Protein Alignment frac and svep1

DIOPT Version :10

• Sequence 1: NP_648137.3
• Gene: frac / 38850
• FlyBaseID: FBgn0035798
• Length: 1618
• Species: Drosophila melanogaster
• Sequence 2: NP_001429572.1
• Gene: svep1 / 567357
• ZFINID: ZDB-GENE-110726-1
• Length: 3615
• Species: Danio rerio
• Alignment Length: 1786
• Identity: 370/1786 - (20%)
• Similarity: 533/1786 - (29%)
• Gaps: 707/1786 - (39%)

  Fly    35 EDPKVSDSLAASLDMSC--SSAKILPPEINHGRVSVF-------DRRRRGKKVFLVAFFVCDD-- 88
            |:|:.||:..|.|::|.  ||..|.|.    |..||:       ...|..:.:..|....|:.
Zfish   665 EEPQFSDNSGAQLNISSTHSSGDIFPV----GETSVYYTATDPSGNNRTCELIITVRGSTCEKPF 725

  Fly    89 ---NYDF----------------------ENGISEMFCSNQK-W----VDEIPTCIPQLN----- 118
               |.||                      :|.:...||:|.. |    ..:.|.|  .||
Zfish   726 VPVNGDFSCAKTKEGMNCTLICRQGYSLAQNAVHSYFCANNGIWEPPRSPDRPDC--SLNRIANN 788

  Fly   119 ----FEEHDEKVGYD----LEDYSDE-------TVPN------------------------DYVE 144
                ||...:....|    :..:|.|       ||||                        ||..
Zfish   789 GFKPFEMLFKASRCDDLNLVRSFSGEFSNVLKNTVPNICGGDDVSCKLEMTLPAQCLEYNYDYPN 853

  Fly   145 ---------NSDIDEDDDEEVSEREPPPPPPPPVVDGADSKPEPQIVIEINDDHANEVVESEPAL 200
                     .|:....:.|:.:..:            :...||.|:..:.:..|.:.:.......
Zfish   854 GFAIGPGGWGSNWGSQNGEDYAYFD------------SGFAPEHQLQKDASSQHGSHMRTKRHRK 906

  Fly   201 AETETENEVLE---NET-----PLKAEVQTDVLNSS---NASVKVTN--------DPYEPTFLDN 246
            ....|..:.::   |.|     ||......:::|..   .|..::||        .|:. ||
Zfish   907 ITGPTREQKIQIHFNITASIPLPLSRNDSAEIVNQKRLLRALEQLTNRLKRTLAKQPFS-TF--- 967

  Fly   247 NCGEDNGGCAHICKRLLYPDENQPINK---CDCREGYTLDPNDYASCLDIDECLESNGGCSEICE 308
                      |:...::..|.....:|   ..||.|..|.                    ..:|.
Zfish   968 ----------HVSSEMIVADPKSLESKKATLYCRPGSVLK--------------------GRVCV 1002

  Fly   309 NLP-GEY------KC-SCQEGYYLDESG----KSCVD------INECANPELSSNCQGACENLPG 355
            ..| |.|      :| ||..|.|.:|.|    |||.|      ::..:..|..:.||....:|.|
Zfish  1003 LCPVGTYFSLEYAECESCWRGSYQNEEGQMECKSCPDGSSTPYLHSRSQAECKAQCQPGSSSLTG 1067

  Fly   356 SYRCVEPLEENPEITEVVENPIEKTNEVPVNVSESQPAGKTCNSGFQLSADGTDC---------- 410
            ...|                             ||.|.|:     :|......||
Zfish  1068 LETC-----------------------------ESCPLGE-----YQPGFGSQDCLSCPSTTTTV 1098

  Fly   411 ----QDINECEVDGPEDLDNNAVCQQKCENTIGSFRC-TCVEGYHLLEDQRSCALDSCTDLENPQ 470
                .|:|||.|.          |.....:..|...| .|...|:..|:.||..| ||.......
Zfish  1099 NRGALDVNECGVP----------CSAGHFSRTGLVPCYPCPRDYYQPEEGRSYCL-SCPFYGTTT 1152

  Fly   471 LNRTRCAHECQD-----LPEGSYRCVCP-----KGYELSEDQ-HSCLVQESPCSTEKGVEKCSPG 524
            :...|...:|..     ||:.......|     |.|:.|... |.||:  :||..:        |
Zfish  1153 ITGARAIQQCSSFGSSFLPKEESATTAPEVIVRKDYQASSQMFHECLL--NPCQNQ--------G 1207

  Fly   525 TCLASEDNTSFSCICPTGYRSEAFSCQ-DIDECAEDTHLCSH--TCQNTPGGYQCQCPEG----- 581
            ||  .|....:.|.|..|:...  .|: |||||  |:..|.:  .|::..|.:||||..|
Zfish  1208 TC--EEVGVGYVCTCLPGFTGA--KCESDIDEC--DSAPCQNGGLCRDGMGDFQCQCQPGFVGLL 1266

  Fly   582 ----LNLVEEYTCLAENLC--EVNNNGC-------------------------EQICLTARGG-V 614
                :|......||.|.:|  |||...|                         |.:|....|| .
Zfish  1267 CEAEVNECSSSPCLNEGICVDEVNYFSCSCPDGFTGPRCEMEINECASSPCQNEGVCKDLEGGYF 1331

  Fly   615 CACREGFRLSADGKSCE-DVDECL---VNNGGCQQVCRNLPGSYGCICAAGYELLKLDGIRG-YC 674
            |.|.:||    .|.:|| ||:||.   ..|||   .|.:....:.|.|..||        || .|
Zfish  1332 CTCAQGF----TGDNCEVDVNECYSAPCLNGG---TCVDAINDFRCECVNGY--------RGRLC 1381

  Fly   675 -FDIDECSQRTHGCSDQMLCENLNGSYTCLCPPG-----------YALGL-------------DN 714
             .|:|:|....  |.:...|.:...::||.||||           |:..|             |.
Zfish  1382 QVDVDDCELNL--CLNGATCVDGVATFTCRCPPGFNGTRCETEMPYSFDLEFEVSGIHGYVMMDG 1444

  Fly   715 HI--VTSLNSSF---ITDSTSSETP---------SAHTCLD-------------IDECSLANGNC 752
            |:  :|.:..:|   .:|:.:..||         :|...:|             |.:|...|...
Zfish  1445 HMPSLTQITCTFWMRSSDTVNYGTPVSYAVEGSDNAFLLIDYNGWVLYVNGKERITDCPAVNDGL 1509

  Fly   753 SH---------------FCQNEP--GG----FQCACPLGYALSEDMRTCQDIDECLDS------- 789
            .|               :....|  ||    .....|.|.||.    ..||.|:..|.
Zfish  1510 WHHIGVTWRSKDGDWRVYIDGSPSDGGKGLSIGTTIPGGGALV----LGQDQDQRGDGFNPVESF 1570

  Fly   790 NGQCSQLCL-------NQPGGFACACETGFE-----LTPDGFG--------------CAD--IDE 826
            .|..|||.:       .|....|.:|....:     ..||..|              |||  :.|
Zfish  1571 VGTLSQLNIWNYVLTPQQIRSLASSCPHDLQKGNVFAWPDFLGGVTGRVKTTSKSIFCADCPLVE 1635

  Fly   827 CSQDYGNCSDICINLLGTHACACERGYELAKDKLS-CLDVDECAGLLSGGCSH-ECINKAGTFEC 889
            .|..:...|...::.......:|..|:.|..:.:. ||:        .|..|| |.|  ....||
Zfish  1636 TSVPHLLSSSKAVSPGSKVQFSCSPGFYLVGEPVQLCLN--------RGQWSHAEPI--CERVEC 1690

  Fly   890 GCP----LGYILNDDGRSCSPALVGCPPGTQRSADGCAPIEC-NPGYTLGSDDKCVDIDECQKQN 949
            |.|    .|....:|..:.|..|..|.||....  |.:.::| |.|..:|:...|:|:|||...:
Zfish  1691 GPPPDLEHGQYHGEDFYAGSSVLYQCKPGFYLL--GESKMQCTNNGKWIGNPPACLDVDECSLGS 1753

  Fly   950 GGCSH-RCSNTEGSFKC-------------------------------------------SCPPG 970
            ....| .|.||:||..|                                           ||..|
Zfish  1754 ECDEHASCQNTDGSHICTCIAPYSGDGRNCTEPVKCKDPGVPEFGQREGTNFIMGSEVVFSCKEG 1818

  Fly   971 YEL-DSDQKTCQDIDECDQDKTSCITGTC----INEIG-------------GFRCEFPKFPVLPE 1017
            ||| .|.|.||.:.....||...|...:|    :.:.|             .|.||....|:.|
Zfish  1819 YELIGSSQLTCTEEGFWKQDVPYCKALSCPHPTLPKYGILKGANFTYGSKVTFSCEKGYVPLEP- 1882

  Fly  1018 IPTASSLPESPKIELKTPKYPDFTELSNEIPENPKKPAEFDYP---------------------- 1060
                  :....:.:||..:.|...:     |....:|...||.
Zfish  1883 ------IESQCQSDLKWSREPHICQ-----PITCGEPPVVDYAEYTLNGKIYRSTLSYTCIEGYR 1936

  Fly  1061 -----EPKFPSLPKWEGLPKLPPLADIPTSKAPVPLRPEVPKSLWVNQLQPRDLCPRFQAPRNGK 1120
                 |.:..|..:|...|  |..|.:...|.| ||:..|.|.
Zfish  1937 LQGAMELQCESSGEWTSPP--PMCARVDCGKPP-PLKDAVIKG---------------------- 1976

  Fly  1121 SHCNRYRHKQKLFYYSRCRISCNSGYILQGPEIKSCDANGIWEGPETKCVAINQPRAQSPGICPA 1185
               :.:....|::|.      |..||.|.|.|.:.|..:|.|....::||    ||:..|
Zfish  1977 ---DNFTLGSKIYYI------CKDGYTLLGAETQECLPSGNWTRNSSQCV----PRSCGP----- 2023

  Fly  1186 LKPAQNGVILPASCTQGPSRFGDVCRLQCNAGFVSTGSLLTACMMLQGWSFGADLNCQPFGNGLL 1250
              |.|....||.:   |...|||:....|:.|:.:..:....|.....|:       .|.|.|:
Zfish  2024 --PPQVDHALPDT---GHQLFGDIAIYFCDDGYTAGNNTKLFCNAQGVWA-------PPDGFGI- 2075

  Fly  1251 GNQLSPMWNSPKTVTPHQIQNVEQIRPYINCPENVVILLHAGEQKAHVTLQRPQTNVKNGRLVAH 1315
                           ||.|.|.        |                   |||.
Zfish  2076 ---------------PHCIANF--------C-------------------QRPP----------- 2087

  Fly  1316 PAWAGQLQGHLPAGVHKVDFRVNDPE----TKLTIKC------HTIITVKAATPRESNPFTLFRI 1370
                     .||   |.:...:|.|:    |:::.||      :|..|:|.....|..|..
Zfish  2088 ---------DLP---HAILDSINKPKYASNTEVSYKCEEGFVLNTTGTLKCLIGGEWTPSP---- 2136

  Fly  1371 SDYS----RSSLPRPAPFATLSTGSSFSFPA 1397
            ||..    |.|.|.......:| |:::.|.|
Zfish  2137 SDIGCMPVRCSKPESIEKGYVS-GNNYGFGA 2166

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_648137.3	FXa_inhibition	296..331	CDD:464251	12/46 (26%)
		cEGF	396..415	CDD:463661	4/32 (13%)
		FXa_inhibition	425..458	CDD:464251	7/33 (21%)
		FXa_inhibition	476..505	CDD:464251	8/39 (21%)
		EGF_CA	552..>581	CDD:214542	13/30 (43%)
		FXa_inhibition	596..630	CDD:464251	14/61 (23%)
		FXa_inhibition	636..>664	CDD:464251	9/30 (30%)
		EGF_CA	676..711	CDD:214542	12/45 (27%)
		FXa_inhibition	745..780	CDD:464251	10/55 (18%)
		FXa_inhibition	786..821	CDD:464251	11/67 (16%)
		vWFA	<821..861	CDD:469594	9/41 (22%)
		FXa_inhibition	874..904	CDD:464251	11/34 (32%)
		FXa_inhibition	945..980	CDD:464251	16/79 (20%)
		PTZ00449	<1017..>1098	CDD:185628	18/107 (17%)
		CCP	1110..1170	CDD:153056	11/59 (19%)
		CCP	1183..1235	CDD:153056	11/51 (22%)
		HYR	1468..1536	CDD:460572
svep1	NP_001429572.1	None