DRSC/TRiP Functional Genomics Resources

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Protein Alignment frac and LTBP3

DIOPT Version :10

Sequence 1:NP_648137.3 Gene:frac / 38850 FlyBaseID:FBgn0035798 Length:1618 Species:Drosophila melanogaster
Sequence 2:NP_001123616.1 Gene:LTBP3 / 4054 HGNCID:6716 Length:1303 Species:Homo sapiens


Alignment Length:1299 Identity:317/1299 - (24%)
Similarity:431/1299 - (33%) Gaps:443/1299 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   160 EPP-PPPPPPVVDGADSKPEPQIVIEINDDHANEVVESEPALAETETENEVLENETPLKAEVQTD 223
            :|| |...||....|       .::.:.....:..|::.|.:......:       |.:|.||..
Human   193 DPPGPGEGPPAQHAA-------FLVPLGPGQISAEVQAPPPVVNVRVHH-------PPEASVQVH 243

  Fly   224 VLNSSNASVKVTND-------PYEPTFLDNNCGEDNGGCAHICKRLLYPDENQPINKC--DCREG 279
            .:.||||.....:.       |..|.                      |...:|:.:|  |....
Human   244 RIESSNAESAAPSQHLLPHPKPSHPR----------------------PPTQKPLGRCFQDTLPK 286

  Fly   280 YTLDPNDYASCLDIDECLESNG---GCSEICENLP--------------GEYKCSCQEGYYLDES 327
            .....|........::|..|.|   |.|: |...|              ||....|.:||....|
Human   287 QPCGSNPLPGLTKQEDCCGSIGTAWGQSK-CHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNS 350

  Fly   328 GKSCVDINECANPELSSNCQ-GACENLPGSYRCVEPLEEN--PEITE-VVENPIEKTNEVPVNVS 388
             ..|.||||||.|.:   |: |.|.|.|||||||.|...:  |..|: :.:.|.||:....:...
Human   351 -THCQDINECAMPGV---CRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSP 411

  Fly   389 ESQ---PAGK-------TCNSGFQLSADGTDCQDINECEVDGPEDLDNNAVCQQKCENTIGSFR- 442
            |.|   |...       .|:.|   .|.|..||   .|..||                 ..:|: 
Human   412 EHQCQHPLTTRLTRQLCCCSVG---KAWGARCQ---RCPTDG-----------------TAAFKE 453

  Fly   443 -CTCVEGYHLL------------------------------------------EDQRSCALDS-- 462
             |...:|||:|                                          |::|....||  
Human   454 ICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPV 518

  Fly   463 -----------------------------------------------------CTDLENPQLNRT 474
                                                                 .|:.:..:||:.
Human   519 SEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQN 583

  Fly   475 RCAH-ECQDLPEGSYRCVCPKGYELSEDQHSCLVQESPCSTEKGVEKCSPGTCLASEDNTSFSCI 538
            .|.| ||...|. .|.|.|..||. |..||...|..:.|.    .|.|.||..:......|::|.
Human   584 ICGHGECVPGPP-DYSCHCNPGYR-SHPQHRYCVDVNECE----AEPCGPGRGICMNTGGSYNCH 642

  Fly   539 CPTGYR----SEAFSCQDIDECAEDTHLCSH--TCQNTPGGYQCQCPEGLNLVEEYTCLAENLCE 597
            |..|||    :...||.|::|||: .|||..  .|.|.||.|:|.                    
Human   643 CNRGYRLHVGAGGRSCVDLNECAK-PHLCGDGGFCINFPGHYKCN-------------------- 686

  Fly   598 VNNNGCEQICLTARGGVCACREGFRLSADGKS-CEDVDECLVNNGGCQQVCRNLPGSYGCI-CAA 660
                               |..|:||.|.... |||:|||...:......|.|.|||:.|| |..
Human   687 -------------------CYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQP 732

  Fly   661 GYELLKLDGIRGYCFDIDECSQRTHGCSDQMLCENLNGSYTCLCPPGYALGLDNHIVTSLNSSFI 725
            ||   :..| .|.|.|::||::.: .||... ||||.||:.|.|..|||                
Human   733 GY---RSQG-GGACRDVNECAEGS-PCSPGW-CENLPGSFRCTCAQGYA---------------- 775

  Fly   726 TDSTSSETPSAHTCLDIDECSLANGNCSHFCQNEPGGFQCACPLGYALSEDMRTCQDIDECLDSN 790
                  ..|...:|||:|||...:...:..|.|.||.|||.|..||.||.|...|:||||| |..
Human   776 ------PAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDEC-DFP 833

  Fly   791 GQC-SQLCLNQPGGFACACETGFELTPDGFGCADIDECSQDYGNC--SDICINLLGTHACACERG 852
            ..| ...|:|..|.:.|.|..|..|. .|..|.||||||||...|  ...|.||.|::.|.|:.|
Human   834 AACIGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEG 897

  Fly   853 YELAKDKLSCLDVD-----------------------------ECAGLLSGGCSHEC------IN 882
            :...:|:..|.:|:                             ||...|..|....|      :.
Human   898 FTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVY 962

  Fly   883 KAGTFECGCPLGYILNDDGRSCSPALVGCPPGTQRSADGC-----------APIECNPGYTL--- 933
            .:..|...||.|.....|....:   .|.|  ..|..|.|           ..:...|||..   
Human   963 SSAEFHSLCPDGKGYTQDNNIVN---YGIP--AHRDIDECMLFGSEICKEGKCVNTQPGYECYCK 1022

  Fly   934 ------GSDDKCVDIDECQKQNGGCSHRCSNTEGSFKCSCPPGYELDSDQKTC-----QDIDECD 987
                  |:..:|||:|||..::...:..|.||.|.::|:|.|..|....|:.|     .|:||| 
Human  1023 QGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDEC- 1086

  Fly   988 QDKTSCITGTCINEIGGFRCEFPKFPVLPEIPTAS----SLPESPKIELKTPKYPDFTELS-NEI 1047
            ||..:|..|.|:|..|.:|||...    |.:|..|    .|||||     ..:.|:..::. ::.
Human  1087 QDPAACRPGRCVNLPGSYRCECRP----PWVPGPSGRDCQLPESP-----AERAPERRDVCWSQR 1142

  Fly  1048 PENPKKPAEFDYPEPKFPSLPKWEGLPKLPPLADIPTSKAPVPLRPEVPKSLWVNQLQPRDLCPR 1112
            .|:.........|...|......:|..                         |..|.:|   || 
Human  1143 GEDGMCAGPLAGPALTFDDCCCRQGRG-------------------------WGAQCRP---CP- 1178

  Fly  1113 FQAPRNGKSHCNRYRHKQKLFY--------------------YSRCRISCNSGYILQGPEIKSCD 1157
               ||...|||...:.:...|:                    ...||  |.||..:..|....|:
Human  1179 ---PRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECR--CVSGRCVPRPGGAVCE 1238

  Fly  1158 ANGIW--EGPETKCVAINQPRAQSPGICPALKPAQNGVILPAS-CTQGPSRFGDVCRLQCNAGF 1218
            ..|.:  :....:||.|::        |..|.  |.|::..:. |......|    |..|.|||
Human  1239 CPGGFQLDASRARCVDIDE--------CRELN--QRGLLCKSERCVNTSGSF----RCVCKAGF 1288

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fracNP_648137.3 FXa_inhibition 296..331 CDD:464251 13/51 (25%)
cEGF 396..415 CDD:463661 6/18 (33%)
FXa_inhibition 425..458 CDD:464251 8/76 (11%)
FXa_inhibition 476..505 CDD:464251 13/29 (45%)
EGF_CA 552..>581 CDD:214542 13/30 (43%)
FXa_inhibition 596..630 CDD:464251 5/34 (15%)
FXa_inhibition 636..>664 CDD:464251 11/28 (39%)
EGF_CA 676..711 CDD:214542 16/34 (47%)
FXa_inhibition 745..780 CDD:464251 14/34 (41%)
FXa_inhibition 786..821 CDD:464251 11/35 (31%)
vWFA <821..861 CDD:469594 18/41 (44%)
FXa_inhibition 874..904 CDD:464251 7/35 (20%)
FXa_inhibition 945..980 CDD:464251 10/34 (29%)
PTZ00449 <1017..>1098 CDD:185628 12/85 (14%)
CCP 1110..1170 CDD:153056 16/81 (20%)
CCP 1183..1235 CDD:153056 11/37 (30%)
HYR 1468..1536 CDD:460572
LTBP3NP_001123616.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 247..282 9/56 (16%)
TB 291..>321 CDD:459903 7/30 (23%)
EGF_CA 355..390 CDD:214542 19/37 (51%)
TB 414..455 CDD:459903 12/63 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 478..552 4/73 (5%)
PHA03247 <487..577 CDD:223021 5/89 (6%)
EGF_CA 616..659 CDD:214542 12/46 (26%)
EGF_CA 660..694 CDD:238011 16/73 (22%)
EGF_CA 703..736 CDD:214542 14/35 (40%)
EGF_CA 744..783 CDD:214542 17/62 (27%)
EGF_CA 785..825 CDD:214542 17/39 (44%)
EGF_CA 826..865 CDD:214542 15/40 (38%)
EGF_CA 866..899 CDD:214542 16/32 (50%)
TB 929..971 CDD:459903 6/41 (15%)
EGF_CA 1036..>1064 CDD:214542 10/27 (37%)
EGF_CA 1082..1117 CDD:214542 16/39 (41%)
TB 1146..>1181 CDD:459903 9/66 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1188..1219 1/30 (3%)
Blue background indicates that the domain is not in the aligned region.

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