DRSC/TRiP Functional Genomics Resources

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Protein Alignment frac and EFEMP2

DIOPT Version :9

Sequence 1:NP_001137905.1 Gene:frac / 38850 FlyBaseID:FBgn0035798 Length:1618 Species:Drosophila melanogaster
Sequence 2:NP_058634.4 Gene:EFEMP2 / 30008 HGNCID:3219 Length:443 Species:Homo sapiens


Alignment Length:329 Identity:114/329 - (34%)
Similarity:141/329 - (42%) Gaps:74/329 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   617 CREGFRLSADGKSCEDVDECLVNNGGC--QQVCRNLPGSYGCI---------------------- 657
            |.:|:....|.:.|.||:|||.....|  :..|.|..|.|.|:                      
Human    39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPA 103

  Fly   658 -----CAAGYELLKLDGIRGYCFDIDECSQRTHGCSDQMLCENLNGSYTCLCPPGY-ALGLDNHI 716
                 |..|||....|.    |.|:|||:|..|.|.....|.||.|||.|.||.|| .:|.:   
Human   104 QHPNPCPPGYEPDDQDS----CVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPE--- 161

  Fly   717 VTSLNSSFITDSTSSETPSAHTCLDIDECSLANGNCSHFCQNEPGGFQCACPLGYALSEDMRTCQ 781
                                  |:|||||...  .|.|.|.|.||.|:|.|..|:.|..:.|:|.
Human   162 ----------------------CVDIDECRYR--YCQHRCVNLPGSFRCQCEPGFQLGPNNRSCV 202

  Fly   782 DIDECLDSNGQCSQLCLNQPGGFACACETGFELTPDGFGCADIDECSQDYGNCSDICINLLGTHA 846
            |::|| |....|.|.|.|..|.|.|.|..|:||..|||.|:||||||.....|...|||..|..:
Human   203 DVNEC-DMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCINEPGRFS 266

  Fly   847 CACERGYELAKDKLSCLDVDECAGLLSGG--CS--HECINKAGTFEC----GCPLGYILNDDGRS 903
            |.|.:||:|...:| |.|:|||.   ||.  ||  ..|:|..|.:.|    .|...||...:.|.
Human   267 CHCPQGYQLLATRL-CQDIDECE---SGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENRC 327

  Fly   904 CSPA 907
            ..||
Human   328 LCPA 331

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fracNP_001137905.1 FXa_inhibition 296..331 CDD:291342
cEGF 396..415 CDD:289433
FXa_inhibition 425..458 CDD:291342
FXa_inhibition 476..505 CDD:291342
vWFA <550..586 CDD:294047
FXa_inhibition 596..630 CDD:291342 3/12 (25%)
FXa_inhibition 636..>664 CDD:291342 11/56 (20%)
EGF_CA 676..715 CDD:284955 19/39 (49%)
FXa_inhibition 745..780 CDD:291342 13/34 (38%)
FXa_inhibition 786..821 CDD:291342 16/34 (47%)
FXa_inhibition 827..862 CDD:291342 13/34 (38%)
FXa_inhibition 874..904 CDD:291342 11/37 (30%)
FXa_inhibition 945..980 CDD:291342
CCP 1110..1170 CDD:153056
CCP 1183..1235 CDD:153056
DUF5011 1468..1536 CDD:295940
EFEMP2NP_058634.4 EGF_CA 123..163 CDD:214542 19/64 (30%)
EGF_CA 164..197 CDD:214542 16/34 (47%)
vWFA <198..238 CDD:294047 17/40 (43%)
vWFA <241..276 CDD:294047 16/34 (47%)
EGF_CA 283..>310 CDD:304395 11/29 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24034
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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