DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment frac and fbln2

DIOPT Version :9

Sequence 1:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster
Sequence 2:	XP_001341277.2	Gene:	fbln2 / 553503	ZFINID:	ZDB-GENE-060711-1	Length:	1408	Species:	Danio rerio

Alignment Length:	1004	Identity:	244/1004 - (24%)
Similarity:	362/1004 - (36%)	Gaps:	338/1004 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 IPQLNFEEHDEKVGYDLEDYSDETVPNDYVENSDIDEDDDEEVSEREPPPPPPPPVVDGADSKPE 178
            ||.....||:|.|. ::|                 ||.....|:.||||
Zfish   500 IPAETLPEHEESVA-EVE-----------------DEHKRLAVNHREPP---------------- 530

  Fly   179 PQIVIEINDDHANEVVESEPALAETETENEVLENETPLKAEVQTDVLNSSNASVKVTNDPYEP-- 241
                    :||....|::...|...:.|.|.::: |..|...:.:..:..:....||..|..|
Zfish   531 --------EDHKQLPVKNTKPLEHPKPEEEHVQS-TSAKHNTELERKHQWHLFSPVTFSPTSPPS 586

  Fly   242 --------TFLDNNCGEDNGGCAHICKRLLYPDENQPINKCDCREGYTLDPNDYASCLDIDECLE 298
                    .|.:.....||      ..|..:.||...:..|               |:...:..|
Zfish   587 NKQSHSLFNFREEEDEADN------TLRAAFVDEQGLVESC---------------CVAGQKWAE 630

  Fly   299 SNGGC----------SEICENLPGEYKCS-------CQEGYYLDESGKSCVDINECANPELSSNC 346
            .|..|          |.:| .:..:..||       ||.|....::|::|...:.....:..::|
Zfish   631 ENQQCNRMAVKTEDISSVC-GVVQQQCCSGALRESRCQAGIIAAKAGRACQRNSPLCGEDSQTDC 694

  Fly   347 QGACE------------------NLPGSY---RCVEPLEENPEITEVVENPIEKTNEVPVNVSES 390
            ...|.                  :.|..:   .|.|..||...:..:.:....:...:|..||:|
Zfish   695 CNCCALGLRLRREGKGCEAHQYLSYPCGHVFLTCCEDAEEGLPLPTIKKKQRPQPTALPKRVSDS 759

  Fly   391 QPAGKTCNSGFQLSADGTDCQDINECEVDGPEDLDNN-------AVCQQKCENTIGSFRCTCVEG 448
            |...:..::|           |::.. |:..|||::.       ::|...|.||..|:.|.|..|
Zfish   760 QFWKQALSAG-----------DVDPA-VNSLEDLEHGDRCQRFASLCHHTCINTRDSYLCACHPG 812

  Fly   449 YHLLEDQRSCALDSCTD--------------------------LENPQLNRTRCAHEC---QDLP 484
            |.||:|..:|..::..:                          |.||......|:.:|   |:|.
Zfish   813 YTLLQDGHTCVSENQEEDNRVSEEDRIPTTVPDKQQTTTQMPVLHNPCAGNGLCSQKCTVVQELA 877

  Fly   485 EGSYRCVCPKGYELSEDQHSCLVQESPCSTEKGVEKCSPGTCLASEDNTSFSCICPTGYRSEAFS 549
            :    |.|..|:.|..|.|                                             :
Zfish   878 Q----CSCFPGFFLKPDGH---------------------------------------------T 893

  Fly   550 CQDIDECAEDTHLCS--HTCQNTPGGYQCQCPEGLNLVEEYTCLAENLCEVNNNGCEQICLTARG 612
            |:|::||....|.||  ..|:|..|.|||:                   .||.
Zfish   894 CEDVNECLNGRHNCSLDEVCKNHEGSYQCE-------------------RVNE------------ 927

  Fly   613 GVCACREGFRLSADGKSCEDVDECLVNNGGCQ--QVCRNLPGSYGC----ICAAGYELLKLDGIR 671
               .|.:|| :....:.|.||:||:.|...|:  :.|.|..|.:.|    :|::||:|.     .
Zfish   928 ---MCHKGF-IHKHNRDCVDVNECVTNTHTCRADERCVNSVGGFVCERMILCSSGYQLR-----N 983

  Fly   672 GYCFDIDECSQRTHGCSDQMLCENLNGSYTC----LCPPGYALGLDNHIVTSLNSSFITDSTSSE 732
            |.|.|||||..|||.|.....|:|.:||:||    .|..|:
Zfish   984 GVCEDIDECVIRTHNCGMGFQCQNTDGSFTCKPKQRCLTGF------------------------ 1024

  Fly   733 TPSAH-TCLDIDECSLANGNCS--HFCQNEPGGFQC-----ACPLGYALSEDMRTCQDIDECLDS 789
            |..:| .|:||||||.....|:  ..|.|..|.:.|     .|..||..|.|...|.|:|||...
Zfish  1025 TQDSHGNCIDIDECSSVREPCTTGFNCINTVGSYTCQRKIIMCSRGYHSSPDGARCIDVDECQTG 1089

  Fly   790 NGQC--SQLCLNQPGGFACACETGFELTPDGFGCADIDECSQDYGN-CSDICINLLGTHACACER 851
            ..:|  .|:|.|.||...|.|:||::.......|.|::||.:..|. |:..|.|..|::.|:|..
Zfish  1090 THRCGEGQICHNLPGSHRCDCQTGYQYDTIRQLCVDVNECWRYPGRLCAQTCENTPGSYQCSCTT 1154

  Fly   852 GYELAKDKLSCLDVDECAGLLSGGCSHECINKAGTFECGCPLGYILNDDGRSCSPALVGCPPGTQ 916
            |:.||.|..:|.|::||.   |..||.||.|..|:::|.|..||.|.:||.:|.
Zfish  1155 GFSLAFDGKNCEDINECD---SNPCSQECANIYGSYQCYCRAGYYLKEDGHTCE----------- 1205

  Fly   917 RSADGCAPIECNPGYTLGSDDKCVDIDECQKQNGG-CSHRCSNTEGSFKCSCPP-GYELDSDQKT 979
                                    |||||.:..|. |:..|.|..||:.|:||| ||.:.::.:|
Zfish  1206 ------------------------DIDECSQSIGNLCAFECVNVPGSYTCACPPHGYSMSANGRT 1246

  Fly   980 CQDIDECDQDKTSC-ITGTCINEIGGFRC 1007
            |||||||.....:| .:.||.|..|||||
Zfish  1247 CQDIDECAIGSHNCSASQTCFNIQGGFRC 1275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342	11/51 (22%)
		cEGF	396..415	CDD:289433	2/18 (11%)
		FXa_inhibition	425..458	CDD:291342	12/39 (31%)
		FXa_inhibition	476..505	CDD:291342	10/31 (32%)
		vWFA	<550..586	CDD:294047	13/37 (35%)
		FXa_inhibition	596..630	CDD:291342	5/33 (15%)
		FXa_inhibition	636..>664	CDD:291342	10/33 (30%)
		EGF_CA	676..715	CDD:284955	17/42 (40%)
		FXa_inhibition	745..780	CDD:291342	12/41 (29%)
		FXa_inhibition	786..821	CDD:291342	11/36 (31%)
		FXa_inhibition	827..862	CDD:291342	12/35 (34%)
		FXa_inhibition	874..904	CDD:291342	13/29 (45%)
		FXa_inhibition	945..980	CDD:291342	13/36 (36%)
		CCP	1110..1170	CDD:153056
		CCP	1183..1235	CDD:153056
		DUF5011	1468..1536	CDD:295940
fbln2	XP_001341277.2	ANATO	694..734	CDD:294031	5/39 (13%)
		FXa_inhibition	794..822	CDD:291342	12/27 (44%)
		cEGF	878..899	CDD:289433	8/69 (12%)
		EGF_CA	896..>922	CDD:304395	10/25 (40%)
		EGF_CA	943..>980	CDD:284955	12/36 (33%)
		EGF_CA	988..1032	CDD:304395	19/67 (28%)
		EGF_CA	1034..1081	CDD:214542	16/46 (35%)
		EGF_CA	1082..1115	CDD:214542	14/32 (44%)
		vWFA	<1116..1164	CDD:294047	15/47 (32%)
		cEGF	1147..1170	CDD:289433	8/22 (36%)
		cEGF	1186..1209	CDD:289433	10/57 (18%)
		cEGF	1228..1252	CDD:289433	12/23 (52%)
		EGF_CA	1249..>1285	CDD:284955	14/27 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2524
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940