DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment frac and arr

DIOPT Version :10

Sequence 1:NP_648137.3 Gene:frac / 38850 FlyBaseID:FBgn0035798 Length:1618 Species:Drosophila melanogaster
Sequence 2:NP_524737.2 Gene:arr / 44279 FlyBaseID:FBgn0000119 Length:1678 Species:Drosophila melanogaster


Alignment Length:1115 Identity:230/1115 - (20%)
Similarity:346/1115 - (31%) Gaps:312/1115 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   296 CLESNGGCSEICENLPGEYKCSCQEGYYLDESGKSCVDINECANPELSSNCQGACENLPGSYR-- 358
            |...|||||.:|.|.|.:|.|.|...|.|....::||                    :|.::.  
  Fly   668 CAVRNGGCSHLCLNRPRDYVCRCAIDYELANDKRTCV--------------------VPAAFLLF 712

  Fly   359 ---------CVEPLEENPEITEVVENPIEKTNEVPVNVSESQP--AGKTCNSGFQLSADGTDCQD 412
                     .:|..|.|.....:....:...:.:.|:|:|.:.  ..:.....|:...:|:..|.
  Fly   713 SRQEHIGRISIEYNEGNHNDERIPFKDVRDAHALDVSVAERRIYWTDQKSKCIFRAFLNGSYVQR 777

  Fly   413 INECEVDGPED-----LDNNAVCQQKCENTI------GSFRCTCVEGYHLLEDQRSCALDSCTD- 465
            |.:..:.||:.     |.||..........|      ||.|...:  :..:|:.||..|:.... 
  Fly   778 IVDSGLIGPDGIAVDWLANNIYWSDAEARRIEVARLDGSSRRVLL--WKGVEEPRSLVLEPRRGY 840

  Fly   466 ---LENPQLNRTRCAHECQDLP---EGSYRCVCPKGYELSEDQHS----CLVQESPCSTEK---- 516
               .|:|..:..|.|.:..||.   .|:....     .|:.||.:    ...|..|...|.    
  Fly   841 MYWTESPTDSIRRAAMDGSDLQTIVAGANHAA-----GLTFDQETRRLYWATQSRPAKIESADWD 900

  Fly   517 --------GVEKCSPGTCLASEDNTSFSCICPTGYRSEAFSCQDIDECAEDTHLCSHTCQNTPGG 573
                    |.:...|......:|...:|          .::..||    |..|       .|.|.
  Fly   901 GKKRQILVGSDMDEPYAVSLYQDYVYWS----------DWNTGDI----ERVH-------KTTGQ 944

  Fly   574 YQCQCPEGLNLVEEYTCLAE------NLCEVNNNGCEQICLT---ARGGVCACREGFRLSADGKS 629
            .:.....|:..:.......:      |.|:|||.||..:||.   .||..|||...::|:.||.|
  Fly   945 NRSLVHSGMTYITSLLVFNDKRQTGVNPCKVNNGGCSHLCLAQPGRRGMTCACPTHYQLAKDGVS 1009

  Fly   630 CEDVDECLVNNGGCQQVC--RNLPGSYGC------ICAAGYELLKLDGIRGYCFDIDECSQRTHG 686
            |......::.:   |:.|  |.||.:..|      :.......:..|.|..:.:.|:   .|:|.
  Fly  1010 CIPPRNYIIFS---QRNCFGRLLPNTTDCPNIPLPVSGKNIRAVDYDPITHHIYWIE---GRSHS 1068

  Fly   687 CSDQMLCENLNGSYTCLCPPG---YALGLD-------------NHI-VTSL--NSSFITDSTSSE 732
            ....:    .||:...|....   :.|.:|             |.| |||.  .|..:.|:..||
  Fly  1069 IKRSL----ANGTKVSLLANSGQPFDLAIDIIGRLLFWTCSQSNSINVTSFLGESVGVIDTGDSE 1129

  Fly   733 TP---SAHTC------LDIDECSLANGNCSHFCQNEPGGFQCACPLGY------ALSEDMRTCQD 782
            .|   :.|..      .|:       |:.....:....|.: ...|.|      ||:.|    |.
  Fly  1130 KPRNIAVHAMKRLLFWTDV-------GSHQAIIRARVDGNE-RVELAYKLEGVTALALD----QQ 1182

  Fly   783 ID----------ECLDSNGQCSQLCLNQP----------GGFACACE--TGFE-LTPDGF----- 819
            .|          :.:|.||:..:..::..          |||....:  ||.| :|.:|.     
  Fly  1183 SDMIYYAHGKRIDAIDINGKNKKTLVSMHISQVINIAALGGFVYWLDDKTGVERITVNGERRSAE 1247

  Fly   820 -----GCADI-------------DECSQDYGNCSDICI----NLLGTH-ACACERGYELAKDKLS 861
                 ...||             ..|......||.|||    .:..|. .|:|.:...|.:||.:
  Fly  1248 LQRLPQITDIRAVWTPDPKVLRNHTCMHSRTKCSHICIASGEGIARTRDVCSCPKHLMLLEDKEN 1312

  Fly   862 CLDVDECAGLLSGGCSHECINKAGTFECGCPLGYILNDDGRSCSPAL---------------VGC 911
            |.....|      |..|        |.|..|:..| :|..:.|.||.               |||
  Fly  1313 CGAFPAC------GPDH--------FTCAAPVSGI-SDVNKDCIPASWRCDGQKDCPDKSDEVGC 1362

  Fly   912 PPGTQRSADGCAPIECNPGYTLGSDDKCVDIDECQKQNGGCSHRCSNTEGSFKCS----CPPGYE 972
            |  |.| ||   ...|..|..:.....|.....|  .||.....|....|.|:|.    |.....
  Fly  1363 P--TCR-AD---QFSCQSGECIDKSLVCDGTTNC--ANGHDEADCCKRPGEFQCPINKLCISAAL 1419

  Fly   973 LDSDQKTCQD-----IDECDQDKTSCITGT-----------------------CINEIGGFRCEF 1009
            |....:.|.|     .|.|.|.:.:..|..                       |...||..|.| 
  Fly  1420 LCDGWENCADGADESSDICLQRRMAPATDKRAFMILIGATMITIFSIVYLLQFCRTRIGKSRTE- 1483

  Fly  1010 PKFPVLPEIPTASSLPESPKIELKTPKYPDFTELSNEIPENPKKPAEFDYPEPKFPSLPKWEGLP 1074
            ||.....:..:.|:|.:|.::. |.....|...:|.....|.....:.::......|......:.
  Fly  1484 PKDDQATDPLSPSTLSKSQRVS-KIASVADAVRMSTLNSRNSMNSYDRNHITGASSSTTNGSSMV 1547

  Fly  1075 KLPPLADIPTSKAPVPLRPEVPKSLWVNQLQP-----RDLCPRFQAPRNGKSHCNRYRHKQKLFY 1134
            ..|  .:.|.|.|....||.....: :||..|     .|:|....:....||:.|..........
  Fly  1548 AYP--INPPPSPATRSRRPYRHYKI-INQPPPPTPCSTDICDESDSNYTSKSNSNNSNGGATKHS 1609

  Fly  1135 YSRCRISCNSGYILQ----GPEIKSCDANGIWEGPETKCVAINQPRAQSPGICPALKPAQNGVIL 1195
            .|........||..:    .|..:|...:.:...||:.|..  .|.::|......|.|       
  Fly  1610 SSSAAACLQYGYDSEPYPPPPTPRSHYHSDVRIVPESSCPP--SPSSRSSTYFSPLPP------- 1665

  Fly  1196 PASCTQGPSR 1205
            |.|..|.|||
  Fly  1666 PPSPVQSPSR 1675

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fracNP_648137.3 FXa_inhibition 296..331 CDD:464251 14/34 (41%)
cEGF 396..415 CDD:463661 4/18 (22%)
FXa_inhibition 425..458 CDD:464251 8/38 (21%)
FXa_inhibition 476..505 CDD:464251 7/35 (20%)
EGF_CA 552..>581 CDD:214542 6/28 (21%)
FXa_inhibition 596..630 CDD:464251 16/36 (44%)
FXa_inhibition 636..>664 CDD:464251 6/35 (17%)
EGF_CA 676..711 CDD:214542 6/37 (16%)
FXa_inhibition 745..780 CDD:464251 7/40 (18%)
FXa_inhibition 786..821 CDD:464251 11/57 (19%)
vWFA <821..861 CDD:469594 14/57 (25%)
FXa_inhibition 874..904 CDD:464251 7/29 (24%)
FXa_inhibition 945..980 CDD:464251 9/38 (24%)
PTZ00449 <1017..>1098 CDD:185628 14/80 (18%)
CCP 1110..1170 CDD:153056 11/63 (17%)
CCP 1183..1235 CDD:153056 8/23 (35%)
HYR 1468..1536 CDD:460572
arrNP_524737.2 LY 162..201 CDD:214531
NHL 168..503 CDD:302697
NHL repeat 172..237 CDD:271320
LY 252..293 CDD:214531
NHL repeat 261..298 CDD:271320
NHL repeat 303..339 CDD:271320
NHL repeat 341..419 CDD:271320
NHL repeat 428..476 CDD:271320
LY 472..511 CDD:214531
NHL repeat 477..503 CDD:271320
Ldl_recept_b 534..574 CDD:459654
LY 558..599 CDD:214531
LY 600..641 CDD:214531
FXa_inhibition 668..703 CDD:464251 14/34 (41%)
YncE <736..886 CDD:442618 30/156 (19%)
LY 776..818 CDD:214531 10/41 (24%)
LY 905..946 CDD:214531 10/61 (16%)
FXa_inhibition 973..1010 CDD:464251 16/36 (44%)
YncE <1047..1191 CDD:442618 31/162 (19%)
LDLa 1319..1362 CDD:238060 12/57 (21%)
LDLa 1365..1399 CDD:238060 9/39 (23%)
LDLa 1399..1433 CDD:197566 8/33 (24%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.