DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment frac and FBN1

DIOPT Version :9

Sequence 1:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster
Sequence 2:	NP_000129.3	Gene:	FBN1 / 2200	HGNCID:	3603	Length:	2871	Species:	Homo sapiens

Alignment Length:	1277	Identity:	360/1277 - (28%)
Similarity:	474/1277 - (37%)	Gaps:	397/1277 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   230 ASVKVTNDPYEPTFLD-NNCGEDNGGCAH-ICKRLLYPDENQPINKCDCREGYTLDPNDYASCLD 292
            |:.::||.  :|.|.| |.|......|.| .|:..:      ...||.|..|:.|| ::..:|.|
Human  1015 ATKEITNG--KPFFKDINECKMIPSLCTHGKCRNTI------GSFKCRCDSGFALD-SEERNCTD 1070

  Fly   293 IDECLESNGGCSE-ICENLPGEYKCSCQEGYYLDESG----KSCVDINECANPELSSNCQ-GACE 351
            ||||..|...|.. .|.|.||:::|.|.|||   |||    |:|:||:||....|.  |: |.|.
Human  1071 IDECRISPDLCGRGQCVNTPGDFECKCDEGY---ESGFMMMKNCMDIDECQRDPLL--CRGGVCH 1130

  Fly   352 NLPGSYRCVEP--LEENPEITEVVE-NPIEKTNEVPVNVSESQPAGK---TCNSGFQLSADGTDC 410
            |..|||||..|  .:.:|.|:..:: |..|.:..:..|.......||   .||.|:..:.|...|
Human  1131 NTEGSYRCECPPGHQLSPNISACIDINECELSAHLCPNGRCVNLIGKYQCACNPGYHSTPDRLFC 1195

  Fly   411 QDINECEVDGPEDLDNNAVCQQKCENTIGSFRCTCVEGYHLLEDQRSCA-LDSCTDLENPQLNRT 474
            .||:||.:       .|..|:..|.|:.||:.|:|..|:.|:.|||||. :|.|.|  ||.:
Human  1196 VDIDECSI-------MNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTDIDECED--NPNI--- 1248

  Fly   475 RC-AHECQDLPEGSYRCVCPKGYELSEDQHSCLVQESPCSTEKGVEKCSPGTCLASEDNT----- 533
             | ..:|.::| |.|||:|..|:..|||..:| |..:.|.....:  |..|||    :||
Human  1249 -CDGGQCTNIP-GEYRCLCYDGFMASEDMKTC-VDVNECDLNPNI--CLSGTC----ENTKGSFI 1304

  Fly   534 ----------------------------------------SFSCICPTGYRSEAFSCQDIDECAE 558
                                                    ||.|.|..|:..:...|.|:|||:.
Human  1305 CHCDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGWIGDGIKCTDLDECSN 1369

  Fly   559 DTHLCSH--TCQNTPGGYQCQCPEGLNLVEEYTCLAENLCEVNNNGC-EQICLTARGGV-CACRE 619
            .||:||.  .|:||.|.|:|.|.||.. .:.:||...:.|..|.|.| ...||.|.||. |.|..
Human  1370 GTHMCSQHADCKNTMGSYRCLCKEGYT-GDGFTCTDLDECSENLNLCGNGQCLNAPGGYRCECDM 1433

  Fly   620 GFRLSADGKSCEDVDECLVNNGGCQQVCRNLPGSYGCICAAGYELLKLDGIRGYCFDIDECSQRT 684
            ||..|||||:|||:|||.:.|......|.||||.:.|.|..|||   ||...|.|.|::||...|
Human  1434 GFVPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCECEIGYE---LDRSGGNCTDVNECLDPT 1495

  Fly   685 HGCSDQMLCENLNGSYTCLCPP------------------------------------------- 706
            ...|..  |.|..|||.|.|||
Human  1496 TCISGN--CVNTPGSYICDCPPDFELNPTRVGCVDTRSGNCYLDIRPRGDNGDTACSNEIGVGVS 1558

  Fly   707 --------GYALGLDNHIVTSLNSS---FITDSTSSETPSAHTCL--DIDECSLANGNC-SHFCQ 757
                    |.|.|....:..::|:|   .:........|:..|.:  |||||....|.| ...|.
Human  1559 KASCCCSLGKAWGTPCEMCPAVNTSEYKILCPGGEGFRPNPITVILEDIDECQELPGLCQGGKCI 1623

  Fly   758 NEPGGFQCACPLGYALSEDMRTCQDIDECLDSNGQCSQ-LCLNQPGGFACACETGFELTPDGFGC 821
            |..|.|||.||.||.|:||.|.|.|::|| ::.|.|.. .|.|..|.:.|.|...:.....|..|
Human  1624 NTFGSFQCRCPTGYYLNEDTRVCDDVNEC-ETPGICGPGTCYNTVGNYTCICPPDYMQVNGGNNC 1687

  Fly   822 ----------------------------------------------------------------- 821

Human  1688 MDMRRSLCYRNYYADNQTCDGELLFNMTKKMCCCSYNIGRAWNKPCEQCPIPSTDEFATLCGSQR 1752

  Fly   822 ------------ADIDECSQDYGNCSD-ICINLLGTHACACERGYELAKDKLSCLDVDEC----- 868
                        .|||||.:..|.|.: :|||::|:..|.|..|:......|.|.|:|||
Human  1753 PGFVIDIYTGLPVDIDECREIPGVCENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPV 1817

  Fly   869 ----------AG-----------LLSGG--------------CSH-ECINKAGTFECGCPLGYIL 897
                      ||           ..|.|              ||| :||:..|:|.|.|..|:..
Human  1818 CQRNAECINTAGSYRCDCKPGYRFTSTGQCNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKT 1882

  Fly   898 NDDGRSC----SPALVGCPPGTQRSADGCAPIECNPGYTLGSDDKCVDIDECQKQNGG-CSH-RC 956
            |||...|    ......|..||.|:..|.....||.|:.|..::.|:|:|||...||. |.: :|
Human  1883 NDDQTMCLDINECERDACGNGTCRNTIGSFNCRCNHGFILSHNNDCIDVDECASGNGNLCRNGQC 1947

  Fly   957 SNTEGSFKCSCPPGYELDSDQKTCQDIDECDQDKTSCITGTCINEIGGFRCEFPKFPVLPEIPTA 1021
            .||.|||:|.|..|||:..|.:||.||:||..:...|..|||.|..|.:||..|
Human  1948 INTVGSFQCQCNEGYEVAPDGRTCVDINECLLEPRKCAPGTCQNLDGSYRCICP----------- 2001

  Fly  1022 SSLPESPKIELKTPKYPDFTELSNEIPE--------NPKKPAEFDYPEPKFPSL----------- 1067
                  |...|:..|..|..|...| ||        |.:  ..|....|:..||
Human  2002 ------PGYSLQNEKCEDIDECVEE-PEICALGTCSNTE--GSFKCLCPEGFSLSSSGRRCQDLR 2057

  Fly  1068 -----PKWEGLPKLPPLADIPTSK-----------------APVPLRPEVPKSLWVNQLQPRDLC 1110
                 .|:||     .....|.|:                 .|..|.|..|...:      |.:|
Human  2058 MSYCYAKFEG-----GKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAF------RQIC 2111

  Fly  1111 PR----FQAPRNG---KSHCNR---YRHKQKLFYYSRCRISCNSGYILQGPEIKSCD-------- 1157
            |.    ...|.:.   ...|..   .:|.|.:......|..|..||||.|.|....|
Human  2112 PYGSGIIVGPDDSAVDMDECKEPDVCKHGQCINTDGSYRCECPFGYILAGNECVDTDECSVGNPC 2176

  Fly  1158 ----------------ANGIWEGPETKCVAINQPRAQSPGIC 1183
                            ..|...||...|..||: .||:|.:|
Human  2177 GNGTCKNVIGGFECTCEEGFEPGPMMTCEDINE-CAQNPLLC 2217

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342	16/39 (41%)
		cEGF	396..415	CDD:289433	7/18 (39%)
		FXa_inhibition	425..458	CDD:291342	13/32 (41%)
		FXa_inhibition	476..505	CDD:291342	12/29 (41%)
		vWFA	<550..586	CDD:294047	18/37 (49%)
		FXa_inhibition	596..630	CDD:291342	18/35 (51%)
		FXa_inhibition	636..>664	CDD:291342	11/27 (41%)
		EGF_CA	676..715	CDD:284955	17/89 (19%)
		FXa_inhibition	745..780	CDD:291342	17/35 (49%)
		FXa_inhibition	786..821	CDD:291342	9/35 (26%)
		FXa_inhibition	827..862	CDD:291342	11/35 (31%)
		FXa_inhibition	874..904	CDD:291342	14/44 (32%)
		FXa_inhibition	945..980	CDD:291342	16/36 (44%)
		CCP	1110..1170	CDD:153056	18/93 (19%)
		CCP	1183..1235	CDD:153056	1/1 (100%)
		DUF5011	1468..1536	CDD:295940
FBN1	NP_000129.3	TB	195..>228	CDD:334208
		EGF_CA	246..>276	CDD:214542
		EGF_CA	288..329	CDD:214542
		TB	345..389	CDD:334208
		EGF_CA	490..521	CDD:214542
		EGF_CA	530..571	CDD:214542
		EGF_CA	572..612	CDD:214542
		EGF_CA	613..646	CDD:214542
		TB	670..711	CDD:334208
		EGF_CA	723..763	CDD:311536
		EGF_CA	765..806	CDD:238011
		TB	862..>894	CDD:334208
		TB	967..1009	CDD:334208
		EGF_CA	1070..1104	CDD:214542	17/36 (47%)
		EGF_CA	1113..1149	CDD:214542	15/37 (41%)
		EGF_CA	1155..1188	CDD:214542	8/32 (25%)
		vWFA	<1194..1235	CDD:350880	17/47 (36%)
		EGF_3	1326..1361	CDD:315598	5/34 (15%)
		EGF_3	1367..1402	CDD:315598	14/35 (40%)
		cEGF	1426..1449	CDD:338440	13/22 (59%)
		EGF_CA	1446..1486	CDD:214542	18/42 (43%)
		EGF_CA	1487..1518	CDD:214542	14/32 (44%)
		TB	1549..1590	CDD:334208	5/40 (13%)
		EGF_CA	1606..1638	CDD:214542	16/31 (52%)
		EGF_CA	1648..1687	CDD:214542	11/39 (28%)
		TB	1706..1749	CDD:334208	0/42 (0%)
		EGF_CA	1766..>1797	CDD:214542	13/30 (43%)
		EGF_CA	1808..1840	CDD:214542	6/31 (19%)
		vWFA	<1847..1886	CDD:350880	12/38 (32%)
		EGF_CA	1930..1971	CDD:311536	19/40 (48%)
		EGF_CA	1973..2008	CDD:238011	15/51 (29%)
		EGF_CA	2013..2053	CDD:354843	10/42 (24%)
		TB	2070..2112	CDD:334208	7/47 (15%)
		EGF_CA	2127..2165	CDD:214542	11/37 (30%)
		EGF_CA	2166..2205	CDD:214542	4/38 (11%)
		vWFA	<2289..2328	CDD:350880
		TB	2356..2391	CDD:334208
		vWFA	<2442..2482	CDD:350880
		cEGF	2465..2488	CDD:338440
		EGF_CA	2485..>2516	CDD:354843
		EGF_CA	2524..2566	CDD:214542
		EGF_CA	2567..>2596	CDD:214542
		EGF_CA	2607..2638	CDD:214542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BA2W
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D4721at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100900
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1431
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.720