DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment frac and si:ch73-173h19.3

DIOPT Version :9

Sequence 1:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster
Sequence 2:	NP_001103991.1	Gene:	si:ch73-173h19.3 / 563864	ZFINID:	ZDB-GENE-081104-245	Length:	397	Species:	Danio rerio

Alignment Length:	310	Identity:	92/310 - (29%)
Similarity:	125/310 - (40%)	Gaps:	70/310 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   613 GVCACRE---GFRLSADGKSCEDV---------DECLVNNGGCQQVCRNLPGSYGCICAAGYELL 665
            |:|.|..   .|.:|.:.::.|.|         ||..:..       |.|...:.|:|..|||
Zfish     3 GICLCLSVAVHFAVSQEAEAQEPVTYTASRPTFDEHDIYE-------RELWELFDCLCTEGYE-- 58

  Fly   666 KLDGIRGYCFDIDECSQRTHGCSDQMLCENLNGSYTCL-----------------CP-------- 705
             .|..:..|.|||||......|...|.|.|..|.|.||                 .|
Zfish    59 -FDFEKQICKDIDECKTVLEACKGGMKCINHFGGYLCLPHNARIIVSNGEGEPTTAPPVERFQPV 122

  Fly   706 -PGYALGLDNHIVTSLNSS------FITDSTSSETPSAHTCLDIDECSLANGNCSHFCQNEPGGF 763
             |..:.|..:.::.|.:.|      |:.|       |.:.|.|::||..|| .|.|.|.|..|.:
Zfish   123 IPQISRGEFSRVIQSSSHSIQCGVGFMAD-------SQNYCRDVNECLTAN-PCQHQCYNLMGSY 179

  Fly   764 QCACPLGYALSEDMRTCQDIDECLDSNGQCSQLCLNQPGGFACACETGFELTPDGFGCADIDECS 828
            .|.|.:|:.|:.|..:||||:||..||..|...|:|:||.|.|||..|::|..... |.|||||.
Zfish   180 ICQCEVGFELASDSVSCQDINECEISNYICQFQCVNEPGAFHCACPEGYQLQGPRM-CQDIDECE 243

  Fly   829 QDYGNC--SDICINLLGTHAC----ACERGY-ELAKDKLSCLDVDECAGL 871
            ....||  .::|.|..|...|    .|...| :..:.:..|.....|.||
Zfish   244 TGAHNCREDEMCWNYYGGFRCYPRDPCREPYVKTGEGRCRCQSQTVCRGL 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342
		cEGF	396..415	CDD:289433
		FXa_inhibition	425..458	CDD:291342
		FXa_inhibition	476..505	CDD:291342
		vWFA	<550..586	CDD:294047
		FXa_inhibition	596..630	CDD:291342	5/19 (26%)
		FXa_inhibition	636..>664	CDD:291342	6/27 (22%)
		EGF_CA	676..715	CDD:284955	16/64 (25%)
		FXa_inhibition	745..780	CDD:291342	13/34 (38%)
		FXa_inhibition	786..821	CDD:291342	14/34 (41%)
		FXa_inhibition	827..862	CDD:291342	9/41 (22%)
		FXa_inhibition	874..904	CDD:291342
		FXa_inhibition	945..980	CDD:291342
		CCP	1110..1170	CDD:153056
		CCP	1183..1235	CDD:153056
		DUF5011	1468..1536	CDD:295940
si:ch73-173h19.3	NP_001103991.1	EGF_CA	158..188	CDD:214542	13/30 (43%)
		EGF_CA	198..229	CDD:214542	16/30 (53%)
		EGF_CA	238..282	CDD:284955	13/43 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24034
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010