DRSC/TRiP Functional Genomics Resources

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Protein Alignment frac and VWCE

DIOPT Version :10

Sequence 1:NP_648137.3 Gene:frac / 38850 FlyBaseID:FBgn0035798 Length:1618 Species:Drosophila melanogaster
Sequence 2:NP_689931.2 Gene:VWCE / 220001 HGNCID:26487 Length:955 Species:Homo sapiens


Alignment Length:1051 Identity:226/1051 - (21%)
Similarity:321/1051 - (30%) Gaps:405/1051 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   270 PINKCDCREGYTLDPNDYASCLDIDE---CLESNGGCSEICENLPGEYKC-------SCQE---- 320
            |:....|..|..:.|| ..||.|.::   |.|::|.|        |||.|       .|||    
Human    69 PLCSFGCGSGICIAPN-VCSCQDGEQGATCPETHGPC--------GEYGCDLTCNHGGCQEVARV 124

  Fly   321 ---GYYLDES--GKSCVDINECANPELSSNCQGACENLPGSYRCVEPLEENPEITEVVENPIEKT 380
               |:.:.|:  |..|.||:||    ::|:|:|.|.|..|.:.|                     
Human   125 CPVGFSMTETAVGIRCTDIDEC----VTSSCEGHCVNTEGGFVC--------------------- 164

  Fly   381 NEVPVNVSESQPAGKTCNSGFQLSADGTDCQDINECEVDGPEDLDNNAVCQQKCENTIGSFRCTC 445
                           .|..|.|||||...|||.:|| :..|        |||:|:|:|||::|:|
Human   165 ---------------ECGPGMQLSADRHSCQDTDEC-LGTP--------CQQRCKNSIGSYKCSC 205

  Fly   446 VEGYHLLEDQRSCA-LDSCTDLENPQLNRTRCAHECQDLPEGSYRCVCPKGYELSEDQHSC---- 505
            ..|:||..::.||. ::.|   ..| |.|..|.|.|.: ..||:.|.|..|:.|..|:.||    
Human   206 RTGFHLHGNRHSCVDVNEC---RRP-LERRVCHHSCHN-TVGSFLCTCRPGFRLRADRVSCEAFP 265

  Fly   506 --------LVQ--ESPCS-----TEKGVEKCSPG----------------TCLASED-------- 531
                    ::|  :.|..     .|.|....|||                |.|.|..        
Human   266 KAVLAPSAILQPRQHPSKMLLLLPEAGRPALSPGHSPPSGAPGPPAGVRTTRLPSPTPRLPTSSP 330

  Fly   532 -------NTSFSCICPTG-----------YRSEAFSCQDIDECAEDTHL------CSH------- 565
                   :|..:...||.           .:.|...........|...|      |.|       
Human   331 SAPVWLLSTLLATPVPTASLLGNLRPPSLLQGEVMGTPSSPRGPESPRLAAGPSPCWHLGAMHES 395

  Fly   566 -TCQNTPGGYQCQCPEGLNLVEEYTCLAENLCEVNNNGCEQICLTARGGVC-AC----------R 618
             :....||..||.|.:|....|:..|.|         .|.....:..||.| :|          .
Human   396 RSRWTEPGCSQCWCEDGKVTCEKVRCEA---------ACSHPIPSRDGGCCPSCTGCFHSGVVRA 451

  Fly   619 EGFRLSADGKSCEDVDECLVNNGGC------QQVCRNLPGSYGCICAAGYELLKLDGIRGYCFDI 677
            ||...|...::| .|..||..|..|      ...|:..|.:..|.|..         :|.|....
Human   452 EGDVFSPPNENC-TVCVCLAGNVSCISPECPSGPCQTPPQTDCCTCVP---------VRCYFHGR 506

  Fly   678 ------------DECSQRTHGCSDQMLCENLNGSYTCLCPPGYALGLDNHIVTSLNSSFITDSTS 730
                        |||:                   ||:|..|           .:..||:     
Human   507 WYADGAVFSGGGDECT-------------------TCVCQNG-----------EVECSFM----- 536

  Fly   731 SETPSAHTCLDIDECSLANGNCSHFCQNEPGGFQCA-------------------CPLGYALSED 776
               |........:|..|..|.|...||.......|:                   |.|....::.
Human   537 ---PCPELACPREEWRLGPGQCCFTCQEPTPSTGCSLDDNGVEFPIGQIWSPGDPCELCICQADG 598

  Fly   777 MRTCQDIDECLDS-------NGQCSQLCLNQPGG---------------------FACACETGFE 813
            ..:|:..| |:||       .|||   |.:...|                     .:|.|..|  
Human   599 SVSCKRTD-CVDSCPHPIRIPGQC---CPDCSAGCTYTGRIFYNNETFPSVLDPCLSCICLLG-- 657

  Fly   814 LTPDGFGCADID---ECSQDY---GNCSDICINLLGTHACACERGYELAKDKLSCLDVDECAGLL 872
                ...|:.:|   .|:..:   |.|..:|      ..|..| |.::|..::..||.:.|.   
Human   658 ----SVACSPVDCPITCTYPFHPDGECCPVC------RDCNYE-GRKVANGQVFTLDDEPCT--- 708

  Fly   873 SGGCSHECINKAGTFECGCPLGYILNDD---GRSCS-PALV------GCPPGTQRSADGCAPIEC 927
                           .|.|.||.:..:.   .|:|: |||:      .||       |..:|:|.
Human   709 ---------------RCTCQLGEVSCEKVPCQRACADPALLPGDCCSSCP-------DSLSPLEE 751

  Fly   928 NPGYTLGSDDKCVDIDECQKQNGGCSHRCSNTEGSFKCSCPPGYELDSDQKTCQDIDECDQDKTS 992
            ..|.   |....|...:..:...|      :||....||..||....|..:....:.:.      
Human   752 KQGL---SPHGNVAFSKAGRSLHG------DTEAPVNCSSCPGPPTASPSRPVLHLLQL------ 801

  Fly   993 CITGTCINEIGGFRCEFPKFPVLPEIPTASSLPESPKIELKTPKYPDFTELSNEIPENPKKPAEF 1057
                       ..|....|...||..|..:..|.|..:.| |..:|.....|..:...|..|   
Human   802 -----------LLRTNLMKTQTLPTSPAGAHGPHSLALGL-TATFPGEPGASPRLSPGPSTP--- 851

  Fly  1058 DYPEPKFPSLP-KWEGLPKLPPL----------ADIPTSKAPVP-----------LRPEVPKSLW 1100
                |..|:|| ...|.|:.||:          |.|.:...|:|           :....|....
Human   852 ----PGAPTLPLASPGAPQPPPVTPERSFSASGAQIVSRWPPLPGTLLTEASALSMMDPSPSKTP 912

  Fly  1101 VNQLQPRDLCP 1111
            :..|.||.|.|
Human   913 ITLLGPRVLSP 923

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fracNP_648137.3 FXa_inhibition 296..331 CDD:464251 14/50 (28%)
cEGF 396..415 CDD:463661 10/18 (56%)
FXa_inhibition 425..458 CDD:464251 13/32 (41%)
FXa_inhibition 476..505 CDD:464251 10/28 (36%)
EGF_CA 552..>581 CDD:214542 9/42 (21%)
FXa_inhibition 596..630 CDD:464251 8/44 (18%)
FXa_inhibition 636..>664 CDD:464251 8/33 (24%)
EGF_CA 676..711 CDD:214542 7/46 (15%)
FXa_inhibition 745..780 CDD:464251 8/53 (15%)
FXa_inhibition 786..821 CDD:464251 11/62 (18%)
vWFA <821..861 CDD:469594 10/45 (22%)
FXa_inhibition 874..904 CDD:464251 5/32 (16%)
FXa_inhibition 945..980 CDD:464251 8/34 (24%)
PTZ00449 <1017..>1098 CDD:185628 22/102 (22%)
CCP 1110..1170 CDD:153056 1/2 (50%)
CCP 1183..1235 CDD:153056
HYR 1468..1536 CDD:460572
VWCENP_689931.2 EGF_CA 142..180 CDD:214542 18/77 (23%)
FXa_inhibition 190..218 CDD:464251 13/27 (48%)
EGF_CA 220..262 CDD:214542 15/46 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 292..329 7/36 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 360..380 2/19 (11%)
VWC 386..440 CDD:450195 15/62 (24%)
VWC 443..>488 CDD:450195 10/45 (22%)
VWC 501..559 CDD:450195 15/95 (16%)
VWC 572..625 CDD:214564 11/56 (20%)
VWC 629..684 CDD:450195 8/60 (13%)
VWC 687..742 CDD:450195 16/73 (22%)
PHA03247 <726..944 CDD:223021 52/239 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 812..889 21/84 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 903..955 6/21 (29%)
Blue background indicates that the domain is not in the aligned region.

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