DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment frac and FBLN1

DIOPT Version :9

Sequence 1:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster
Sequence 2:	NP_006477.3	Gene:	FBLN1 / 2192	HGNCID:	3600	Length:	703	Species:	Homo sapiens

Alignment Length:	661	Identity:	194/661 - (29%)
Similarity:	275/661 - (41%)	Gaps:	183/661 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   445 CVEGYHLLEDQRSCALDSCTDLENPQLNRTRCAH-ECQDLPEGSYRCVCPKGYELSEDQHSCLVQ 508
            |.:|:.:...|:.|:|...|:.:..::.:.:|.| :.::|.       |..|..|:.:|
Human    37 CADGHRMATHQKDCSLPYATESKECRMVQEQCCHSQLEELH-------CATGISLANEQ------ 88

  Fly   509 ESPCSTEKGVEKCSPGTCLASEDNTSFS----------CICPTGYRSEAFSCQDI----DECAED 559
             ..|:|..|             ||.|..          |:.....:::..||:..    .:|.:.
Human    89 -DRCATPHG-------------DNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQV 139

  Fly   560 THLCSHTCQNT----PGGYQCQCPEGLNLVEE----YTCLAENLCEVNNNGCEQICL-TARGGVC 615
            ...|....|.|    .||.| :..:.:.:.||    |   ..:.|. ....|:|.|. |....||
Human   140 FQACCVKSQETGDLDVGGLQ-ETDKIIEVEEEQEDPY---LNDRCR-GGGPCKQQCRDTGDEVVC 199

  Fly   616 ACREGFRLSADGKSCEDVDECLVNNGGCQ--QVCRNLPGSYGC----ICAAGYELLKLDGIRGYC 674
            :|..|::|.:||.|||||:||:..:..|:  :.|.|..||:.|    .|..||||.:.:.    |
Human   200 SCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNS----C 260

  Fly   675 FDIDECSQRTHGCSDQMLCENLNGSYTC----LCPPGYALGLDNHIVTSLNSSFITDSTSSETPS 735
            .|||||....|.|....:|:|..||:.|    .|                .|.||.|:..:
Human   261 KDIDECESGIHNCLPDFICQNTLGSFRCRPKLQC----------------KSGFIQDALGN---- 305

  Fly   736 AHTCLDIDECSLANGNC--SHFCQNEPGGFQCA-----CPLGYALSEDMRTCQDIDECLDSNGQC 793
               |:||:||...:..|  .|.|.|..|.:.|.     |..||.|:|:...|.|:|||......|
Human   306 ---CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPC 367

  Fly   794 SQ--LCLNQPGGFACACETGFELTPDGFG--CADIDECSQDYGN-CSDICINLLGTHACACERGY 853
            .:  .|:|.||.|.|.|:||:..  ||..  |.|::||.:..|. |...|.|.||::.|:|..|:
Human   368 GKGHRCVNSPGSFRCECKTGYYF--DGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGF 430

  Fly   854 ELAKDKLSCLDVDECAGLLSGGCSHECINKAGTFECGCPLGYILNDDGRSCSPALVGCPPGTQRS 918
            .|:.|..||.|::||:   |..||.||.|..|:::|.|..||.|:|
Human   431 RLSVDGRSCEDINECS---SSPCSQECANVYGSYQCYCRRGYQLSD------------------- 473

  Fly   919 ADGCAPIECNPGYTLGSDDKCVDIDECQKQNGG--CSHRCSNTEGSFKCSCP-PGYELDSDQKTC 980
            .||..               |.|||||....||  ||:||.|..|||:|||| .||.|..:.:.|
Human   474 VDGVT---------------CEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNC 523

  Fly   981 QDIDECDQDKTSC-ITGTCINEIGGFRCEFPKFPVLPEIPTASSLPESPKIELKTPKYPDFTELS 1044
            ||||||.....:| |..||.|..|||||                                   |:
Human   524 QDIDECVTGIHNCSINETCFNIQGGFRC-----------------------------------LA 553

  Fly  1045 NEIPENPKKPA 1055
            .|.|||.::.|
Human   554 FECPENYRRSA 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342
		cEGF	396..415	CDD:289433
		FXa_inhibition	425..458	CDD:291342	3/12 (25%)
		FXa_inhibition	476..505	CDD:291342	7/29 (24%)
		vWFA	<550..586	CDD:294047	8/43 (19%)
		FXa_inhibition	596..630	CDD:291342	12/34 (35%)
		FXa_inhibition	636..>664	CDD:291342	10/33 (30%)
		EGF_CA	676..715	CDD:284955	13/42 (31%)
		FXa_inhibition	745..780	CDD:291342	12/41 (29%)
		FXa_inhibition	786..821	CDD:291342	13/38 (34%)
		FXa_inhibition	827..862	CDD:291342	12/35 (34%)
		FXa_inhibition	874..904	CDD:291342	12/29 (41%)
		FXa_inhibition	945..980	CDD:291342	18/37 (49%)
		CCP	1110..1170	CDD:153056
		CCP	1183..1235	CDD:153056
		DUF5011	1468..1536	CDD:295940
FBLN1	NP_006477.3	vWFA	<395..438	CDD:320736	15/42 (36%)
		cEGF	421..444	CDD:315355	8/22 (36%)
		cEGF	460..484	CDD:315355	11/57 (19%)
		vWFA	<479..522	CDD:320736	23/42 (55%)
		cEGF	504..528	CDD:315355	13/23 (57%)
		EGF_CA	525..>561	CDD:311536	20/70 (29%)
		ANATO	30..79	CDD:237984	9/48 (19%)
		ANATO	97..152	CDD:237984	10/54 (19%)
		EGF_CA	216..259	CDD:311536	15/42 (36%)
		EGF_CA	262..>298	CDD:328759	14/51 (27%)
		EGF_CA	308..355	CDD:214542	15/46 (33%)
		Self-association and FN1-binding, calcium is necessary for homotypic binding, but not for heterotypic binding	356..440		32/85 (38%)
		EGF_CA	356..389	CDD:238011	14/32 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2524
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940