DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment frac and Ltbp1

DIOPT Version :9

Sequence 1:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster
Sequence 2:	NP_064303.2	Gene:	Ltbp1 / 268977	MGIID:	109151	Length:	1712	Species:	Mus musculus

Alignment Length:	1044	Identity:	287/1044 - (27%)
Similarity:	411/1044 - (39%)	Gaps:	307/1044 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 EEVSEREPPPPPPPPVVDGADSKPEPQIVIEINDDHANEVVESEPALAETETENEVLENE----- 213
            :.|::...|||.|        :|.||...:..:.:|.....|.|...|..|.|...|:.|
Mouse   755 QPVAKSTHPPPLP--------AKEEPVEALTSSWEHGPRGAEPEVVTAPPEKEIPSLDQEKTRLE 811

  Fly   214 ---------------------------TPLKAEVQTDVLNSSNASVKVTNDPYEPTFLDNNC--G 249
                                       .|:..||..:...||.:.|..   |.:.|.: |.|  .
Mouse   812 PGQPQLSPGVSTIHLHPQFPVVVEKTSPPVPVEVAPEASTSSASQVIA---PTQVTEI-NECTVN 872

  Fly   250 EDNGGCAHICKRLLYPDENQPIN-KCDCREGYTLDPNDYASCLDIDECLESNGGCSE-ICENLPG 312
            .|..|..|..        |.|:. .|.|.|||... .....|:|||||.:....||: .|||..|
Mouse   873 PDICGAGHCI--------NLPVRYTCICYEGYKFS-EQLRKCVDIDECAQVRHLCSQGRCENTEG 928

  Fly   313 EYKCSCQEGYYLDESGKSCVDINECANPELSSNCQ-GACENLPGSYRCVEPLEENPEITEVVENP 376
            .:.|.|..|:...|.|.:|:|::||..|::   |: |.|.|..|::||
Mouse   929 SFLCVCPAGFMASEEGTNCIDVDECLRPDM---CRDGRCINTAGAFRC----------------- 973

  Fly   377 IEKTNEVPVNVSESQPAGKTCNSGFQLSADGTDCQDINECEVDGPEDLDNNAVCQQKCENTIGSF 441
                              :.|:||:::|..|. |:||:||       |..:...:::|.||.||:
Mouse   974 ------------------EYCDSGYRMSRRGY-CEDIDEC-------LKPSTCPEEQCVNTPGSY 1012

  Fly   442 RCT-CVEGYHLLEDQ----------RSCALDSCTDLENPQL-------NRTRCAHECQDLPE--- 485
            :|. |.||:.....|          :.|...|||:||...:       :.|.....|||:.|
Mouse  1013 QCVPCTEGFRGWNGQCLDVDECLQPKVCTNGSCTNLEGSYMCSCHRGYSPTPDHRHCQDIDECQQ 1077

  Fly   486 -------------GSYRCVCPKGYELSEDQHSCLVQESPCSTEKGVEK------CSPGTCLASED 531
                         ||:||.|.:||:||..:..|          :.:::      ||.|.|..:|.
Mouse  1078 GNLCMNGQCRNTDGSFRCTCGQGYQLSAAKDQC----------EDIDECEHHHLCSHGQCRNTEG 1132

  Fly   532 NTSFSCICPTGYRSEAFS--CQDIDECAEDTHLC-SHTCQNTPGGYQCQCPEGLNLVEEYTCLAE 593
              ||.|:|..|||:....  |:||:||.||:.:| ...|.||.|.|.|.||:|..|.:
Mouse  1133 --SFQCVCNQGYRASVLGDHCEDINECLEDSSVCQGGDCINTAGSYDCTCPDGFQLND------- 1188

  Fly   594 NLCEVNNNGCEQI--------------CLTARGGV-CACREGFRLSADGKSCEDVDECLVNNGGC 643
                  |.||:.|              ||..:|.. |.|.:||.:||||::|||:||| |||..|
Mouse  1189 ------NKGCQDINECAQPGLCGSHGECLNTQGSFHCVCEQGFSISADGRTCEDIDEC-VNNTVC 1246

  Fly   644 QQ--VCRNLPGSYGCICAAGYELLKLDGIRGYCFDIDECSQRTHGCSDQMLCENLNGSYTCLCP- 705
            ..  .|.|..||:.|:|..|::..: || :| |.|::|| :...|...:..|||:.||:.|:|.
Mouse  1247 DSHGFCDNTAGSFRCLCYQGFQAPQ-DG-QG-CVDVNEC-ELLSGVCGEAFCENVEGSFLCVCAD 1307

  Fly   706 --PGYA-------------LGLD-------NHIVTSLNSSFITDSTSSETPSAHTCLDIDECSLA 748
              ..|:             .|:|       .....:||.:.:.|:..:...:...|.    |:..
Mouse  1308 ENQEYSPMTGQCRSRVTEDSGVDRQPREEKKECYYNLNDASLCDNVLAPNVTKQECC----CTSG 1368

  Fly   749 NG---NCSHF-CQNE-PGGFQCACPLGYAL------SEDM--RTCQDIDECL------DSNGQCS 794
            .|   ||..| |..: ...|...||.|..|      |.|.  ...:|.||||      ..||
Mouse  1369 AGWGDNCEIFPCPVQGTAEFTEMCPRGKGLVPAGESSYDTGGENYKDADECLLFGEEICKNG--- 1430

  Fly   795 QLCLNQPGGFACACETGFELTPDGFGCADIDECSQDYGNCSD-ICINLLGTHACACERGYELAKD 858
             .|||...|:.|.|:.|....|....|.|:||| ||..:|.| .|:|..|::.|.|.....|...
Mouse  1431 -YCLNTQPGYECYCKQGTYYDPVKLQCFDMDEC-QDPNSCIDGQCVNTEGSYNCFCTHPMVLDAS 1493

  Fly   859 KLSCL------------DV--DECAGLLSGG--CSHECINKAGTF-ECGCPLGYILNDDGRSCSP 906
            :..|:            ||  |.|...||..  ||...:.|..|: ||.|..|...   |..|
Mouse  1494 EKRCVQPTESNEQIEETDVYQDLCWEHLSEEYVCSRPLVGKQTTYTECCCLYGEAW---GMQC-- 1553

  Fly   907 ALVGCPPGTQRSADGCAPIECNPGYT-----LGSD-------------------DKCVD------ 941
            ||  ||   .:.:|..|.: ||...|     .|.|                   |:.::
Mouse  1554 AL--CP---MKDSDDYAQL-CNIPVTGRRRPYGRDALVDFSEQYGPETDPYFIQDRFLNSFEELQ 1612

  Fly   942 IDECQKQNGGCSHRCSNTEGSFKCSCPPGYELDSDQKTCQDIDECDQ--DKTS-CITGTCINEIG 1003
            .:||...||..:.||...:..:.|.|..||.||..:.||.|::||.:  ::.| |....|||..|
Mouse  1613 AEECGILNGCENGRCVRVQEGYTCDCFDGYHLDMAKMTCVDVNECSELNNRMSLCKNAKCINTEG 1677

  Fly  1004 GFRC 1007
            .::|
Mouse  1678 SYKC 1681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342	12/35 (34%)
		cEGF	396..415	CDD:289433	8/18 (44%)
		FXa_inhibition	425..458	CDD:291342	10/43 (23%)
		FXa_inhibition	476..505	CDD:291342	13/44 (30%)
		vWFA	<550..586	CDD:294047	18/36 (50%)
		FXa_inhibition	596..630	CDD:291342	15/48 (31%)
		FXa_inhibition	636..>664	CDD:291342	12/29 (41%)
		EGF_CA	676..715	CDD:284955	14/61 (23%)
		FXa_inhibition	745..780	CDD:291342	13/47 (28%)
		FXa_inhibition	786..821	CDD:291342	12/40 (30%)
		FXa_inhibition	827..862	CDD:291342	11/35 (31%)
		FXa_inhibition	874..904	CDD:291342	9/32 (28%)
		FXa_inhibition	945..980	CDD:291342	11/34 (32%)
		CCP	1110..1170	CDD:153056
		CCP	1183..1235	CDD:153056
		DUF5011	1468..1536	CDD:295940
Ltbp1	NP_064303.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..118
		EGF_CA	618..>648	CDD:214542
		TB	681..716	CDD:279073
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	753..799		13/51 (25%)
		EGF_CA	907..947	CDD:284955	16/39 (41%)
		EGF_CA	949..985	CDD:214542	15/73 (21%)
		EGF_CA	990..1023	CDD:238011	14/39 (36%)
		EGF_CA	1030..1070	CDD:214542	7/39 (18%)
		EGF_CA	1071..1102	CDD:214542	8/30 (27%)
		EGF_CA	1112..1152	CDD:214542	12/41 (29%)
		EGF_CA	1153..1189	CDD:214542	17/48 (35%)
		EGF_CA	1194..1235	CDD:214542	12/40 (30%)
		EGF_CA	1236..1277	CDD:214542	18/44 (41%)
		8-Cys3 region. /evidence=ECO:0000250\|UniProtKB:Q14766	1335..1402		15/70 (21%)
		TB	1350..1387	CDD:279073	8/40 (20%)
		EGF_CA	1458..>1484	CDD:214542	12/26 (46%)
		C-terminal domain. /evidence=ECO:0000250\|UniProtKB:Q14766	1498..1712		52/195 (27%)
		TB	1527..1563	CDD:279073	14/45 (31%)
		EGF_CA	1653..>1687	CDD:214542	10/29 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D4721at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42398
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24034
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020