DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment frac and Vwa2

DIOPT Version :9

Sequence 1:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster
Sequence 2:	NP_766428.2	Gene:	Vwa2 / 240675	MGIID:	2684334	Length:	791	Species:	Mus musculus

Alignment Length:	222	Identity:	50/222 - (22%)
Similarity:	80/222 - (36%)	Gaps:	67/222 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   361 EPLEENPEITEVVENPIEKTNEVPVNVSESQPAGKTCNSGFQLSADGTDCQ-DINECE---VDGP 421
            ||.:.:..:.|.||   :.||.:...:|.|    ..|.     :|| .||: :.:.||   ::..
Mouse   198 EPKDRHVLLAEQVE---DATNGLLSTLSSS----ALCT-----TAD-PDCRVEPHPCERRTLETV 249

  Fly   422 EDLDNNAVCQQKCENTIGSFRCTCVEGYHLLEDQRSCALDSCTDLENPQLNRTRCAHECQDLPEG 486
            .:|..||:|.:      ||.:.                 |:...|..|..:..|.   .|..|..
Mouse   250 RELAGNALCWR------GSRQA-----------------DTVLALPCPFYSWKRV---FQTHPAN 288

  Fly   487 SYRCVCPKGYELSEDQHSCLVQESPCSTEKGVEKC-SPGTCLASEDNTSFSCICPTGYRSEAFSC 550
            .||.:||                .||.:    :.| :.|||: .|....:.|:||..:..|....
Mouse   289 CYRTICP----------------GPCDS----QPCQNGGTCI-PEGVDRYHCLCPLAFGGEVNCA 332

  Fly   551 QDID-ECAEDT-HLCSHTCQNTPGGYQ 575
            ..:. ||..|. .|...:...|.||::
Mouse   333 PKLSLECRIDVLFLLDSSAGTTLGGFR 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342
		cEGF	396..415	CDD:289433	5/19 (26%)
		FXa_inhibition	425..458	CDD:291342	5/32 (16%)
		FXa_inhibition	476..505	CDD:291342	6/28 (21%)
		vWFA	<550..586	CDD:294047	7/28 (25%)
		FXa_inhibition	596..630	CDD:291342
		FXa_inhibition	636..>664	CDD:291342
		EGF_CA	676..715	CDD:284955
		FXa_inhibition	745..780	CDD:291342
		FXa_inhibition	786..821	CDD:291342
		FXa_inhibition	827..862	CDD:291342
		FXa_inhibition	874..904	CDD:291342
		FXa_inhibition	945..980	CDD:291342
		CCP	1110..1170	CDD:153056
		CCP	1183..1235	CDD:153056
		DUF5011	1468..1536	CDD:295940
Vwa2	NP_766428.2	vWA_collagen	50..204	CDD:238749	2/5 (40%)
		EGF	298..328	CDD:278437	9/34 (26%)
		VWA	342..515	CDD:278519	5/18 (28%)
		vWFA	530..687	CDD:294047
		EGF_CA	712..747	CDD:238011
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	762..791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000