DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment frac and Egf

DIOPT Version :9

Sequence 1:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster
Sequence 2:	NP_036974.2	Gene:	Egf / 25313	RGDID:	2542	Length:	1132	Species:	Rattus norvegicus

Alignment Length:	971	Identity:	223/971 - (22%)
Similarity:	326/971 - (33%)	Gaps:	336/971 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   248 CGEDNGGCAHICKRLLYPDENQPINKCDCREGYTLDPNDYASCLDIDECLESNGGCSEICENLPG 312
            |.:..|.|.:   .|...|.|.  :.|.|.|||||. .|...|.|::||...|.||:..|||:||
  Rat   319 CKQRRGQCLY---SLSERDPNS--DSCACAEGYTLS-RDRKYCEDVNECALQNHGCTLGCENIPG 377

  Fly   313 EYKCSCQEGYYLDESGKSCVDINECANPELSSNCQGACENLPGSYRCVEPLEENPEITEVVENPI 377
            .|.|:|..|:.|...||.|.::..|  |...|.|         |:.|:
  Rat   378 SYYCTCPTGFVLLPDGKRCHELVAC--PGNRSEC---------SHDCI----------------- 414

  Fly   378 EKTNEVPVNVSESQPAGKTCNSGFQLSADGTDCQDINECEVDGPEDLDNNAVCQQKC-ENTIGSF 441
             .|::.|:.:         |.:|..|..||..|        .|....||.. |.|.| ..::.|:
  Rat   415 -LTSDGPLCI---------CPAGSVLGKDGKTC--------TGCSSPDNGG-CSQICLPLSLASW 460

  Fly   442 RCTCVEGYHLLEDQRSCALD-------------------SCTD---------------------- 465
            .|.|..||.|..|::|||..                   ..||
  Rat   461 ECDCFPGYDLQLDRKSCAASGPQPFLLFANSQDIRHMHFDGTDYKTLLSRQMGMVFALDYDPVES 525

  Fly   466 -----------LENPQLN---RTRCAHECQDLPEG--------------SYRCVCPKGYELSEDQ 502
                       :|...|:   |.|...|..|.|||              |.:.|. :|.:||...
  Rat   526 KIYFAQTALKWIERANLDGSQRERLITEGVDTPEGLAVDWIGRRIYWTDSGKSVI-EGSDLSGKH 589

  Fly   503 HSCLVQES----------PCS-----TEKGVEKCSPGTCLASEDNT---SFSCICPTGYRSEAFS 549
            |..:::||          |.:     |:.|:......:.|...|.|   |.:.:.|:|..
  Rat   590 HQIIIKESISRPRGIAVHPKARRLFWTDTGMSPRIESSSLQGSDRTLIASSNLLEPSGIA----- 649

  Fly   550 CQDIDECAEDTHLCS-----------------HTCQNTPGGYQCQCPEGLNLVEEYTCLAE---- 593
               ||...:..:.|.                 ...||..|.     |..|.:.|::...::
  Rat   650 ---IDYLTDTLYWCDTKLSVIEMADLDGSKRRRLTQNDVGH-----PFSLAVFEDHVWFSDWAIP 706

  Fly   594 NLCEVN-NNGCEQICLTARGGVCACREGFRLSADGKSCEDVDECLVNNGGCQQVCRNLPGSYGCI 657
            ::..|| ..|..::.|  ||.:  .:....:.....:....|.||..||||:.:|:...|:..|:
  Rat   707 SVIRVNKRTGQNRVRL--RGSM--LKPSSLVVVHPLAKPGADPCLHRNGGCEHICQESLGTAQCL 767

  Fly   658 CAAGYELLKLDGIRGYCFDIDECSQRTHGCSDQMLCENLNGSYTCLCPPGYALGLDNHIVTSLNS 722
            |..|: :...||        ..|..|.   .||:|.             |....|...:.:..||
  Rat   768 CREGF-VKAPDG--------KMCLTRK---DDQILA-------------GDNADLSKEVASLDNS 807

  Fly   723 --SFITDS--TSSETPSAHTCLD----IDECSLANGNC-SH-FCQNEPGGFQCACPLGYALSEDM 777
              :::.|.  |.|.|..|...:.    .|:|  ..|.| || .|.:|.....|.|..|:|  .|.
  Rat   808 PKAYVPDDDRTESSTLVAEIMVSGLNYEDDC--GPGGCGSHAHCISEGEAAVCQCLKGFA--GDG 868

  Fly   778 RTCQDIDECLDSNGQC---SQLCLNQPGGFACACETGFELTPDGFGCADIDECSQDYGNCSD--I 837
            ..|.|||||...:..|   |..|:|..||:.|.|..|:|  .||..|.|:|||.|....||:  .
  Rat   869 NLCSDIDECELGSSDCPPTSSRCINTEGGYVCQCSEGYE--GDGIYCLDVDECQQGSHGCSENAT 931

  Fly   838 CINLLGTHACACERGYELAKDKLSCLDVDECAGLLSGGCSHECINKAGTFECGCPLGYILNDDGR 902
            |.|..|.:.|.|                                       .|||     :..|.
  Rat   932 CTNTEGGYNCTC---------------------------------------AGCP-----SAPGL 952

  Fly   903 SC----SPALVGCPPGTQRSADGCAPIE-----CNPGYTLGSDDKCVDIDECQKQNGGCSHRCSN 958
            .|    ||:|:|        .|||..:.     |.|.|    |..|:        |||.   |..
  Rat   953 PCPDSTSPSLLG--------KDGCHWVRNSITGCPPSY----DGYCL--------NGGV---CMY 994

  Fly   959 TEG--SFKCSCPPGYELDSDQKTCQDID---------ECDQDKTSCITGTCINEI---------G 1003
            .|.  .:.|:|..||    ..:.||..|         :..|.....:...|:..:         |
  Rat   995 VESVDRYVCNCVIGY----IGERCQHRDLRWWKLRHADYGQRHDITVVSVCVVALALLLLLGMWG 1055

  Fly  1004 GF----RCEFPKFPVLPEIPTASSL----PESPKIELKTPKYPDFTEL-SNEIPENPKKPA 1055
            .:    |.:..:....|...::|::    |:|....:.:...|.|..| .::.|:|.:.||
  Rat  1056 TYYYRTRKQLSESSKKPSEESSSNVSSNGPDSSGAGVSSGPQPWFVVLEEHQQPKNGRLPA 1116

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342	16/34 (47%)
		cEGF	396..415	CDD:289433	6/18 (33%)
		FXa_inhibition	425..458	CDD:291342	12/33 (36%)
		FXa_inhibition	476..505	CDD:291342	11/42 (26%)
		vWFA	<550..586	CDD:294047	8/52 (15%)
		FXa_inhibition	596..630	CDD:291342	6/34 (18%)
		FXa_inhibition	636..>664	CDD:291342	11/27 (41%)
		EGF_CA	676..715	CDD:284955	7/38 (18%)
		FXa_inhibition	745..780	CDD:291342	12/36 (33%)
		FXa_inhibition	786..821	CDD:291342	13/37 (35%)
		FXa_inhibition	827..862	CDD:291342	9/36 (25%)
		FXa_inhibition	874..904	CDD:291342	4/29 (14%)
		FXa_inhibition	945..980	CDD:291342	9/36 (25%)
		CCP	1110..1170	CDD:153056
		CCP	1183..1235	CDD:153056
		DUF5011	1468..1536	CDD:295940
Egf	NP_036974.2	LDL-receptor class B 1	87..128
		LDL-receptor class B 2	129..170
		LY	152..193	CDD:214531
		LDL-receptor class B 3	171..212
		LDL-receptor class B 4	213..259
		cEGF	339..360	CDD:403760	10/21 (48%)
		FXa_inhibition	361..396	CDD:405372	16/34 (47%)
		FXa_inhibition	402..437	CDD:405372	13/72 (18%)
		FXa_inhibition	444..477	CDD:405372	12/33 (36%)
		LDL-receptor class B 5	484..524		2/39 (5%)
		LY	505..547	CDD:214531	2/41 (5%)
		LDL-receptor class B 6	525..567		9/41 (22%)
		LY	548..590	CDD:214531	11/42 (26%)
		LDL-receptor class B 7	568..610		9/42 (21%)
		LY	591..634	CDD:214531	6/42 (14%)
		LDL-receptor class B 8	611..654		10/50 (20%)
		LY	634..677	CDD:214531	7/50 (14%)
		LDL-receptor class B 9	655..697		7/46 (15%)
		LY	678..719	CDD:214531	9/45 (20%)
		FXa_inhibition	746..781	CDD:405372	13/43 (30%)
		EGF_CA	839..871	CDD:419698	11/33 (33%)
		EGF_CA	873..913	CDD:214542	17/41 (41%)
		EGF_3	919..>943	CDD:403986	8/23 (35%)
		PHA03099	<974..>1016	CDD:165381	15/60 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1068..1096		4/27 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000