DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment frac and crb

DIOPT Version :9

Sequence 1:NP_001137905.1 Gene:frac / 38850 FlyBaseID:FBgn0035798 Length:1618 Species:Drosophila melanogaster
Sequence 2:NP_001247284.1 Gene:crb / 42896 FlyBaseID:FBgn0259685 Length:2253 Species:Drosophila melanogaster


Alignment Length:1771 Identity:381/1771 - (21%)
Similarity:559/1771 - (31%) Gaps:629/1771 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   181 IVIEINDDH-----ANEVVESEPALAETETENEVLENE---TPLKAEVQTDVLNSSNASVKVTND 237
            |||.:.:|.     |...|.......:.:...::|:|.   ...|.|.....|:...|:....|.
  Fly   133 IVISVLNDFLQISLAGPAVHGPNNRLDVKLPYQLLDNRWHTLQFKYEYGNLYLHVDRAASIFANS 197

  Fly   238 PYEPTFLDNN----------CGEDNGGCAHICKRLLYPDENQPINK-----------------CD 275
            .|...||.|.          .|....||      ||.....|.:|.                 |.
  Fly   198 TYNSQFLTNQDIGYKDAILILGNSFSGC------LLDGPGLQFVNNSTVQNVVFGHCPLTPGPCS 256

  Fly   276 CREGYTLDPNDYASCLDIDECLESNGGCSEICENLPGEYKCSCQEGYYLDESGKSCVDIN--ECA 338
            ..:.:|..|:::  ||: |.|: .:|.||    :.|..|:|.|...|    |||:|...|  .||
  Fly   257 DHDLFTRLPDNF--CLN-DPCM-GHGTCS----SSPEGYECRCTARY----SGKNCQKDNGSPCA 309

  Fly   339 -NPELSSNCQ--GAC-ENLPGSYRC-VEPLEENPEI-TEVVENPIEKTN---------------- 381
             ||     |:  |:| ||..|.|:| .:|....... |||..:|:.:||                
  Fly   310 KNP-----CENGGSCLENSRGDYQCFCDPNHSGQHCETEVNIHPLCQTNPCLNNGACVVIGGSGA 369

  Fly   382 --------------EVPVNVSESQPAGKTCN-----SGFQLSADGTD-----CQ-DINECEVDGP 421
                          ||..:...|||.....:     :||.....||.     || :::||:    
  Fly   370 LTCECPKGYAGARCEVDTDECASQPCQNNGSCIDRINGFSCDCSGTGYTGAFCQTNVDECD---- 430

  Fly   422 EDLDNNAVCQQKCENTIGSFRCTCVEGY--HLLEDQRSCALDSCTDLENPQLNRTRCAHECQDLP 484
               .|..:...:|.:|.|.:.|.|::|:  .:.:...:|....|       ||    ...|.|.|
  Fly   431 ---KNPCLNGGRCFDTYGWYTCQCLDGWGGEICDRPMTCQTQQC-------LN----GGTCLDKP 481

  Fly   485 EGSYRCVCPKGY--ELSEDQHSCLVQ---ESPCSTEKGVEKCSPGT------CLASEDN------ 532
            .| ::|:||..|  ||.:...||..|   :|.|...|.|  |.||:      ||.:...      
  Fly   482 IG-FQCLCPPEYTGELCQIAPSCAQQCPIDSECVGGKCV--CKPGSSGPIGHCLPTTTTPTPEQE 543

  Fly   533 -------------------TSFSCICP-----------TGYR--------SEAFSCQDIDECAED 559
                               |:.:.|.|           ||.|        |.......::.|.::
  Fly   544 PTTTPRTTPNPNPAIPNTLTTTTKIPPITTSRTLVGTTTGSRRPPQQPLQSPTQRSASLNACPQE 608

  Fly   560 THLCSHTCQNTPGGYQCQCPEGLNLVEEYTCLAEN--------LCEVNNNGCEQICLTARGGVCA 616
            ..|...||....|.|.|.|..|..   .|.|....        |..:|.|.....||  .||.|:
  Fly   609 NCLNGGTCLGYSGNYSCICASGYT---GYNCQTSTGDGASALALTPINCNATNGKCL--NGGTCS 668

  Fly   617 -------CREGFRLSADGKSCEDVDECLVNNGGCQQ--VC-RNLPGSYGCICAAGYELLKLDGIR 671
                   |..|:    .|..||..:.|...|  ||:  || :|     .|:|.            
  Fly   669 MNGTHCYCAVGY----SGDRCEKAENCSPLN--CQEPMVCVQN-----QCLCP------------ 710

  Fly   672 GYCFDIDECSQ-RTHGCSDQMLCENL-NGSYTCLCPPGYALGLDNHIVTSLNSSFITDSTSSETP 734
                :...|:| .|..|.:...|.:| ||.|.|.|..|:                          
  Fly   711 ----ENKVCNQCATQPCQNGGECVDLPNGDYECKCTRGW-------------------------- 745

  Fly   735 SAHTC-LDIDECSLANGNCSH-FCQNEPGGFQCACPLGYALSEDMRTCQDIDECLDSNGQCSQLC 797
            :..|| .|:|||:|....|.: .|:||.|.::|.|..|:.   .:....|:||||.........|
  Fly   746 TGRTCGNDVDECTLHPKICGNGICKNEKGSYKCYCTPGFT---GVHCDSDVDECLSFPCLNGATC 807

  Fly   798 LNQPGGFACACETGFELTPDGFGC-ADIDECSQDYGNCSDICINLLGTHACACERGYELAKDKLS 861
            .|:...:.|.|:.|:|    |..| .|||||..:..:....||:.:....|.|..|   ...::.
  Fly   808 HNKINAYECVCQPGYE----GENCEVDIDECGSNPCSNGSTCIDRINNFTCNCIPG---MTGRIC 865

  Fly   862 CLDVDECAG--LLSGGCSHECINKAGTFECGCP-LGYILNDDGRSCSPALVGCPPGTQRSADGCA 923
            .:|:|:|.|  .|:||   :||::.|.|.|.|. .||    :|.:|...:..|......:...|.
  Fly   866 DIDIDDCVGDPCLNGG---QCIDQLGGFRCDCSGTGY----EGENCELNIDECLSNPCTNGAKCL 923

  Fly   924 P------IECNPGYTLGSDDKC-VDIDECQ----KQNGGCSHRCS-------------------- 957
            .      .:|:.||   ....| .||:||:    :.||.|..|.:                    
  Fly   924 DRVKDYFCDCHNGY---KGKNCEQDINECESNPCQYNGNCLERSNITLYQMSRITDLPKVFSQPF 985

  Fly   958 ---NTEGSFKCSCPPGYELDSDQKTCQ-DIDECDQDKTSCITGTCINEIGGFRCEFPKFPVLPEI 1018
               |..| ::|.|.||.    ..|.|: :|:|||.:..| ..|.|.:.||.:.||.         
  Fly   986 SFENASG-YECVCVPGI----IGKNCEININECDSNPCS-KHGNCNDGIGTYTCEC--------- 1035

  Fly  1019 PTASSLPESPKIELKTPKYPDFTELSNEIPENPKKPAEFDYPEPKFPSLPKWEGLPKLPPLADIP 1083
                                                      ||.|      ||           
  Fly  1036 ------------------------------------------EPGF------EG----------- 1041

  Fly  1084 TSKAPVPLRPEVPKSLWVNQLQPRDLCPRFQAPRNGKSHCNRYRHKQKLFYYSR-----CRISCN 1143
             :...:.:                             ..|:||...|:...|.:     |  .|:
  Fly  1042 -THCEINI-----------------------------DECDRYNPCQRGTCYDQIDDYDC--DCD 1074

  Fly  1144 SGY------ILQGPEIKSCDANGIWEGPETKCVAINQPRAQSPGICPALKPAQNGVILPASCTQG 1202
            :.|      :|    :|.||.|....|                |.|  |....|.|....:||..
  Fly  1075 ANYGGKNCSVL----LKGCDQNPCLNG----------------GAC--LPYLINEVTHLYNCTCE 1117

  Fly  1203 PSRFGDVCRLQCNAGFVSTGSLLTACMMLQGWSFGADLNCQ---PFGNGLLGNQLSPMWNSPKTV 1264
            ....||.|........|:|..:.......:|:    |:|.|   ...||:|....:...|.|   
  Fly  1118 NGFQGDKCEKTTTLSMVATSLISVTTEREEGY----DINLQFRTTLPNGVLAFGTTGEKNEP--- 1175

  Fly  1265 TPHQIQNVEQIRPYINCPENVVILLHAGEQKAHVTLQRPQTNVKNGRLVAHPAWAGQLQGHLPAG 1329
                   |..|...||           |....|.:|......|..|..:....|           
  Fly  1176 -------VSYILELIN-----------GRLNLHSSLLNKWEGVFIGSKLNDSNW----------- 1211

  Fly  1330 VHKVDFRVNDPETKLTIKCHTIITVKAA--TPRESNPF--------TLFRISDYSRSSLPRPAPF 1384
             |||...:|.....|:......|....:  |...|.|.        |:..:..|.|....:|:.|
  Fly  1212 -HKVFVAINTSHLVLSANDEQAIFPVGSYETANNSQPSFPRTYLGGTIPNLKSYLRHLTHQPSAF 1275

  Fly  1385 A----TLSTGSSFSFPAFKALDATPKPVSFTKFQVF----PDSESSE----HSKLGSSSFFRL-- 1435
            .    .:.....:.||     |.....:|:||.:..    |.:|..:    ||....:..:..  
  Fly  1276 VGCMQDIMVNGKWIFP-----DEQDANISYTKLENVQSGCPRTEQCKPNPCHSNGECTDLWHTFA 1335

  Fly  1436 ----EPLF-HESSKLISAAPASSENTR----VDLGSDTSNYCPPS---IEVYLKENQNLRSVVW- 1487
                .|.| |.....::||....|||.    :...:|.:.....|   |.::::..:....|.: 
  Fly  1336 CHCPRPFFGHTCQHNMTAATFGHENTTHSAVIVETTDVARRAIRSILDISMFIRTREPTGQVFYL 1400

  Fly  1488 -DEPR----------------FEGKLLKIYKSHFPGS--LFKVG--------DHAI--------- 1516
             .:||                ..|:||  .|..|.|:  .:.||        :|.|         
  Fly  1401 GTDPRKAPTKNIGDSYVAAKLHGGELL--VKMQFSGTPEAYTVGGQKLDNGYNHLIEVVRNQTLV 1463

  Fly  1517 --KYEATTTDGKTLSCTFF-----IYVRSAKPT-----PAPTEPKI------SFDSEPETL---S 1560
              |...|....||||.|..     :|:....||     .|.|||.|      ....|..|:   :
  Fly  1464 QVKLNGTEYFRKTLSTTGLLDAQVLYLGGPAPTRESLLGATTEPGIIPVPGAGIPIEDTTVPKEA 1528

  Fly  1561 DVSQTYV------VCPDKEPVRVTAESVSLPVGCTLKNIRP--------KSRSPKE--------- 1602
            |.|:.|.      |......:.:..|..||.|.....|.:|        .|..|.|         
  Fly  1529 DDSRDYFKGIIQDVKVSNGSLNLIVEMYSLNVTDVQVNAKPLGAVTIDRASVLPGEVSDDLCRKN 1593

  Fly  1603 --LKRGKLTSLWHQYT 1616
              |...:..:.|:.||
  Fly  1594 PCLHNAECRNTWNDYT 1609

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fracNP_001137905.1 FXa_inhibition 296..331 CDD:291342 12/34 (35%)
cEGF 396..415 CDD:289433 6/29 (21%)
FXa_inhibition 425..458 CDD:291342 7/34 (21%)
FXa_inhibition 476..505 CDD:291342 10/30 (33%)
vWFA <550..586 CDD:294047 9/35 (26%)
FXa_inhibition 596..630 CDD:291342 10/40 (25%)
FXa_inhibition 636..>664 CDD:291342 9/30 (30%)
EGF_CA 676..715 CDD:284955 12/40 (30%)
FXa_inhibition 745..780 CDD:291342 10/35 (29%)
FXa_inhibition 786..821 CDD:291342 9/34 (26%)
FXa_inhibition 827..862 CDD:291342 6/34 (18%)
FXa_inhibition 874..904 CDD:291342 11/30 (37%)
FXa_inhibition 945..980 CDD:291342 12/61 (20%)
CCP 1110..1170 CDD:153056 14/70 (20%)
CCP 1183..1235 CDD:153056 12/51 (24%)
DUF5011 1468..1536 CDD:295940 22/114 (19%)
crbNP_001247284.1 LamG 91..228 CDD:238058 21/100 (21%)
EGF_CA 386..423 CDD:238011 7/36 (19%)
EGF_CA 425..460 CDD:238011 9/41 (22%)
EGF 466..495 CDD:278437 12/40 (30%)
EGF 605..633 CDD:278437 9/30 (30%)
EGF_CA 716..750 CDD:238011 11/59 (19%)
EGF_CA 753..789 CDD:238011 13/38 (34%)
EGF_CA 792..828 CDD:238011 12/39 (31%)
EGF_CA 830..865 CDD:238011 10/37 (27%)
EGF_CA 868..905 CDD:238011 16/43 (37%)
EGF_CA 907..943 CDD:238011 5/38 (13%)
EGF_CA 1009..1045 CDD:238011 16/105 (15%)
EGF_CA 1047..1082 CDD:238011 8/65 (12%)
Laminin_G_1 1155..1290 CDD:278483 29/167 (17%)
EGF 1316..1346 CDD:278437 4/29 (14%)
Laminin_G_1 1388..1550 CDD:278483 34/163 (21%)
EGF_CA <1593..1622 CDD:238011 4/17 (24%)
Laminin_G_2 1692..1828 CDD:280389
EGF_CA 1901..1937 CDD:238011
EGF_CA 1939..1974 CDD:238011
EGF_CA 2057..2094 CDD:238011
EGF_CA 2096..2133 CDD:238011
EGF_CA 2137..2175 CDD:238011
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.910

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