DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment frac and efemp2a

DIOPT Version :9

Sequence 1:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster
Sequence 2:	NP_001008587.1	Gene:	efemp2a / 494044	ZFINID:	ZDB-GENE-041212-8	Length:	440	Species:	Danio rerio

Alignment Length:	338	Identity:	113/338 - (33%)
Similarity:	148/338 - (43%)	Gaps:	80/338 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   673 YCFDIDECSQRTHGCSDQMLCENLNGSYTCLCPPGYALGLDNHIVTSLNSSFITDSTSSETPSAH 737
            :|.||:||...|..|..:|.|.|..|.|.||                       ..::|..|:|.
Zfish    46 HCKDINECETITEACKGEMKCFNHYGGYLCL-----------------------PRSASVIPAAE 87

  Fly   738 TCLDIDECSLANGNCSHFCQNEPGGFQCACPLGYALSEDMRTCQDIDECLDSNGQC--SQLCLNQ 800
            ....||. ||.|.      .:||..   :||.|:...:|  :|.|:|||...:..|  ||.|.|.
Zfish    88 PPNQIDP-SLENR------VSEPFN---SCPPGFEPQQD--SCVDVDECERDSHDCQPSQQCFNT 140

  Fly   801 PGGFACACETGFELTPDGFGCADIDECSQDYGNCSDICINLLGTHACACERGYELAKDKLSCLDV 865
            .|.|:|.|..|:...  |..|.|||||...|  |...|:|:.|:.:|.||.|::||.:..||:||
Zfish   141 EGSFSCQCPDGYRKV--GTECIDIDECRYRY--CQHRCVNVPGSFSCQCEPGFQLAGNNRSCIDV 201

  Fly   866 DECAGLLSGGCSHECINKAGTFECGCPLGYILNDDGRSCSPALVGCPPGTQRSADGCAPIECNPG 930
            |||.  :...||..|.|..|||.|.|..||.|..||.:|:
Zfish   202 DECG--MGAPCSQWCYNTYGTFLCRCEQGYELGPDGFACN------------------------- 239

  Fly   931 YTLGSDDKCVDIDECQKQNGGCSHRCSNTEGSFKCSCPPGYELDSDQKTCQDIDECDQDKTSCIT 995
                      |||||...:..|.::|.|..|.|.|.||.||:| ...:.||||:||:.....|..
Zfish   240 ----------DIDECSYSSYLCQYQCVNEHGKFSCVCPEGYQL-LGTRLCQDINECETGAHQCSD 293

  Fly   996 G-TCINEIGGFRC 1007
            | ||:|..||.:|
Zfish   294 GQTCVNIHGGHKC 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342
		cEGF	396..415	CDD:289433
		FXa_inhibition	425..458	CDD:291342
		FXa_inhibition	476..505	CDD:291342
		vWFA	<550..586	CDD:294047
		FXa_inhibition	596..630	CDD:291342
		FXa_inhibition	636..>664	CDD:291342
		EGF_CA	676..715	CDD:284955	13/38 (34%)
		FXa_inhibition	745..780	CDD:291342	9/34 (26%)
		FXa_inhibition	786..821	CDD:291342	12/36 (33%)
		FXa_inhibition	827..862	CDD:291342	12/34 (35%)
		FXa_inhibition	874..904	CDD:291342	14/29 (48%)
		FXa_inhibition	945..980	CDD:291342	12/34 (35%)
		CCP	1110..1170	CDD:153056
		CCP	1183..1235	CDD:153056
		DUF5011	1468..1536	CDD:295940
efemp2a	NP_001008587.1	EGF_CA	120..159	CDD:284955	15/40 (38%)
		EGF_CA	161..190	CDD:214542	14/30 (47%)
		cEGF	180..203	CDD:289433	10/22 (45%)
		EGF_CA	200..238	CDD:284955	19/39 (49%)
		EGF_CA	240..271	CDD:214542	14/30 (47%)
		EGF_CA	280..>307	CDD:304395	12/27 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24034
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010