DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment frac and Fbln2

DIOPT Version :9

Sequence 1:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster
Sequence 2:	XP_006236984.1	Gene:	Fbln2 / 282583	RGDID:	628685	Length:	1221	Species:	Rattus norvegicus

Alignment Length:	975	Identity:	273/975 - (28%)
Similarity:	390/975 - (40%)	Gaps:	236/975 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 DIDEDDDEEVSE---REPPPPPPPPVVDG-----------------ADSK--PEPQIVIE----- 184
            ||||:::|||.|   .|||....|..:|.                 |::|  ||..::.|
  Rat   270 DIDEEEEEEVEEILATEPPVAGSPGRLDSLPTTSPARPGLPVQEKEAEAKAGPEENLIPEAQATS 334

  Fly   185 --INDDHANEVVES-----EPALA-ETETENEVLENETPLKAEVQTDVLNSSNASVKVTNDPYEP 241
              :..:.|..:.:|     .|:|| ::.:|:.:..:..|..:.:..|....|.:.......|..|
  Rat   335 RSVTQEGAAPLPKSGLAGLSPSLATDSSSEDALKSSSQPTLSTLPPDRAQVSPSPETPEEIPQRP 399

  Fly   242 TFLDNNCGEDNGGCAHICKRLLYPDENQPINKCDCREGYTLDPNDYASC--------LDIDECLE 298
            ..|..:..|::..          |:....:.:.| .:|.|.|..:  :|        :|.|||.|
  Rat   400 QLLPRSRAEEDTD----------PNSVHSVPRGD-PDGSTKDLVE--TCCAAGQQWAIDNDECQE 451

  Fly   299 --SNGGCSEICENLPGEYKC-------SCQEGYYLDESGKSC-VDINECANPELSSNC------- 346
              .||..|::| .:...:.|       ||..|....:.|::| .:.|:.....|...|
  Rat   452 IPENGAQSDVC-RIAQRHCCISYLKEKSCVAGVMGAKEGETCGAEDNDTCGVSLYKQCCDCCGLG 515

  Fly   347 -----QG-ACENLPG-SYRCVEPL-----EENPEITEVVENPIEKTNEVPVNVSESQPAGKTCNS 399
                 :| :||:.|. .|.|...:     .|.|.|...|..|.| ....|..|||::...:..
  Rat   516 LRVRAEGQSCESNPNLGYPCSHVMLSCCEGEEPLIVPEVRRPPE-PGATPRRVSETEMGSREA-- 577

  Fly   400 GFQLSADGTDCQ--------DINECEVDGPEDLDNNAVCQQKCENTIGSFRCTCVEGYHLLEDQR 456
               ||. ||:.:        |.:||.:...|      :||..|.||:||:||.|..|:.|..|.|
  Rat   578 ---LSL-GTEAELPNSLPGDDQDECLMLPGE------LCQHLCINTVGSYRCACFPGFELQGDGR 632

  Fly   457 SCALDSCTDLENPQLNRTRCAHECQDLPEGSYRCVCPKGYELSEDQHSCLVQESPCSTEKGVEKC 521
            :|..|...    |||:..|     :..|......|.|....|...|.:......||..
  Rat   633 TCRPDGGA----PQLDTAR-----ESAPRSESAQVSPNTIPLPVPQPNTCKDNGPCRQ------- 681

  Fly   522 SPGTCLASEDNTSFSCICPTGYRSEAFSCQDIDECAEDTHLCS--HTCQNTPGGYQC-----QCP 579
               .|....|....||.......::..||:|.|||...||.||  ..|.||.|.:.|     .|.
  Rat   682 ---VCRVIGDTAMCSCFPGYAIMADGVSCEDQDECLMGTHDCSWKQFCVNTLGSFYCVNHTVLCA 743

  Fly   580 EGLNLVEEYTCLAENLCEVNNNGCEQI--CLTARGG-----VCACREGFRLSADGKSCEDVDECL 637
            ||..|.....|:..|.|..:.:.|.:.  |:...|.     ...|..|:.|: ||: |.|||||:
  Rat   744 EGYILNAHRKCVDINECVTDLHTCTRAEHCVNTPGSFQCYKALTCEPGYVLT-DGE-CTDVDECV 806

  Fly   638 VNNGGCQQ--VCRNLPGSYGC----ICAAGYELLKLDGIRGYCFDIDECSQRTHGCSDQMLCENL 696
            .....||.  .|:|..||:.|    .|..|:    |....|.|.||:||:.....|.....|.|.
  Rat   807 TGTHNCQAGFSCQNTKGSFYCQARQRCMDGF----LQDPEGNCVDINECTSLLEPCRSGFSCINT 867

  Fly   697 NGSYTC-----LCPPGYALGLDNHIVTSLNSSFITDSTSSETPSAHTCLDIDECSLANGNC--SH 754
            .|||||     :|..||      |          .:...||      |:|::||......|  ..
  Rat   868 VGSYTCQRNPLVCRRGY------H----------ANEEGSE------CVDVNECETGVHRCGEGQ 910

  Fly   755 FCQNEPGGFQCACPLGYALSEDMRTCQDIDECLDSNGQ-CSQLCLNQPGGFACACETGFELTPDG 818
            .|.|.||.::|.|..|:......|||.|::||..|.|: |...|.|.||.:.|:|..||.|..||
  Rat   911 LCYNLPGSYRCDCKPGFQRDAFGRTCIDVNECWISPGRLCQHTCENTPGSYRCSCAAGFLLAADG 975

  Fly   819 FGCADIDECSQDYGNCSDICINLLGTHACACERGYELAKDKLSCLDVDEC---AGLLSGGCSHEC 880
            ..|.|::||  :...||..|.|:.|::.|.|.:||:||:|..:|.|:|||   ||:|   |:..|
  Rat   976 KHCEDVNEC--ETRRCSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGIL---CTFRC 1035

  Fly   881 INKAGTFECGCP-LGYILNDDGRSCSPALVGCPPGTQRSADGCAPIECNPGYTLGSDDKCVDIDE 944
            :|..|:::|.|| .||.:..:||||.                                   |:||
  Rat  1036 VNVPGSYQCACPEQGYTMMANGRSCK-----------------------------------DLDE 1065

  Fly   945 CQKQNGGCS--HRCSNTEGSFKC---SCPPGY----ELDSDQKTCQDIDECDQDKTSCITGTCIN 1000
            |......||  ..|.|.:|||:|   .|||.|    |...::.|||||.|| |...:.||...:|
  Rat  1066 CALGTHNCSEAETCHNIQGSFRCLRFDCPPNYVRVSETKCERTTCQDISEC-QTSPARITHYQLN 1129

Fly 1001 1000
Rat 1130 1129

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342	11/43 (26%)
		cEGF	396..415	CDD:289433	5/26 (19%)
		FXa_inhibition	425..458	CDD:291342	14/32 (44%)
		FXa_inhibition	476..505	CDD:291342	5/28 (18%)
		vWFA	<550..586	CDD:294047	18/42 (43%)
		FXa_inhibition	596..630	CDD:291342	9/40 (23%)
		FXa_inhibition	636..>664	CDD:291342	10/33 (30%)
		EGF_CA	676..715	CDD:284955	15/43 (35%)
		FXa_inhibition	745..780	CDD:291342	10/36 (28%)
		FXa_inhibition	786..821	CDD:291342	15/35 (43%)
		FXa_inhibition	827..862	CDD:291342	13/34 (38%)
		FXa_inhibition	874..904	CDD:291342	11/30 (37%)
		FXa_inhibition	945..980	CDD:291342	14/43 (33%)
		CCP	1110..1170	CDD:153056
		CCP	1183..1235	CDD:153056
		DUF5011	1468..1536	CDD:295940
Fbln2	XP_006236984.1	fibronec_FbpA	<284..>394	CDD:411474	19/109 (17%)
		ANATO	428..479	CDD:237984	13/53 (25%)
		ANATO	505..553	CDD:412122	10/47 (21%)
		FXa_inhibition	606..634	CDD:405372	14/27 (52%)
		vWFA	<707..749	CDD:412136	17/41 (41%)
		EGF_CA	756..>792	CDD:419698	6/35 (17%)
		EGF_CA	801..845	CDD:311536	16/47 (34%)
		EGF_CA	847..893	CDD:311536	18/67 (27%)
		EGF_CA	895..937	CDD:214542	13/41 (32%)
		EGF_CA	938..979	CDD:214542	17/40 (43%)
		cEGF	999..1022	CDD:403760	9/22 (41%)
		EGF_CA	1019..1061	CDD:214542	19/44 (43%)
		EGF_CA	1062..1110	CDD:311536	17/47 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910