DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment frac and EYS

DIOPT Version :9

Sequence 1:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster
Sequence 2:	NP_001278938.1	Gene:	EYS / 346007	HGNCID:	21555	Length:	3165	Species:	Homo sapiens

Alignment Length:	1609	Identity:	341/1609 - (21%)
Similarity:	555/1609 - (34%)	Gaps:	553/1609 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 FLDNNCGEDNGGCAH--ICKRLLYPDE-NQPINKCDCREGYTLDPNDYASCLDIDEC-------- 296
            :|:|...:....|.|  :||     || |:|  :|.|...|.    .....:::|.|
Human   563 YLENTTDDQENECQHEAVCK-----DEINRP--RCSCSLSYI----GRLCVVNVDYCLGNHSISV 616

  Fly   297 ------LESNGGCS-------EICE------------------NLPGEYKCSCQEGYYLDESGKS 330
                  |..|..||       .|||                  :|.|.:...|..|:    .|..
Human   617 HGLCLALSHNCNCSGLQRYERNICEIDTEDCKSASCKNGTTSTHLRGYFFRKCVPGF----KGTQ 677

  Fly   331 C-VDINECANPELSSNCQ-GA-CENLPGSY--RCVEPLEENPEITEVVENPIEKTNEVPVNVSES 390
            | :||:|||    |..|: || |.:.||:|  :||.|.       :||:.
Human   678 CEIDIDECA----SHPCKNGATCIDQPGNYFCQCVPPF-------KVVDG--------------- 716

  Fly   391 QPAGKTCNSGFQLSADGTDC-QDINECEVDGPEDLDNNAVCQQKCENTIGSFRCTCV---EGYHL 451
              ....||.|:.    |..| |||::|.::..|   :|:.    |::...|::|.|:   ||...
Human   717 --FSCLCNPGYV----GIRCEQDIDDCILNACE---HNST----CKDLHLSYQCVCLSDWEGNFC 768

  Fly   452 LEDQRSCALDSCTDLENPQLNRTRCAHECQDLPEGSYRCVCPKGY---ELSEDQHSCLVQESPCS 513
            .::...|.::.|.:      |.|     |.||.: ||||.|..|:   ..||:.:.|  ...||
Human   769 EQESNECKMNPCKN------NST-----CTDLYK-SYRCECTSGWTGQNCSEEINEC--DSDPC- 818

  Fly   514 TEKGVEKCSPGTCLASEDNTSFSCICPTGYRSEAFSCQDIDECAEDTHLCS---HTCQNTPGGYQ 575
                   .:.|.|..|.....|.|:||..|..:.        |.:..:||.   :.|:|..
Human   819 -------MNGGLCHESTIPGQFVCLCPPLYTGQF--------CHQRYNLCDLLHNPCRNNS---- 864

  Fly   576 CQCPEGLNLVEEYTCLAENLCEVNNNGCEQICLTARGGVCACREGFRLSADGKSCE-DVDECLVN 639
                         ||||  |.:.|.:             |.|||.|    :||:|| ||.:||..
Human   865 -------------TCLA--LVDANQH-------------CICREEF----EGKNCEIDVKDCLFL 897

  Fly   640 NGGCQQV--CRNLPGSYGCICAAGYELLKLDGIRGYC-FDIDECSQRTHGCSDQMLCENLNGSYT 701
            :  ||..  |.::..::.|||..|:.       ...| .:|:|||  :..|.:...|.:|...:.
Human   898 S--CQDYGDCEDMVNNFRCICRPGFS-------GSLCEIEINECS--SEPCKNNGTCVDLTNRFF 951

  Fly   702 CLCPPGYALGLDNHIVTSLNSSFITDSTSSETPSAHTC-LDIDECSLANGNCSHFCQNEPGGFQC 765
            |.|.|.|            :..|              | ||:::|.::.......|.....|:.|
Human   952 CNCEPEY------------HGPF--------------CELDVNKCKISPCLDEENCVYRTDGYNC 990

  Fly   766 ACPLGYALSEDMRTCQ-DIDECLDSNGQCSQLCLNQPGGFACACETGFELTPDGFG--C-ADIDE 826
            .|..||.    ...|: ::||||........:|::....:.|.|::||      ||  | .:.::
Human   991 LCAPGYT----GINCEINLDECLSEPCLHDGVCIDGINHYTCDCKSGF------FGTHCETNAND 1045

  Fly   827 CSQD---YGNCSDICINLLGTHACACERGYELAKDKLSCLDVDECAGLLSGGCSHE--CINKAGT 886
            |..:   :|.|::    |:..:.|:|:......:.|:.   :::|..:   .|.:|  |...|..
Human  1046 CLSNPCLHGRCTE----LINEYPCSCDADGTSTQCKIK---INDCTSI---PCMNEGFCQKSAHG 1100

  Fly   887 FECGCPLGYILNDDGRSCSPALVGCPPGTQRSADGCAPIECN-------------PGYTLGSDDK 938
            |.|.||.||    .|..|           ::|.|.||..|.|             ||:|.  |.:
Human  1101 FTCICPRGY----TGAYC-----------EKSIDNCAEPELNSVICLNGGICVDGPGHTF--DCR 1148

  Fly   939 C----------VDIDECQKQNGGCSH--RCSNTEGSFKCSCPPGY-------ELDSDQKTCQDID 984
            |          ::|:||  .:..|.|  .|.:....:.|.|.||:       ||:....:|  :.
Human  1149 CLPGFSGQFCEININEC--SSSPCLHGADCEDHINGYVCKCQPGWSGHHCENELECIPNSC--VH 1209

  Fly   985 E------------CDQDKTSCITG-TCINEIGGFRCEFPKFPVLPEIPTAS-SLPESPKIELKTP 1035
            |            |.....:|..| .|.:||....|..|.|.....|.|.: ::|.|   |....
Human  1210 ELCMENEPGSTCLCTPGFMTCSIGLLCGDEIRRITCLTPIFQRTDPISTQTYTIPPS---ETLVS 1271

  Fly  1036 KYPDFTELSNEIPENPKKPAEFD-YPEPKFPSLPKWEGLPK--LPPLADIPTSKAPVPLRPEVPK 1097
            .:|..        :..:.||..| ||..:.   ||..|:.|  :.|...:.|.:...||...:.:
Human  1272 SFPSI--------KATRIPAIMDTYPVDQG---PKQTGIVKHDILPTTGLATLRISTPLESYLLQ 1325

  Fly  1098 SLWVNQLQPRDLCPRFQAPRNGKSHCNRYRHKQKLFYYSRCRISCNSGYILQGPEIKSCDANGIW 1162
            .|.|.    |:|..:.....:.....:|:               .|.|  ::.|.....|...:.
Human  1326 ELIVT----RELSAKHSLLSSADVSSSRF---------------LNFG--IRDPAQIVQDKTSVS 1369

  Fly  1163 EGP-ETKCVAIN----QPRAQSPGICPALK-----PAQN-------GVILPASCTQGPSRFGDVC 1210
            ..| .|....:.    ..||::|.|..:|.     |.|:       .|.|.|:.|....|.....
Human  1370 HMPIRTSAATLGFFFPDRRARTPFIMSSLMSDFIFPTQSLLFENCQTVALSATPTTSVIRSIPGA 1434

  Fly  1211 RLQCN------AGFVSTGSLLTACMMLQGWSFGADLNCQPFGNG----------LLGNQLSPMWN 1259
            .::.|      .||:...:.::|..::   |.||..:.:.:...          ||...:||::.
Human  1435 DIELNRQSLLSRGFLLIAASISATPVV---SRGAQEDIEEYSADSLISRREHWRLLSPSMSPIFP 1496

  Fly  1260 SPKTVTPHQIQNVEQIRPYINCPENVVIL----LHAGEQKA----------HVTLQRPQTNVKNG 1310
            :...::                 :.|.||    ||....||          ..:..:..||:|:
Human  1497 AKVIIS-----------------KQVTILNSSALHRFSTKAFNPSEYQAITEASSNQRLTNIKS- 1543

  Fly  1311 RLVAHPAWAGQLQGHLPAGVHKVDFRVNDPETKLTIKCHTIITVKAATPRE----------SNPF 1365
                                     :..|...:|:..|.|....:..:.||          |:.:
Human  1544 -------------------------QAADSLRELSQTCATCSMTEIKSSREFSDQVLHSKQSHFY 1583

  Fly  1366 TLFRISDYSRSSLPRPAPFATLSTGSSFSFPAFKALDATPKPVSFTKF-QVFPDSESSEHSKLGS 1429
            ..|.::....:|........|:::|.|||    .|.:.||. |:||:. .:||..:|::.:.|.|
Human  1584 ETFWMNSAILASWYALMGAQTITSGHSFS----SATEITPS-VAFTEVPSLFPSKKSAKRTILSS 1643

  Fly  1430 SSFFRLEPLFHESSKL----------ISAAPASSENTRVDLGSDTSNYCPPSIEVYLKENQNLRS 1484
            |    ||.....||.|          :|..|:.:      :.||..             |.:|.|
Human  1644 S----LEESITLSSNLDVNLCLDKTCLSIVPSQT------ISSDLM-------------NSDLTS 1685

  Fly  1485 -VVWDEPRFEGKLLKIYKSHFPGSLFKVGDHAIKYEATTTDGKTLSCTFFIYVRSAKPTPA---- 1544
             :..||......:||:.|..             :|..|....:.|:....:.:..:|.:..
Human  1686 KMTTDELSVSENILKLLKIR-------------QYGITMGPTEVLNQESLLDMEKSKGSHTLFKL 1737

  Fly  1545 -PTEPKISFDSEPETLSDVS-QTYV-----------------VCPDKEPVRV--------TAESV 1582
             |::..:.|:...:...||: :||.                 ..||...|..        ...::
Human  1738 HPSDSSLDFELNLQIYPDVTLKTYSEITHANDFKNNLPPLTGSVPDFSEVTTNVAFYTVSATPAL 1802

  Fly  1583 SLPVGCTLKNIRP--------KSRSPKELKRGKLTSLWH-----QYTNF 1618
            |:....::..|||        .:...||:|.....|.|.     ||..|
Human  1803 SIQTSSSMSVIRPDWPYFTDYMTSLKKEVKTSSEWSKWELQPSVQYQEF 1851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342	13/73 (18%)
		cEGF	396..415	CDD:289433	8/19 (42%)
		FXa_inhibition	425..458	CDD:291342	7/35 (20%)
		FXa_inhibition	476..505	CDD:291342	11/31 (35%)
		vWFA	<550..586	CDD:294047	5/38 (13%)
		FXa_inhibition	596..630	CDD:291342	8/33 (24%)
		FXa_inhibition	636..>664	CDD:291342	9/29 (31%)
		EGF_CA	676..715	CDD:284955	11/38 (29%)
		FXa_inhibition	745..780	CDD:291342	7/34 (21%)
		FXa_inhibition	786..821	CDD:291342	9/36 (25%)
		FXa_inhibition	827..862	CDD:291342	7/37 (19%)
		FXa_inhibition	874..904	CDD:291342	11/31 (35%)
		FXa_inhibition	945..980	CDD:291342	10/43 (23%)
		CCP	1110..1170	CDD:153056	7/60 (12%)
		CCP	1183..1235	CDD:153056	12/69 (17%)
		DUF5011	1468..1536	CDD:295940	11/68 (16%)
EYS	NP_001278938.1	Plasmod_Pvs28	195..>283	CDD:283826
		EGF_CA	681..731	CDD:238011	22/81 (27%)
		EGF_CA	733..769	CDD:238011	11/42 (26%)
		EGF_CA	773..806	CDD:238011	13/44 (30%)
		EGF_CA	810..846	CDD:238011	11/53 (21%)
		EGF_CA	890..926	CDD:238011	11/44 (25%)
		EGF_CA	929..964	CDD:238011	12/62 (19%)
		EGF_CA	966..1002	CDD:238011	8/39 (21%)
		EGF_CA	1004..1040	CDD:238011	11/41 (27%)
		EGF_CA	1080..1115	CDD:238011	13/52 (25%)
		EGF_CA	1118..1159	CDD:238011	10/42 (24%)
		EGF_CA	1161..1197	CDD:238011	10/37 (27%)
		LamG	1886..2044	CDD:238058
		LamG	2149..2315	CDD:238058
		Laminin_G_2	2461..2582	CDD:280389
		EGF_CA	2657..2689	CDD:238011
		LamG	2740..2877	CDD:214598
		Laminin_G_2	3007..3138	CDD:280389
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154592
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930