DRSC/TRiP Functional Genomics Resources

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Protein Alignment frac and LTBP2

DIOPT Version :10

Sequence 1:NP_648137.3 Gene:frac / 38850 FlyBaseID:FBgn0035798 Length:1618 Species:Drosophila melanogaster
Sequence 2:NP_000419.1 Gene:LTBP2 / 4053 HGNCID:6715 Length:1821 Species:Homo sapiens


Alignment Length:1273 Identity:344/1273 - (27%)
Similarity:473/1273 - (37%) Gaps:393/1273 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   145 NSDI----DEDDDEEVSE--RE---------PPPPPPPPVVDGADSKPEPQIVIEINDDHANEVV 194
            :|||    .:.::||::.  ||         |.|....|:....|:..|...:.:..|..|.:|.
Human   734 SSDIRLSMRKAEEEELARPPREQGQRSSGALPGPAERQPLRVVTDTWLEAGTIPDKGDSQAGQVT 798

  Fly   195 ESEPALAETETENEVLENET--PLK----AEVQTDVLNSSNASVKVTNDPYEPTFLD-------N 246
            .|     .|.....|..|.|  |:.    ||:|.:.:..|...:...:.|    .:|       |
Human   799 TS-----VTHAPAWVTGNATTPPMPEQGIAEIQEEQVTPSTDVLVTLSTP----GIDRCAAGATN 854

  Fly   247 NCGEDNGGCAHICKRLLYPDENQPINKCDCREGYTLDPNDYASCLDIDECLESNGGCSEICENLP 311
            .||.  |.|.::      ||.    .:|.|..||.|.|:. |.|.|.:|||.........|.|..
Human   855 VCGP--GTCVNL------PDG----YRCVCSPGYQLHPSQ-AYCTDDNECLRDPCKGKGRCINRV 906

  Fly   312 GEYKCSCQEGYYLDESG--KSCVDINECANPELSSNCQGACENLPGSYRCVEPLEENPEITEVVE 374
            |.|.|.|..||.|..||  :.|.|||||..|.:.|.  |.|.|..|||.|               
Human   907 GSYSCFCYPGYTLATSGATQECQDINECEQPGVCSG--GQCTNTEGSYHC--------------- 954

  Fly   375 NPIEKTNEVPVNVSESQPAGKTCNSGFQLSADGTDCQDINECEVDGPEDLDNNAVCQQ-KCENTI 438
                                 .|:.|:.:...| .|||||||...|        .|.. :|.|:.
Human   955 ---------------------ECDQGYIMVRKG-HCQDINECRHPG--------TCPDGRCVNSP 989

  Fly   439 GSFRC-TCVEGYHLLEDQRSCALDSCTDLENPQLNRTRCAH-ECQDLPEGSYRCVCPKGYELSED 501
            ||:.| .|.|||   ..|..    ||.|: |..|....||| :|.:| |||:||.|.:|||::.|
Human   990 GSYTCLACEEGY---RGQSG----SCVDV-NECLTPGVCAHGKCTNL-EGSFRCSCEQGYEVTSD 1045

  Fly   502 QHSCL-VQESPCSTEKGVEKCSPGTCLASEDNTSFSC-ICPTGY--RSEAFSCQDIDECAEDTHL 562
            :..|. |.|  |::.   ..|..|.||.:|.  ||:| .|..||  ..:..:|:|:||||.....
Human  1046 EKGCQDVDE--CASR---ASCPTGLCLNTEG--SFACSACENGYWVNEDGTACEDLDECAFPGVC 1103

  Fly   563 CSHTCQNTPGGYQCQCPEGLNLVEEYTCLAENLCEVNNNGCEQICLTARGGVCACREGFRLSADG 627
            .|..|.||.|.:.|:                                      .|..|:|.|..|
Human  1104 PSGVCTNTAGSFSCK--------------------------------------DCDGGYRPSPLG 1130

  Fly   628 KSCEDVDECLVNNGGC-QQVCRNLPGSYGCICAAGYELLKLDGIRGYCFDIDECSQRTHGCSDQM 691
            .||||||||......| ...|:|..|||.|:|..|::|  .:|.  .|.|::||....| |:...
Human  1131 DSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQL--ANGT--VCEDVNECMGEEH-CAPHG 1190

  Fly   692 LCENLNGSYTCLCPPGYALGLDNHIVTSLNSSFITDSTSSETPSAHTCLDIDECSLANGNCSHFC 756
            .|.|.:||:.|||.||:                    .|:|  ...:|.|:|||:..:......|
Human  1191 ECLNSHGSFFCLCAPGF--------------------VSAE--GGTSCQDVDECATTDPCVGGHC 1233

  Fly   757 QNEPGGFQCACPLGYALSEDMRTCQDIDECLD-SNGQC-SQLCLNQPGGFAC--ACETGFELTPD 817
            .|..|.|.|.|..|:..|.:...|.|||||.| .:..| :..|.|.||.:.|  .|:.||.:.|:
Human  1234 VNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPN 1298

  Fly   818 GFGCADIDECSQD-----YGNCSDICINLLGTHACACERGYELAKDKLSCLDVDECAGLLSGGCS 877
            | .|.|||||:.|     :|    .|.|..|:..|.|::|:|::.....|:||:||..:|:...:
Human  1299 G-DCIDIDECANDTMCGSHG----FCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGA 1358

  Fly   878 HECINKAGTFECGC---------------PLGYILNDDGRSCSPALVG--CPPGTQRSA----DG 921
            ..|.|..|:|.|.|               |.|    ..|:|.|.|..|  .|..|:...    .|
Human  1359 ALCENVEGSFLCLCASDLEEYDAQEGHCRPRG----AGGQSMSEAPTGDHAPAPTRMDCYSGQKG 1419

  Fly   922 CAPIE-------------CNPGYTLG-------SDDKC--------------------------V 940
            .||..             |..|.:.|       |:|..                          .
Human  1420 HAPCSSVLGRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYT 1484

  Fly   941 DIDECQKQNGG-CSH-RCSNTEGSFKCSCPPGYELDSDQKTCQDIDECDQDKTSCITGTCINEIG 1003
            |.|||.....| |.: ||.||...:.|.|.||:..|:..|.|:|.||| || .:|..|.|:|..|
Human  1485 DADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDEC-QD-LACENGECVNTEG 1547

  Fly  1004 GFRCEFPKFPVLPEIPTASSLPESPKIELKTPKYPD--------FTELSNEIPENPKKPAEFDYP 1060
            .|.| |...|:..::.....:..:.    .|...||        :.:::|::...|.:.....|.
Human  1548 SFHC-FCSPPLTLDLSQQRCMNSTS----STEDLPDHDIHMDICWKKVTNDVCSEPLRGHRTTYT 1607

  Fly  1061 EPKFPSLPKWEGLPKL-PP--------LADIPTSKA---------------PVP----------- 1090
            |........|.....| ||        |.::...:|               |.|           
Human  1608 ECCCQDGEAWSQQCALCPPRSSEVYAQLCNVARIEAEREAGVHFRPGYEYGPGPDDLHYSIYGPD 1672

  Fly  1091 -------LRPE--VPKSLWVN--------------QLQPRDLCPRFQAPRNGKSHCNRYRHKQKL 1132
                   |.||  ||:..:.|              .|||.:|.|.:.|     ||.......:.|
Human  1673 GAPFYNYLGPEDTVPEPAFPNTAGHSADRTPILESPLQPSELQPHYVA-----SHPEPPAGFEGL 1732

  Fly  1133 FYYSRCRI--SCNSGYILQGPEIKSCDANGIWEG-----PETKCVAINQPRAQSPGICPALKPAQ 1190
             ....|.|  .|.:|..::..|..:||.   :||     ....||.:|:        |..|    
Human  1733 -QAEECGILNGCENGRCVRVREGYTCDC---FEGFQLDAAHMACVDVNE--------CDDL---- 1781

  Fly  1191 NGVILPA-SCTQGPSRFGDVC-------RLQCNAGFVS 1220
            ||   || .|..|      .|       |..|:.|:|:
Human  1782 NG---PAVLCVHG------YCENTEGSYRCHCSPGYVA 1810

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fracNP_648137.3 FXa_inhibition 296..331 CDD:464251 13/36 (36%)
cEGF 396..415 CDD:463661 7/18 (39%)
FXa_inhibition 425..458 CDD:464251 11/34 (32%)
FXa_inhibition 476..505 CDD:464251 15/29 (52%)
EGF_CA 552..>581 CDD:214542 11/28 (39%)
FXa_inhibition 596..630 CDD:464251 5/33 (15%)
FXa_inhibition 636..>664 CDD:464251 10/28 (36%)
EGF_CA 676..711 CDD:214542 14/34 (41%)
FXa_inhibition 745..780 CDD:464251 9/34 (26%)
FXa_inhibition 786..821 CDD:464251 13/38 (34%)
vWFA <821..861 CDD:469594 15/44 (34%)
FXa_inhibition 874..904 CDD:464251 9/44 (20%)
FXa_inhibition 945..980 CDD:464251 13/36 (36%)
PTZ00449 <1017..>1098 CDD:185628 20/132 (15%)
CCP 1110..1170 CDD:153056 14/66 (21%)
CCP 1183..1235 CDD:153056 13/46 (28%)
HYR 1468..1536 CDD:460572
LTBP2NP_000419.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 229..339
Heparin-binding 232..249
Cell attachment site. /evidence=ECO:0000255 375..377
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 510..544
TB 561..>595 CDD:459903
EGF_CA 622..>651 CDD:214542
TB 681..724 CDD:459903
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 744..772 6/27 (22%)
EGF_CA 845..879 CDD:238011 12/45 (27%)
EGF_CA 887..918 CDD:214542 11/30 (37%)
EGF_CA 930..>960 CDD:214542 15/67 (22%)
EGF_CA 970..1005 CDD:238011 16/45 (36%)
EGF_CA 1010..1041 CDD:214542 15/32 (47%)
EGF_CA 1051..1092 CDD:214542 14/47 (30%)
EGF_CA 1093..1123 CDD:429571 12/67 (18%)
EGF_CA 1135..1175 CDD:214542 16/43 (37%)
EGF_CA 1176..1217 CDD:214542 16/63 (25%)
EGF_CA 1218..1249 CDD:214542 11/30 (37%)
EGF_CA 1303..1335 CDD:238011 13/35 (37%)
TB 1423..1463 CDD:459903 5/39 (13%)
EGF_CA 1485..1518 CDD:214542 14/32 (44%)
TB 1593..1636 CDD:459903 7/42 (17%)
C-terminal domain. /evidence=ECO:0000269|PubMed:17293099 1639..1821 43/202 (21%)
EGF_CA 1774..>1808 CDD:214542 12/54 (22%)
PHA03247 <31..165 CDD:223021
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 38..58
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 81..165
Heparin-binding 94..115
Blue background indicates that the domain is not in the aligned region.

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