DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment frac and Vwa2

DIOPT Version :9

Sequence 1:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster
Sequence 2:	XP_003749194.3	Gene:	Vwa2 / 307988	RGDID:	1562000	Length:	792	Species:	Rattus norvegicus

Alignment Length:	224	Identity:	47/224 - (20%)
Similarity:	79/224 - (35%)	Gaps:	71/224 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   361 EPLEENPEITEVVENPIEKTNEVPVNVSESQPAGKTCNSGFQLSADGTDCQ-DINECE---VDGP 421
            ||.|::..:.|.||   :.||.:...:|.|    ..|.     :|| .||: :...||   ::..
  Rat   207 EPKEQHVLLAEQVE---DATNGLLSTLSSS----LLCT-----TAD-PDCRVEAYPCERRTLETM 258

  Fly   422 EDLDNNAVCQQ--KCENTIGSFRCTCVEGYHLLEDQRSCALDSCTDLENPQLNRTRCAHECQDLP 484
            .:|.:||:|.:  :..:|:.:..|.......:.                            |..|
  Rat   259 RELASNALCWRGSRQADTVLAVPCPFYSWKRVF----------------------------QTHP 295

  Fly   485 EGSYRCVCPKGYELSEDQHSCLVQESPCSTEKGVEKC-SPGTCLASEDNTSFSCICPTGYRSEAF 548
            ...||.:||                .||.:    :.| :.|||: .|....:.|:||..:..|..
  Rat   296 ANCYRTICP----------------GPCDS----QPCQNGGTCI-PEGVDRYHCLCPLAFGGEVN 339

  Fly   549 SCQDID-ECAEDT-HLCSHTCQNTPGGYQ 575
            ....:. ||..|. .|...:...||.|::
  Rat   340 CAPKLSLECRIDVLFLLDSSAGTTPEGFR 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342
		cEGF	396..415	CDD:289433	5/19 (26%)
		FXa_inhibition	425..458	CDD:291342	5/34 (15%)
		FXa_inhibition	476..505	CDD:291342	6/28 (21%)
		vWFA	<550..586	CDD:294047	7/28 (25%)
		FXa_inhibition	596..630	CDD:291342
		FXa_inhibition	636..>664	CDD:291342
		EGF_CA	676..715	CDD:284955
		FXa_inhibition	745..780	CDD:291342
		FXa_inhibition	786..821	CDD:291342
		FXa_inhibition	827..862	CDD:291342
		FXa_inhibition	874..904	CDD:291342
		FXa_inhibition	945..980	CDD:291342
		CCP	1110..1170	CDD:153056
		CCP	1183..1235	CDD:153056
		DUF5011	1468..1536	CDD:295940
Vwa2	XP_003749194.3	vWA_collagen	59..213	CDD:238749	3/5 (60%)
		EGF	307..337	CDD:278437	9/34 (26%)
		vWFA	350..510	CDD:294047	5/19 (26%)
		vWFA	539..689	CDD:294047
		EGF_CA	726..756	CDD:238011
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000