DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment frac and LTBP1

DIOPT Version :9

Sequence 1:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster
Sequence 2:	XP_011531155.1	Gene:	LTBP1 / 4052	HGNCID:	6714	Length:	1722	Species:	Homo sapiens

Alignment Length:	1020	Identity:	290/1020 - (28%)
Similarity:	412/1020 - (40%)	Gaps:	257/1020 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 EEVSEREPPPPPPPPVVDGADSKPEPQIVIEINDDHANEVVESEPALAETETENEVLENE----- 213
            :.|::...|||.|        :|.||...:..:.:|...|.|.|.|.|..|.|...|:.|
Human   763 QPVAKSTHPPPLP--------AKEEPVEALTFSREHGPGVAEPEVATAPPEKEIPSLDQEKTKLE 819

  Fly   214 ----------------------------TPLKAEVQTDVLNSSNASVKVTNDPYEPTFLDNNC-- 248
                                        .|:..||..:...||.:.|..   |.:.|.: |.|
Human   820 PGQPQLSPGISTIHLHPQFPGIVIEKTSPPVPVEVAPEASTSSASQVIA---PTQVTEI-NECTV 880

  Fly   249 GEDNGGCAHICKRLLYPDENQPIN-KCDCREGYTLDPNDYASCLDIDECLESNGGCSE-ICENLP 311
            ..|..|..|..        |.|:. .|.|.|||... .....|:|||||.:....||: .|||..
Human   881 NPDICGAGHCI--------NLPVRYTCICYEGYRFS-EQQRKCVDIDECTQVQHLCSQGRCENTE 936

  Fly   312 GEYKCSCQEGYYLDESGKSCVDINECANPELSSNCQGACENLPGSYRCVEPLEENPEIT------ 370
            |.:.|.|..|:...|.|.:|:|::||..|::..  :|.|.|..|::|| |..:....:|
Human   937 GSFLCICPAGFMASEEGTNCIDVDECLRPDVCG--EGHCVNTVGAFRC-EYCDSGYRMTQRGRCE 998

  Fly   371 EVVE--NPIEKTNEVPVNVSESQPAGKTCNSGFQLSADGTDCQDINECEVDGPEDLDNNAVCQQK 433
            ::.|  ||....:|..||...|... ..|..||: ..:| .|.|::||       |:.|......
Human   999 DIDECLNPSTCPDEQCVNSPGSYQC-VPCTEGFR-GWNG-QCLDVDEC-------LEPNVCANGD 1053

  Fly   434 CENTIGSFRCTCVEGYHLLEDQRSCALDSCTDLENPQLNRTRCAHECQDLPEGSYRCVCPKGYEL 498
            |.|..||:.|:|.:||....|.:     .|.|::..|........:|:: .|||:||.|.:||:|
Human  1054 CSNLEGSYMCSCHKGYTRTPDHK-----HCRDIDECQQGNLCVNGQCKN-TEGSFRCTCGQGYQL 1112

  Fly   499 SEDQHSCLVQESPCSTEKGVEK------CSPGTCLASEDNTSFSCICPTGYRSEAFS--CQDIDE 555
            |..:..|          :.:::      |:.|.|..:|.  ||.|:|..|||:....  |:||:|
Human  1113 SAAKDQC----------EDIDECQHRHLCAHGQCRNTEG--SFQCVCDQGYRASGLGDHCEDINE 1165

  Fly   556 CAEDTHLCSH-TCQNTPGGYQCQCPEGLNLVEEYTCLAENLCE-VNNNGCEQICLTARGGV-CAC 617
            |.||..:|.. .|.||.|.|.|.||:|..|.:..||...|.|| ....|.:..||...|.. |.|
Human  1166 CLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNTEGSFHCVC 1230

  Fly   618 REGFRLSADGKSCEDVDECLVNNGGCQQ--VCRNLPGSYGCICAAGYELLKLDGIRGYCFDIDEC 680
            ::||.:||||::|||:||| |||..|..  .|.|..||:.|:|..|::..: || :| |.|::||
Human  1231 QQGFSISADGRTCEDIDEC-VNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQ-DG-QG-CVDVNEC 1291

  Fly   681 SQRTHGCSDQMLCENLNGSYTCLCPPGYALGLDNHIVTSLNSSFITDSTSSETPSAHTC------ 739
             :...|...:..|||:.||:.|:|                     .|.....:|....|
Human  1292 -ELLSGVCGEAFCENVEGSFLCVC---------------------ADENQEYSPMTGQCRSRTST 1334

  Fly   740 -LDID---------ECSLANGNCSHFCQN--EPG--------------GFQC---ACP-LGYALS 774
             ||:|         || ..|.|.:..|.|  .|.              |..|   .|| ||.|..
Human  1335 DLDVDVDQPKEEKKEC-YYNLNDASLCDNVLAPNVTKQECCCTSGVGWGDNCEIFPCPVLGTAEF 1398

  Fly   775 EDM-------------------RTCQDIDECL------DSNGQCSQLCLNQPGGFACACETGFEL 814
            .:|                   ...:|.||||      ..||    .|||...|:.|.|:.|...
Human  1399 TEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNG----FCLNTRPGYECYCKQGTYY 1459

  Fly   815 TPDGFGCADIDECSQDYGNCSD-ICINLLGTHACACERGYELAKDKLSCL------------DV- 865
            .|....|.|:||| ||..:|.| .|:|..|::.|.|.....|...:..|:            ||
Human  1460 DPVKLQCFDMDEC-QDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQIEETDVY 1523

  Fly   866 -DECAGLLSGG--CSHECINKAGTF-ECGCPLGYILNDDGRSCSPALVGCP-------------- 912
             |.|...||..  ||...:.|..|: ||.|..|...   |..|  ||  ||
Human  1524 QDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAW---GMQC--AL--CPLKDSDDYAQLCNIP 1581

  Fly   913 -PGTQRSADGCAPIECNPGYTLGSD-----DKCVD------IDECQKQNGGCSHRCSNTEGSFKC 965
             .|.::.....|.::.:..||..:|     |:.::      .:||...||..:.||...:..:.|
Human  1582 VTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTC 1646

  Fly   966 SCPPGYELDSDQKTCQDIDECDQ--DKTS-CITGTCINEIGGFRC 1007
            .|..||.||:.:.||.|::|||:  ::.| |....|||..|.::|
Human  1647 DCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKC 1691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342	12/35 (34%)
		cEGF	396..415	CDD:289433	6/18 (33%)
		FXa_inhibition	425..458	CDD:291342	10/32 (31%)
		FXa_inhibition	476..505	CDD:291342	11/28 (39%)
		vWFA	<550..586	CDD:294047	18/36 (50%)
		FXa_inhibition	596..630	CDD:291342	14/35 (40%)
		FXa_inhibition	636..>664	CDD:291342	12/29 (41%)
		EGF_CA	676..715	CDD:284955	11/38 (29%)
		FXa_inhibition	745..780	CDD:291342	14/73 (19%)
		FXa_inhibition	786..821	CDD:291342	12/40 (30%)
		FXa_inhibition	827..862	CDD:291342	11/35 (31%)
		FXa_inhibition	874..904	CDD:291342	9/32 (28%)
		FXa_inhibition	945..980	CDD:291342	11/34 (32%)
		CCP	1110..1170	CDD:153056
		CCP	1183..1235	CDD:153056
		DUF5011	1468..1536	CDD:295940
LTBP1	XP_011531155.1	EGF_CA	626..>656	CDD:214542
		TB	689..724	CDD:279073
		cEGF	897..919	CDD:289433	8/22 (36%)
		EGF_CA	916..956	CDD:284955	16/39 (41%)
		EGF_CA	958..998	CDD:214542	12/42 (29%)
		EGF_CA	999..1032	CDD:238011	10/34 (29%)
		EGF_CA	1039..1078	CDD:214542	14/50 (28%)
		EGF_CA	1080..1111	CDD:214542	10/31 (32%)
		EGF_CA	1121..1161	CDD:214542	11/41 (27%)
		EGF_CA	1162..1202	CDD:214542	18/39 (46%)
		EGF_CA	1203..1244	CDD:214542	15/40 (38%)
		EGF_CA	1245..1286	CDD:214542	18/44 (41%)
		TB	1360..1397	CDD:279073	9/36 (25%)
		TB	1537..1573	CDD:279073	14/42 (33%)
		EGF_CA	1663..>1697	CDD:214542	11/29 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D4721at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24034
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020