-GYMGGYVCECPAGYSGDS---CEDDVDEC---------------ASQ 1131

  Fly  1188 PAQNG-----VILPASCTQGPSRFGDVCRL---QCNAGFVSTGSLLT-----ACMMLQGWSFGAD 1239
            |.|||     ::....|:..|...|.:|.:   .|..| .|..|.|.     .|:.|.|   |..
  Rat  1132 PCQNGGSCIDLVAHYLCSCPPGTLGVLCEINEDDCGPG-PSLDSGLRCLHNGTCVDLVG---GFR 1192

  Fly  1240 LNCQPFGNGLLGNQLSPMWNSPKTVTPHQIQNVEQIRPYINCPENVVILLHAGEQKAHV--TLQR 1302
            .||.|...||                 |...::.:.||. .|        ||    ||.  .||.
  Rat  1193 CNCPPGYTGL-----------------HCEADINECRPG-TC--------HA----AHTRDCLQD 1227

  Fly  1303 PQTNVKNGRLVAHPAW-------------------AGQLQGHLPAGVHKVDFRVNDPETKLTIKC 1348
            |..:.   |.:..|.:                   .||.:..|..|            ..||..|
  Rat  1228 PGGHF---RCICLPGFTGPRCQTALFPCESQPCQHGGQCRPSLGRG------------GGLTFTC 1277

  Fly  1349 HTIITVKAATPRESNPFTLFRISDYSRS----SLPRPAPFATLSTG------SSFSFPAFKALDA 1403
            |.:           .||...|....:||    ..|...|....:.|      ...|.|:.:...|
  Rat  1278 HCV-----------QPFWGLRCERVARSCRELQCPVGIPCQQTARGPRCACPPGLSGPSCRVSRA 1331

  Fly  1404 TPKPVSFTKFQVFPDSESSEHSKLGSSSFFRL------------EPLFHESSKLISAAPASSENT 1456
            :|...:.|.....|.........:.|..|||.            .|         ||||...|..
  Rat  1332 SPSGATNTSCAATPCLHGGSCLPVQSVPFFRCVCAPGWGGPRCETP---------SAAPEVPEEP 1387

  Fly  1457 RVDLGSDTSNYCPPSIEVYLKENQNLRSVVWDEPRFEGKLLKIYKSHFPGSLFKVGDHAIKYEAT 1521
            |          ||.:.....:.:||...                :.:.||..:..||.::..:..
  Rat  1388 R----------CPRAACQAKRGDQNCDR----------------ECNSPGCGWDGGDCSLNVDDP 1426

  Fly  1522 TTDGKTLSCTFFIYVRSAKPTPAPTEPKISFDS-------EPETLSDVSQTYVVCPD 1571
            ....:.|.|  :....:::..||.:.|...:|:       ...|.:.|.:.|  |.|
  Rat  1427 WRQCEALQC--WRLFNNSRCDPACSSPACLYDNFDCYSGGRDRTCNPVYKKY--CAD 1479

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fracNP_001137905.1 FXa_inhibition 296..331 CDD:291342 10/35 (29%)
cEGF 396..415 CDD:289433 5/27 (19%)
FXa_inhibition 425..458 CDD:291342 10/41 (24%)
FXa_inhibition 476..505 CDD:291342 10/32 (31%)
vWFA <550..586 CDD:294047 17/62 (27%)
FXa_inhibition 596..630 CDD:291342 13/43 (30%)
FXa_inhibition 636..>664 CDD:291342 11/32 (34%)
EGF_CA 676..715 CDD:284955 13/38 (34%)
FXa_inhibition 745..780 CDD:291342 15/71 (21%)
FXa_inhibition 786..821 CDD:291342 10/34 (29%)
FXa_inhibition 827..862 CDD:291342 7/38 (18%)
FXa_inhibition 874..904 CDD:291342 10/29 (34%)
FXa_inhibition 945..980 CDD:291342 12/37 (32%)
CCP 1110..1170 CDD:153056 16/62 (26%)
CCP 1183..1235 CDD:153056 17/64 (27%)
DUF5011 1468..1536 CDD:295940 10/67 (15%)
Notch3NP_064472.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20 1/1 (100%)
EGF_CA 160..197 CDD:238011 14/42 (33%)
EGF_CA 238..274 CDD:238011 4/35 (11%)
EGF_CA 276..313 CDD:238011 11/43 (26%)
EGF_CA 316..351 CDD:238011 11/43 (26%)
EGF_CA 393..431 CDD:238011 14/37 (38%)
EGF_CA 433..469 CDD:238011 3/35 (9%)
EGF_CA 471..507 CDD:238011 10/41 (24%)
EGF_CA 509..545 CDD:238011 16/38 (42%)
EGF_CA 547..582 CDD:238011 5/34 (15%)
EGF_CA 585..620 CDD:238011 15/45 (33%)
EGF_CA 622..656 CDD:238011 4/33 (12%)
EGF_CA 660..>688 CDD:238011 3/27 (11%)
EGF_CA 698..731 CDD:238011 13/35 (37%)
EGF_CA 738..772 CDD:238011 11/37 (30%)
EGF_CA 812..848 CDD:238011 17/39 (44%)
EGF_CA 851..886 CDD:238011 6/37 (16%)
EGF_CA 889..924 CDD:238011 14/35 (40%)
EGF_CA 931..962 CDD:238011 6/30 (20%)
EGF_CA 965..1000 CDD:238011 4/34 (12%)
EGF_CA 1087..1122 CDD:238011 8/38 (21%)
EGF_CA 1124..1160 CDD:238011 9/50 (18%)
EGF_CA 1173..1205 CDD:238011 12/51 (24%)
NL 1382..1419 CDD:197463 9/62 (15%)
LNR 1 1389..1429 8/55 (15%)
NL 1423..1460 CDD:197463 6/38 (16%)
LNR 2 1430..1467 6/38 (16%)
LNR 3 1469..1507 4/13 (31%)
Notch 1473..1502 CDD:395019 3/9 (33%)
NOD 1510..1562 CDD:399654
NODP 1580..1639 CDD:400155
JMTM_Notch3 1620..1711 CDD:411987
ANKYR <1779..1895 CDD:223738
ANK repeat 1790..1838 CDD:293786
ANK repeat 1840..1871 CDD:293786
ANK 1 1840..1869
ANKYR 1860..2026 CDD:223738
ANK repeat 1873..1905 CDD:293786
ANK 2 1873..1903
ANK repeat 1907..1938 CDD:293786
ANK 3 1907..1936
ANK repeat 1940..1971 CDD:293786
ANK 4 1940..1969
ANK repeat 1973..2004 CDD:293786
ANK 5 1973..2002
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2026..2046
PHA03247 <2029..2316 CDD:223021
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2059..2129
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2197..2319
DUF3454 2213..2269 CDD:403221
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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