DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment frac and Scube2

DIOPT Version :9

Sequence 1:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster
Sequence 2:	XP_003749018.1	Gene:	Scube2 / 499241	RGDID:	1563998	Length:	972	Species:	Rattus norvegicus

Alignment Length:	967	Identity:	240/967 - (24%)
Similarity:	333/967 - (34%)	Gaps:	353/967 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   278 EGYTLDPNDYASCLDIDECLESNGGC--SEICENLPGEYKCSCQEGYYLDESGKSCVDINECANP 340
            :|.|..|.:     |:|||.:....|  ..:|:|.|..|||||:.||  ...|:.|.|::||.|
  Rat    38 QGRTNGPPE-----DVDECAQGLDDCHADALCQNTPTSYKCSCKPGY--QGEGRQCEDMDECDN- 94

  Fly   341 ELSSNCQGACENLPGSYRCVEPLEENPEITEVVENPIEKTNEVPVNVSESQPAGKTCNSGFQLSA 405
            .|:..|...|.|:||:|||                                    ||..||.|:.
  Rat    95 ALNGGCVHDCLNIPGNYRC------------------------------------TCFDGFMLAH 123

  Fly   406 DGTDCQDINECEVDGPEDLDNNAVCQQKCENTIGSFRCTCVEGYHLLEDQRSCALD-----SCTD 465
            ||.:|.|::||       |:||..||..|.|.:||:.|.|.||:.|.::|.:|...     ||.:
  Rat   124 DGHNCLDVDEC-------LENNGGCQHTCTNVMGSYECRCKEGFFLSDNQHTCIHRSEEGLSCMN 181

  Fly   466 LENPQLNRTRCAHECQDLPEGSYRCVCPKGYELSEDQHSCLVQESPCSTEKGVEKCSPGTCLASE 530
            .::      .|||.|::.|.||..|.|..|:||:::|..|::
  Rat   182 KDH------GCAHICKEAPRGSIACECRPGFELAKNQRDCIL----------------------- 217

  Fly   531 DNTSFSCICPTGYRSEAFSCQDIDECAEDTHLCSHTCQNTPGGYQCQC-------PEGLNLVEEY 588
                                    .|......|.|:|::|..|.:|.|       .:|.:.:|:.
  Rat   218 ------------------------TCNHGNGGCQHSCEDTAEGPECSCHPHYRLHADGRSCLEQE 258

  Fly   589 TCLAE----------------------NLCEVNNNGCEQICLTARGGV-CACREGFRLSADGKSC 630
            ..:.|                      ..|.|||.||::.|.....|| |:|..||.|..|||:|
  Rat   259 GTMLEGTESNATSVADGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPSGFTLQLDGKTC 323

  Fly   631 EDVDECLVNNGGCQQVCRNLPGSYGCICAAGYELLKLDGIRGYCFDIDECS-QRTHGCSDQMLCE 694
            :|:|||...||||...|:|..||:.|.|..|::||..:   ..|.|:|||| :||  |...  |.
  Rat   324 KDIDECQTRNGGCNHFCKNTVGSFDCSCRKGFKLLTDE---KSCQDVDECSLERT--CDHS--CI 381

  Fly   695 NLNGSYTCLCPPGYALGLDNHIVTSLNSSFITDSTSSETPSAHTCLDIDECSLANGNCSHFCQNE 759
            |..|::||.|..||.|....|                       |.|.:|||:.||.|...|.|.
  Rat   382 NHPGTFTCACNRGYTLYSFTH-----------------------CGDTNECSVNNGGCQQVCVNT 423

  Fly   760 PGGFQCACPLGYALSEDMRTCQDIDECL--DSNGQCSQLCLNQPGGFAC--ACETGFELT----- 815
            .||::|.|..||.|..:.:.|.::...|  .:..:.|..|....||..|  .|.:|..|:
  Rat   424 VGGYECQCHPGYKLHWNKKDCVEVKGVLPTSTTPRVSLHCGKSGGGDRCFLRCHSGIHLSSGLQE 488

  Fly   816 -------------------PDGFGCADIDECSQDY----GNCS--DICINLLGTHACACERGYEL 855
                               ...||.......|..:    |.||  ...::..|......||...:
  Rat   489 AYSVTCGSPSLRSRQQKSNDSAFGDVVTVRTSVTFKLNEGKCSLQKAKLSPEGLRPALPERHSSV 553

  Fly   856 AKD----KLSCLDVDECAGLL------------------------SGGCSHECINK--------- 883
            .:.    .|:|....:..|.|                        :..|:..|:.|
  Rat   554 KESFHYANLTCSPGKQVLGALGRPNAPKEMFITVEFERETYQKEVTASCNLSCVVKRTEKRLRKA 618

  Fly   884 -------------------------------AGTFECGCPLGYILNDDGRSCSPALVGCPPGTQR 917
                                           :|..|..|.:|     .||..|...: |.|| :.
  Rat   619 VRTLKKAAHREQFHLQLSGTDLDVAKKFPRVSGQQEETCGVG-----QGREESQCGL-CQPG-EY 676

  Fly   918 SADGCAPIECNPGYTLGSDDKCVDIDECQKQNGG-------------------CS---------H 954
            ||||.||  |.| ..||:....|....|....||                   ||         |
  Rat   677 SADGFAP--CQP-CALGTFQPDVGRTSCLPCGGGLPTKHLGATSFHDCETRVQCSPGHFYNTTTH 738

  Fly   955 RCSNTE--------GSFKC-SCPPGYELDSDQKTCQDIDECDQDKTSCITGTCINEIGGFR--CE 1008
            ||....        |...| |||.....|.|..|  :|.:|...|       |..|:|.|.  .|
  Rat   739 RCIRCPLGTYQPEFGKNNCVSCPGNTTTDFDGST--NITQCKNRK-------CGGELGDFTGYIE 794

  Fly  1009 FPKFPVLPEIPTASSLPESPKIELKTPKYPDFTELSNEIPENPKKPAEFDYPEPKFP 1065
            .|.:|                     ..||..:|.:..|...||:......||...|
  Rat   795 SPNYP---------------------GNYPANSECTWTINPPPKRRILIVVPEIFLP 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342	13/36 (36%)
		cEGF	396..415	CDD:289433	9/18 (50%)
		FXa_inhibition	425..458	CDD:291342	14/32 (44%)
		FXa_inhibition	476..505	CDD:291342	13/28 (46%)
		vWFA	<550..586	CDD:294047	9/42 (21%)
		FXa_inhibition	596..630	CDD:291342	17/34 (50%)
		FXa_inhibition	636..>664	CDD:291342	12/27 (44%)
		EGF_CA	676..715	CDD:284955	17/39 (44%)
		FXa_inhibition	745..780	CDD:291342	14/34 (41%)
		FXa_inhibition	786..821	CDD:291342	10/62 (16%)
		FXa_inhibition	827..862	CDD:291342	8/44 (18%)
		FXa_inhibition	874..904	CDD:291342	9/69 (13%)
		FXa_inhibition	945..980	CDD:291342	15/71 (21%)
		CCP	1110..1170	CDD:153056
		CCP	1183..1235	CDD:153056
		DUF5011	1468..1536	CDD:295940
Scube2	XP_003749018.1	EGF_3	51..86	CDD:289699	13/36 (36%)
		FXa_inhibition	97..128	CDD:291342	15/66 (23%)
		FXa_inhibition	134..169	CDD:291342	16/41 (39%)
		FXa_inhibition	179..215	CDD:291342	14/41 (34%)
		FXa_inhibition	219..254	CDD:291342	9/34 (26%)
		FXa_inhibition	288..323	CDD:291342	17/34 (50%)
		vWFA	<314..363	CDD:294047	23/51 (45%)
		vWFA	<361..397	CDD:294047	17/42 (40%)
		FXa_inhibition	409..444	CDD:291342	14/34 (41%)
		GCC2_GCC3	674..721	CDD:285001	15/50 (30%)
		GCC2_GCC3	730..777	CDD:285001	12/48 (25%)
		CUB	782..893	CDD:238001	16/70 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I10713
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910