DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment frac and Matn2

DIOPT Version :9

Sequence 1:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster
Sequence 2:	XP_216941.8	Gene:	Matn2 / 299996	RGDID:	1305353	Length:	954	Species:	Rattus norvegicus

Alignment Length:	576	Identity:	176/576 - (30%)
Similarity:	256/576 - (44%)	Gaps:	81/576 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   344 SNCQGACENLPGSYRCVEPLEEN-PEITEVVEN--PIEKTNEVPVNVSESQPAGKTCNSGFQLSA 405
            |..:||           .||.|| |.:..:|.:  |.:...||         |.|..|:|..:.|
  Rat   148 SEAEGA-----------RPLRENVPRVIMIVTDGRPQDSVAEV---------ASKARNTGILIFA 192

  Fly   406 DGTDCQDINECEVDGPEDLDNNAVCQQKCENTIGSFRCTCVEGYHLLEDQRSCALDSCTDLENPQ 470
            .|....|:|..:..|.|...::..       .:.:|  :.:|....:...:.|.:..|:.||:
  Rat   193 IGVGQVDLNTLKAIGSEPHKDHVF-------LVANF--SQIESLTSVFQNKLCTVHMCSVLEH-- 246

  Fly   471 LNRTRCAHECQDLPEGSYRCVCPKGYELSEDQHSCLVQESPCSTE-KGVEKCSPGTCLASEDNTS 534
                .|||.|.:.| |||.|.|.:||.|..||.:|.:|:. |:|| .|.|:      |......|
  Rat   247 ----NCAHFCINTP-GSYTCKCKQGYILGPDQKTCRIQDL-CATEDHGCEQ------LCVNMLGS 299

  Fly   535 FSCICPTGY--RSEAFSCQDIDECAEDTHLCSHTCQNTPGGYQCQCPEGLNL-VEEYTCLAENLC 596
            |.|.|.:||  ..:...|..:|.||.:.|.|.|.|.|..|.|.|:|.||..| |::.||...:.|
  Rat   300 FVCHCYSGYTLAEDGKQCTAVDYCASENHRCEHECVNAEGSYLCRCHEGFALNVDKKTCSKIDYC 364

  Fly   597 EVNNNGCEQICLTAR-GGVCACREGFRLSADGKSCEDVDECLVNNGGCQQVCRNLPGSYGCICAA 660
            ..:::||:..|:.|: ...|.|.:||.|:.|.|:|..::.|.:|..||:..|.|....:.|.|..
  Rat   365 ASSDHGCQHECVNAQTSAFCRCLKGFMLNPDRKTCRRINYCALNKPGCEHECVNTEEGHYCRCRR 429

  Fly   661 GYELLKLDGIRGYCFDIDECSQRTHGCSDQMLCENLNGSYTCLCPPGYALGLDNHIVTSLNSSFI 725
            ||   .||.....|..:|.|:|:.|||  :.||.|...|:.|.|..|:.:..|
  Rat   430 GY---TLDPNGKTCSRVDHCAQQDHGC--EQLCLNTEESFVCQCSEGFLINDD------------ 477

  Fly   726 TDSTSSETPSAHTCLDIDECSLANGNCSHFCQNEPGGFQCACPLGYALSEDMRTCQDIDECLDSN 790
                      ..||...|.|.|:|..|.:.|.|....|.|.||.|:.|..|.:||..:|.|...:
  Rat   478 ----------LKTCSRADYCLLSNHGCEYSCVNTDKSFACQCPEGHVLRSDGKTCAKLDSCALGD 532

  Fly   791 GQCSQLCLNQPGGFACACETGFELTPDGFGCADIDEC-SQDYGNCSDICINLLGTHACACERGYE 854
            ..|...|::....|.|.|..|:.|..||..|...|.| :.|:| |..:|:|...::.|.|..|:.
  Rat   533 HGCEHSCVSSEDSFVCRCFEGYVLRDDGKTCRREDVCQAVDHG-CEHLCVNSGESYICKCLEGFR 596

  Fly   855 LAKDKLSCLDVDECAGLLSGGCSHECINKAGTFECGCPLGYILNDDGRSCSPALVG 910
            ||:|...|...|.|.. :..||.|.|:|...::.|.|..|::|.:|||.|.....|
  Rat   597 LAEDGKRCRRKDVCKS-IQHGCEHICVNNGNSYLCRCSEGFVLAEDGRHCKRCTEG 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342
		cEGF	396..415	CDD:289433	5/18 (28%)
		FXa_inhibition	425..458	CDD:291342	2/32 (6%)
		FXa_inhibition	476..505	CDD:291342	15/28 (54%)
		vWFA	<550..586	CDD:294047	16/36 (44%)
		FXa_inhibition	596..630	CDD:291342	12/34 (35%)
		FXa_inhibition	636..>664	CDD:291342	10/27 (37%)
		EGF_CA	676..715	CDD:284955	14/38 (37%)
		FXa_inhibition	745..780	CDD:291342	13/34 (38%)
		FXa_inhibition	786..821	CDD:291342	10/34 (29%)
		FXa_inhibition	827..862	CDD:291342	12/35 (34%)
		FXa_inhibition	874..904	CDD:291342	12/29 (41%)
		FXa_inhibition	945..980	CDD:291342
		CCP	1110..1170	CDD:153056
		CCP	1183..1235	CDD:153056
		DUF5011	1468..1536	CDD:295940
Matn2	XP_216941.8	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BA2W
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810