DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment frac and matn4

DIOPT Version :9

Sequence 1:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster
Sequence 2:	XP_005155921.1	Gene:	matn4 / 497348	ZFINID:	ZDB-GENE-050208-64	Length:	944	Species:	Danio rerio

Alignment Length:	723	Identity:	205/723 - (28%)
Similarity:	297/723 - (41%)	Gaps:	176/723 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   293 IDECLESNGGCSEICENLPGEYKCSCQEGYYLDESGKSCVDINECANPELSSNCQGACENLPGSY 357
            :|.||||:.||..|||:.||.|:|.|..||.|:|.||:|..|:.||  |...:|:..|...|||:
Zfish   214 MDLCLESDHGCEHICESSPGSYQCLCLPGYTLNEDGKTCTPIDLCA--EGKHDCEQICIASPGSF 276

  Fly   358 RCVEPLEENPEITEVVENPIEKTNEVPVNVSESQPAGKTCNSGFQLSADGTDCQDINECEVDGPE 422
            .|                                    .||:|:.|:.|...|:.|:.|..
Zfish   277 TC------------------------------------DCNTGYTLNDDKKTCKMIDYCSF---- 301

  Fly   423 DLDNNAVCQQKCENTIGSFRCTCVEGYHLLEDQRSCA-LDSCTDLENPQLNRTRCAHECQDLPEG 486
               .|..|:.||.:.:..|.|.|.|||.|.||.::|. :|.|:      .....|.|||..:.:
Zfish   302 ---GNDSCEHKCVSVLNGFNCRCDEGYSLNEDLKTCTMIDYCS------FGNDSCEHECVSVLQ- 356

  Fly   487 SYRCVCPKGYELSEDQHSCLVQESPCSTEKGVEKCSPGTCLASEDNTSFSCICPTGYRSEAFSCQ 551
            |:.|.|..||.|:||:.:|.:
Zfish   357 SFYCQCRDGYTLNEDETTCTM-------------------------------------------- 377

  Fly   552 DIDECAEDTHLCSHTCQNTPGGYQCQCPEGLNLVEEY-TCLAENLCEVNNNGCEQICLTA-RGGV 614
             ||.|:.....|.|.|.:...|:.|:|.||.:|.::. ||...:.|...|:.||..|::. :|..
Zfish   378 -IDYCSFGNDSCEHECVSVLNGFHCRCNEGYSLNDDLKTCTMIDYCSFGNDSCEHECVSVLKGFH 441

  Fly   615 CACREGFRLSADGKSCEDVDECLVNNGGCQQVCRNLPGSYGCICAAGYELLKLDGIRGYCFDIDE 679
            |.|.:|:.|:.|.|:|..:|.|...|..|:..|.::...:.|||..||   .|:..:..|..||.
Zfish   442 CRCNDGYTLNDDKKTCTMIDYCSFGNDSCEHECVSVLKGFHCICNEGY---SLNDDKKTCTMIDY 503

  Fly   680 CSQRTHGCSDQMLCENLNGSYTCLCPPGYALGLDNHIVTSLNSSFITDSTSSETPSAHTCLDIDE 744
            ||.....|..:  |.::...:.|:|..||:|..|.                      .||..||.
Zfish   504 CSFGNDSCEHE--CVSVLKGFHCICNDGYSLNDDK----------------------KTCTMIDY 544

  Fly   745 CSLANGNCSHFCQNEPGGFQCACPLGYALSEDMRTCQDIDECLDSNGQCSQLCLNQPGGFACACE 809
            ||..|.:|.|.|.:...||.|.|..||:|:.|::||..||.|...|..|...|::...||.|.|:
Zfish   545 CSFGNDSCEHQCVSVLKGFNCRCNEGYSLNGDLKTCTMIDYCSFGNDSCEHECVSVLNGFHCRCK 609

  Fly   810 TGFELTPDGFGCADIDECSQDYGN--CSDICINLLGTHACACERGYELAKDKLSCLDVDECAGLL 872
            .|:.|..|...|..||.||  :||  |...|:::|....|.|..||.|.:|..:| ..|.....:
Zfish   610 DGYTLNEDKKTCTMIDYCS--FGNHSCDHHCVSVLNGFFCRCNEGYTLQEDGKTC-QSDNLCNTV 671

  Fly   873 SGGCSHECINKAGTFECGCPLGYILNDDGRSCSPALVGCPPGTQRSADGCAPIECNPGYTLGSDD 937
            ..||.::|::..|::.|.||.|::|.|||:||         ||.|::
Zfish   672 EHGCEYQCVSTPGSYHCICPEGHVLQDDGKSC---------GTCRTS------------------ 709

  Fly   938 KCVDIDECQKQNGGCSHRCSNTEGSFKCSCPPGYELDSDQKTCQDIDECDQDKTSCITGTCINEI 1002
               :||.....:|..|.|            |..:|| ..|...|.:|:.|........| .:...
Zfish   710 ---NIDLVLLIDGSKSVR------------PQNFEL-VKQFVNQVVDQLDVSAKGTRVG-LVQYS 757

  Fly  1003 GGFRCEFP 1010
            ...|.|||
Zfish   758 SRVRTEFP 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342	20/34 (59%)
		cEGF	396..415	CDD:289433	7/18 (39%)
		FXa_inhibition	425..458	CDD:291342	13/32 (41%)
		FXa_inhibition	476..505	CDD:291342	12/28 (43%)
		vWFA	<550..586	CDD:294047	12/35 (34%)
		FXa_inhibition	596..630	CDD:291342	12/34 (35%)
		FXa_inhibition	636..>664	CDD:291342	9/27 (33%)
		EGF_CA	676..715	CDD:284955	12/38 (32%)
		FXa_inhibition	745..780	CDD:291342	14/34 (41%)
		FXa_inhibition	786..821	CDD:291342	11/34 (32%)
		FXa_inhibition	827..862	CDD:291342	13/36 (36%)
		FXa_inhibition	874..904	CDD:291342	12/29 (41%)
		FXa_inhibition	945..980	CDD:291342	7/34 (21%)
		CCP	1110..1170	CDD:153056
		CCP	1183..1235	CDD:153056
		DUF5011	1468..1536	CDD:295940
matn4	XP_005155921.1	vWFA	32..251	CDD:294047	20/36 (56%)
		FXa_inhibition	258..293	CDD:291342	14/72 (19%)
		FXa_inhibition	299..334	CDD:291342	14/41 (34%)
		FXa_inhibition	340..375	CDD:291342	13/41 (32%)
		FXa_inhibition	381..416	CDD:291342	10/34 (29%)
		FXa_inhibition	422..457	CDD:291342	12/34 (35%)
		vWFA	<454..497	CDD:294047	13/45 (29%)
		FXa_inhibition	504..539	CDD:291342	10/58 (17%)
		vWFA	<536..579	CDD:294047	18/64 (28%)
		FXa_inhibition	586..621	CDD:291342	11/34 (32%)
		vWFA	<618..661	CDD:294047	16/44 (36%)
		vWFA	<659..702	CDD:294047	14/43 (33%)
		vWFA	711..944	CDD:294047	17/69 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I11309
eggNOG	1	0.900	-	-		E33208_3BA2W
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810