DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment frac and COL6A5

DIOPT Version :9

Sequence 1:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster
Sequence 2:	NP_001265227.1	Gene:	COL6A5 / 256076	HGNCID:	26674	Length:	2614	Species:	Homo sapiens

Alignment Length:	692	Identity:	134/692 - (19%)
Similarity:	221/692 - (31%)	Gaps:	246/692 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VAFASASP-SSERKRKNVMNIPEDPKVSDSLAASLDMSCSSAKILPPEINHGRVSVFDRR----- 72
            :|..|.|| .|.|::...:....|....|:.....:...:|.:.|..|...||..::...
Human  2008 IALLSYSPWESSRRKMGTVKTEFDFITYDNQLLMKNHIQTSFQQLNGEATIGRALLWTTENLFPE 2072

  Fly    73 ----RRGKKVFLVAFFVCDDNYDFENGISEMF----CSNQKWVDEIPTCIPQLNFEEHDEKVGYD 129
                |:.|.:|:|:   ..:||:.:..:..|.    |  |.:|    ..:..|.....|     |
Human  2073 TPYLRKHKVIFVVS---AGENYERKEFVKMMALRAKC--QGYV----IFVISLGSTRKD-----D 2123

  Fly   130 LEDYSDETVPNDYVENSDIDEDDDEEVSEREPP------------PPPPPPVVDGADSKPEPQIV 182
            :|:.:...:....::...|.:.|...:::...|            |||
Human  2124 MEELASYPLDQHLIQLGRIHKPDLNYIAKFLKPFLYSVRRGFNQYPPP----------------- 2171

  Fly   183 IEINDDHANEVVESEPALAETETENEVLENE-TPLKAEVQTDVLNSSNASVKVTNDPYEPTFLDN 246
                      ::|....|.....||  ::|: .....|:|.|.|..:....:..|...|..|:..
Human  2172 ----------MLEDACRLINLGGEN--IQNDGFQFVTELQEDFLGGNGFIGQELNSGRESPFVKT 2224

  Fly   247 NCGEDNGG--CAHICKRLLYPDENQPINKCDCREGYTLDPN--DYASCLDIDECLESNGGCSEIC 307
               ||||.  ..::..::..| :...||       |..|..  :.||.....|    |.|..|..
Human  2225 ---EDNGSDYLVYLPSQMFEP-QKLMIN-------YEKDQKSAEIASLTSGHE----NYGRKEEP 2274

  Fly   308 ENL--PGEYKCSCQEGYYLDESGKSCVDINECANPELSSNCQGACENLPGSYRCVEPLEENPEIT 370
            ::.  ||:  .|.|| ||:|.:  ..:|    |:..:.|:               |..|....||
Human  2275 DHTYEPGD--VSLQE-YYMDVA--FLID----ASQRVGSD---------------EFKEVKAFIT 2315

  Fly   371 EVVE------NPIEKTNEVPVNVSESQPAG----------------KTCNSGFQLSADGTDCQDI 413
            .|::      .|:..|....|.|....|.|                .|.||..|:.....|.|.:
Human  2316 SVLDYFHIAPTPLTSTLGDRVAVLSYSPPGYMPNTEECPVYLEFDLVTYNSIHQMKHHLQDSQQL 2380

  Fly   414 N---------ECEVD----GPEDL------------DNNAVCQQKCENTIGSFRCTCVEGYHL-- 451
            |         :..:|    |..:|            :.|::.:....|.  |.|..| :||.:
Human  2381 NGDVFIGHALQWTIDNVFVGTPNLRKNKVIFVISAGETNSLDKDVLRNV--SLRAKC-QGYSIFV 2442

  Fly   452 -----------LEDQRSCALDSCTDLENPQLNRTRCAHECQDLPEGSY--RCVCP---------K 494
                       ||:..|..||.    ...||.||   |:    |:.:|  :.|.|         .
Human  2443 FSFGPKHNDKELEELASHPLDH----HLVQLGRT---HK----PDWNYIIKFVKPFVHLIRRAIN 2496

  Fly   495 GYELSEDQHSCLVQESPCSTEKGVEKCSPGTCLASEDNTSFSCICPTGYRSEAFSCQDIDECAED 559
            .|...:.:.:|:...|| :.|.|      ||                                |:
Human  2497 KYPTEDMKATCVNMTSP-NPENG------GT--------------------------------EN 2522

  Fly   560 THLCSHTCQNTPGGYQCQCPEGLNLVEEYTCLAENLCEVNNN 601
            |.|.      .||.|:.:...| :|.:|:...|::|..:.||
Human  2523 TVLL------LPGIYEIKTENG-DLFDEFDSQAQHLLVLGNN 2557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342	11/36 (31%)
		cEGF	396..415	CDD:289433	7/27 (26%)
		FXa_inhibition	425..458	CDD:291342	9/45 (20%)
		FXa_inhibition	476..505	CDD:291342	6/39 (15%)
		vWFA	<550..586	CDD:294047	8/35 (23%)
		FXa_inhibition	596..630	CDD:291342	2/6 (33%)
		FXa_inhibition	636..>664	CDD:291342
		EGF_CA	676..715	CDD:284955
		FXa_inhibition	745..780	CDD:291342
		FXa_inhibition	786..821	CDD:291342
		FXa_inhibition	827..862	CDD:291342
		FXa_inhibition	874..904	CDD:291342
		FXa_inhibition	945..980	CDD:291342
		CCP	1110..1170	CDD:153056
		CCP	1183..1235	CDD:153056
		DUF5011	1468..1536	CDD:295940
COL6A5	NP_001265227.1	Nonhelical region	19..1394
		vWFA	29..195	CDD:294047
		VWA	236..404	CDD:278519
		vWA_collagen	441..590	CDD:238749
		YfbK	445..>593	CDD:225187
		vWA_collagen	627..787	CDD:238749
		YfbK	813..>980	CDD:225187
		VWA	814..985	CDD:278519
		VWA	1005..1172	CDD:278519
		Collagen	1394..1447	CDD:189968
		Triple-helical region	1395..1728
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1404..1693
		Cell attachment site. /evidence=ECO:0000255	1430..1432
		Collagen	1443..1520	CDD:189968
		Collagen	1485..1576	CDD:189968
		Collagen	1564..1623	CDD:189968
		Collagen	1597..1657	CDD:189968
		Collagen	1645..1730	CDD:189968
		VWA	1759..1918	CDD:278519
		vWFA_subfamily_ECM	1962..2137	CDD:238727	27/142 (19%)
		vWFA_subfamily_ECM	2290..2467	CDD:238727	37/204 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910