Protein Alignment frac and NOTCH1

DIOPT Version :9

• Sequence 1: NP_001137905.1
• Gene: frac / 38850
• FlyBaseID: FBgn0035798
• Length: 1618
• Species: Drosophila melanogaster
• Sequence 2: NP_060087.3
• Gene: NOTCH1 / 4851
• HGNCID: 7881
• Length: 2555
• Species: Homo sapiens
• Identity: / - (0%)
• Similarity: / - (0%)
• Gaps: / - (0%)

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342
		cEGF	396..415	CDD:289433
		FXa_inhibition	425..458	CDD:291342
		FXa_inhibition	476..505	CDD:291342
		vWFA	<550..586	CDD:294047
		FXa_inhibition	596..630	CDD:291342
		FXa_inhibition	636..>664	CDD:291342
		EGF_CA	676..715	CDD:284955
		FXa_inhibition	745..780	CDD:291342
		FXa_inhibition	786..821	CDD:291342
		FXa_inhibition	827..862	CDD:291342
		FXa_inhibition	874..904	CDD:291342
		FXa_inhibition	945..980	CDD:291342
		CCP	1110..1170	CDD:153056
		CCP	1183..1235	CDD:153056
		DUF5011	1468..1536	CDD:295940
NOTCH1	NP_060087.3	EGF_CA	142..175	CDD:238011
		EGF_CA	178..216	CDD:238011
		EGF_CA	223..255	CDD:238011
		EGF_CA	257..293	CDD:238011
		EGF_CA	295..332	CDD:238011
		EGF_CA	335..370	CDD:238011
		EGF_CA	412..450	CDD:238011
		Interaction with DLL4. /evidence=ECO:0000250|UniProtKB:Q07008	420..421
		Interaction with DLL4. /evidence=ECO:0000250|UniProtKB:Q07008	448..452
		EGF_CA	452..488	CDD:238011
		EGF_CA	490..526	CDD:238011
		EGF_CA	528..564	CDD:238011
		EGF_CA	566..601	CDD:238011
		EGF_CA	603..639	CDD:238011
		EGF_CA	678..713	CDD:238011
		EGF_CA	717..750	CDD:238011
		EGF_CA	755..789	CDD:238011
		EGF_CA	791..827	CDD:238011
		EGF_CA	869..905	CDD:238011
		EGF_CA	907..943	CDD:238011
		EGF_CA	945..981	CDD:238011
		EGF_CA	988..1019	CDD:238011
		EGF_CA	1021..1057	CDD:238011
		EGF	1063..1093	CDD:278437
		EGF_CA	1146..1180	CDD:238011
		EGF_CA	1184..1219	CDD:238011
		EGF_CA	<1238..1265	CDD:238011
		EGF_CA	1267..1305	CDD:238011
		NL	1442..1479	CDD:197463
		LNR 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00525	1449..1489
		Notch	1487..1522	CDD:278494
		LNR 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00525	1490..1531
		Notch	1525..1561	CDD:278494
		LNR 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00525	1532..1571
		NOD	1567..1618	CDD:284282
		NODP	1672..1729	CDD:284987
		Interaction with PSEN1. /evidence=ECO:0000269|PubMed:30598546	1728..1760
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1780..1808
		Ank_2	<1873..1958	CDD:289560
		ANK repeat	1880..1925	CDD:293786
		ANK	1922..2034	CDD:238125
		ANK repeat	1927..1958	CDD:293786
		ANK 1. /evidence=ECO:0000255	1927..1956
		Ank_2	1932..2025	CDD:289560
		HIF1AN-binding. /evidence=ECO:0000250	1947..1955
		ANK repeat	1960..1991	CDD:293786
		ANK 2. /evidence=ECO:0000255	1960..1990
		ANK	1989..2113	CDD:238125
		ANK repeat	1994..2025	CDD:293786
		ANK 3. /evidence=ECO:0000255	1994..2023
		Ank_2	1999..2091	CDD:289560
		HIF1AN-binding. /evidence=ECO:0000250	2014..2022
		ANK repeat	2027..2058	CDD:293786
		ANK 4. /evidence=ECO:0000255	2027..2056
		ANK repeat	2060..2091	CDD:293786
		ANK 5. /evidence=ECO:0000255	2060..2089
		ANK 6	2095..2122
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2151..2194
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2379..2447
		Med25_SD1	<2429..2514	CDD:288132
		DUF3454	2479..2540	CDD:288764
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2483..2555

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910