DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment frac and CG31999

DIOPT Version :9

Sequence 1:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster
Sequence 2:	NP_001284712.1	Gene:	CG31999 / 43777	FlyBaseID:	FBgn0051999	Length:	917	Species:	Drosophila melanogaster

Alignment Length:	935	Identity:	249/935 - (26%)
Similarity:	349/935 - (37%)	Gaps:	322/935 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 ESEPALAETETENEVL-ENETPLKAEVQTDVLNSSNASVKVTNDPYEPTFLDNNCGEDNGGCAHI 258
            :.:|.:.|.:..|.:. |.|.|..:|      ...|.::.:|.|       |:.||:....||||
  Fly   152 KDQPGIDEIDKANSITDEGELPFVSE------EDMNVTIVLTGD-------DDICGKIENLCAHI 203

  Fly   259 CKRLL-------YP----DEN----QPINKCDCREGYTLDPNDYASCLDIDECLESNGGC--SEI 306
            |:...       :|    |.|    .|:....|..||.||..| ..|:|||||.|....|  |:.
  Fly   204 CENTFDAYQCKCHPGFMLDNNNVTCSPMKTQICPSGYNLDKLD-NKCIDIDECREDLHDCKSSQY 267

  Fly   307 CENLPGEYKC------SCQEGYYLDESGKSCVDINECANPELSSNCQGACENLPGSYRCVEPLEE 365
            |.|..|.|.|      .|..|::.|....:|.|..:|.:                 .:||:.
  Fly   268 CHNTNGGYHCLNVKEKECPPGFHYDHDYDACKDDYKCKD-----------------RKCVKI--- 312

  Fly   366 NPEITEVVENPIEKTNEVPVNVSESQPAGKTCNSGFQLSADGTDCQDINECEVDGPEDLDNNAV- 429
                                         ::|:.||.|. :|| |.||:||   ..:.|:|..|
  Fly   313 -----------------------------QSCDKGFSLH-NGT-CSDIDEC---SHKSLNNCHVN 343

  Fly   430 CQQKCENTIGSFRCTCVEGYHLLEDQRSCALDSCTDLENPQLNRTRCAHECQDLPEGSYRCVCPK 494
            ..|:|.||:||:.|.|:.|::|     ...|:.|.|:           :||
  Fly   344 SNQECVNTVGSYSCNCLPGFNL-----DATLNKCVDI-----------NEC-------------- 378

  Fly   495 GYELSEDQHSCLVQESPCSTEKGVEKCSPGTCLASEDNT--SFSCI----CPTGY--RSEAFSCQ 551
                |.:.|:||          ..::|         |||  |:.|.    |.|||  .:|..:|.
  Fly   379 ----SINNHNCL----------PTQRC---------DNTIGSYICTRLQSCGTGYTLNAETGNCD 420

  Fly   552 DIDECAEDTHLC--SHTCQNTPGGYQC-------------------------------QCPEGLN 583
            |.|||...||.|  ::.|.||.|.::|                               :.|..|.
  Fly   421 DDDECTLSTHNCPSNYDCHNTRGSFRCYRKISTMLTTRTTSTTVPPLSLENARRSFTSRYPYPLA 485

  Fly   584 LVEEYTCLAENLCEVNNNGCEQICLTARGGVCACREGFRLSADGKSCEDVDECLVNNG-GCQQVC 647
            :..||:         .||  :.|....|   ..|..||..:..| :|.|.:||:..|. |..:.|
  Fly   486 VHPEYS---------QNN--DSISTNRR---VDCSPGFYRNTLG-ACIDTNECMEQNPCGNHERC 535

  Fly   648 RNLPGSYGC----ICAAGYELLKLDGIRGYCFDIDECSQRTHGCSDQMLCENLNGSYTCLCPPGY 708
            .|..|.:.|    .|:.||: ..:||  ..|.|||||....|.|.::.:|.|.||.:.|.||.|:
  Fly   536 INTNGHFRCESLLQCSPGYK-STVDG--KSCIDIDECDTGEHNCGERQICRNRNGGFVCSCPIGH 597

  Fly   709 ALGLDNHIVTSLNSSFITDSTSSETPSAHTCLDIDECSLANGNC--SHFCQNEPGGFQCACPLGY 771
            .|                   ......|.||:|.:||:|....|  :..|.|..|.:.|.|..|:
  Fly   598 EL-------------------KRSIGGASTCVDTNECALEQRVCPLNAQCFNTIGAYYCECKAGF 643

  Fly   772 ALSED---MRTCQDIDECLDSNGQCSQLCLNQPGGFACACETGFELTPDGFGCADIDECS--QDY 831
            ....|   ...|.|||||....|.|.|.|||..||:.|.|.:|::|.||...|.||:||.  :||
  Fly   644 QKKSDGNNSTQCFDIDECQVIPGLCQQKCLNFWGGYRCTCNSGYQLGPDNRTCNDINECEVHKDY 708

  Fly   832 GNCSDICINLLGTHACACERGYELAKDKLSCLDVDECAGLLSGGCSHECINKAGTFECGCPLGYI 896
            ..|..:|||..|::.|:|.|||.||.|..:|.||||||        .:.||:..|
  Fly   709 KLCMGLCINTPGSYQCSCPRGYILAADMNTCRDVDECA--------TDSINQVCT---------- 755

  Fly   897 LNDDGRSCSPALVGCPPGTQRSADGCAPIECNPGYTLGSDDKCVDIDECQKQNGGCSHRCSNTEG 961
                ||:                                     ||             |:|..|
  Fly   756 ----GRN-------------------------------------DI-------------CTNIRG 766

  Fly   962 SFKC---SCPPGYELDSDQKTCQDIDECDQDKTSCITGTCINEIGGFRCEFPKFPVLPEIPTASS 1023
            |:||   :||.||.:|.:||     :.|.|:...|....|..:...|...|..|.....||
  Fly   767 SYKCTTVNCPLGYSIDPEQK-----NRCRQNLNFCEGEECYTQPSAFTYNFITFVSKLMIP---- 822

  Fly  1024 LPESPKI-ELKTPKYPDFTELSNEI 1047
             |:...| .|:.|.:.|..|...:|
  Fly   823 -PDGRTIFTLRGPLWYDNIEFDLKI 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342	12/42 (29%)
		cEGF	396..415	CDD:289433	9/18 (50%)
		FXa_inhibition	425..458	CDD:291342	12/33 (36%)
		FXa_inhibition	476..505	CDD:291342	4/28 (14%)
		vWFA	<550..586	CDD:294047	15/68 (22%)
		FXa_inhibition	596..630	CDD:291342	8/33 (24%)
		FXa_inhibition	636..>664	CDD:291342	10/32 (31%)
		EGF_CA	676..715	CDD:284955	16/38 (42%)
		FXa_inhibition	745..780	CDD:291342	10/39 (26%)
		FXa_inhibition	786..821	CDD:291342	15/34 (44%)
		FXa_inhibition	827..862	CDD:291342	16/36 (44%)
		FXa_inhibition	874..904	CDD:291342	5/29 (17%)
		FXa_inhibition	945..980	CDD:291342	13/37 (35%)
		CCP	1110..1170	CDD:153056
		CCP	1183..1235	CDD:153056
		DUF5011	1468..1536	CDD:295940
CG31999	NP_001284712.1	vWFA	<189..227	CDD:294047	12/44 (27%)
		EGF_CA	251..293	CDD:238011	15/41 (37%)
		EGF_CA	328..>363	CDD:214542	15/37 (41%)
		EGF_CA	519..564	CDD:214542	14/47 (30%)
		EGF_CA	565..601	CDD:238011	16/54 (30%)
		EGF_CA	611..651	CDD:284955	12/39 (31%)
		vWFA	<655..695	CDD:294047	20/39 (51%)
		cEGF	678..701	CDD:289433	10/22 (45%)
		EGF_CA	698..>730	CDD:214542	14/31 (45%)
		cEGF	721..744	CDD:289433	11/22 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D11446at33392
OrthoFinder	1	1.000	-	-		FOG0002570
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24034
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2524
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.050