DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment frac and Fbln5

DIOPT Version :9

Sequence 1:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster
Sequence 2:	XP_006240521.1	Gene:	Fbln5 / 29158	RGDID:	2594	Length:	461	Species:	Rattus norvegicus

Alignment Length:	396	Identity:	127/396 - (32%)
Similarity:	172/396 - (43%)	Gaps:	92/396 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   639 NNGGCQQVCRNL-------------PGSYGCICAAGYELLKLDGIRGYCFDIDECSQRTHGCSDQ 690
            |:|.|:|  |.:             ||:....|..|::   ||...|.|.|||||......|...
  Rat    10 NSGHCRQ--RRMILTVTILALWLPHPGNAQQQCTNGFD---LDRQTGQCLDIDECRTIPEACRGD 69

  Fly   691 MLCENLNGSYTCL--CPPGYALGLDNHIVTSLN------------SSFITDST------SSETPS 735
            |:|.|.||.|.|:  ..|.|.....|...||.:            |::.|.|.      ..:...
  Rat    70 MMCVNQNGGYLCIPRTNPVYRGPYSNPYSTSYSGPYPAAAPPVPASNYPTISRPLVCRFGYQMDE 134

  Fly   736 AHTCLDIDECSLANGNC--SHFCQNEPGGFQCACPLGYALSEDMRTCQDIDECLDSNGQCSQLCL 798
            .:.|:|:|||:..:..|  :..|.|..||:.|:|..||.|.|..  |.|||||  ..|.|.|||.
  Rat   135 GNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQ--CLDIDEC--RYGYCQQLCA 195

  Fly   799 NQPGGFACACETGFELTPDGFGCADIDECSQDYGNCSDICINLLGTHACACERGYELAKDKLSCL 863
            |.||.::|.|..||.|..||..|.|::||..: ..|...|:|..|:..|.|:.||||.:|.:.|.
  Rat   196 NVPGSYSCTCNPGFTLNDDGRSCQDVNECETE-NPCVQTCVNTYGSFICRCDPGYELEEDGIHCS 259

  Fly   864 DVDECAGLLSGGCSHECINKAGTFECGCPLGYILNDDGRSCSPALVGCPPGTQRSADGCAPIECN 928
            |:|||: .....|.|||:|:.|::.|.||.||:|.:|.|||.
  Rat   260 DMDECS-FSEFLCQHECVNQPGSYFCSCPPGYVLLEDNRSCQ----------------------- 300

  Fly   929 PGYTLGSDDKCVDIDECQKQNGGCS--HRCSNTEGSFKC----SCPPGYELDSDQKTCQDIDECD 987
                        ||:||:.:|..|:  ..|.|.:|.|||    .|...|.|..|.: |.    |.
  Rat   301 ------------DINECEHRNHTCTPLQTCYNLQGGFKCIDPIVCEEPYLLIGDNR-CM----CP 348

  Fly   988 QDKTSC 993
            .:.|.|
  Rat   349 AENTGC 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342
		cEGF	396..415	CDD:289433
		FXa_inhibition	425..458	CDD:291342
		FXa_inhibition	476..505	CDD:291342
		vWFA	<550..586	CDD:294047
		FXa_inhibition	596..630	CDD:291342
		FXa_inhibition	636..>664	CDD:291342	9/37 (24%)
		EGF_CA	676..715	CDD:284955	15/40 (38%)
		FXa_inhibition	745..780	CDD:291342	12/36 (33%)
		FXa_inhibition	786..821	CDD:291342	16/34 (47%)
		FXa_inhibition	827..862	CDD:291342	12/34 (35%)
		FXa_inhibition	874..904	CDD:291342	14/29 (48%)
		FXa_inhibition	945..980	CDD:291342	13/40 (33%)
		CCP	1110..1170	CDD:153056
		CCP	1183..1235	CDD:153056
		DUF5011	1468..1536	CDD:295940
Fbln5	XP_006240521.1	vWFA	<134..178	CDD:294047	16/43 (37%)
		cEGF	200..223	CDD:289433	9/22 (41%)
		EGF_CA	220..258	CDD:214542	14/38 (37%)
		FXa_inhibition	271..299	CDD:291342	14/27 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24034
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010