DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment frac and EYS

DIOPT Version :10

Sequence 1:NP_648137.3 Gene:frac / 38850 FlyBaseID:FBgn0035798 Length:1618 Species:Drosophila melanogaster
Sequence 2:NP_001278938.1 Gene:EYS / 346007 HGNCID:21555 Length:3165 Species:Homo sapiens


Alignment Length:1609 Identity:341/1609 - (21%)
Similarity:555/1609 - (34%) Gaps:553/1609 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   243 FLDNNCGEDNGGCAH--ICKRLLYPDE-NQPINKCDCREGYTLDPNDYASCLDIDEC-------- 296
            :|:|...:....|.|  :||     || |:|  :|.|...|.    .....:::|.|        
Human   563 YLENTTDDQENECQHEAVCK-----DEINRP--RCSCSLSYI----GRLCVVNVDYCLGNHSISV 616

  Fly   297 ------LESNGGCS-------EICE------------------NLPGEYKCSCQEGYYLDESGKS 330
                  |..|..||       .|||                  :|.|.:...|..|:    .|..
Human   617 HGLCLALSHNCNCSGLQRYERNICEIDTEDCKSASCKNGTTSTHLRGYFFRKCVPGF----KGTQ 677

  Fly   331 C-VDINECANPELSSNCQ-GA-CENLPGSY--RCVEPLEENPEITEVVENPIEKTNEVPVNVSES 390
            | :||:|||    |..|: || |.:.||:|  :||.|.       :||:.               
Human   678 CEIDIDECA----SHPCKNGATCIDQPGNYFCQCVPPF-------KVVDG--------------- 716

  Fly   391 QPAGKTCNSGFQLSADGTDC-QDINECEVDGPEDLDNNAVCQQKCENTIGSFRCTCV---EGYHL 451
              ....||.|:.    |..| |||::|.::..|   :|:.    |::...|::|.|:   ||...
Human   717 --FSCLCNPGYV----GIRCEQDIDDCILNACE---HNST----CKDLHLSYQCVCLSDWEGNFC 768

  Fly   452 LEDQRSCALDSCTDLENPQLNRTRCAHECQDLPEGSYRCVCPKGY---ELSEDQHSCLVQESPCS 513
            .::...|.::.|.:      |.|     |.||.: ||||.|..|:   ..||:.:.|  ...|| 
Human   769 EQESNECKMNPCKN------NST-----CTDLYK-SYRCECTSGWTGQNCSEEINEC--DSDPC- 818

  Fly   514 TEKGVEKCSPGTCLASEDNTSFSCICPTGYRSEAFSCQDIDECAEDTHLCS---HTCQNTPGGYQ 575
                   .:.|.|..|.....|.|:||..|..:.        |.:..:||.   :.|:|..    
Human   819 -------MNGGLCHESTIPGQFVCLCPPLYTGQF--------CHQRYNLCDLLHNPCRNNS---- 864

  Fly   576 CQCPEGLNLVEEYTCLAENLCEVNNNGCEQICLTARGGVCACREGFRLSADGKSCE-DVDECLVN 639
                         ||||  |.:.|.:             |.|||.|    :||:|| ||.:||..
Human   865 -------------TCLA--LVDANQH-------------CICREEF----EGKNCEIDVKDCLFL 897

  Fly   640 NGGCQQV--CRNLPGSYGCICAAGYELLKLDGIRGYC-FDIDECSQRTHGCSDQMLCENLNGSYT 701
            :  ||..  |.::..::.|||..|:.       ...| .:|:|||  :..|.:...|.:|...:.
Human   898 S--CQDYGDCEDMVNNFRCICRPGFS-------GSLCEIEINECS--SEPCKNNGTCVDLTNRFF 951

  Fly   702 CLCPPGYALGLDNHIVTSLNSSFITDSTSSETPSAHTC-LDIDECSLANGNCSHFCQNEPGGFQC 765
            |.|.|.|            :..|              | ||:::|.::.......|.....|:.|
Human   952 CNCEPEY------------HGPF--------------CELDVNKCKISPCLDEENCVYRTDGYNC 990

  Fly   766 ACPLGYALSEDMRTCQ-DIDECLDSNGQCSQLCLNQPGGFACACETGFELTPDGFG--C-ADIDE 826
            .|..||.    ...|: ::||||........:|::....:.|.|::||      ||  | .:.::
Human   991 LCAPGYT----GINCEINLDECLSEPCLHDGVCIDGINHYTCDCKSGF------FGTHCETNAND 1045

  Fly   827 CSQD---YGNCSDICINLLGTHACACERGYELAKDKLSCLDVDECAGLLSGGCSHE--CINKAGT 886
            |..:   :|.|::    |:..:.|:|:......:.|:.   :::|..:   .|.:|  |...|..
Human  1046 CLSNPCLHGRCTE----LINEYPCSCDADGTSTQCKIK---INDCTSI---PCMNEGFCQKSAHG 1100

  Fly   887 FECGCPLGYILNDDGRSCSPALVGCPPGTQRSADGCAPIECN-------------PGYTLGSDDK 938
            |.|.||.||    .|..|           ::|.|.||..|.|             ||:|.  |.:
Human  1101 FTCICPRGY----TGAYC-----------EKSIDNCAEPELNSVICLNGGICVDGPGHTF--DCR 1148

  Fly   939 C----------VDIDECQKQNGGCSH--RCSNTEGSFKCSCPPGY-------ELDSDQKTCQDID 984
            |          ::|:||  .:..|.|  .|.:....:.|.|.||:       ||:....:|  :.
Human  1149 CLPGFSGQFCEININEC--SSSPCLHGADCEDHINGYVCKCQPGWSGHHCENELECIPNSC--VH 1209

  Fly   985 E------------CDQDKTSCITG-TCINEIGGFRCEFPKFPVLPEIPTAS-SLPESPKIELKTP 1035
            |            |.....:|..| .|.:||....|..|.|.....|.|.: ::|.|   |....
Human  1210 ELCMENEPGSTCLCTPGFMTCSIGLLCGDEIRRITCLTPIFQRTDPISTQTYTIPPS---ETLVS 1271

  Fly  1036 KYPDFTELSNEIPENPKKPAEFD-YPEPKFPSLPKWEGLPK--LPPLADIPTSKAPVPLRPEVPK 1097
            .:|..        :..:.||..| ||..:.   ||..|:.|  :.|...:.|.:...||...:.:
Human  1272 SFPSI--------KATRIPAIMDTYPVDQG---PKQTGIVKHDILPTTGLATLRISTPLESYLLQ 1325

  Fly  1098 SLWVNQLQPRDLCPRFQAPRNGKSHCNRYRHKQKLFYYSRCRISCNSGYILQGPEIKSCDANGIW 1162
            .|.|.    |:|..:.....:.....:|:               .|.|  ::.|.....|...:.
Human  1326 ELIVT----RELSAKHSLLSSADVSSSRF---------------LNFG--IRDPAQIVQDKTSVS 1369

  Fly  1163 EGP-ETKCVAIN----QPRAQSPGICPALK-----PAQN-------GVILPASCTQGPSRFGDVC 1210
            ..| .|....:.    ..||::|.|..:|.     |.|:       .|.|.|:.|....|.....
Human  1370 HMPIRTSAATLGFFFPDRRARTPFIMSSLMSDFIFPTQSLLFENCQTVALSATPTTSVIRSIPGA 1434

  Fly  1211 RLQCN------AGFVSTGSLLTACMMLQGWSFGADLNCQPFGNG----------LLGNQLSPMWN 1259
            .::.|      .||:...:.::|..::   |.||..:.:.:...          ||...:||::.
Human  1435 DIELNRQSLLSRGFLLIAASISATPVV---SRGAQEDIEEYSADSLISRREHWRLLSPSMSPIFP 1496

  Fly  1260 SPKTVTPHQIQNVEQIRPYINCPENVVIL----LHAGEQKA----------HVTLQRPQTNVKNG 1310
            :...::                 :.|.||    ||....||          ..:..:..||:|: 
Human  1497 AKVIIS-----------------KQVTILNSSALHRFSTKAFNPSEYQAITEASSNQRLTNIKS- 1543

  Fly  1311 RLVAHPAWAGQLQGHLPAGVHKVDFRVNDPETKLTIKCHTIITVKAATPRE----------SNPF 1365
                                     :..|...:|:..|.|....:..:.||          |:.:
Human  1544 -------------------------QAADSLRELSQTCATCSMTEIKSSREFSDQVLHSKQSHFY 1583

  Fly  1366 TLFRISDYSRSSLPRPAPFATLSTGSSFSFPAFKALDATPKPVSFTKF-QVFPDSESSEHSKLGS 1429
            ..|.::....:|........|:::|.|||    .|.:.||. |:||:. .:||..:|::.:.|.|
Human  1584 ETFWMNSAILASWYALMGAQTITSGHSFS----SATEITPS-VAFTEVPSLFPSKKSAKRTILSS 1643

  Fly  1430 SSFFRLEPLFHESSKL----------ISAAPASSENTRVDLGSDTSNYCPPSIEVYLKENQNLRS 1484
            |    ||.....||.|          :|..|:.:      :.||..             |.:|.|
Human  1644 S----LEESITLSSNLDVNLCLDKTCLSIVPSQT------ISSDLM-------------NSDLTS 1685

  Fly  1485 -VVWDEPRFEGKLLKIYKSHFPGSLFKVGDHAIKYEATTTDGKTLSCTFFIYVRSAKPTPA---- 1544
             :..||......:||:.|..             :|..|....:.|:....:.:..:|.:..    
Human  1686 KMTTDELSVSENILKLLKIR-------------QYGITMGPTEVLNQESLLDMEKSKGSHTLFKL 1737

  Fly  1545 -PTEPKISFDSEPETLSDVS-QTYV-----------------VCPDKEPVRV--------TAESV 1582
             |::..:.|:...:...||: :||.                 ..||...|..        ...::
Human  1738 HPSDSSLDFELNLQIYPDVTLKTYSEITHANDFKNNLPPLTGSVPDFSEVTTNVAFYTVSATPAL 1802

  Fly  1583 SLPVGCTLKNIRP--------KSRSPKELKRGKLTSLWH-----QYTNF 1618
            |:....::..|||        .:...||:|.....|.|.     ||..|
Human  1803 SIQTSSSMSVIRPDWPYFTDYMTSLKKEVKTSSEWSKWELQPSVQYQEF 1851

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fracNP_648137.3 FXa_inhibition 296..331 CDD:464251 13/73 (18%)
cEGF 396..415 CDD:463661 8/19 (42%)
FXa_inhibition 425..458 CDD:464251 7/35 (20%)
FXa_inhibition 476..505 CDD:464251 11/31 (35%)
EGF_CA 552..>581 CDD:214542 5/31 (16%)
FXa_inhibition 596..630 CDD:464251 8/33 (24%)
FXa_inhibition 636..>664 CDD:464251 9/29 (31%)
EGF_CA 676..711 CDD:214542 11/34 (32%)
FXa_inhibition 745..780 CDD:464251 7/34 (21%)
FXa_inhibition 786..821 CDD:464251 9/36 (25%)
vWFA <821..861 CDD:469594 8/43 (19%)
FXa_inhibition 874..904 CDD:464251 11/31 (35%)
FXa_inhibition 945..980 CDD:464251 10/43 (23%)
PTZ00449 <1017..>1098 CDD:185628 19/84 (23%)
CCP 1110..1170 CDD:153056 7/60 (12%)
CCP 1183..1235 CDD:153056 12/69 (17%)
HYR 1468..1536 CDD:460572 11/68 (16%)
EYSNP_001278938.1 EGF_CA 215..253 CDD:238011
EGF_CA 681..731 CDD:238011 22/81 (27%)
EGF_CA 733..769 CDD:214542 11/42 (26%)
EGF_CA 773..806 CDD:238011 13/44 (30%)
EGF_CA 810..846 CDD:238011 11/53 (21%)
EGF_CA 890..926 CDD:238011 11/44 (25%)
EGF_CA 929..964 CDD:238011 12/62 (19%)
EGF_CA 966..1002 CDD:238011 8/39 (21%)
EGF_CA 1004..1040 CDD:238011 11/41 (27%)
EGF_CA 1080..1115 CDD:238011 13/52 (25%)
EGF_CA 1118..1159 CDD:238011 10/42 (24%)
EGF_CA 1161..1197 CDD:238011 10/37 (27%)
LamG 1886..2044 CDD:238058
LamG 2149..2315 CDD:238058
LamG 2459..2582 CDD:214598
EGF 2614..2644 CDD:394967
EGF_CA 2657..2689 CDD:238011
LamG 2740..2877 CDD:214598
LamG 2977..3138 CDD:238058
Blue background indicates that the domain is not in the aligned region.

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