DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment frac and NPNT

DIOPT Version :9

Sequence 1:NP_001137905.1 Gene:frac / 38850 FlyBaseID:FBgn0035798 Length:1618 Species:Drosophila melanogaster
Sequence 2:XP_011530122.1 Gene:NPNT / 255743 HGNCID:27405 Length:613 Species:Homo sapiens


Alignment Length:587 Identity:142/587 - (24%)
Similarity:193/587 - (32%) Gaps:178/587 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   687 CSDQMLCE------NLNGSYTCLCPPGYA---LGLDNHIVTSLNSSF------ITDSTSSETPSA 736
            |..:.:|:      ...|...|.|.||||   ...|.||...|:...      ..|..::..||.
Human    72 CQLKAVCQPRCKHGECIGPNKCKCHPGYAGKTCNQDEHIPAPLDQGSEQPLFQPLDHQATSLPSR 136

  Fly   737 HTCLDIDECSLANGNCSHFCQNEPGGFQCACPLGYALSEDMRTCQDIDECLDSNGQCSQLCLNQP 801
                |::||.|....|.|.|.|..|.::|.|..||.|..| .:|.....|  |...|...|....
Human   137 ----DLNECGLKPRPCKHRCMNTYGSYKCYCLNGYMLMPD-GSCSSALTC--SMANCQYGCDVVK 194

  Fly   802 GGFACACET-GFELTPDGFGCADIDECSQDYGNCSDI--CINLLGTHACACERGYELAKDKLSCL 863
            |...|.|.: |.:|.|||..|.|:|||:....:|...  |:|..|::.|.|.:|::|.       
Human   195 GQIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLM------- 252

  Fly   864 DVDECAGLLSGGCSHECINKAGTFECGCPLGYILNDDGRSCSPALVGCPPGTQRSADGCAPIECN 928
                                           ||                                
Human   253 -------------------------------YI-------------------------------- 254

  Fly   929 PGYTLGSDDKCVDIDECQKQNGGCSH--RCSNTEGSFKCSCPPGYELDSDQKTCQDIDECDQDKT 991
                 |...:|.|||||......||.  ||.|..||:||.|..||:  .|..||..|.:...:.:
Human   255 -----GGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQ--GDGLTCVYIPKVMIEPS 312

  Fly   992 SCI-----TGTC----------INEIGGFRCEFPKFPVLPEI--------PTASSLPESPKIELK 1033
            ..|     .||.          |.::|..... ||.|.:|.|        ||....|:...|...
Human   313 GPIHVPKGNGTILKGDTGNNNWIPDVGSTWWP-PKTPYIPPIITNRPTSKPTTRPTPKPTPIPTP 376

  Fly  1034 TPKYPDFTELSNEIPENPKKPAEFDYPEPKFPSLPKWEGLPKLPPLADIPTSKAPVPLR----PE 1094
            .|..|..|||...:|             |..|..|. .||..:.|.|..|.....|..|    |:
Human   377 PPPPPLPTELRTPLP-------------PTTPERPT-TGLTTIAPAASTPPGGITVDNRVQTDPQ 427

  Fly  1095 VPK-SLWVNQLQPRDLCPRFQAPRNGKSHCNRYRHKQKLFYYSRCRISCNSGYILQGPEIKSCDA 1158
            .|: .:::.:....||...|:..| |.|..:..:....:..:     |||..:.|.| .|:..|.
Human   428 KPRGDVFIPRQPSNDLFEIFEIER-GVSADDEAKDDPGVLVH-----SCNFDHGLCG-WIREKDN 485

  Fly  1159 NGIWEGPETKCVAINQPRAQSPGICPALKPAQNGVILPASCTQGPSRFGDVCRLQCNAG-FVSTG 1222
            :..||                    |...|| .|..|..|..:.|.  |...||....| .:.:|
Human   486 DLHWE--------------------PIRDPA-GGQYLTVSAAKAPG--GKAARLVLPLGRLMHSG 527

  Fly  1223 SL 1224
            .|
Human   528 DL 529

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fracNP_001137905.1 FXa_inhibition 296..331 CDD:291342
cEGF 396..415 CDD:289433
FXa_inhibition 425..458 CDD:291342
FXa_inhibition 476..505 CDD:291342
vWFA <550..586 CDD:294047
FXa_inhibition 596..630 CDD:291342
FXa_inhibition 636..>664 CDD:291342
EGF_CA 676..715 CDD:284955 10/36 (28%)
FXa_inhibition 745..780 CDD:291342 13/34 (38%)
FXa_inhibition 786..821 CDD:291342 12/35 (34%)
FXa_inhibition 827..862 CDD:291342 9/36 (25%)
FXa_inhibition 874..904 CDD:291342 2/29 (7%)
FXa_inhibition 945..980 CDD:291342 14/36 (39%)
CCP 1110..1170 CDD:153056 13/59 (22%)
CCP 1183..1235 CDD:153056 13/43 (30%)
DUF5011 1468..1536 CDD:295940
NPNTXP_011530122.1 FXa_inhibition 141..175 CDD:291342 13/34 (38%)
cEGF 198..220 CDD:289433 9/21 (43%)
EGF_CA 217..>249 CDD:284955 10/31 (32%)
EGF_3 266..301 CDD:289699 14/36 (39%)
MAM 470..611 CDD:279023 21/84 (25%)
MAM 470..609 CDD:99706 21/84 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.