DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment frac and fbn2a

DIOPT Version :9

Sequence 1:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster
Sequence 2:	XP_021334963.1	Gene:	fbn2a / 558217	ZFINID:	ZDB-GENE-090112-4	Length:	698	Species:	Danio rerio

Alignment Length:	731	Identity:	192/731 - (26%)
Similarity:	267/731 - (36%)	Gaps:	194/731 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   392 PAGKTCNSGFQLSA--------DGTDCQ-DINECEVDGPEDLDNNAVCQQKCEN---TIGSFRCT 444
            |.|:|..:.|..|:        :|..|: |..:|............||::.|:|   .||..||.
Zfish     5 PGGQTATTCFTKSSKQCNIRCMNGGVCEDDYCQCPKGYTGSFCGQPVCEKNCQNGGHCIGPNRCA 69

  Fly   445 CVEGYHLLEDQRSCALDSCTDLENPQLNRTRCAHECQDLPEGSYRCVCPKGYELSEDQHSCLVQE 509
            |  ||.....|  |..|..|.....|::..:||.:..:.......|....|.........|....
Zfish    70 C--GYGFTGPQ--CERDYRTGPCFIQVHSRKCAGQSSEFVCSKALCCATVGQAWGHSCEQCPPIS 130

  Fly   510 SPC------STEKGV-----------EKCSPGTCLASEDNT--SFSCICPTGYRSEA--FSCQDI 553
            |||      :|..|.           :.|..|.|:    ||  |:.|.||.||:...  ..|:|:
Zfish   131 SPCTRGFIPNTRTGACQDVDECKVVPDLCKGGRCI----NTLGSYQCTCPVGYQQHVSILKCEDV 191

  Fly   554 DECAEDTHLC--SHTCQNTPGGYQCQCPEGLNLVEEYTCLAENLCEVNNNGCEQICLTARGGVCA 616
            |||:.....|  .| |.|:.|.:.|.||.|..|..:.|                .||....|:|
Zfish   192 DECSTIERACEAGH-CINSAGSFSCVCPSGYVLSADRT----------------RCLDQHTGIC- 238

  Fly   617 CREGFRLSADGKSCEDVD------ECLVNNGGC------QQVCRNLPGS--YGCICAAGYELLKL 667
                |....:|:...::.      :|..:.|.|      .::| .:|||  |..||..|
Zfish   239 ----FASVVNGRCAHEISGRFNKIQCCCDRGRCWSQRTTHEMC-PVPGSDEYLRICLVG------ 292

  Fly   668 DGIRGYCFDIDECSQRTHGC-----SDQML-CENLNGSY-------------------------- 700
            ..:.||..:..|.|...|..     :||:| ..|.||..
Zfish   293 SALSGYNEEDPEMSPHHHSSFSVSPNDQILHPHNGNGQIKPQIRQTPQILQFPQIPQIPRHDNGF 357

  Fly   701 --------------TC-----LCPPGYALGLDNHIVTSLNSSFITDSTSSETPSAHTCLDIDECS 746
                          .|     ||..|..:.:::......|:.|..|:...       |.|:|||.
Zfish   358 KPQRPVVSVNETVNRCRLLPNLCLNGRCIPMESDYRCDCNTGFKEDNRGE-------CSDVDECE 415

  Fly   747 L---ANGNCSHFCQNEPGGFQCACPLGYALSEDMRTCQDIDECLDSNGQCSQ-LCLNQPGGFACA 807
            .   |||||.    |.||.:.|.|..|:......:||.||||||.:...|.. .|||..|.|.|.
Zfish   416 FDPCANGNCI----NTPGSYYCRCHTGFLRVPGKQTCIDIDECLQNGVLCKNGRCLNTEGSFQCI 476

  Fly   808 CETGFELTPDGFGCADIDECSQDYGNCSDICINLLGTHACACERGYELAKDKLSCLDVDECAGLL 872
            |.:||:|:|||..|.|.|||:......:.:|||..|:..|.|:.|:.|......|.|:|||.  .
Zfish   477 CNSGFKLSPDGRNCVDHDECAATNMCLNGMCINEDGSFKCVCKPGFTLNSSGRYCTDIDECR--T 539

  Fly   873 SGGCSH-ECINKAGTFECGCPLGYILNDDGRSCSPALVG-----------CPPGTQRS------- 918
            .|.|.: .|:|..|:|.|.|..|..:..|||:|....:.           |....||:
Zfish   540 PGVCMNGRCVNTQGSFRCECFAGLTVGIDGRTCVDTHMRSTCYGAVKRGLCLRPFQRAVTKSQCC 604

  Fly   919 --------ADGCAP----------IECNPGYTLGSDDKCVDIDECQKQNGGCSHR-CSNTEGSFK 964
                    .:.|.|          :.|..|....:|.|  ||:||......||:. |.|..|:|:
Zfish   605 CANPDYAFGEPCHPCPAKHSAEFQVLCASGVGFSADGK--DINECALDPDICSNGVCENLRGNFR 667

  Fly   965 CSCPPGYELDSDQKTC 980
            |.|..|||.|...:.|
Zfish   668 CVCNIGYESDQSGRNC 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342
		cEGF	396..415	CDD:289433	6/27 (22%)
		FXa_inhibition	425..458	CDD:291342	12/35 (34%)
		FXa_inhibition	476..505	CDD:291342	4/28 (14%)
		vWFA	<550..586	CDD:294047	15/37 (41%)
		FXa_inhibition	596..630	CDD:291342	6/33 (18%)
		FXa_inhibition	636..>664	CDD:291342	11/35 (31%)
		EGF_CA	676..715	CDD:284955	13/89 (15%)
		FXa_inhibition	745..780	CDD:291342	12/37 (32%)
		FXa_inhibition	786..821	CDD:291342	16/35 (46%)
		FXa_inhibition	827..862	CDD:291342	9/34 (26%)
		FXa_inhibition	874..904	CDD:291342	12/30 (40%)
		FXa_inhibition	945..980	CDD:291342	13/35 (37%)
		CCP	1110..1170	CDD:153056
		CCP	1183..1235	CDD:153056
		DUF5011	1468..1536	CDD:295940
fbn2a	XP_021334963.1	EGF_CA	148..180	CDD:214542	10/35 (29%)
		vWFA	<188..226	CDD:320736	15/38 (39%)
		TB	247..288	CDD:307020	8/41 (20%)
		EGF_CA	410..>439	CDD:214542	14/32 (44%)
		cEGF	472..495	CDD:315355	11/22 (50%)
		cEGF	513..536	CDD:315355	6/22 (27%)
		EGF_CA	533..573	CDD:214542	16/41 (39%)
		TB	590..630	CDD:307020	5/39 (13%)
		EGF_CA	643..683	CDD:328759	16/39 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D4721at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100900
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820