DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment frac and FBLN2

DIOPT Version :9

Sequence 1:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster
Sequence 2:	NP_001004019.1	Gene:	FBLN2 / 2199	HGNCID:	3601	Length:	1231	Species:	Homo sapiens

Alignment Length:	1022	Identity:	275/1022 - (26%)
Similarity:	382/1022 - (37%)	Gaps:	285/1022 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 ENGISEMFCS-NQKWVDEIPTCI---PQLNFEEH--------------DEKVGYDLEDYSDETVP 139
            |..::|...: ..:.:|.:||..   |.|..:|.              :|.:..|.:..|..|.|
Human   289 EMAVTEQLAAGGHRGLDGLPTTAPAGPSLPIQEERAEAGARAEAGARPEENLILDAQATSRSTGP 353

  Fly   140 NDYVENSDIDEDDDEEVSEREPPPPPPPPVVDGADSKPEPQIVIEINDDHANEVVESEPALAETE 204
            ........:.:  ...|..:..|..|..||      ||.|..::..:...|..:    |...|..
Human   354 EGVTHAPSLGK--AALVPTQAVPGSPRDPV------KPSPHNILSTSLPDAAWI----PPTREVP 406

  Fly   205 TENEVLENETPLKAEVQTDVLNSSNASVKVTNDPYEPTFLDNNCGE------DNGGCAHICKRLL 263
            .:.:||.:.   ..|..||. ||.::..:.:.:......::..|..      ||..|..|
Human   407 RKPQVLPHS---HVEEDTDP-NSVHSIPRSSPEGSTKDLIETCCAAGQQWAIDNDECLEI----- 462

  Fly   264 YPDENQPINKC-----DCREGYTLDPNDYASCLDIDE---C-LESNGGC-----SEICENLPGEY 314
             |:.....|.|     .|...|..:.:..|..|...|   | .|.|..|     .:.|:
Human   463 -PESGTEDNVCRTAQRHCCVSYLQEKSCMAGVLGAKEGETCGAEDNDSCGISLYKQCCD------ 520

  Fly   315 KCSCQEGYYLDESGKSCVDINECANPELSSNCQ----GACENLPGSYRCVEPLEENPEITEVVEN 375
             | |..|..:...|:||.     :||.|...|.    ..||.            |.|.|...|..
Human   521 -C-CGLGLRVRAEGQSCE-----SNPNLGYPCNHVMLSCCEG------------EEPLIVPEVRR 566

  Fly   376 PIEKTNEVPVNVSESQPAGKTCNSGFQLSADGTDCQDINECEVDGPED--LDNNAVCQQKCENTI 438
            |.|.. ..|..|||::.||:..     ||. ||:.:..|....|..::  |....:||..|.||:
Human   567 PPEPA-AAPRRVSEAEMAGREA-----LSL-GTEAELPNSLPGDDQDECLLLPGELCQHLCINTV 624

  Fly   439 GSFRCTCVEGYHLLEDQRSC---------------ALDS--------CTDLENPQLNRTR----C 476
            ||:.|.|..|:.|.:|.|:|               ||.|        ...|..||.|..:    |
Human   625 GSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTIPLPLPQPNTCKDNGPC 689

  Fly   477 AHECQDLPEGSYRCVCPKGYEL------SEDQHSCLVQESPCSTEKGVEKCSPGTCLASEDNT-- 533
            ...|..: .||..|.|..||.:      .|||..||:....||..:        .|:    ||
Human   690 KQVCSTV-GGSAICSCFPGYAIMADGVSCEDQDECLMGAHDCSRRQ--------FCV----NTLG 741

  Fly   534 SFSCI-----CPTGYRSEAF-SCQDIDECAEDTHLCS--HTCQNTPGGYQCQCPEGLNLVEEYTC 590
            ||.|:     |..||...|. .|.||:||..|.|.||  ..|.||.|.:.|           |..
Human   742 SFYCVNHTVLCADGYILNAHRKCVDINECVTDLHTCSRGEHCVNTLGSFHC-----------YKA 795

  Fly   591 LAENLCEVNNNGCEQICLTARGGVCACREGFRLSADGKSCEDVDECLVNNGGCQQ--VCRNLPGS 653
            |                        .|..|:.|. ||: |||||||.:....||.  :|:|..||
Human   796 L------------------------TCEPGYALK-DGE-CEDVDECAMGTHTCQPGFLCQNTKGS 834

  Fly   654 YGC----ICAAGYELLKLDGIRGYCFDIDECSQRTHGCSDQMLCENLNGSYTC-----LCPPGYA 709
            :.|    .|..|:    |....|.|.||:||:..:..|.....|.|..|||||     :|..||.
Human   835 FYCQARQRCMDGF----LQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYH 895

  Fly   710 LGLDNHIVTSLNSSFITDSTSSETPSAHTCLDIDECSLANGNC--SHFCQNEPGGFQCACPLGYA 772
            ..              .|.|.        |:|::||......|  ...|.|.||.::|.|..|:.
Human   896 AS--------------DDGTK--------CVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQ 938

  Fly   773 LSEDMRTCQDIDECLDSNGQ-CSQLCLNQPGGFACACETGFELTPDGFGCADIDECSQDYGNCSD 836
            .....|.|.|::||..|.|: |...|.|..|.:.|:|.:||.|..||..|.|::||...  .||.
Human   939 RDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQ--RCSQ 1001

  Fly   837 ICINLLGTHACACERGYELAKDKLSCLDVDEC---AGLLSGGCSHECINKAGTFECGCP-LGYIL 897
            .|.|:.|::.|.|.:||:||:|..:|.|:|||   ||:|   |:..|:|..|:::|.|| .||.:
Human  1002 ECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGIL---CTFRCLNVPGSYQCACPEQGYTM 1063

  Fly   898 NDDGRSCSPALVGCPPGTQRSADGCAPIECNPGYTLGSDDKCVDIDECQKQNGGCS--HRCSNTE 960
            ..:||||.                                   |:|||......||  ..|.|.:
Human  1064 TANGRSCK-----------------------------------DVDECALGTHNCSEAETCHNIQ 1093

  Fly   961 GSFKC---SCPPGY----ELDSDQKTCQDIDECDQDKTSCITGTCIN 1000
            |||:|   .|||.|    :...::.||.|..|| |:..:.||...:|
Human  1094 GSFRCLRFECPPNYVQVSKTKCERTTCHDFLEC-QNSPARITHYQLN 1139

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342	9/40 (23%)
		cEGF	396..415	CDD:289433	4/18 (22%)
		FXa_inhibition	425..458	CDD:291342	13/32 (41%)
		FXa_inhibition	476..505	CDD:291342	11/34 (32%)
		vWFA	<550..586	CDD:294047	14/37 (38%)
		FXa_inhibition	596..630	CDD:291342	5/33 (15%)
		FXa_inhibition	636..>664	CDD:291342	10/33 (30%)
		EGF_CA	676..715	CDD:284955	15/43 (35%)
		FXa_inhibition	745..780	CDD:291342	10/36 (28%)
		FXa_inhibition	786..821	CDD:291342	14/35 (40%)
		FXa_inhibition	827..862	CDD:291342	13/34 (38%)
		FXa_inhibition	874..904	CDD:291342	11/30 (37%)
		FXa_inhibition	945..980	CDD:291342	13/43 (30%)
		CCP	1110..1170	CDD:153056
		CCP	1183..1235	CDD:153056
		DUF5011	1468..1536	CDD:295940
FBLN2	NP_001004019.1	ANATO	430..490	CDD:237984	10/65 (15%)
		ANATO	515..563	CDD:237984	16/72 (22%)
		FXa_inhibition	616..644	CDD:291342	13/27 (48%)
		vWFA	<717..759	CDD:294047	16/53 (30%)
		EGF_CA	766..>802	CDD:214542	16/70 (23%)
		EGF_CA	811..855	CDD:284955	16/47 (34%)
		EGF_CA	857..904	CDD:214542	17/68 (25%)
		EGF_CA	905..947	CDD:214542	12/41 (29%)
		vWFA	<946..986	CDD:294047	16/39 (41%)
		cEGF	970..993	CDD:289433	9/22 (41%)
		cEGF	1009..1032	CDD:289433	9/22 (41%)
		cEGF	1051..1075	CDD:289433	10/58 (17%)
		EGF_CA	1072..1120	CDD:284955	16/47 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2524
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940