DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment frac and FBN2

DIOPT Version :9

Sequence 1:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster
Sequence 2:	NP_001990.2	Gene:	FBN2 / 2201	HGNCID:	3604	Length:	2912	Species:	Homo sapiens

Alignment Length:	1427	Identity:	381/1427 - (26%)
Similarity:	520/1427 - (36%)	Gaps:	523/1427 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   241 PTFLD-NNCGEDNGGCAH-ICKRLLYPDENQPINKCDCREGYTLDPNDYASCLDIDECLESNGGC 303
            |.:.| |.|....|.|.: .|:..:      ...||.|..|:.||..: .:|.|||||..|...|
Human  1069 PFYKDINECKAFPGMCTYGKCRNTI------GSFKCRCNSGFALDMEE-RNCTDIDECRISPDLC 1126

  Fly   304 -SEICENLPGEYKCSCQEGYYLDESG----KSCVDINEC-ANPELSSNCQ-GACENLPGSYRCVE 361
             |.||.|.||.::|.|.|||   |||    |:|:||:|| .||.|   |: |.|.|..||::|..
Human  1127 GSGICVNTPGSFECECFEGY---ESGFMMMKNCMDIDECERNPLL---CRGGTCVNTEGSFQCDC 1185

  Fly   362 PL--EENPEITEVVENPIEKTNEVPV--NVSESQPAGK----------TCNSGFQLSADGTDCQD 412
            ||  |.:|...:.|:     .||..:  |:..:   ||          :||.|:|.:.|...|.|
Human  1186 PLGHELSPSREDCVD-----INECSLSDNLCRN---GKCVNMIGTYQCSCNPGYQATPDRQGCTD 1242

  Fly   413 INECEVDGPEDLDNNAVCQQKCENTIGSFRCTCVEGYHLLEDQRSCA-LDSCTDLENPQLNRTRC 476
            |:||.:       .|..|..:|.|:.||:.|:|.|||.|:.|.|||| :|.|.:  ||.:    |
Human  1243 IDECMI-------MNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECEN--NPDI----C 1294

  Fly   477 -AHECQDLPEGSYRCVCPKGYELSEDQHSCL-VQE----------SPCSTEKG------------ 517
             ..:|.::| |.|||:|..|:..|.|..:|: |.|          ..|...||
Human  1295 DGGQCTNIP-GEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSV 1358

  Fly   518 ---------VEKCSPG--------TCLASEDNTSFSCICPTGYRSEAFSCQDIDECAEDTHLCS- 564
                     |::|..|        :||....  ||.|.|..|:......|.|:|||:..||.||
Human  1359 KKGTTGCTDVDECEIGAHNCDMHASCLNIPG--SFKCSCREGWIGNGIKCIDLDECSNGTHQCSI 1421

  Fly   565 -HTCQNTPGGYQCQCPEGLNLVEEYTCLAENLCEVNNNGCEQ-ICLTARGGV-CACREGFRLSAD 626
             ..|.||||.|:|.|.||.. .:.:||...:.|..|.|.||. .||...|.. |.|..||..::|
Human  1422 NAQCVNTPGSYRCACSEGFT-GDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASD 1485

  Fly   627 GKSCEDVDECLVNNGGCQQVCRNLPGSYGCICAAGYELLKLDGIRGYCFDIDECSQRTH------ 685
            .:||:|:|||...|......|.||||.:.|||..|||   ||...|.|.|||||:...:
Human  1486 SRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYE---LDRTGGNCTDIDECADPINCVNGLC 1547

  Fly   686 ----------------------GC----------------------------------------- 687
                                  ||
Human  1548 VNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGK 1612

  Fly   688 ----------------------------------------------------------------- 687

Human  1613 AWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCEC 1677

  Fly   688 -------SDQMLCENLN------------------GSYTCLCPPGYALGLDNHIVTSLNSSFITD 727
                   .|..:||:::                  |:|||:|||.|......|....:..||...
Human  1678 PQGYYLSEDTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYR 1742

  Fly   728 S---TSSE------------------------------TPSA-----------------HT--CL 740
            |   |:.|                              ||..                 ||  .:
Human  1743 SYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAV 1807

  Fly   741 DIDECSLANGNCSH-FCQNEPGGFQCACPLGYALSEDMRTCQDIDECLDSNGQCSQL--CLNQPG 802
            |||||....|.|:: .|.|:.|.|:|.||.|::.::.:..|:|||||.:.:..|.:.  |:|.||
Human  1808 DIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPG 1872

  Fly   803 GFACACETGFELTPDGFGCADIDECSQDYGNCS-DICINLLGTHACACERGYELAKDKLSCLDVD 866
            .:.|.|..||:|:|:| .|.|.:||.:....|| .:|::|.|::.|.|..|::.::|:..|:|||
Human  1873 SYRCECAAGFKLSPNG-ACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVD 1936

  Fly   867 ECAGLLSGGCSHECINKAGTFECGCPLGYIL---ND--DGRSCSPALVG--CPPGTQRSADGCAP 924
            ||.....|  :..|.|..|::.|.|..|:.|   ||  |...|| :..|  |..|...:..|...
Human  1937 ECERHPCG--NGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECS-SFFGQVCRNGRCFNEIGSFK 1998

  Fly   925 IECNPGYTLGSDDK-CVDIDECQKQNGGCS-HRCSNTEGSFKCSCPPGYELDSDQKTCQDIDECD 987
            ..||.||.|..|.| |:|.:||....|.|| ..|.|.||||:|.||||||:.|:  .|.||:|||
Human  1999 CLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSE--NCIDINECD 2061

  Fly   988 QDKTSCITGTCINEIGGFRCEFPKFPVLPE-----IPTASSLPESPKIELKTPKYPDFTELSNEI 1047
            :|...|:.|:|.|..|||:|..|...||.:     ..|..|.              .||..
Human  2062 EDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSF--------------CFTNF---- 2108

  Fly  1048 PENPKKPAEFDYPEPKFPSLPKWEGLPKLPPLADIPTSKAPVPLRPEVPKSLWVNQLQPRDLCPR 1112
             ||.|            .|:||           ...|:||.. ...::|...|.:   |.:|||:
Human  2109 -ENGK------------CSVPK-----------AFNTTKAKC-CCSKMPGEGWGD---PCELCPK 2145

  Fly  1113 -----FQ-----------APRNGKSHCNRYRHKQKLFYYSRC-------RISCNSGYILQGPEIK 1154
                 ||           :..:.:...|.......:....:|       |..|..||.|....::
Human  2146 DDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVR 2210

  Fly  1155 -------------------------SCDAN-GIWEGPETKCVAINQPRAQSP------------- 1180
                                     .|:.| |...||...|..||: .||:|
Human  2211 CVDTDECSIGNPCGNGTCTNVIGSFECNCNEGFEPGPMMNCEDINE-CAQNPLLCAFRCMNTFGS 2274

  Fly  1181 ----------------------------------------------GICP---ALKPAQNGVILP 1196
                                                          .|||   |.:|...|.:..
Human  2275 YECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDE 2339

  Fly  1197 ASCTQGPSRFGDVC------------RLQCNAGFVSTGSLLTACM-MLQGWSFGADLN--CQ 1243
            ..|...|.    :|            |.:||.||.|:.| .|.|: ..||..|...|.  ||
Human  2340 NECRTKPG----ICENGRCVNIIGSYRCECNEGFQSSSS-GTECLDNRQGLCFAEVLQTICQ 2396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342	18/39 (46%)
		cEGF	396..415	CDD:289433	8/18 (44%)
		FXa_inhibition	425..458	CDD:291342	14/32 (44%)
		FXa_inhibition	476..505	CDD:291342	11/29 (38%)
		vWFA	<550..586	CDD:294047	19/37 (51%)
		FXa_inhibition	596..630	CDD:291342	13/35 (37%)
		FXa_inhibition	636..>664	CDD:291342	12/27 (44%)
		EGF_CA	676..715	CDD:284955	18/197 (9%)
		FXa_inhibition	745..780	CDD:291342	11/35 (31%)
		FXa_inhibition	786..821	CDD:291342	13/36 (36%)
		FXa_inhibition	827..862	CDD:291342	10/35 (29%)
		FXa_inhibition	874..904	CDD:291342	11/34 (32%)
		FXa_inhibition	945..980	CDD:291342	18/35 (51%)
		CCP	1110..1170	CDD:153056	16/108 (15%)
		CCP	1183..1235	CDD:153056	19/67 (28%)
		DUF5011	1468..1536	CDD:295940
FBN2	NP_001990.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..52
		Interaction with MFAP4. /evidence=ECO:0000269\|PubMed:26601954	149..359
		TB	225..258	CDD:279073
		EGF_CA	276..>306	CDD:214542
		EGF_CA	318..358	CDD:284955
		TB	375..412	CDD:279073
		EGF_CA	535..565	CDD:214542
		EGF_CA	575..616	CDD:214542
		EGF_CA	617..649	CDD:238011
		cEGF	638..661	CDD:289433
		EGF_CA	658..698	CDD:214542
		TB	715..751	CDD:279073
		cEGF	790..813	CDD:289433
		EGF_CA	810..845	CDD:238011
		TB	907..>935	CDD:279073
		TB	1012..1047	CDD:279073
		EGF_CA	1115..1149	CDD:214542	19/36 (53%)
		EGF_CA	1158..1190	CDD:214542	16/34 (47%)
		EGF_CA	1200..1232	CDD:214542	8/39 (21%)
		cEGF	1223..1245	CDD:289433	8/21 (38%)
		FXa_inhibition	1246..1281	CDD:291342	15/41 (37%)
		Plasmod_Pvs28	1293..1446	CDD:283826	46/160 (29%)
		EGF_3	1371..1406	CDD:289699	9/36 (25%)
		EGF_3	1412..1447	CDD:289699	15/35 (43%)
		EGF_CA	1532..1563	CDD:214542	5/30 (17%)
		TB	1593..1628	CDD:279073	0/34 (0%)
		EGF_CA	1650..1683	CDD:238011	0/32 (0%)
		cEGF	1672..1695	CDD:289433	3/22 (14%)
		Interaction with MFAP4. /evidence=ECO:0000269\|PubMed:26601954	1735..2171		145/487 (30%)
		TB	1749..1786	CDD:279073	3/36 (8%)
		EGF_CA	1808..1840	CDD:214542	15/31 (48%)
		vWFA	<1847..1888	CDD:294047	17/40 (43%)
		vWFA	<1887..1929	CDD:294047	13/42 (31%)
		EGF_CA	1934..1968	CDD:214542	13/35 (37%)
		EGF_CA	1973..2015	CDD:214542	14/42 (33%)
		EGF_CA	2056..2096	CDD:214542	17/39 (44%)
		TB	2113..2150	CDD:279073	12/51 (24%)
		EGF_CA	2171..2212	CDD:214542	7/40 (18%)
		EGF_CA	2213..2252	CDD:214542	5/38 (13%)
		vWFA	<2251..2290	CDD:294047	6/39 (15%)
		TB	2397..2432	CDD:279073	381/1427 (27%)
		EGF_CA	2449..2490	CDD:214542
		vWFA	<2489..2529	CDD:294047
		vWFA	<2527..2563	CDD:294047
		EGF_CA	2614..>2643	CDD:214542
		Cadherin_repeat	<2826..>2873	CDD:206637
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D4721at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100900
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1431
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820