DRSC/TRiP Functional Genomics Resources

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Protein Alignment frac and LTBP3

DIOPT Version :9

Sequence 1:NP_001137905.1 Gene:frac / 38850 FlyBaseID:FBgn0035798 Length:1618 Species:Drosophila melanogaster
Sequence 2:XP_011543334.1 Gene:LTBP3 / 4054 HGNCID:6716 Length:1312 Species:Homo sapiens


Alignment Length:1303 Identity:320/1303 - (24%)
Similarity:429/1303 - (32%) Gaps:460/1303 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   155 EVSEREPPPPPPPPVVDGADSKPEPQIVIEINDDHANEVVESEPALAETETENEVLENETPLKAE 219
            ::|.....||.||||     ..|.|  |:.:...|                         |.:|.
Human   216 QISAEALRPPRPPPV-----QAPPP--VVNVRVHH-------------------------PPEAS 248

  Fly   220 VQTDVLNSSNASVKVTND-------PYEPTFLDNNCGEDNGGCAHICKRLLYPDENQPINKC--D 275
            ||...:.||||.....:.       |..|.                      |...:|:.:|  |
Human   249 VQVHRIESSNAESAAPSQHLLPHPKPSHPR----------------------PPTQKPLGRCFQD 291

  Fly   276 CREGYTLDPNDYASCLDIDECLESNG---GCSEICENLP--------------GEYKCSCQEGYY 323
            .........|........::|..|.|   |.|: |...|              ||....|.:||.
Human   292 TLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSK-CHKCPQLQYTGVQKPGPVRGEVGADCPQGYK 355

  Fly   324 LDESGKSCVDINECANPELSSNCQ-GACENLPGSYRCVEPLEEN--PEITE-VVENPIEKTNEVP 384
            ...| ..|.||||||.|.:   |: |.|.|.|||||||.|...:  |..|: :.:.|.||:....
Human   356 RLNS-THCQDINECAMPGV---CRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFR 416

  Fly   385 VNVSESQ---PAGK-------TCNSGFQLSADGTDCQDINECEVDGPEDLDNNAVCQQKCENTIG 439
            :...|.|   |...       .|:.|   .|.|..||   .|..||                 ..
Human   417 LVSPEHQCQHPLTTRLTRQLCCCSVG---KAWGARCQ---RCPTDG-----------------TA 458

  Fly   440 SFR--CTCVEGYHLL------------------------------------------EDQRSCAL 460
            :|:  |...:|||:|                                          |::|....
Human   459 AFKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTT 523

  Fly   461 DS-------------------------------------------------------CTDLENPQ 470
            ||                                                       .|:.:..:
Human   524 DSPVSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECR 588

  Fly   471 LNRTRCAH-ECQDLPEGSYRCVCPKGYELSEDQHSCLVQESPCSTEKGVEKCSPGTCLASEDNTS 534
            ||:..|.| ||...|. .|.|.|..||. |..||...|..:.|.    .|.|.||..:......|
Human   589 LNQNICGHGECVPGPP-DYSCHCNPGYR-SHPQHRYCVDVNECE----AEPCGPGRGICMNTGGS 647

  Fly   535 FSCICPTGYR----SEAFSCQDIDECAEDTHLCSH--TCQNTPGGYQCQCPEGLNLVEEYTCLAE 593
            ::|.|..|||    :...||.|::|||: .|||..  .|.|.||.|:|.                
Human   648 YNCHCNRGYRLHVGAGGRSCVDLNECAK-PHLCGDGGFCINFPGHYKCN---------------- 695

  Fly   594 NLCEVNNNGCEQICLTARGGVCACREGFRLSADGKS-CEDVDECLVNNGGCQQVCRNLPGSYGCI 657
                                   |..|:||.|.... |||:|||...:......|.|.|||:.||
Human   696 -----------------------CYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCI 737

  Fly   658 -CAAGYELLKLDGIRGYCFDIDECSQRTHGCSDQMLCENLNGSYTCLCPPGYALGLDNHIVTSLN 721
             |..||   :..| .|.|.|::||::.: .||... ||||.||:.|.|..|||            
Human   738 ACQPGY---RSQG-GGACRDVNECAEGS-PCSPGW-CENLPGSFRCTCAQGYA------------ 784

  Fly   722 SSFITDSTSSETPSAHTCLDIDECSLANGNCSHFCQNEPGGFQCACPLGYALSEDMRTCQDIDEC 786
                      ..|...:|||:|||...:...:..|.|.||.|||.|..||.||.|...|:|||||
Human   785 ----------PAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDEC 839

  Fly   787 LDSNGQC-SQLCLNQPGGFACACETGFELTPDGFGCADIDECSQDYGNC--SDICINLLGTHACA 848
             |....| ...|:|..|.:.|.|..|..|. .|..|.||||||||...|  ...|.||.|::.|.
Human   840 -DFPAACIGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCV 902

  Fly   849 CERGYELAKDKLSCLDVD-----------------------------ECAGLLSGGCSHEC---- 880
            |:.|:...:|:..|.:|:                             ||...|..|....|    
Human   903 CDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYP 967

  Fly   881 --INKAGTFECGCPLGYILNDDGRSCSPALVGCPPGTQRSADGC-----------APIECNPGYT 932
              :..:..|...||.|.....|....:   .|.|  ..|..|.|           ..:...|||.
Human   968 CPVYSSAEFHSLCPDGKGYTQDNNIVN---YGIP--AHRDIDECMLFGSEICKEGKCVNTQPGYE 1027

  Fly   933 L---------GSDDKCVDIDECQKQNGGCSHRCSNTEGSFKCSCPPGYELDSDQKTC-----QDI 983
            .         |:..:|||:|||..::...:..|.||.|.::|:|.|..|....|:.|     .|:
Human  1028 CYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDV 1092

  Fly   984 DECDQDKTSCITGTCINEIGGFRCEFPKFPVLPEIPTAS----SLPESPKIELKTPKYPDFTELS 1044
            ||| ||..:|..|.|:|..|.:|||...    |.:|..|    .|||||     ..:.|:..::.
Human  1093 DEC-QDPAACRPGRCVNLPGSYRCECRP----PWVPGPSGRDCQLPESP-----AERAPERRDVC 1147

  Fly  1045 -NEIPENPKKPAEFDYPEPKFPSLPKWEGLPKLPPLADIPTSKAPVPLRPEVPKSLWVNQLQPRD 1108
             ::..|:.........|...|......:|..                         |..|.:|  
Human  1148 WSQRGEDGMCAGPLAGPALTFDDCCCRQGRG-------------------------WGAQCRP-- 1185

  Fly  1109 LCPRFQAPRNGKSHCNRYRHKQKLFY--------------------YSRCRISCNSGYILQGPEI 1153
             ||    ||...|||...:.:...|:                    ...||  |.||..:..|..
Human  1186 -CP----PRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECR--CVSGRCVPRPGG 1243

  Fly  1154 KSCDANGIW--EGPETKCVAINQPRAQSPGICPALKPAQNGVILPAS-CTQGPSRFGDVCRLQCN 1215
            ..|:..|.:  :....:||.|::        |..|.  |.|::..:. |......|    |..|.
Human  1244 AVCECPGGFQLDASRARCVDIDE--------CRELN--QRGLLCKSERCVNTSGSF----RCVCK 1294

  Fly  1216 AGF 1218
            |||
Human  1295 AGF 1297

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fracNP_001137905.1 FXa_inhibition 296..331 CDD:291342 13/51 (25%)
cEGF 396..415 CDD:289433 6/18 (33%)
FXa_inhibition 425..458 CDD:291342 8/76 (11%)
FXa_inhibition 476..505 CDD:291342 13/29 (45%)
vWFA <550..586 CDD:294047 14/37 (38%)
FXa_inhibition 596..630 CDD:291342 5/34 (15%)
FXa_inhibition 636..>664 CDD:291342 11/28 (39%)
EGF_CA 676..715 CDD:284955 16/38 (42%)
FXa_inhibition 745..780 CDD:291342 14/34 (41%)
FXa_inhibition 786..821 CDD:291342 11/35 (31%)
FXa_inhibition 827..862 CDD:291342 13/36 (36%)
FXa_inhibition 874..904 CDD:291342 7/35 (20%)
FXa_inhibition 945..980 CDD:291342 10/34 (29%)
CCP 1110..1170 CDD:153056 16/81 (20%)
CCP 1183..1235 CDD:153056 11/37 (30%)
DUF5011 1468..1536 CDD:295940
LTBP3XP_011543334.1 EGF_CA 364..399 CDD:214542 19/37 (51%)
TB 424..459 CDD:279073 10/57 (18%)
EGF_CA 625..668 CDD:214542 12/46 (26%)
EGF_CA 669..703 CDD:238011 16/73 (22%)
EGF_CA 712..745 CDD:214542 14/35 (40%)
EGF_CA 753..792 CDD:214542 17/62 (27%)
EGF_CA 794..834 CDD:214542 17/39 (44%)
EGF_CA 835..874 CDD:214542 15/40 (38%)
EGF_CA 875..908 CDD:214542 16/32 (50%)
TB 938..975 CDD:279073 5/36 (14%)
EGF_CA 1045..>1073 CDD:214542 10/27 (37%)
EGF_CA 1091..1126 CDD:214542 16/39 (41%)
TB 1157..1190 CDD:279073 9/64 (14%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D4721at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24034
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
33.020

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