DRSC/TRiP Functional Genomics Resources

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Protein Alignment frac and ltbp3

DIOPT Version :10

Sequence 1:NP_648137.3 Gene:frac / 38850 FlyBaseID:FBgn0035798 Length:1618 Species:Drosophila melanogaster
Sequence 2:NP_001244070.1 Gene:ltbp3 / 562912 ZFINID:ZDB-GENE-060526-130 Length:1258 Species:Danio rerio


Alignment Length:1119 Identity:281/1119 - (25%)
Similarity:399/1119 - (35%) Gaps:347/1119 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   177 PEPQIVI-----EINDDHANEVVESEPALAETETENEVLENETPLKAEVQTDVLNSSNASVKVTN 236
            |:..:||     ..|..|:.:.|...|.... :.:....:..||.:|       .|||....:||
Zfish   180 PDTSVVIHPLDQSENKPHSTKTVARLPPTTH-KPKGRCFQETTPKQA-------CSSNPLPGLTN 236

  Fly   237 DPYEPTFLDNNCGEDNGGCAHICKRLLYPDENQPINK---CDCREGYTLDPNDYASCLDIDECLE 298
            .......:.|:.|::.   .:.|..|.|.:::|.|.:   ..|.:||....:.:  |.||:||:.
Zfish   237 QEDCCGSVGNSWGQNK---CYKCPLLPYTEKHQAIVEDFASTCPQGYKRLNSTH--CQDINECMM 296

  Fly   299 SNGGCSEICENLPGEYKCSCQEGYYLDESGK---SCVDINEC-------------ANPELS---- 343
            |....:..|.|..|.::|:|:.||.|.|..:   :.|::..|             .:..||    
Zfish   297 SGVCWNGECLNTRGSFRCTCKPGYVLKERTRCVAATVELGYCFRMVTETGKCEHALSTRLSQEMC 361

  Fly   344 ---------SNCQGACENLPGSYRCVEPLEE-----------------------NPEITEV--VE 374
                     |||:...::...|:..:.|..:                       ||: |||  .|
Zfish   362 CCTVGKAWGSNCERCPQDGTASFNKICPAGKGMSLQTYHGTLTFQPFLTSIEHINPD-TEVKPPE 425

  Fly   375 NPIEKTNEVPVNVSESQPAG--------KTCNSGFQLSADGTDCQDINECEVDGPED---LDNNA 428
            .||:.|  .|:::|.....|        |.......|.....|..::::.:| .|.|   |::|.
Zfish   426 VPIQTT--TPMHLSPISTHGPRRPVIVAKPTTPPIVLVPPEADSHEVSQTQV-SPMDECKLNSNI 487

  Fly   429 VCQQKCENTIGSFRCTCVEGY--HLL----EDQRSCALDSCTDLENPQLNRTRCAHECQDLPEGS 487
            .....|.||...|.|.|..||  |.|    ||:..|....|        .|..|.:..     ||
Zfish   488 CGHGVCANTQNGFMCHCYPGYRSHALTKRCEDENECDAQPC--------GRGVCLNVL-----GS 539

  Fly   488 YRCVCPKGYELSE---------DQHSCLVQE-----SPCSTEKGVEKCS--PG------------ 524
            |:|.|..||.|||         |.:.||..|     ..|..::|..||.  ||            
Zfish   540 YKCNCHHGYRLSEISSGKRSCSDINECLNTEICGVGGQCINQQGSYKCECLPGFRKKIQKPPHCE 604

  Fly   525 ---TCLASE-------DNT--SFSCI-CPTGYRSEAFSCQDIDECAEDTHLCSHTCQNTPGGYQC 576
               .||..:       :||  |:.|: |..|||:|...|.|||||.:.....:..|:|..|.|:|
Zfish   605 DINECLEPDICPNEQCENTLGSYECLPCQPGYRAERGVCHDIDECKKHGVCLNGRCENLAGSYRC 669

  Fly   577 QCPEGLNLVEEYTCLAENLCEVNNNGCEQI-------------CLTARGGV-CACREGFRLSADG 627
            .|.||.            |.|.|..||..|             |:...|.. |.|..|::.:.:|
Zfish   670 LCNEGF------------LPEANRKGCRDINECQDNRLCANGHCINTDGSFRCQCYAGYQPTQEG 722

  Fly   628 KSCEDVDECLVNNGGCQQ-VCRNLPGSYGCICAAGYELLKLDGIRGYCFDIDECSQRTHGCSDQM 691
            ..|||::|| .....||: .|.|..|||.|.|..||   .|:..| :|.||:||......|....
Zfish   723 SHCEDINEC-KRAANCQRGRCINTMGSYRCECQKGY---TLENGR-HCKDINECDGERSLCQPHG 782

  Fly   692 LCENLNGSYTCLCPPGYALGLDNH-----------IVTSLNSSFITDSTSSETPSAHTCL----- 740
            :|||..|.|.|:|..|:.|..|.|           ...:|:.:...||..:...:...|.     
Zfish   783 VCENRQGGYVCVCNDGFRLSEDKHSCEKIESDKKECYLNLDDTVFCDSVLATNVTKQECCCSIGV 847

  Fly   741 --------------------------------------------DIDECSL-ANGNCSH-FCQNE 759
                                                        |||||.| :|..|.. .|.|.
Zfish   848 GWGDHCEIYPCPVYRSAEYHSLCPIGRGFYHDQEKIEYGFVAHRDIDECVLFSNEICKEGRCMNT 912

  Fly   760 PGGFQCACPLGYALSEDMRTCQDIDECLDSNGQCSQLCLNQPGGFACACETGFELTPDGFG--CA 822
            ..||:|.|..|:....::..|.|:|||.|.:...:..|:|..|.|.|.|:..:  .||.:.  |.
Zfish   913 QPGFECYCQQGFYYDSNLLECIDVDECHDESLCINGHCVNTRGSFYCVCDPPW--VPDAYNKKCV 975

  Fly   823 -----DIDECSQDYGNCSD-ICINLLGTHACACERGYELAKDKLSCL----------------DV 865
                 .|||| ||..||.: .|:|...::.|.|...:.||.|:.||:                ||
Zfish   976 FPTIIGIDEC-QDPANCKNGQCVNTQDSYYCLCSPPWTLASDRNSCVTPEEQAVMGVSVVHLTDV 1039

  Fly   866 DECAGLLSGGCSH-ECINKAGTFECGC--PLGY------ILNDD--------------------- 900
            :||..  ...|.: .|:|..|:|.|.|  ||.:      .:.||                     
Zfish  1040 NECED--PSYCRNGRCVNTPGSFHCICTQPLTFSAALKQCVYDDRTAAHKDICFQEVDEDHMCTM 1102

  Fly   901 ----------------GRSCSPALVGCPP--------------GTQRSADG---CAPIECNPGYT 932
                            ||...|....||.              .|:...:|   .|....||   
Zfish  1103 PRNELTVTYSECCCHYGRGWGPECRTCPMRNTVLFNRLCEMHLETESDGEGDFLAAFSTYNP--- 1164

  Fly   933 LGSDDKCVDIDECQKQNGGCSHRCSNTEGSFKCSCPPGYELDSDQKTCQDIDEC---DQDKTSCI 994
             ..|....|.|||...||    ||..:.....|.|..|:.||..:..|.|||||   ...::.|.
Zfish  1165 -EGDSSEEDSDECSCANG----RCVRSYLGTMCECNTGFVLDHSRTRCTDIDECAGRGTGQSPCK 1224

  Fly   995 TGTCINEIGGFRCE 1008
            ...|||..|.|||:
Zfish  1225 NARCINTFGSFRCQ 1238

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fracNP_648137.3 FXa_inhibition 296..331 CDD:464251 11/37 (30%)
cEGF 396..415 CDD:463661 2/18 (11%)
FXa_inhibition 425..458 CDD:464251 13/38 (34%)
FXa_inhibition 476..505 CDD:464251 12/37 (32%)
EGF_CA 552..>581 CDD:214542 11/28 (39%)
FXa_inhibition 596..630 CDD:464251 11/47 (23%)
FXa_inhibition 636..>664 CDD:464251 12/28 (43%)
EGF_CA 676..711 CDD:214542 13/34 (38%)
FXa_inhibition 745..780 CDD:464251 11/36 (31%)
FXa_inhibition 786..821 CDD:464251 10/36 (28%)
vWFA <821..861 CDD:469594 16/45 (36%)
FXa_inhibition 874..904 CDD:464251 13/75 (17%)
FXa_inhibition 945..980 CDD:464251 10/34 (29%)
PTZ00449 <1017..>1098 CDD:185628
CCP 1110..1170 CDD:153056
CCP 1183..1235 CDD:153056
HYR 1468..1536 CDD:460572
ltbp3NP_001244070.1 TB 228..263 CDD:459903 9/37 (24%)
EGF_CA 290..>320 CDD:214542 10/29 (34%)
TB 346..388 CDD:459903 6/41 (15%)
EGF_CA 562..594 CDD:214542 10/31 (32%)
EGF_CA 605..640 CDD:214542 10/34 (29%)
EGF_CA 645..>675 CDD:214542 12/29 (41%)
EGF_CA 686..726 CDD:214542 7/39 (18%)
EGF_CA 727..766 CDD:214542 16/43 (37%)
EGF_CA 767..809 CDD:214542 16/41 (39%)
TB 828..870 CDD:459903 3/41 (7%)
EGF_CA 935..>965 CDD:214542 11/29 (38%)
EGF_CA 982..1012 CDD:214542 12/30 (40%)
EGF_CA 1038..>1064 CDD:214542 10/27 (37%)
TB 1099..1141 CDD:459903 5/41 (12%)
EGF_CA 1209..>1243 CDD:214542 13/30 (43%)
Blue background indicates that the domain is not in the aligned region.

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