DRSC/TRiP Functional Genomics Resources

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Protein Alignment frac and Efemp2

DIOPT Version :9

Sequence 1:NP_001137905.1 Gene:frac / 38850 FlyBaseID:FBgn0035798 Length:1618 Species:Drosophila melanogaster
Sequence 2:XP_006230804.1 Gene:Efemp2 / 293677 RGDID:1359496 Length:471 Species:Rattus norvegicus


Alignment Length:447 Identity:126/447 - (28%)
Similarity:158/447 - (35%) Gaps:179/447 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   615 CACREGFR------------------------LSADGKSCEDVDECLVNNGGCQQVCRNLPGSYG 655
            |.|.||||                        |.....|.:|.:|               |.|| 
  Rat    16 CECTEGFRRHSPRMLPFASCLPGSLLLWAFLLLLLGAASPQDSEE---------------PDSY- 64

  Fly   656 CICAAGYELLKLDGIRGYCFDIDECSQRTHGCSDQMLCENLNGSYTCL----------------- 703
            ..|..|||   .|....:|.|::||......|..:|.|.|..|.|.||                 
  Rat    65 TECTDGYE---WDADSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVISDLHSEGPPP 126

  Fly   704 ----------CPPGYALGLDNHIVTSLNSSFITDSTSSETPSAHTCLDIDECSLANGNC--SHFC 756
                      |||||                       |.....:|:|:|||:.|..:|  |..|
  Rat   127 PAASAQHPNPCPPGY-----------------------EPDEQESCVDVDECTQAIHDCRPSQDC 168

  Fly   757 QNEPGGFQCACPLGYALSEDMRTCQDIDECLDSNGQCSQLCLNQPGGFACACETGFELTPDGFGC 821
            .|.||.:||.||.||.                                        ::.|:   |
  Rat   169 HNLPGSYQCTCPDGYR----------------------------------------KIGPE---C 190

  Fly   822 ADIDECSQDYGNCSDICINLLGTHACACERGYELAKDKLSCLDVDECAGLLSGGCSHECINKAGT 886
            .|||||...|  |...|:||.|:..|.||.|::|..:..||:||:||.  :...|...|.|..||
  Rat   191 VDIDECRYRY--CQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECD--MGAPCEQRCFNSYGT 251

  Fly   887 FECGCPLGYILNDDGRSCSPALVGCPPGTQRSADGCAPIECNPGYTLGSDDKCVDIDECQKQNGG 951
            |.|.|..||.|:.||.|||                                   |||||...:..
  Rat   252 FLCRCNQGYELHRDGFSCS-----------------------------------DIDECSYSSYL 281

  Fly   952 CSHRCSNTEGSFKCSCPPGYELDSDQKTCQDIDECDQDKTSCITG-TCINEIGGFRC 1007
            |.:||.|..|.|.|.||.||:|.: .:.|||||||:.....|... ||:|..||:||
  Rat   282 CQYRCVNEPGRFSCHCPQGYQLLA-TRLCQDIDECETGAHQCSEAQTCVNFHGGYRC 337

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fracNP_001137905.1 FXa_inhibition 296..331 CDD:291342
cEGF 396..415 CDD:289433
FXa_inhibition 425..458 CDD:291342
FXa_inhibition 476..505 CDD:291342
vWFA <550..586 CDD:294047
FXa_inhibition 596..630 CDD:291342 7/38 (18%)
FXa_inhibition 636..>664 CDD:291342 6/27 (22%)
EGF_CA 676..715 CDD:284955 16/65 (25%)
FXa_inhibition 745..780 CDD:291342 14/36 (39%)
FXa_inhibition 786..821 CDD:291342 1/34 (3%)
FXa_inhibition 827..862 CDD:291342 12/34 (35%)
FXa_inhibition 874..904 CDD:291342 13/29 (45%)
FXa_inhibition 945..980 CDD:291342 13/34 (38%)
CCP 1110..1170 CDD:153056
CCP 1183..1235 CDD:153056
DUF5011 1468..1536 CDD:295940
Efemp2XP_006230804.1 EGF_CA 151..191 CDD:214542 18/82 (22%)
EGF_CA 192..225 CDD:214542 16/34 (47%)
vWFA <226..266 CDD:294047 17/41 (41%)
vWFA <269..304 CDD:294047 18/69 (26%)
EGF_CA 311..>338 CDD:304395 13/27 (48%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 49 1.000 Domainoid score I11481
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24034
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
44.010

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